期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 187, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2022.109882
关键词
Diabetic wound healing; Exosomes; Mechanism
资金
- National Natural Science Foundation of China [81700706]
- 345 Talent Project of Shengjing hospital, the Clinical research project of Liaoning Diabetes Medical Nutrition Prevention Society [LNSTNBYXYYFZXH-RS01B]
- Natural Science Foundation of Liaoning Province [2021-MS-182]
- Science Foundation of Liaoning Education Department [LK201603]
- virtual simulation experiment teaching project of China Medical University [2020-47]
This article reviews the mechanism of exosomes in diabetic wound healing, including promoting angiogenesis, collagen synthesis, and inhibiting inflammation. It also discusses the combined use of exosomes and hydrogels or dressings to prolong their presence in the wound. These studies contribute to a better understanding of diabetic wound treatment.
Poor wound healing can seriously affect the health of patients with diabetes and result in a heavy medical burden. Recently, exosomes have been considered the key substances involved in the healing of diabetic wounds. The important cells related to the process of diabetic wound healing include endothelial cells (ECs), fibroblasts, macrophages, and keratinocytes. Accumulating evidence indicates that exosomes participate in intercellular communication by regulating the expression of biologically functional molecules and modulating the aforementioned cells through various pathways, thereby promoting angiogenesis, collagen synthesis as well as inhibiting inflammation. This article reviews the mechanism of exosomes in the aforementioned cells and their role in diabetic wound healing. This review further discusses the combined use of exosomes and hydrogels or dressings to prolong the residence time of exosomes in wounds. A better understanding of the mechanism through which exosomes participate in wound healing in diabetes and its impact on the wound healing process may provide insights into the future treatment of diabetic wounds.
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