Article
Medicine, Research & Experimental
S. G. Passon, A. R. Schmidt, M. Wittmann, M. Velten, T. Baehner
Summary: Continuous infusion of ampicillin/sulbactam in critically ill patients showed therapeutic concentrations exceeding the minimum inhibitory concentration (MIC) breakpoint in all measurements and above the 4-fold MIC in the majority of analyses. However, patients with acute kidney injury had significantly higher serum concentrations, while impaired renal function and increased renal clearance affected drug levels.
Article
Infectious Diseases
Veronique Goncette, Nathalie Layios, Julie Descy, Frederic Frippiat
Summary: This study evaluated the effectiveness of continuous infusion of CAZ/AVI in clinical practice, showing promising results with good therapeutic efficacy and no adverse events.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Infectious Diseases
Tatjana Khromov, Gry Helene Dihazi, Phillipp Brockmeyer, Andreas Fischer, Frank Streit
Summary: The study evaluated the CLAM-2000 automated preanalytical sample preparation module with LC-MS/MS as a method for 24/7 TDM of beta-lactam antibiotics in routine clinical diagnostics. The method showed good linearity, accuracy, and precision, with stable internal standards stored in the instrument.
Article
Infectious Diseases
Julie Gorham, Fabio S. Taccone, Maya Hites
Summary: Obesity is associated with increased risks of comorbidities, postoperative infections, and nosocomial infections. The pharmacokinetics and pharmacodynamics of antibiotics are affected by obesity, leading to increased risks of antibiotic therapy failure and toxicity. Precision dosing of antibiotics using therapeutic drug monitoring may improve the management of critically ill obese patients with infections.
Article
Infectious Diseases
G. Macheda, N. El Helali, G. Pean de Ponfilly, M. Kloeckner, P. Garcon, M. Maillet, V Tolsma, C. Mory, A. Le Monnier, B. Pilmis
Summary: This study retrospectively analyzed therapeutic drug monitoring (TDM) data of patients with infective endocarditis (IE) and found that current guidelines may lead to unnecessarily high drug concentrations in most patients. TDM benefits predominate in patients with altered renal function, but probably limit adverse effects related to overdosing in most patients.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Clare Murray, Eva Galvan, Carlos Ontiveros, Yilun Deng, Haiyan Bai, Alvaro Souto Padron, Kathryn Hinchee-Rodriguez, Myrna G. Garcia, Anand Kornepati, Jose Conejo-Garcia, Tyler J. Curiel
Summary: The interaction between tumor surface-expressed PDL1 and immune cell PD1 plays a role in evading antitumor immunity, and tumor-intrinsic PDL1 signals can contribute to drug resistance. This study identifies the antibiotic cefepime as a potential drug that can deplete tumor PDL1, increase tumor sensitivity to DNA-damaging agents, and activate immune signals, offering a potential strategy to improve tumor treatment efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jason Brandon Katz, Purav Shah, Cesar A. Trillo, Mohammad H. Alshaer, Charles Peloquin, Jorge Lascano
Summary: Cystic fibrosis patients with pulmonary exacerbations who received therapeutic drug monitoring of beta-lactams experienced decreased exacerbations, longer intervals to exacerbation, and a lower decline in lung function (FEV1% predicted).
RESPIRATORY MEDICINE
(2023)
Review
Infectious Diseases
Emmanuel Novy, Hugo Martiniere, Claire Roger
Summary: Beta-lactams (BL) are commonly used antibiotics for critically ill patients with sepsis or septic shock, but their concentrations can be unpredictable in the context of critical illness. Therapeutic drug monitoring (TDM) of BL in the ICU has gained attention, but there are barriers to its implementation and interpretation. Recent clinical studies have not shown improved mortality with TDM in ICU patients. This review discusses the value and complexity of TDM in critically ill patients and the need for further studies on clinical outcomes and future aspects of TDM.
Article
Microbiology
Ashlan J. Kunz Coyne, Mohammad Alshaer, Anthony M. Casapao, Veena Venugopalan, Carmen Isache, Jason Ferreira, Christopher A. Jankowski
Summary: This study compared clinical outcomes in hospitalized patients with Pseudomonas aeruginosa pneumonia or bloodstream infection who received beta-lactam antibiotic infusions with and without the guidance of therapeutic drug monitoring. The results showed that therapeutic drug monitoring decreased the odds of treatment failure, but also increased the risk of infection-related readmissions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Engineering, Multidisciplinary
Tingting Xu, Yuqi Guo, Yang Ji, Baohong Wang, Kai Zhou
Summary: Carbapenem resistance is a major challenge for global public health, and understanding resistance mechanisms is crucial for guiding the development of new treatments. Optimizing current drug use and monitoring resistant pathogens are necessary.
Review
Infectious Diseases
Amy Legg, Sinead Carmichael, Ming G. Chai, Jason A. Roberts, Menino O. Cotta
Summary: Beta-lactam antibiotics are commonly used in critically ill patients to treat infections, but the optimal exposure targets for these drugs are still debated. Overcoming pharmacokinetic and pharmacodynamic challenges in the intensive care unit is necessary to achieve desired exposures. Therapeutic drug monitoring has shown promise for determining if the desired exposures are reached, but more research is needed to determine its impact on infection-related outcomes. Improving the efficiency of sampling and reporting results in at-risk patients is important for an ideal beta-lactam TDM service.
Article
Multidisciplinary Sciences
Uwe Liebchen, Hanna Salletmeier, Simon Kallee, Christina Scharf, Lucas Huebner, Alexandra Weber, Michael Zoller
Summary: This study aimed to investigate the optimal loading doses of meropenem before continuous infusion in critically ill patients, recommending a loading dose of 0.5 g in extreme scenarios for better target attainment following continuous infusion.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Javier Martinez-Casanova, Erika Esteve-Pitarch, Helena Colom-Codina, Victor Daniel Gumucio-Sanguino, Sara Cobo-Sacristan, Evelyn Shaw, Kristel Maisterra-Santos, Joan Sabater-Riera, Xose L. Perez-Fernandez, Raul Rigo-Bonnin, Fe Tubau-Quintano, Jordi Carratala, Ariadna Padulles-Zamora
Summary: This study aimed to characterize the pharmacokinetics of piperacillin after continuous infusion administration in critically ill adult patients and determine the optimal dosing regimen. The population pharmacokinetic approach was used to analyze piperacillin concentrations from 106 patients. Creatinine clearance was found to be the most predictive factor of piperacillin clearance. The model developed can be used for initial dose guidance and therapeutic drug monitoring.
Article
Infectious Diseases
Mariana Castanheira, Timothy B. Doyle, Lalitagauri M. Deshpande, Rodrigo E. Mendes, Helio S. Sader
Summary: Research on carbapenem-resistant Enterobacterales (CRE) without carbapenemase genes revealed complex resistance mechanisms, limited activity of most beta-lactam agents, and effective inhibition by ceftazidime/avibactam. Further studies are needed to understand the diverse resistance mechanisms and optimize treatment strategies for these isolates.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Review
Infectious Diseases
Timothy N. Luxton, Natalie King, Christoph Walti, Lars J. C. Jeuken, Jonathan A. T. Sandoe
Summary: Adjusting dosing regimens based on carbapenem levels may improve patient exposure to carbapenems. However, there is limited research on the impact of carbapenem therapeutic drug monitoring (TDM) on health outcomes and antimicrobial resistance (AMR). Further optimization and standardization of TDM practices are needed.
Article
Surgery
Manon Launay, Joelle Guitard, Richard Dorent, Yoann Prevot, Florent Prion, Laurence Beaumont, Benjamin Kably, Lucien Lecuyer, Eliane M. Billaud, Romain Guillemain
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Review
Peripheral Vascular Disease
Benjamin Kably, Eliane M. Billaud, Pierre Boutouyrie, Michel Azizi
CURRENT HYPERTENSION REPORTS
(2020)
Article
Medicine, General & Internal
Michel Azizi, Kintur Sanghvi, Manish Saxena, Philippe Gosse, John P. Reilly, Terry Levy, Lars C. Rump, Alexandre Persu, Jan Basile, Michael J. Bloch, Joost Daemen, Melvin D. Lobo, Felix Mahfoud, Roland E. Schmieder, Andrew S. P. Sharp, Michael A. Weber, Marc Sapoval, Pete Fong, Atul Pathak, Pierre Lantelme, David Hsi, Sripal Bangalore, Adam Witkowski, Joachim Weil, Benjamin Kably, Neil C. Barman, Helen Reeve-Stoffer, Leslie Coleman, Candace K. McClure, Ajay J. Kirtane
Summary: Renal denervation through ultrasound treatment shows promising results in reducing blood pressure for patients with resistant hypertension, with greater effectiveness compared to a sham procedure within 2 months and similar safety outcomes. This may provide an alternative approach for patients with resistant hypertension to avoid adding more antihypertensive medications.
Article
Peripheral Vascular Disease
Benjamin Kably, Eliane M. Billaud, Audrey Derobertmasure, Anne Blanchard, Pierre Boutouyrie, Michel Azizi
Summary: Urinary measurement of AcSDKP can serve as a reliable method for assessing adherence to ACEI treatment, showing good consistency and correlation with ACEI metabolite concentrations.
JOURNAL OF HYPERTENSION
(2022)
Review
Peripheral Vascular Disease
Dan Lane, Alexander Lawson, Angela Burns, Michel Azizi, Michel Burnier, Donald J. L. Jones, Benjamin Kably, Kamlesh Khunti, Reinhold Kreutz, Prashanth Patel, Alexandre Persu, Wilko Spiering, Stefan W. Toennes, Maciej Tomaszewski, Bryan Williams, Pankaj Gupta, Indranil Dasgupta
Summary: Nonadherence to antihypertensive medication is common, and chemical adherence testing is a reliable method to detect nonadherence, especially in patients with apparent treatment-resistant hypertension. Testing should be done in specific situations, such as in those with resistant hypertension or those on multiple antihypertensives with inadequate blood pressure control. Verbal consent should be obtained before testing, and results should be discussed with the patient for better understanding.
Review
Medical Laboratory Technology
Benjamin Kably, Manon Launay, Audrey Derobertmasure, Sandrine Lefeuvre, Eric Dannaoui, Eliane M. Billaud
Summary: The increasing burden of invasive fungal infections presents growing challenges for antifungal therapeutic drug monitoring. Monitoring drug exposure is crucial for managing fungal infections, especially in highly variable patients. Integrating clinical pharmacology into patient care is increasingly recognized as essential in managing antifungal therapy.
THERAPEUTIC DRUG MONITORING
(2022)
Article
Infectious Diseases
Leo Mimram, Sophie Magreault, Younes Kerroumi, Dominique Salmon, Benjamin Kably, Simon Marmor, Anne-Sophie Jannot, Vincent Jullien, Valerie Zeller
Summary: This study developed a population PK model of orally administered clindamycin in patients with prosthetic joint infections and used simulations to determine the probability of achieving effective concentrations under different MIC values and dosing regimens. The findings suggest that the currently recommended regimen is effective in most cases, but adjustments in dose and frequency may be needed for specific MIC values.
Article
Cardiac & Cardiovascular Systems
Michel Azizi, Felix Mahfoud, Michael A. Weber, Andrew S. P. Sharp, Roland E. Schmieder, Philipp Lurz, Melvin D. Lobo, Naomi D. L. Fisher, Joost Daemen, Michael J. Bloch, Jan Basile, Kintur Sanghvi, Manish Saxena, Philippe Gosse, J. Stephen Jenkins, Terry Levy, Alexandre Persu, Benjamin Kably, Lisa Claude, Helen Reeve-Stoffer, Candace McClure, Ajay J. Kirtane
Summary: This study aims to evaluate the long-term effects and safety of ultrasound RDN for patients with resistant hypertension. The results show that after 2 months of treatment, both the uRDN group and the sham group had similar antihypertensive effects, but the uRDN group required fewer additional medications.
