Review
Oncology
Lucia Cerrito, Irene Mignini, Maria Elena Ainora, Carolina Mosoni, Antonio Gasbarrini, Maria Assunta Zocco
Summary: Hepatocellular carcinoma (HCC) risk is increased in nonalcoholic fatty liver disease (NAFLD), even without cirrhosis. New noninvasive tests have been proposed to predict HCC risk, and imaging techniques evaluating liver stiffness have gained increasing importance in this context.
Article
Radiology, Nuclear Medicine & Medical Imaging
Atsushi Tada, Toshiyuki Nagai, Yoshiya Kato, Kazunori Omote, Noriko Oyama-Manabe, Satonori Tsuneta, Yusuke Kudo, Mutsumi Nishida, Michikazu Nakai, Yuki Takahashi, Kohei Saiin, Seiichiro Naito, Yuta Kobayashi, Sakae Takenaka, Yoshifumi Mizuguchi, Kiwamu Kamiya, Takao Konishi, Takuma Sato, Kohsuke Kudo, Toshihisa Anzai
Summary: Liver stiffness measured by MRE is a predictor of clinical outcomes in patients with heart failure, independent of liver disease.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Duygu Demirtas, Emre Unal, Ilkay S. Idilman, Zuhal Akcoren, Mehmet Akif Goktas, Meryem Seda Boyraz, Sevilay Karahan, Diclehan Orhan, Mithat Haliloglu, Musturay Karcaaltincaba, Hasan Ozen
Summary: Magnetic resonance elastography (MRE) shows good agreement with the Ishak scoring system in evaluating liver fibrosis in children. MRE-LS values differ significantly among different Ishak fibrosis stages. MRE has high sensitivity and specificity for assessing liver fibrosis in pediatric patients.
INSIGHTS INTO IMAGING
(2023)
Article
Gastroenterology & Hepatology
Nabil Noureddin, Veeral Ajmera, Jaclyn Bergstrom, Richele Bettencourt, Daniel Q. Huang, Harris Siddiqi, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramzan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Rohit Loomba
Summary: MEFIB-Index and MAST-Score, which combine MRI-based biomarkers and blood tests, can predict the risk of hepatic decompensation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Virology
Mayu Higuchi, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Koji Yamashita, Yuka Hayakawa, Shuhei Sekiguchi, Leona Osawa, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Nobuyuki Enomoto, Namiki Izumi
Summary: Most patients achieved sustained virological response (SVR) with direct-acting antivirals (DAA) therapy, but some patients, especially those with advanced fibrosis, did not show improvement in liver stiffness after achieving SVR. Despite obtaining SVR, improvement in liver stiffness could not be obtained in some cases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Gastroenterology & Hepatology
Veeral Ajmera, Kaleb Tesfai, Erick Sandoval, Scarlett Lopez, Vanessa Cervantes, Egbert Madamba, Ricki Bettencourt, Pinelopi Manousou, Lisa Richards, Rohit Loomba
Summary: Validation of the AGA clinical pathway in a prospectively recruited cohort with T2DM revealed a low false negative rate and avoided specialty referral in a large percentage of patients. The AASLD pathway with FIB-4 + ELF resulted in a high rate of specialty referral, which improved with utilization of higher ELF cut-points.
Article
Gastroenterology & Hepatology
Jia-xu Liang, Javier Ampuero, Hao Niu, Kento Imajo, Mazen Noureddin, Jaideep Behari, Dae Ho Lee, Richard L. Ehman, Fredrik Rorsman, Johan Vessby, Juan R. Lacalle, Ferenc E. Mozes, Michael Pavlides, Quentin M. Anstee, Stephen A. Harrison, Javier Castell, Rohit Loomba, Manuel Romero-Gomez
Summary: This individual patient data meta-analysis aimed to establish stiffness cut-off values for magnetic resonance elastography (MRE) in staging liver fibrosis and assess potential confounding factors. The results showed that MRE has excellent diagnostic performance for significant fibrosis, advanced fibrosis, and cirrhosis. However, elevated inflammatory activity and GGT level may lead to overestimation of early liver fibrosis, while the degree of steatosis and body mass index (BMI) do not affect the results.
JOURNAL OF HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Shi, Ya-fei Qi, Gong-yu Lan, Qijun Wu, Bing Ma, Xian-yi Zhang, Ruo-yun Ji, Yu-jia Ma, Yang Hong
Summary: The study evaluated the value of multiparametric three-dimensional MR elastography in chronic hepatitis B and C, showing its potential in detecting early necroinflammation, distinguishing necroinflammation from liver fibrosis, and correlating with hepatic venous pressure gradient.
Article
Gastroenterology & Hepatology
Karim T. Osman, Daniel B. Maselli, Ilkay S. Idilman, Daniel J. Rowan, Jason K. Viehman, William S. Harmsen, Denise M. Harnois, Elizabeth J. Carey, Andrea A. Gossard, Nicholas F. LaRusso, Keith D. Lindor, Sudhakar K. Venkatesh, John E. Eaton
Summary: This study aimed to describe the diagnostic and prognostic performance of TE and MRE in patients with PBC, finding that LS measurements by both TE and MRE outperformed biochemical markers in predicting histologic advanced fibrosis and hepatic decompensation, offering additional prognostic value beyond existing serologic predictive tools.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sakura Kirino, Nobuharu Tamaki, Masayuki Kurosaki, Yuka Takahashi, Mayu Higuchi, Yoshie Itakura, Yuki Tanaka, Kento Inada, Shun Ishido, Koji Yamashita, Tsubasa Nobusawa, Hiroaki Matsumoto, Yuka Hayakawa, Tatsuya Kakegawa, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Ryuichi Okamoto, Namiki Izumi
Summary: This study found that shear wave measurement (SWM) has high diagnostic accuracy for advanced fibrosis and may be used as a screening tool for liver fibrosis in the general population.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Gastroenterology & Hepatology
Jiaxu Liang, Bo Qiu, Suo Yin, Yong Chen, Sijia Zhang
Summary: This study evaluates the accuracy of liver stiffness measurement (LSM) by magnetic resonance elastography (MRE) in predicting postoperative complications in patients with malignant liver tumors. The results suggest that LSM by MRE is a significant predictor of postoperative outcomes in patients undergoing liver resection.
Article
Multidisciplinary Sciences
Kessarin Thanapirom, Sirinporn Suksawatamnuay, Natthaporn Tanpowpong, Bundit Chaopathomkul, Supachaya Sriphoosanaphan, Panarat Thaimai, Nunthiya Srisoonthorn, Sombat Treeprasertsuk, Piyawat Komolmit
Summary: There is an urgent need for non-invasive tests (NITs) to monitor treatment response and disease progression in chronic liver disease. Different imaging techniques and serum markers show significant correlation with magnetic resonance elastography (MRE), which is considered the reference standard. The current NITs demonstrate good correlation and accuracy in monitoring treatment outcomes in patients with chronic liver diseases.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Nilay Danis, Sharon R. Weeks, Ahyoung Kim, Azarakhsh Baghdadi, Maryam Ghadimi, Ihab R. Kamel, Behnam Saberi, Tinsay Woreta, Jacqueline Garonzik-Wang, Benjamin Philosophe, Ahmet Gurakar, Rohit Loomba
Summary: Living donor liver transplantation (LDLT) has increased in the United States over the past decade in an effort to reduce waitlist mortality, but organ shortage remains an issue. The rise in nonalcoholic fatty liver disease (NAFLD) in the general population poses challenges for expanding the living liver donor pool. A clinical assessment algorithm that thoroughly evaluates for NAFLD and fibrosis is crucial for the safe expansion of LDLT.
LIVER TRANSPLANTATION
(2022)
Review
Gastroenterology & Hepatology
Monica A. Tincopa, Rohit Loomba
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common and challenging form of chronic liver disease. Non-alcoholic steatohepatitis (NASH), the more severe form of NAFLD, is difficult to diagnose without a liver biopsy. Non-invasive tests are needed to accurately identify patients with at-risk NASH and monitor treatment response. There is also a need for non-invasive tests to assess the risk of clinical outcomes. This review discusses the advancements in non-invasive tests for diagnosing and monitoring NAFLD and NASH.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Adriana Roca-Fernandez, Rajarshi Banerjee, Helena Thomaides-Brears, Alison Telford, Arun Sanyal, Stefan Neubauer, Thomas E. Nichols, Betty Raman, Celeste McCracken, Steffen E. Petersen, Ntobeko A. B. Ntusi, Daniel J. Cuthbertson, Michele Lai, Andrea Dennis, Amitava Banerjee
Summary: This study found that early signs of liver disease, measured by cT1, were associated with an increased risk of cardiovascular disease. Liver disease activity (cT1) was associated with major CVD events, CVD hospitalisation, and all-cause mortality, while liver fat (PDFF) was not associated.
JOURNAL OF HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Tolga Gidener, Ross Dierkhising, Kristin C. Mara, Terry M. Therneau, Sudhakar K. Venkatesh, Richard L. Ehman, Meng Yin, Alina M. Allen
Review
Pathology
Michael Torbenson, Sudhakar K. Venkatesh, Thorvardur R. Halfdanarson, Patrick J. Navin, Patrick Kamath, Lori A. Erickson
Summary: Primary hepatic neuroendocrine tumors and primary hepatic neuroendocrine carcinomas are rare and challenging to diagnose if they are primary to the liver or metastatic. The lack of a uniform definition for primary hepatic neuroendocrine neoplasms hinders understanding and treatment of these rare tumors. This article proposes a multidisciplinary definition and guidelines for diagnosing a neuroendocrine tumor/neuroendocrine carcinomas as being primary to the liver.
Article
Gastroenterology & Hepatology
Prowpanga Udompap, Terry M. Therneau, Rachel E. Canning, Joanne T. Benson, Alina M. Allen
Summary: The study aimed to examine the performance of the American Gastroenterological Association (AGA) clinical pathway in the US population. Based on the analysis of National Health and Nutrition Examination Survey data, the study found that the current clinical pathway for risk stratification and management of NAFLD would lead to overutilization of vibration-controlled transient elastography (VCTE). An alternative strategy using diabetes and Fibrosis-4 (FIB-4) score was proposed to improve the pathway's performance and minimize unnecessary testing.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Chen, Zhen Zhang, Juan Liu, Chengjie Li, Meng Yin, Lisha Nie, Bin Song
Summary: This study aimed to assess MRI-based biomarkers for characterizing the kidney in healthy volunteers and to consider variations in anatomic factors and hydration states. The results showed that renal multiparametric MRI quantifications were affected by regional variation, side variation, and hydration states.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Dermatology
Danielle Firkus, Omar M. Abu Saleh, Mark J. J. Enzler, Paul J. Jannetto, Kristin Mara, Paschalis Vergidis, Christina G. Rivera, Ryan W. Stevens
Summary: This retrospective cohort study compared the clinical outcomes and adverse drug events of blastomycosis patients using itraconazole alone versus the combination of itraconazole and hydroxy-itraconazole. The study found that combining itraconazole and hydroxy-itraconazole at a concentration higher than 1.0 mcg/ml is effective in treating blastomycosis, while patients with a concentration lower than this had a higher mortality rate.
Article
Gastroenterology & Hepatology
Jiahui Li, Xin Lu, Zheng Zhu, Kyle J. Kalutkiewicz, Taofic Mounajjed, Terry M. Therneau, Sudhakar K. Venkatesh, Yi Sui, Kevin J. Glaser, Safa Hoodeshenas, Armando Manduca, Vijay H. Shah, Richard L. Ehman, Alina M. Allen, Meng Yin
Summary: This study explored the performance of several magnetic resonance imaging parameters in diagnosing at-risk NASH. Magnetic resonance elastography-assessed liver stiffness (LS) showed the highest accuracy in diagnosing at-risk NASH. Proton density fat fraction (PDFF) had the highest performance in diagnosing NASH with any fibrosis stage.
Article
Medicine, General & Internal
Stephanie S. Faubion, Felicity Enders, Mary S. Hedges, Rajeev Chaudhry, Juliana M. Kling, Chrisandra L. Shufelt, Mariam Saadedine, Kristin Mara, Joan M. Griffin, Ekta Kapoor
Summary: This study evaluated the impact of menopause symptoms on work outcomes and estimated the economic impact. The findings showed that menopause symptoms had a negative impact on work outcomes and resulted in an estimated annual economic loss of $1.8 billion in the United States.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Oncology
Marissa Z. Powell, Kristin C. Mara, Radhika Bansal, Matthew A. Hathcock, Arushi Khurana, N. Nora Bennani, Yucai Wang, Jonas Paludo, Jose Villasboas Bisneto, Stephen M. Ansell, Patrick B. Johnston, Yi Lin, Jason N. Barreto
Summary: This study aimed to evaluate the utility of serum procalcitonin (PCT) concentrations as a biomarker of bacterial infection in CAR-T recipients. The results showed that serum PCT concentrations greater than 0.4 ng/mL at the time of first fever after CAR-T infusion were significantly associated with confirmed bacterial infection.
Editorial Material
Gastroenterology & Hepatology
Young-Suk Lim, Allison Kwong, Alina M. Allen
Article
Gastroenterology & Hepatology
Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Quentin M. Anstee, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Amalia Gastaldelli, Hannes Hagstrom, Terry T. K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Norah A. Terrault, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Joern M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi
Summary: Fatty liver disease is a major public health threat, and focused interventions are urgently needed. A consensus-driven action agenda has been developed, which includes 29 priorities such as early diagnosis, addressing the needs of patients with multiple morbidities, and incorporating fatty liver disease into non-communicable disease strategies and guidance.
Article
Pharmacology & Pharmacy
Mikhaila L. Rice, Erin F. Barreto, Andrew D. Rule, Catherine E. Martin, Huong L. Truong, Kristin C. Mara, Kianoush B. Kashani, Carrie A. Thompson, Thomas E. Witzig, Jason N. Barreto
Summary: This study developed a model that can predict the occurrence of AKI in adult lymphoma patients after receiving HDMTX treatment. The model takes into account sociodemographic and clinical factors for prediction.
Review
Radiology, Nuclear Medicine & Medical Imaging
Christopher L. Welle, Patrick J. Navin, Michael C. Olson, Safa Hoodeshenas, Michael S. Torbenson, Sudhakar K. Venkatesh
Summary: Primary sclerosing cholangitis is a chronic liver disease without effective medical treatment, and liver fibrosis is a crucial factor in patient outcome. Magnetic resonance elastography is an accurate non-invasive method for assessing liver fibrosis and is particularly important in evaluating PSC patients.
ABDOMINAL RADIOLOGY
(2023)