Article
Endocrinology & Metabolism
Chenyi Zhong, Liusijie Gao, Li Shu, Zhen Hou, Lingbo Cai, Jie Huang, Jiayin Liu, Yundong Mao
Summary: Endometriosis activity has a negative impact on the outcomes of IVF/ICSI cycles in patients with recurrent implantation failure (RIF). Patients with controlled endometriosis activity showed higher cumulative live birth rates, emphasizing the importance of medical treatment for improved prognosis in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Genia Rozen, Peter Rogers, Wan Tinn Teh, Catharyn J. Stern, Alex Polyakov
Summary: RIF is a disorder with an imprecise definition lacking robust scientific basis, presenting significant challenges in diagnosis and treatment. The concept of 'Theoretical Cumulative Implantation Rate' is proposed to determine RIF diagnosis based on objective data. An updated and standardized definition is needed for patient counseling and research planning.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Paul Pirtea, Dominique De Ziegler, Xin Tao, Li Sun, Yiping Zhan, Jean Marc Ayoubi, Emre Seli, Jason M. Franasiak, Richard T. Scott
Summary: The study retrospectively analyzed data from 4,429 women and found that the true recurrent implantation failure rate is low. For patients capable of producing euploid blastocysts, transferring three embryos can still achieve a high clinical pregnancy rate.
FERTILITY AND STERILITY
(2021)
Article
Medicine, Research & Experimental
Yang Liu, Tianxiang Ni, Qing Zhao, Weiran Cui, Xiangxin Lan, Tingting Zhou, Qian Zhang, Junhao Yan
Summary: This study found that uRIF women with hypercholesterolemia have an increased proportion of aneuploid embryos and a reduced proportion of high-quality embryos, while different types of hyperlipidemia have no correlation with cumulative live birth rate as well as pregnancy and neonatal outcomes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Micah J. Hill
Summary: Recurrent implantation failure presents a challenging clinical dilemma with no consensus diagnostic criteria. Current evidence provides some guidance for clinical investigation and treatment, but further research is needed to establish a consensus diagnosis.
FERTILITY AND STERILITY
(2021)
Article
Reproductive Biology
Hua Lou, Na Li, Yichun Guan, Yuchao Zhang, Dayong Hao, Shihong Cui
Summary: The study aimed to investigate the impact of blastocyst morphologic grading on implantation rate of euploid embryo transfers, revealing that good-quality blastocysts have higher implantation rates, particularly in women under the age of 35.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Fangxiang Mu, Xin Yang, Mei Wang, Lin Liu, Fang Wang
Summary: This meta-analysis aimed to evaluate the effect of G-CSF on the treatment of RM and RIF. The results showed that the use of G-CSF significantly improved the clinical pregnancy rate of RIF patients, but had no significant impact on their abortion rate. For RM patients, the use of G-CSF showed improved clinical pregnancy rates and lower abortion rates than the control group, but the difference was not significant.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Obstetrics & Gynecology
Paul Pirtea, Marcelle I. Cedars, Kate Devine, Baris Ata, Jason Franasiak, Catherine Racowsky, Jim Toner, Richard T. Scott, Dominique de Ziegler, Kurt T. Barnhart
Summary: To date, there is no clear definition and function impairment of recurrent implantation failure (RIF). Therefore, the term RIF is currently used somewhat haphazardly based on clinicians' judgment. International experts in reproductive medicine met in Lugano, Switzerland, in July 2022 to review RIF and determine its diagnosis and management. Rating: 8/10
FERTILITY AND STERILITY
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra E. Mrozikiewicz, Marcin Ozarowski, Piotr Jedrzejczak
Summary: Infertility affects 8-12% of reproductive age couples worldwide, with a significant impact on women experiencing recurrent implantation failure (RIF). RIF is a complex condition involving various physiological and molecular mechanisms, with studies suggesting associations with hormone level imbalances, disturbances of angiogenic and immunomodulatory factors, certain genetic polymorphisms, and ethnicity-related inconsistencies. This review highlights the importance of factors contributing to RIF development, potentially paving the way for new diagnostic and therapeutic solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Marcelo Borges Cavalcante, Manoel Sarno, Ricardo Barini
Summary: LIT has shown improvement in pregnancy outcomes for couples with RM in most studies. The current evidence mainly consists of quasi-experimental studies, with few randomized, double-blind studies. However, the evidence is not convincing for the use of LIT in RIF patients.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Obstetrics & Gynecology
Jason M. Franasiak, Diana Alecsandru, Eric J. Forman, Laura C. Gemmell, Jeffrey M. Goldberg, Natalia Llarena, Cheri Margolis, Joop Laven, Sam Schoenmakers, Emre Seli
Summary: Implantation is a critical step in human reproduction, and recurrent implantation failure can result from various factors. Literature discussing this clinical phenomenon is increasing, and there is not a universally agreed-on definition for it.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Chuan Ling Tang, Qi Yue Li, Feng Lian Chen, Chen Ting Cai, Yue Yan Dong, Yuan Yuan Wu, Jian Zhi Yang, Mei Zhao, Feng Li Chi, Ling Hong, Ai Ai, Miao Xin Chen, Kun Ming Li, Xiao Ming Teng, Zhi Qin Chen
Summary: This study evaluated the effect of atosiban given before fresh embryo transfer on pregnancy outcomes of women with recurrent implantation failure (RIF). The results showed that atosiban treatment did not improve the live birth rate in RIF patients.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kanako Takimoto, Hideto Yamada, Shigeki Shimada, Yoshiyuki Fukushi, Shinichiro Wada
Summary: The aim of this study was to evaluate the association between chronic endometritis and uterine endometrium microbiota with repeated implantation failures and recurrent pregnancy losses. The results suggest that chronic endometritis may be involved in the pathophysiology of recurrent pregnancy losses and repeated implantation failures. Lactobacillus iners and Ureaplasma species may be associated with the etiology of chronic endometritis.
Article
Biochemistry & Molecular Biology
Fangfang Li, Wenxin Gao, Yanmei Li, Yiqing Wang, Lin Liu, Xuehong Zhang
Summary: This study aimed to identify potential biomarkers, explore relevant signaling pathways, and analyze the contribution of immune cell infiltration in recurrent implantation failure (RIF). Ten hub genes were found to predict RIF with high specificity and sensitivity. Protein-protein interaction analysis revealed close interactions between the hub genes and the endometrial receptivity array. Functional enrichment analyses indicated significant downregulation of immune pathways and upregulation of lipid metabolism pathways in RIF. Immune cell infiltration, including various types of cells, was significantly reduced in RIF compared with controls. This study may provide new insights into the diagnosis and treatment of RIF.
Review
Biochemistry & Molecular Biology
Mustapha Benkhalifa, Fabien Joao, Cynthia Duval, Debbie Montjean, Molka Bouricha, Rosalie Cabry, Marie-Claire Belanger, Hatem Bahri, Pierre Miron, Moncef Benkhalifa
Summary: After more than four decades of assisted reproductive technology (ART) practice, the failure of in vitro fertilization (IVF) treatments and recurrent implantation failures (RIFs) and repeated pregnancy loss (RPL) remain significant issues. This article reviews different therapeutic options and suggests that immunomodulation and predictive biomarkers may be promising solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)