期刊
EMBO JOURNAL
卷 41, 期 13, 页码 -出版社
WILEY
DOI: 10.15252/embj.2021110352
关键词
autophagy; effectors; immunity; ubiquitination; xenophagy
资金
- Deutsche Forschungsgemeinschaft (DFG) [GZ: UE188/2-1, SFB1101]
- EU [799433]
- DFG [BO1961/5-2, INST 37/819-1 FUGG, INST 37/965-1 FUGG]
- Swedish research councils VR [2016-04562, 2020-05327]
- FORMAS [2017-01596, 2016-01044]
- BBSRC - Biotechnology and Biological Sciences Research Council [BB/T006102/1]
- NSF IOS Grant [2026368]
- Projekt DEAL
- Swedish Research Council [2016-04562, 2020-05327] Funding Source: Swedish Research Council
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [2026368] Funding Source: National Science Foundation
- Marie Curie Actions (MSCA) [799433] Funding Source: Marie Curie Actions (MSCA)
- Formas [2016-01044, 2017-01596] Funding Source: Formas
- Vinnova [2016-04562, 2017-01596, 2016-01044] Funding Source: Vinnova
Autophagy plays a crucial role in plant-bacteria interactions, where antimicrobial autophagy degrades intracellular pathogens and reveals a pathogen strategy of escaping elimination by hijacking the autophagy mechanism.
Beyond its role in cellular homeostasis, autophagy plays anti- and promicrobial roles in host-microbe interactions, both in animals and plants. One prominent role of antimicrobial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although well-described in animals, the extent to which xenophagy contributes to plant-bacteria interactions remains unknown. Here, we provide evidence that Xanthomonas campestris pv. vesicatoria (Xcv) suppresses host autophagy by utilizing type-III effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defense-related selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in the depletion of a bacterial virulence factor and unravel an unprecedented pathogen strategy to counteract defense-related autophagy in plant-bacteria interactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据