Article
Oncology
Adil Dinia, Samy Ammari, John Filtes, Marion Classe, Antoine Moya-Plana, Francois Bidault, Stephane Temam, Pierre Blanchard, Nathalie Lassau, Philippe Gorphe
Summary: A predictive machine learning model was developed to identify HPV-positive oropharyngeal carcinoma patients at high risk of relapse or death post-treatment. The best model accurately predicted the 5-year risk of relapse-free survival, with a significant difference in relapse-free survival rates between high-risk and low-risk patients.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Susanne Flach, Karen Howarth, Sophie Hackinger, Christodoulos Pipinikas, Pete Ellis, Kirsten McLay, Giovanni Marsico, Tim Forshew, Christoph Walz, Christoph A. Reichel, Olivier Gires, Martin Canis, Philipp Baumeister
Summary: This study demonstrates the potential of ctDNA as a biomarker for detecting minimal residual disease and recurrence in HNSCC and shows the feasibility of personalized ctDNA assays for disease detection prior to clinical recurrence.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Connor J. O'Boyle, Giulia Siravegna, Shohreh Varmeh, Natalia Queenan, Alexa Michel, Kim Chang Sing Pang, Jarrod Stein, Julia C. Thierauf, Peter M. Sadow, William C. Faquin, Wei Wang, Daniel G. Deschler, Kevin S. Emerick, Mark A. Varvares, Jong C. Park, John R. Clark, Annie W. Chan, Paul M. Busse, Ryan B. Corcoran, Lori J. Wirth, Derrick T. Lin, A. John Iafrate, Jeremy D. Richmon, Daniel L. Faden
Summary: POD 1 ctHPVDNA levels are associated with the risk of residual disease in patients with HPV+OPSCC undergoing curative intent surgery and could be used as a personalized biomarker for selecting adjuvant treatment in the future.
Article
Multidisciplinary Sciences
Rex H. Lee, Ritu Roy, Hua Li, Aaron Hechmer, Tian Ran Zhu, Adila Izgutdina, Adam B. Olshen, Daniel E. Johnson, Jennifer R. Grandis
Summary: Currently, there are no clinical strategies utilizing tumor gene expression to inform therapeutic selection for patients with head and neck squamous cell carcinoma (HNSCC). Patient-derived xenografts (PDXs) are translationally relevant preclinical models for human tumors; however, the overall transcriptomic concordance of HNSCC PDXs with primary human HNSCC, especially in HPV+ disease, is understudied. This study characterized 64 HNSCC PDXs at the transcriptomic level and found that PDXs can recapitulate HNSCC molecular subtypes and provide a resource for the discovery of predictive biomarkers for treatment selection in HNSCC.
Article
Oncology
Alex Whitmarsh, Miranda Pring, Steve J. Thomas, Andrea Waylen, Andy R. Ness, Tom Dudding, Michael Pawlita, Nicole Brenner, Tim Waterboer, Lea Schroeder
Summary: The study found that patients with HPV-positive oropharyngeal cancer have better survival rates, especially among younger patients. The HPV antibody pattern may affect survival, while the antibody level does not show a significant difference.
Article
Oncology
Alex Whitmarsh, Miranda Pring, Steve J. Thomas, Andrea Waylen, Andy R. Ness, Tom Dudding, Michael Pawlita, Nicole Brenner, Tim Waterboer, Lea Schroeder
Summary: Patients with HPV-driven oropharyngeal cancer generally experience better survival rates, with younger patients showing a more significant advantage in survival. The HPV antibody pattern may also influence survival, independent of antibody levels.
Article
Oncology
Anders Berglund, Clarisse Muenyi, Erin M. Siegel, Abidemi Ajidahun, Steven A. Eschrich, Denise Wong, Leah E. Hendrick, Ryan M. Putney, Sungjune Kim, D. Neil Hayes, David Shibata
Summary: HPV16 and other HPV types within the same alpha species exhibit distinct methylation profiles in head and neck squamous cell carcinomas (HNSCC). Understanding these differences could provide insights into the clinical behavior of HPV-associated HNSCC and contribute to a better understanding of the biological mechanisms underlying HPV-related tumors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Lucia Oton-Gonzalez, John Charles Rotondo, Carmen Lanzillotti, Elisa Mazzoni, Ilaria Bononi, Maria Rosa Iaquinta, Luca Cerritelli, Nicola Malagutti, Andrea Ciorba, Chiara Bianchini, Stefano Pelucchi, Mauro Tognon, Fernanda Martini
Summary: Classical markers alone may not be enough to classify HPV-positive HNSCC patients, but when combined with serological markers, they are strong prognostic indicators in OPSCC patients. Detection of HPV16 E7 oncoprotein in serum at diagnosis is correlated with disease recurrence and patient overall survival, providing a useful tool for stratifying and monitoring HPV-positive HNSCC patients for worse prognosis.
Article
Oncology
Aurora Gaeta, Marta Tagliabue, Oriana D'Ecclesiis, Lavinia Ghiani, Paolo Maugeri, Rita De Berardinis, Camilla Veneri, Camilla Gaiaschi, Marina Cacace, Luciano D'Andrea, Mohssen Ansarin, Sara Gandini, Susanna Chiocca
Summary: We analyzed the inclusion of sex and/or gender in Head and Neck Cancer clinical studies. Only 5% of studies mentioned sex and/or gender as an analytical variable, with observational studies treating it more than interventional studies. Studies with a sample size greater than 100 and including HPV status were more likely to mention sex and/or gender. In oral cavity-larynx-oropharynx studies, HPV was only mentioned in 18% of cases. There is a need to systematically include sex and/or gender in study design to better understand disease differences and incorporate biological and cultural factors into science and medicine.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Cecilie D. de la Cour, Christian von Buchwald, Christian Dehlendorff, Martin Garset-Zamani, Christian Gronhoj, Amanda-Louise F. Carlander, Soren Friis, Susanne K. Kjaer
Summary: This nationwide cohort study did not find an association between postdiagnostic low-dose aspirin use and cancer-specific mortality in patients with head and neck squamous cell cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Nabil F. F. Saba, Saagar Pamulapati, Bhamini Patel, Mayur Mody, Primoz Strojan, Robert Takes, Antti A. A. Maekitie, Oded Cohen, Pia Pace-Asciak, Jan B. B. Vermorken, Carol Bradford, Arlene Forastiere, Yong Teng, Andreas Wieland, Alfio Ferlito
Summary: Head and neck cancer (HNC) is a common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) being the majority of cases. The incidence of HPV-related OPSCC, caused by human papillomavirus (HPV), is increasing rapidly. Immunotherapy has shown promise in managing recurrent and metastatic HNC, leading to interest in its application for HPV-related OPSCC. This review focuses on the immune characteristics and potential for immunotherapy in this virus-driven cancer.
Article
Oncology
Philippe Gorphe, Marion Classe, Samy Ammari, Gabriel Garcia, Caroline Even, Odile Casiraghi, Ingrid Breuskin, Yungan Tao, Stephane Temam, Pierre Blanchard, Antoine Moya-Plana
Summary: This study analyzed the treatment outcomes and HPV status in patients with oropharyngeal squamous cell carcinoma. The results showed that HPV-positive patients had better survival rates, lower risk of disease progression, and lower risk of death from both OPC disease and intercurrent causes, compared to HPV-negative patients.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Zirong Huo, Shuiting Fu, Chunyue Ma, Surui Sheng
Summary: In cN0 HPV-negative OPSCC, including level IV in the selective neck dissection does not provide significant benefits in terms of disease-free survival, overall survival, or disease-specific survival.
Review
Microbiology
Takashi Hatano, Daisuke Sano, Hideaki Takahashi, Nobuhiko Oridate
Summary: The incidence of oropharyngeal cancer is increasing due to its association with HPV, which can evade the immune system and integrate into the host genome, contributing to oncogenesis.
Article
Oncology
Catherine T. Haring, Lulia A. Kana, Sarah M. Dermody, Collin Brummel, Jonathan B. McHugh, Keith A. Casper, Steven B. Chinn, Kelly M. Malloy, Michelle Mierzwa, Mark E. P. Prince, Andrew J. Rosko, Jennifer Shah, Chaz L. Stucken, Andrew G. Shuman, J. Chad Brenner, Matthew E. Spector, Francis P. Worden, Paul L. Swiecicki
Summary: A retrospective analysis of 447 patients with HNSCC revealed that HPV negativity, high neutrophil/lymphocyte ratio, disease-free interval ≤6 months, and poor performance status were predictors of worse survival. Furthermore, the majority of recurrences and metastases occurred within 6 months to 2 years after treatment completion.
Article
Oncology
Lei Cheng, Lixin Qiu, Ruoxin Zhang, Danwen Qian, Mengyun Wang, Menghong Sun, Xiaodong Zhu, Yanong Wang, Weijian Guo, Qingyi Wei
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
Danwen Qian, Hongliang Liu, Xiaomeng Wang, Jie Ge, Sheng Luo, Edward F. Patz, Patricia G. Moorman, Li Su, Sipeng Shen, David C. Christiani, Qingyi Wei
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Medicine, Research & Experimental
Samantha Tam, Chi-Fang Wu, Ho-Lan Peng, Kristina R. Dahlstrom, Erich M. Sturgis, David R. Lairson
Article
Oncology
Sanjay Shete, Hongliang Liu, Jian Wang, Robert Yu, Erich M. Sturgis, Guojun Li, Kristina R. Dahlstrom, Zhensheng Liu, Christopher I. Amos, Qingyi Wei
Article
Otorhinolaryngology
Chi-Fang Wu, David R. Lairson, Kristina R. Dahlstrom, Joel Fokom Domgue, Shuangshuang Fu, Erich M. Sturgis, Wenyaw Chan
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Review
Otorhinolaryngology
Andrew T. Day, Carole Fakhry, Jasmin A. Tiro, Kristina R. Dahlstrom, Erich M. Sturgis
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2020)
Article
Otorhinolaryngology
Andrew T. Day, Kristina R. Dahlstrom, Rebecca Lee, Maher Karam-Hage, Erich M. Sturgis
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Review
Oncology
Sanjana Balachandra, Samuel B. Kusin, Rebecca Lee, James-Michael Blackwell, Jasmin A. Tiro, Lindsay G. Cowell, Cheng-Ming Chiang, Shwu-Yuan Wu, Sanskriti Varma, Erika L. Rivera, Helen G. Mayo, Lianghao Ding, Baran D. Sumer, Jayanthi S. Lea, Aditya Bagrodia, Linda M. Farkas, Richard Wang, Carole Fakhry, Kristina R. Dahlstrom, Erich M. Sturgis, Andrew T. Day
Summary: This study found that HPV-16 E6 antibodies and circulating HPV-16 DNA are the most representative and promising blood-based biomarkers for HPV-associated cancers. Comparative validity analyses are needed, and further research on biomarkers targeting more high-risk HPV types is warranted.
Article
Oncology
Kristina R. Dahlstrom, Juhee Song, Peter F. Thall, Clifton D. Fuller, Katherine A. Hutcheson, Faye M. Johnson, G. Brandon Gunn, Jack Phan, Steven J. Frank, William H. Morrison, Renata Ferrarotto, David Rosenthal, Erich M. Sturgis, Adam S. Garden
Summary: The study found that older age, smoking history, non-tonsil or base of tongue tumors, and T4 tumors were associated with a higher risk of death in patients with oropharyngeal cancer. Patients receiving intensity-modulated radiation therapy or lower radiation doses had lower mortality rates.
Article
Multidisciplinary Sciences
Chengxue Zhong, Li Xu, Ho-Lan Peng, Samantha Tam, Li Xu, Kristina R. Dahlstrom, Chi-Fang Wu, Shuangshuang Fu, Wenyaw Chan, Erich M. Sturgis, Lois M. Ramondetta, Libin Rong, David R. Lairson, Hongyu Miao
Summary: The study found that increasing HPV vaccine uptake rates in Texas can reduce the incidence of OPC. Establishing a population dynamic model and using computer simulation can help evaluate the public health benefits of HPV vaccines.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Hongliang Liu, Guojun Li, Erich M. Sturgis, Sanjay Shete, Kristina R. Dahlstrom, Mulong Du, Christopher Amos, David C. Christiani, Philip Lazarus, Qingyi Wei
Summary: This study assessed the associations between genetic variants in genes involved in the metabolism of PAHs and TSNA and the risk of squamous cell carcinoma of the head and neck (SCCHN) in European populations. The results showed significant associations between certain genetic variants and the risk of SCCHN, oropharyngeal cancer, and oral cancer. Additionally, the study revealed correlations between these genes and risks of other cancers, smoking behavior, and alcohol dependence.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Ari Schuman, Karen S. Anderson, Andrew T. Day, Jay Ferrell, Erich M. Sturgis, Kristina R. Dahlstrom
Summary: The incidence of HPV-related oropharyngeal cancer will continue to rise in the foreseeable future, and prophylactic vaccination will have limited public health impact. Therefore, it is essential to increase vaccination rates and develop screening methods to identify high-risk individuals for early diagnosis and treatment.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Article
Oncology
Andrew T. Day, Reilly A. Sample, Jordan R. Salley, Dwight Oliver, Kristina R. Dahlstrom, Erich M. Sturgis, Jasmin A. Tiro
Summary: This pilot study evaluated the feasibility of a stepped screening program for oral oncogenic HPV infection. The results showed low recruitment and study completion rates, indicating the need to address the barriers to screening.
CANCER PREVENTION RESEARCH
(2023)
Meeting Abstract
Oncology
Samantha Batman, Craig Messick, Andrea Milbourne, Ming Guo, Mark Munsell, Joel Fokom Domgue, Mila Salcedo, Ashish Deshmukh, Kristina Dahlstrom, Mallory Ogburn, Keith Sigel, Erich Sturgis, Elizabeth Chiao, Kathleen Schmeler
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Anshu Khanna, Eric M. Sturgis, Kristina R. Dahlstrom, Li Xu, Qingyi Wei, Guojun Li, Neil D. Gross
Summary: Smoking and alcohol are major risk factors for head and neck squamous cell carcinoma, while human papillomavirus is also associated. Body mass index's relationship with SCCHN risk varies, with overweight and obese individuals potentially having different risks for developing SCCHN.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)