Article
Immunology
Nina Vindegaard, Liselotte Petersen, Bodil Ingrid Lyng-Rasmussen, Soren Dalsgaard, Michael Eriksen Benros
Summary: Infectious mononucleosis is associated with a 40% increased risk of subsequent depression, especially in the periods one to four years and five years after diagnosis, with no differences according to age or sex.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Emilio-Manuel Paez-Guillan, Joaquin Campos-Franco, Rosario Alende, Yago Garitaonaindia, Arturo Gonzalez-Quintela
Summary: This study found that patients with infectious mononucleosis often exhibit mild, transient hypertriglyceridemia during the acute phase, which decreases during convalescence and is lower than the initial measurement in a majority of cases. It was also observed that older patients are more likely to have hypertriglyceridemia than younger patients, and there is a significant correlation between triglyceride levels and white blood cell counts, total cholesterol levels, and liver damage markers. Further research is needed to understand the mechanisms behind these findings.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Medicine, General & Internal
Emilio-Manuel Paez-Guillan, Joaquin Campos-Franco, Rosario Alende, Hector Lazare, Carmen Beceiro, Arturo Gonzalez-Quintela
Summary: This study aimed to investigate serum bilirubin concentrations in patients with infectious mononucleosis and immune abnormalities associated with jaundice. The results showed that 15.1% of patients had serum bilirubin concentrations between 1.5 and 3 mg/dL, and 12.0% had serum bilirubin > 3 mg/dL. Patients with increased bilirubin concentrations had a distinct clinical presentation and higher levels of immune activation markers.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yangcan Ming, Shengnan Cheng, Zhixin Chen, Wen Su, Shuangyan Lu, Na Wang, Huifu Xu, Lizhe Zhang, Jing Yu, Jianqiao Tang
Summary: This study retrospectively analyzed the pathogens and features of infectious mononucleosis (IM) in children admitted to Wuhan Children's Hospital from 2013 to 2022. The results showed that Epstein-Barr virus (EBV) was the main pathogen, followed by Mycoplasma pneumoniae and cytomegalovirus. Evaluation of blood biomarkers and myocardial damage markers can help physicians take preventive actions to avoid serious complications in children with IM.
Article
Virology
Zhuo Li, Xin Wang, Fahong Jing, Jian Zhou, Yang Han
Summary: This study explored the application value of two laboratory tests in diagnosing EBV-IM in children. The combination of EBV-DNA, EBV-CA IgM, and low-affinity EBV-CA IgG testing showed the highest diagnostic efficacy with a sensitivity of 100% and specificity of 89.8%. The combined immunofluorescence and real-time PCR methods have high sensitivity and specificity in the clinical diagnosis of EBV-IM.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Ting Shi, Linlin Huang, Ling Luo, Qiuyao Yu, Jianmei Tian
Summary: In this study, it was found that plasma EBV-DNA test has a higher diagnostic value than VCA-IgG avidity test in different age stages and over the course of the disease. Peripheral lymphocyte test and plasma EBV-DNA test are suitable for the early stage of the disease, while the VCA-IgG avidity test is suitable for after 7 days of the disease.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Christoph Roderburg, Sarah Krieg, Andreas Krieg, Tom Luedde, Karel Kostev, Sven H. Loosen
Summary: Patients with infectious mononucleosis have a higher incidence of certain types of cancer, especially tumors of the hematopoietic and lymphoid tissues. The study findings support the role of EBV in the development of different malignancies.
Article
Microbiology
Snjezana Zidovec-Lepej, Margarita Batovic, Marija Rozman, Kristian Bodulic, Laura Prtoric, Ante Sokota, Andrea Nikcevic, Petra Simicic, Goran Tesovic
Summary: Through analysis of 73 patients with infectious mononucleosis (IM), it was found that EBV type 1 was predominant and there was a limited repertoire of LMP1 variants, with some patients having multiple LMP1 variants. Co-infections with different LMP1 variants were associated with increased levels of C-reactive protein and decreased neutrophil and platelet counts.
Article
Pediatrics
Xiaoqing Yang, Baohua Lin, Tong Shen
Summary: The aim of this study was to understand the renal damage and clinical features of pediatric patients with acute Epstein-Barr virus (EBV) infection. A total of 41 out of 548 enrolled patients showed renal damage, mainly manifested as hematuria, proteinuria, edema, and hypertension. Compared to the non-renal damage group, patients in the renal damage group had longer fever durations, higher blood EBV-DNA loads, and lower blood CD4(+)/CD8(+) T lymphocyte ratios.
FRONTIERS IN PEDIATRICS
(2023)
Article
Immunology
Zhicheng Ye, Luxi Chen, Huaqing Zhong, Lingfeng Cao, Pan Fu, Jin Xu
Summary: This study investigated the epidemiology and infectious characteristics of Epstein-Barr virus (EBV) infection among children in Shanghai, China from 2017 to 2022. The results showed that EBV was prevalent among children, and coinfection with bacteria or other viruses increased the viral loads of EBV. The primary EBV-related diseases were systemic lupus erythematosus (SLE), immunodeficiency, and infectious mononucleosis (IM).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Clinical Neurology
Klaus Rostgaard, Nete Munk Nielsen, Mads Melbye, Morten Frisch, Henrik Hjalgrim
Summary: Epstein-Barr virus infection is a prerequisite for the development of multiple sclerosis, particularly delayed infections. Siblings provide protection against infectious mononucleosis by occasionally preventing delayed primary Epstein-Barr virus infection. The age difference between siblings determines the level of protection, with closer age gaps providing higher protection.
Article
Pediatrics
Yunyun Zhang, Chengrong Huang, Hao Zhang, Zhi Duan, Qian Liu, Jianfei Li, Qiyin Zong, Yu Wei, Futing Liu, Wanlu Duan, Liwen Chen, Qiang Zhou, Qin Wang
Summary: This study assessed the immune events and laboratory indicators of EBV infection, as well as the clinical usefulness of evaluating AIM patients. Children with AIM showed specific changes in the immune environment, including increased CD8(+) T cells and decreased CD4(+) T cells and B cells. CD8(+) T cells exhibited reduced CD62L expression and increased PD-1 and CTLA-4 expression. During the convalescent phase, CD8(+) T cell frequency and CD62L expression on T cells were restored. Additionally, AST level, CD8(+) T cell number, and CD62L expression on T cells may serve as markers for IM severity and antiviral treatment effectiveness.
FRONTIERS IN PEDIATRICS
(2023)
Article
Immunology
Borre Fevang, Vegard Bruun Bratholm Wyller, Tom Eirik Mollnes, Maria Pedersen, Tarjei Torre Asprusten, Annika Michelsen, Thor Ueland, Kari Otterdal
Summary: The CEBA project followed 200 adolescents with infectious mononucleosis, finding that patients developing chronic fatigue syndrome showed signs of T-cell activation and low-grade chronic inflammation at baseline and after 6 months.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Alfonso Iovieno, Marco Coassin, Fabiana Viscogliosi, Chantal Adani, Luca Cimino, Luigi Fontana
Summary: This article reports two cases of bilateral peripheral deep interstitial keratitis following EBV-related infectious mononucleosis. The disease presented as chronic relapsing posterior interstitial keratitis occurring months after IM.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Allergy
S. Tsabouri, A. Gkoutsias, C. J. Lolis, A. Makis, N. Chaliasos, A. Bartzokas
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2018)
Review
Allergy
Francois Graham, Sophia Tsabouri, Jean-Christoph Caubet
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Pediatrics
Konstantinos Douros, Sophia Tsabouri, Gavriella Feketea, Vasilis Grammeniatis, Eleana Georgia Koliofoti, Marios Papadopoulos, Olympia Sardeli, Maria Triga, Kostas N. Priftis
Article
Allergy
Chrysoula Kosmeri, Ekaterini Siomou, Anna Challa, Sophia Tsabouri
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2019)
Article
Allergy
V. Siafaka, A. Zioga, T. Evrenoglou, D. Mavridis, S. Tsabouri
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2020)
Review
Allergy
Helen A. Brough, Omer Kalayci, Anna Sediva, Eva Untersmayr, Daniel Munblit, Pablo Rodriguez del Rio, Marta Vazquez-Ortiz, Stefania Arasi, Montserrat Alvaro-Lozano, Sophia Tsabouri, Elena Galli, Burcin Beken, Philippe A. Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2020)
Review
Pediatrics
Sophia Tsabouri, Alexandros Makis, Chrysoula Kosmeri, Ekaterini Siomou
PEDIATRIC CLINICS OF NORTH AMERICA
(2021)
Editorial Material
Pediatrics
Konstantinos Douros, Ioanna Loukou, Sophia Tsabouri
Review
Oncology
Chrysoula Kosmeri, Epameinondas Koumpis, Sophia Tsabouri, Ekaterini Siomou, Alexandros Makis
PEDIATRIC BLOOD & CANCER
(2020)
Letter
Pediatrics
Eleni M. Domouzoglou, Sophia Tsabouri, Antonios P. Vlahos, Christos Kittas, Konstantina Gartzonika, Ekaterini Siomou, Alexandros Makis
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Allergy
Francesca Mori, Natalia Blanca-Lopez, Jean-Christoph Caubet, Pascal Demoly, George Du Toit, Eva R. Gomes, Semanur Kuyucu, Antonino Romano, Ozge Soyer, Sophia Tsabouri, Marina Atanaskovic-Markovic
Summary: Dealing with AED HRs is challenging. The primary goal in the diagnosis and management of HRs to AEDs should be trying to accurately identify the causal trigger and simultaneously identify a safe and effective alternative anticonvulsant. There is therefore an ongoing need to improve our knowledge of HS reactions due to AED medications and in particular to improve our diagnostic capabilities.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Allergy
Sophia Tsabouri, Marina Atanaskovic-Markovic
Summary: Childhood rashes are usually benign and can be caused by various factors, including viruses, bacterial toxins, drugs, and allergens. It is often difficult to differentiate between virus-induced and drug-induced skin eruptions, especially during the acute phase. A systematic clinical approach is proposed for timely differential diagnosis and management of rashes in children presenting with a cutaneous eruption while receiving drug therapy.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Editorial Material
Pediatrics
Maria Kostara, Vasileios Giapros, Anastasios Serbis, Ekaterini Siomou, Vasileios Cholevas, Dimitrios Rallis, Sophia Tsabouri
Article
Allergy
Sophia Tsabouri, Stefania Arasi, Burcin Beken, Martin K. Church, Montserrat Alvaro-Lozano, Carlo Caffarelli, Carsten Flohr, Sherief R. Janmohamed, George N. Konstantinou, Susanne Lau, Sebastien Lefevre, Charlotte G. Mortz, Giovanni Pajno, Helena Pite, Krzysztof Rutkowski, Petra Staubach, Lauri-Ann van der Poel, Torsten Zuberbier, Tabi A. Leslie
Summary: Although most pediatric allergists and pediatricians in Europe follow the EAACI/WAO/GA2LEN/EDF guidelines for diagnosing and managing chronic urticaria in children, there is still a significant number who do not. The study shows a large variation in diagnosis and treatment practices, highlighting the need to re-evaluate and standardize guidelines in this area.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Pediatrics
Maria Kostara, Vasiliki Chondrou, Argyro Sgourou, Konstantinos Douros, Sophia Tsabouri
JOURNAL OF PEDIATRIC GENETICS
(2020)
