Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression

Depression in Dementia or Dementia in Depression? Systematic Review of Studies and Hypotheses

(2020) Agnieszka Brzezińska et al.   Current Alzheimer Research

Effects of separate or combined exposure of nonylphenol and octylphenol on central 5-HT system and related learning and memory in the rats

(2019) Huan Liu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Depression in Alzheimer’s Disease: An Alternative Role for Selective Serotonin Reuptake Inhibitors?

(2019) Richard J. Elsworthy et al.   JOURNAL OF ALZHEIMERS DISEASE

Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer’s Dementia in Individuals With Previous Depression

(2018) Claudia Bartels et al.   AMERICAN JOURNAL OF PSYCHIATRY

Incidence and Course of Depression in Patients with Alzheimer's Disease

(2017) Seung-Ho Ryu et al.   Psychiatry Investigation

A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer’s Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis

(2016) Lili Cui et al.   MOLECULAR NEUROBIOLOGY

Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1

(2016) Filippo Caraci et al.   Frontiers in Pharmacology

6-Phenoxy-2-phenylbenzoxazoles, novel inhibitors of receptor for advanced glycation end products (RAGE)

(2015) Kwanghyun Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fine tuning of 4,6-bisphenyl-2-(3-alkoxyanilino)pyrimidine focusing on the activity-sensitive aminoalkoxy moiety for a therapeutically useful inhibitor of receptor for advanced glycation end products (RAGE)

(2015) Young Taek Han et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Depression associated with dementia

(2015) H. Gutzmann et al.   ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE

Antipsychotics, Other Psychotropics, and the Risk of Death in Patients With Dementia

(2015) Donovan T. Maust et al.   JAMA Psychiatry

Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE)

(2014) Young Taek Han et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease

(2012) Yun Suk Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Ligand-Based Design, Synthesis, and Biological Evaluation of 2-Aminopyrimidines, a Novel Series of Receptor for Advanced Glycation End Products (RAGE) Inhibitors

(2012) Young Taek Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans

(2010) Roongpetch Keowkase et al.   NEUROPHARMACOLOGY

Depression in Older Adults

(2009) Amy Fiske et al.   Annual Review of Clinical Psychology

Site-Specific Blockade of RAGE-Vd Prevents Amyloid-  Oligomer Neurotoxicity

(2008) E. Sturchler et al.   JOURNAL OF NEUROSCIENCE

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE