Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia–reperfusion damage

(2021) Francesca M. Alves et al.   Journal of Cachexia Sarcopenia and Muscle

Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction

(2021) Yahui Peng et al.   Skeletal Muscle

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia

(2021) Roberta Sartori et al.   Science Translational Medicine

Iron metabolism and iron disorders revisited in the hepcidin era

(2020) Clara Camaschella et al.   HAEMATOLOGICA

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster

(2020) Hui Wang et al.   MOLECULAR CELL

Cardiac iron concentration in relation to systemic iron status and disease severity in non‐ischaemic heart failure with reduced ejection fraction

(2020) Valentin G. Hirsch et al.   EUROPEAN JOURNAL OF HEART FAILURE

Iron deficiency‐induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria‐containing vesicles

(2020) Pieter A. Leermakers et al.   FASEB JOURNAL

Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?

(2020) Marina Serra et al.   Frontiers in Oncology

Iron deficiency attenuates protein synthesis stimulated by branched-chain amino acids and insulin in myotubes

(2020) Kazuhiko Higashida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Iron overload is related to muscle wasting in patients with cachexia of gastric cancer: using quantitative proteome analysis

(2020) Da Zhou et al.   MEDICAL ONCOLOGY

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength

(2020) A. R. Palla et al.   SCIENCE

Iron: An Essential Element of Cancer Metabolism

(2020) Myriam Y. Hsu et al.   Cells

Mitochondrial Dysfunction in Skeletal Muscle Pathologies

(2019) Johanna Abrigo et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content

(2019) Daria Neyroud et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria

(2019) Jasmin Barman-Aksözen et al.   MOLECULAR GENETICS AND METABOLISM

Ferric Carboxymaltose: A Review in Iron Deficiency

(2018) Lesley J. Scott   DRUGS

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting

(2018) Elisabeth Wyart et al.   Oxidative Medicine and Cellular Longevity

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts

(2018) Huihui Li et al.   Scientific Reports

Iron deficiency as energetic insult to skeletal muscle in chronic diseases

(2018) Magdalena Dziegala et al.   Journal of Cachexia Sarcopenia and Muscle

Chronic energy depletion due to iron deficiency impairs dendritic mitochondrial motility during hippocampal neuron development

(2018) Thomas W. Bastian et al.   JOURNAL OF NEUROSCIENCE

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

(2017) Anthony S. Grillo et al.   SCIENCE

Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice

(2017) Jacob L. Brown et al.   Journal of Cachexia Sarcopenia and Muscle

Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

(2017) Juha J. Hulmi et al.   Journal of Cachexia Sarcopenia and Muscle

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

(2017) Kerstin Boengler et al.   Journal of Cachexia Sarcopenia and Muscle

Effects of intravenous iron therapy in iron-deficient patients with systolic heart failure: a meta-analysis of randomized controlled trials

(2016) Ewa A. Jankowska et al.   EUROPEAN JOURNAL OF HEART FAILURE

Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis

(2016) Jarred W. Rensvold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

(2016) Tomoya Fukawa et al.   NATURE MEDICINE

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

(2016) Roberto Bellelli et al.   Cell Reports

Understanding cachexia as a cancer metabolism syndrome

(2016) P E Porporato   Oncogenesis

Adipocyte iron regulates leptin and food intake

(2015) Yan Gao et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling

(2015) Jing Liu et al.   MOLECULAR PHARMACEUTICS

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

(2015) Tomasa Barrientos et al.   EBioMedicine

Cachexia: a problem of energetic inefficiency

(2014) Josep M. Argilés et al.   Journal of Cachexia Sarcopenia and Muscle

Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia

(2013) H. Ludwig et al.   ANNALS OF ONCOLOGY

Iron and Copper in Mitochondrial Diseases

(2013) Wenjing Xu et al.   Cell Metabolism

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Complementary RNA and Protein Profiling Identifies Iron as a Key Regulator of Mitochondrial Biogenesis

(2013) Jarred W. Rensvold et al.   Cell Reports

Restoring Specific Lactobacilli Levels Decreases Inflammation and Muscle Atrophy Markers in an Acute Leukemia Mouse Model

(2012) Laure B. Bindels et al.   PLoS One

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Iron Regulatory Proteins Secure Mitochondrial Iron Sufficiency and Function

(2010) Bruno Galy et al.   Cell Metabolism

Mitochondrial fission and remodelling contributes to muscle atrophy

(2010) Vanina Romanello et al.   EMBO JOURNAL

The role of iron in mitochondrial function

(2008) Sonia Levi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS