Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models
出版年份 2022 全文链接
标题
Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models
作者
关键词
amyotrophic lateral sclerosis, glutathione transferase omega, glutathionylation, fused in sarcoma, protein aggregation, liquid-liquid phase separation, post-translational modification
出版物
DEVELOPMENTAL CELL
Volume 57, Issue 6, Pages 783-798.e8
出版商
Elsevier BV
发表日期
2022-03-22
DOI
10.1016/j.devcel.2022.02.022
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases
- (2017) Hibiki Kawamata et al. JOURNAL OF CELL BIOLOGY
- Liquid phase condensation in cell physiology and disease
- (2017) Yongdae Shin et al. SCIENCE
- Chemotherapy-Induced Ca 2+ Release Stimulates Breast Cancer Stem Cell Enrichment
- (2017) Haiquan Lu et al. Cell Reports
- Cysteine Modifications in the Pathogenesis of ALS
- (2017) Cristiana Valle et al. Frontiers in Molecular Neuroscience
- Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis
- (2016) Volodya Altanbyek et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Effect of Oxidative Damage on the Stability and Dimerization of Superoxide Dismutase 1
- (2016) Drazen Petrov et al. BIOPHYSICAL JOURNAL
- Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis
- (2016) Su Min Lim et al. Molecular Neurodegeneration
- The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity
- (2016) Wenzhang Wang et al. NATURE MEDICINE
- ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
- (2016) Aarti Sharma et al. Nature Communications
- Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease
- (2015) Chansik Hong et al. BRAIN
- Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
- (2015) Kathleen A. Burke et al. MOLECULAR CELL
- Oxidative Stress in Neurodegenerative Diseases
- (2015) Ewa Niedzielska et al. MOLECULAR NEUROBIOLOGY
- Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
- (2015) Matthias Altmeyer et al. Nature Communications
- FUS Interacts with HSP60 to Promote Mitochondrial Damage
- (2015) Jianwen Deng et al. PLoS Genetics
- FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage
- (2014) Q. Deng et al. JOURNAL OF NEUROSCIENCE
- The phenotypic variability of amyotrophic lateral sclerosis
- (2014) Bart Swinnen et al. Nature Reviews Neurology
- TOR Signaling Couples Oxygen Sensing to Lifespan in C. elegans
- (2014) Michael Schieber et al. Cell Reports
- ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules
- (2013) Caroline Vance et al. HUMAN MOLECULAR GENETICS
- Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models
- (2013) Jordi Magrané et al. HUMAN MOLECULAR GENETICS
- TARDBPandFUSMutations Associated with Amyotrophic Lateral Sclerosis: Summary and Update
- (2013) Serena Lattante et al. HUMAN MUTATION
- Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
- (2013) Hyung-Jun Kim et al. NATURE GENETICS
- State of play in amyotrophic lateral sclerosis genetics
- (2013) Alan E Renton et al. NATURE NEUROSCIENCE
- Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis
- (2013) Luke McAlary et al. Scientific Reports
- The molecular basis of the frontotemporal lobar degeneration–amyotrophic lateral sclerosis spectrum
- (2012) Tim van Langenhove et al. ANNALS OF MEDICINE
- Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS
- (2012) Dorothee Dormann et al. EMBO JOURNAL
- GlutathioneS-Transferase Omega 1 Activity Is Sufficient to Suppress Neurodegeneration in aDrosophilaModel of Parkinson Disease
- (2012) Kiyoung Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)
- (2012) Eva Bentmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking
- (2011) Todd J Cohen et al. EMBO JOURNAL
- Characterization of a Family of RanBP2-Type Zinc Fingers that Can Recognize Single-Stranded RNA
- (2011) Cuong D. Nguyen et al. JOURNAL OF MOLECULAR BIOLOGY
- Accumulation of insoluble forms of FUS protein correlates with toxicity in Drosophila
- (2011) Laetitia Miguel et al. NEUROBIOLOGY OF AGING
- Amyotrophic Lateral Sclerosis Multiprotein Biomarkers in Peripheral Blood Mononuclear Cells
- (2011) Giovanni Nardo et al. PLoS One
- TDP-43 and FUS: a nuclear affair
- (2011) Dorothee Dormann et al. TRENDS IN NEUROSCIENCES
- Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS
- (2011) Zhihui Sun et al. PLOS BIOLOGY
- Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
- (2010) Daryl A. Bosco et al. HUMAN MOLECULAR GENETICS
- I-TASSER: a unified platform for automated protein structure and function prediction
- (2010) Ambrish Roy et al. Nature Protocols
- TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
- (2010) Hans Wils et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target
- (2009) Siân C. Barber et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
- Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation
- (2008) John J. Mieyal et al. ANTIOXIDANTS & REDOX SIGNALING
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