Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

HIV-1 Entry and Membrane Fusion Inhibitors

(2021) Tianshu Xiao et al.   Viruses-Basel

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

(2021) Javad Sharifi-Rad et al.   Cancer Cell International

Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action

(2021) Javad Sharifi-Rad et al.   Frontiers in Pharmacology

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities

(2020) Lin Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel 2-(5-aryl-1H-imidazol-1-yl) derivatives as potential inhibitors of the HIV-1 Vpu and host BST-2 protein interaction

(2020) Thompho J. Rashamuse et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

LIVER FUNCTION IN A COHORT OF YOUNG HIV-HBV CO-INFECTED PATIENTS ON LONG-TERM COMBINED ANTIRETROVIRAL THERAPY

(2020) ADELINA ROȘCA   FARMACIA

Prenylated Chromones from the Fruits of Artocarpus heterophyllus and Their Potential Anti-HIV-1 Activities

(2020) Yan-Hui Fu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis, characterization and anti-HIV activity of polycarboxylic [60]fullerene derivatives obtained in the reaction of C60Cl6 with a hydroquinone ether

(2020) Ilya I. Voronov et al.   TETRAHEDRON LETTERS

Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin

(2020) Alexander Herrmann et al.   Scientific Reports

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

(2020) Bahare Salehi et al.   Biomolecules

Inhibition of HIV-1 RT activity by a new series of 3-(1,3,4-thiadiazol-2-yl)thiazolidin-4-one derivatives

(2020) Maria Rosa Buemi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bioactive prenylated coumarins as potential anti-inflammatory and anti-HIV agents from Clausena lenis

(2020) Yan-Ping Liu et al.   BIOORGANIC CHEMISTRY

Design, synthesis, in vitro and in silico studies of novel 4-oxoquinoline ribonucleoside derivatives as HIV-1 reverse transcriptase inhibitors

(2020) Luana da S.M. Forezi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Comparison of the antiviral activity of the microbicide candidate griffithsin and its tandemers derivatives against different modes of HIV-1 transmission

(2020) Kabamba Alexandre et al.   VIROLOGY

In silico Design of Novel HIV-1 NNRTIs Based on Combined Modeling Studies of Dihydrofuro[3,4-d]pyrimidines

(2020) Yanming Chen et al.   Frontiers in Chemistry

Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors

(2020) Tarek S. Ibrahim et al.   BIOORGANIC CHEMISTRY

Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1

(2020) Yang Yang et al.   BIOORGANIC CHEMISTRY

Phytochemical and pharmacological review of Cinnamomum verum J. Presl-a versatile spice used in food and nutrition

(2020) Neetu Singh et al.   FOOD CHEMISTRY

Development of a pseudovirus assay and evaluation to screen natural products for inhibition of HIV-1 subtype C reverse transcriptase

(2020) Lufuno Grace Mavhandu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ethanolic extract of Artemisia campestris subsp. glutinosa (Besser) Batt. inhibits HIV–1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF–κB pathway

(2020) Apaza Ticona L et al.   JOURNAL OF ETHNOPHARMACOLOGY

Recent advances in natural anti‐HIV triterpenoids and analogs

(2020) Hai‐Feng Wu et al.   MEDICINAL RESEARCH REVIEWS

Ficus plants: State of the art from a phytochemical, pharmacological, and toxicological perspective

(2020) Bahare Salehi et al.   PHYTOTHERAPY RESEARCH

Nutritional and bioactive potential of seagrasses: A review

(2020) Doo Hwan Kim et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Synthesis and antiviral evaluation of 3’-fluoro-4’-modified-5’-norcarbocyclic nucleoside phosphonates

(2019) Christophe Mathe et al.   ChemMedChem

Structure Based Drug Design: Clinically relevant HIV1 Integrase Inhibitors

(2019) Maninder Kaur et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity

(2019) Haifeng Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3,4-seco-Norclerodane Diterpenoids from the Roots of Polyalthia laui

(2019) Zhang-Xin Yu et al.   JOURNAL OF NATURAL PRODUCTS

New targets for HIV drug discovery

(2019) Ana C. Puhl et al.   DRUG DISCOVERY TODAY

Synthesis and Biological Evaluation of 3,9-Dioxatetraasteranes as C2-Symmetric HIV-1 Protease Inhibitors and Docking Study

(2019) Peng Li et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Ibalizumab: A novel monoclonal antibody for the management of multidrug resistant HIV-1 infection

(2019) Mario V. Beccari et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors

(2019) Romeo et al.   MOLECULES

A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies

(2019) Yue-Xian Jin et al.   MOLECULES

Synthesis and in vitro Biological Evaluation of Novel Thymidine Analogs Containing 1H-1,2,3-Triazolyl, 1H-Tetrazolyl, and 2H-Tetrazolyl Fragments

(2019) Elena A. Popova et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Chemical characterization, antioxidant and anti-HIV activities of a Brazilian propolis from Ceará state

(2019) Caroline Cristina Fernandes da Silva et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV

(2019) Shalley N. Kudalkar et al.   ANTIVIRAL RESEARCH

Docking, Synthesis and Biological Evaluation of Novel Diketoquinoline Analogues as HIV-1 Integrase Inhibitor

(2019) Kishore D. Deo et al.   ASIAN JOURNAL OF CHEMISTRY

The Impact of HIV-1 Drug Escape on the Global Treatment Landscape

(2019) D.A. Collier et al.   Cell Host & Microbe

Dual activity of amphiphilic Zn(II) nitroporphyrin derivatives as HIV-1 entry inhibitors and in cancer photodynamic therapy

(2019) Devashish Sengupta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata

(2019) Ya-Si Huang et al.   JOURNAL OF NATURAL PRODUCTS

Chemical diversity and activity profiles of HIV-1 reverse transcriptase inhibitors from plants

(2019) Kazhila C. Chinsembu   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Anti-HIV-1 activity of quinic acid isolated from Helichrysum mimetes using NMR-based metabolomics and computational analysis

(2019) S.E. Yazdi et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Antifungal Activity and Potential Mechanism of N-Butylphthalide Alone and in Combination With Fluconazole Against Candida albicans

(2019) Ying Gong et al.   Frontiers in Microbiology

Doravirine: A Return of the NNRTI Class?

(2019) Sarah R. Blevins et al.   ANNALS OF PHARMACOTHERAPY

Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders

(2019) Laura Fantuzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clinical Pharmacodynamics, Pharmacokinetics, and Drug Interaction Profile of Doravirine

(2019) Alison Boyle et al.   CLINICAL PHARMACOKINETICS

Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains

(2019) KaiJun Jin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment

(2019) Yali Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Hit identification and drug repositioning of potential non-nucleoside reverse transcriptase inhibitors by structure-based approach using computational tools (part II)

(2019) Pretisha Flora Cutinho et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Biological activity and stability analyses of knipholone anthrone, a phenyl anthraquinone derivative isolated from Kniphofia foliosa Hochst.

(2019) Ruth Feilcke et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cordidepsine is A Potential New Anti-HIV Depsidone from Cordia millenii, Baker

(2019) Rostanie Dongmo Zeukang et al.   MOLECULES

N-Substituted Pyrrole Derivative 12m Inhibits HIV-1 Entry by Targeting Gp41 of HIV-1 Envelope Glycoprotein

(2019) Jiayin Qiu et al.   Frontiers in Pharmacology

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach

(2019) Hajar Sirous et al.   Frontiers in Chemistry

Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors

(2019) Yumeng Wu et al.   Acta Pharmaceutica Sinica B

Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity

(2019) Francesca Esposito et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing

(2019) Tong Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities

(2019) Ting Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational design and Structure−Activity relationship of coumarin derivatives effective on HIV-1 protease and partially on HIV-1 reverse transcriptase

(2019) Mei Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-HIV-1 activities of constituents from the rhizomes of Boesenbergia thorelii

(2019) Wisuwat Thongphichai et al.   FITOTERAPIA

New Phosphorus Analogs of Bevirimat: Synthesis, Evaluation of Anti-HIV-1 Activity and Molecular Docking Study

(2019) Elwira Chrobak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prenylated Coumarins from the Fruits of Manilkara zapota with Potential Anti-inflammatory Effects and Anti-HIV Activities

(2019) Yan-Ping Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Novel Thiazolidin-4-ones as Potential Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase

(2019) Petrou et al.   MOLECULES

Daphneodorins A–C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from Daphne odora

(2019) Kouharu Otsuki et al.   ORGANIC LETTERS

A novel isothiocyanate derivative inhibits HIV-1 gene expression and replication by modulating the nuclear matrix associated protein SMAR1

(2019) Jay Trivedi et al.   ANTIVIRAL RESEARCH

Synthesis, molecular docking and biological evaluation of 2-(thiophen-2-yl)-1H-indoles as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

(2019) Marwa El-Hussieny et al.   BIOORGANIC CHEMISTRY

Anti-HIV-1 protease activity of the crude extracts and isolated compounds from Auricularia polytricha

(2019) Chanin Sillapachaiyaporn et al.   BMC Complementary and Alternative Medicine

Design, synthesis and biological evaluation of quinoxaline compounds as anti-HIV agents targeting reverse transcriptase enzyme

(2019) Lucas Fabian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Best practice in research – Overcoming common challenges in phytopharmacological research

(2019) Michael Heinrich et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from Daphne genkwa Guided by UPLC-MSn

(2019) Hua-Ding Zhao et al.   JOURNAL OF NATURAL PRODUCTS

Cytotoxic and anti-HIV-1 activities of triterpenoids and flavonoids isolated from leaves and twigs of Gardenia sessiliflora

(2019) Sariyarach Thanasansurapong et al.   Phytochemistry Letters

Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014–2017)

(2018) Xiaofang Zuo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research

(2018) Gerhard Prinsloo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ellagic acid inhibits HIV-1 infection in vitro : Potential role as a novel microbicide

(2018) A Promsong et al.   ORAL DISEASES

Rilpivirine long-acting for the prevention and treatment of HIV infection

(2018) Francesca Ferretti et al.   Current Opinion in HIV and AIDS

Doravirine

(2018) Marie-Alice Colombier et al.   Current Opinion in HIV and AIDS

Natural product-derived compounds in HIV suppression, remission, and eradication strategies

(2018) Raymond J. Andersen et al.   ANTIVIRAL RESEARCH

Phase 3 Study of Ibalizumab for Multidrug-Resistant HIV-1

(2018) Brinda Emu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological activity of plant extracts and isolated compounds from Alchornea laxiflora: Anti-HIV, antibacterial and cytotoxicity evaluation

(2018) X. Siwe-Noundou et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Design, synthesis and biological evaluation of novel HIV-1 protease inhibitors with pentacyclic triterpenoids as P2-ligands

(2018) Mei Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis and Biological Evaluation of Novel Galloyl Derivatives as HIV-1 RNase H Inhibitors

(2018) Ping Gao et al.   Chemical Biology & Drug Design

Synthesis and anti-HIV activity of guanine modified fluorinated acyclic nucleoside phosphonates derivatives

(2018) Min Luo et al.   CHEMISTRY & BIODIVERSITY

Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3H)-ones

(2018) Maxim B. Nawrozkij et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis of coreceptor recognition by HIV-1 envelope spike

(2018) Md Munan Shaik et al.   NATURE

In vitro antimalarial, antitrypanosomal and HIV-1 integrase inhibitory activities of two Cameroonian medicinal plants: Antrocaryon klaineanum (Anacardiaceae) and Diospyros conocarpa (Ebenaceae)

(2018) Y. Fouokeng et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Bioactive monoterpene indole alkaloids from Nauclea officinalis

(2018) Yan-Ping Liu et al.   BIOORGANIC CHEMISTRY

Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs

(2018) Zhao Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants

(2017) Dongwei Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nanomedicine in the development of anti-HIV microbicides

(2016) José das Neves et al.   ADVANCED DRUG DELIVERY REVIEWS

Computer-aided discovery of anti-HIV agents

(2016) William L. Jorgensen   BIOORGANIC & MEDICINAL CHEMISTRY

Once-daily fosamprenavir with ritonavir in the treatment of HIV infection in therapy-naïve patients

(2016) Magnus Gisslen et al.   Therapeutics and Clinical Risk Management

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

(2015) Peng Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lectins with Anti-HIV Activity: A Review

(2015) Ouafae Akkouh et al.   MOLECULES

Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview

(2015) R Nardacci et al.   Cell Death & Disease

Natural products and drug discovery: a survey of stakeholders in industry and academia

(2015) Vafa Amirkia et al.   Frontiers in Pharmacology

Pharmacokinetic Enhancers in HIV Therapeutics

(2014) Kajal B. Larson et al.   CLINICAL PHARMACOKINETICS

Assessment of Second-Line Antiretroviral Regimens for HIV Therapy in Africa

(2014) Nicholas I. Paton et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV cure research: Advances and prospects

(2014) Caroline P. Passaes et al.   VIROLOGY

Characterization of Binding of Raltegravir to Plasma Proteins

(2013) Caroline Barau et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Raltegravir flexibility and its impact on recognition by the HIV-1 IN targets

(2013) Rohit Arora et al.   JOURNAL OF MOLECULAR RECOGNITION

HIV-1 entry inhibitors: recent development and clinical use

(2013) Timothy J Henrich et al.   Current Opinion in Virology

Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340,In Vitro

(2012) Eve-Irene Lepist et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity

(2012) Shailbala Singh et al.   FITOTERAPIA

Targets for Inhibition of HIV Replication: Entry, Enzyme Action, Release and Maturation

(2012) Saleta Sierra et al.   INTERVIROLOGY

Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41

(2011) Shibo Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antiretroviral drugs

(2010) Erik De Clercq   CURRENT OPINION IN PHARMACOLOGY

Pharmacokinetics and Bioavailability of an Integrase and Novel Pharmacoenhancer-Containing Single-Tablet Fixed-Dose Combination Regimen for the Treatment of HIV

(2010) Polina German et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

(2010) Tinoush Moulaei et al.   STRUCTURE

Pharmacokinetics and Safety of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor, in Healthy Volunteers

(2009) S. Min et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

(2009) Marie-Pierre de Béthune   ANTIVIRAL RESEARCH

The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic

(2009) Samuel Broder   ANTIVIRAL RESEARCH

Pharmacokinetics and Pharmacodynamics of GS-9350: A Novel Pharmacokinetic Enhancer Without Anti-HIV Activity

(2009) A A Mathias et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The history of antiretrovirals: key discoveries over the past 25 years

(2009) Erik De Clercq   REVIEWS IN MEDICAL VIROLOGY

HIV-1 entry inhibitors: an overview

(2009) Daniel R Kuritzkes   Current Opinion in HIV and AIDS

Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV

(2008) Erik De Clercq   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Class-Sparing Regimens for Initial Treatment of HIV-1 Infection

(2008) Sharon A. Riddler et al.   NEW ENGLAND JOURNAL OF MEDICINE

The intracellular activation of lamivudine (3TC) and determination of 2′-deoxycytidine-5′-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells

(2003) Stephen Kewn et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY