Life-or-death decisions in plant immunity

NINJ1 mediates plasma membrane rupture during lytic cell death

(2021) Nobuhiko Kayagaki et al.   NATURE

The chromatin-remodeling protein BAF60/SWP73A regulates the plant immune receptor NLRs

(2021) Chien-Yu Huang et al.   Cell Host & Microbe

The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling

(2021) Guozhi Bi et al.   CELL

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

(2021) Max T. B. Clabbers et al.   Nature Communications

PTI-ETI crosstalk: an integrative view of plant immunity

(2021) Minhang Yuan et al.   CURRENT OPINION IN PLANT BIOLOGY

A karyopherin constrains nuclear activity of the NLR protein SNC1 and is essential to prevent autoimmunity in Arabidopsis

(2021) Min Jia et al.   Molecular Plant

The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity

(2021) Rory N. Pruitt et al.   NATURE

Activation of TIR signalling boosts pattern-triggered immunity

(2021) Hainan Tian et al.   NATURE

Plant “helper” immune receptors are Ca2+-permeable nonselective cation channels

(2021) Pierre Jacob et al.   SCIENCE

Plant E3 ligases SNIPER 1 and SNIPER 2 broadly regulate the homeostasis of sensor NLR immune receptors

(2020) Zhongshou Wu et al.   EMBO JOURNAL

Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response

(2020) Raul Zavaliev et al.   CELL

The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity

(2020) Kathrin Thor et al.   NATURE

Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme

(2020) Shoucai Ma et al.   SCIENCE

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

(2020) Raoul Martin et al.   SCIENCE

NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways

(2019) Jaye M. Platnich et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Reconstitution and structure of a plant NLR resistosome conferring immunity

(2019) Jizong Wang et al.   SCIENCE

Ligand-triggered allosteric ADP release primes a plant NLR complex

(2019) Jizong Wang et al.   SCIENCE

A calmodulin-gated calcium channel links pathogen patterns to plant immunity

(2019) Wang Tian et al.   NATURE

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

Mechanism and Regulation of Gasdermin-Mediated Cell Death

(2019) Shiyu Xia et al.   Cold Spring Harbor Perspectives in Biology

Effector-triggered immunity and pathogen sensing in metazoans

(2019) Natasha Lopes Fischer et al.   Nature Microbiology

Differential regulation of TNL-mediated immune signaling by redundant helper CNLs

(2018) Zhongshou Wu et al.   NEW PHYTOLOGIST

Diverse NLR immune receptors activate defence via the RPW8-NLR NRG1

(2018) Baptiste Castel et al.   NEW PHYTOLOGIST

The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways

(2017) Parimala R. Vajjhala et al.   MOLECULAR IMMUNOLOGY

Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition

(2017) Dingzhong Tang et al.   PLANT CELL

Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity

(2016) Yangnan Gu et al.   CELL

MLKL forms cation channels

(2016) Bingqing Xia et al.   CELL RESEARCH

Large-Scale Analyses of Angiosperm Nucleotide-Binding Site-Leucine-Rich Repeat Genes Reveal Three Anciently Diverged Classes with Distinct Evolutionary Patterns

(2016) Zhu-Qing Shao et al.   PLANT PHYSIOLOGY

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

(2014) Guillermo Arango Duque et al.   Frontiers in Immunology

Systemic Acquired Resistance: Turning Local Infection into Global Defense

(2013) Zheng Qing Fu et al.   Annual Review of Plant Biology

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

(2012) Prajwal Gurung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ionotropic glutamate receptor (iGluR)-like channels mediate MAMP-induced calcium influx inArabidopsis thaliana

(2011) Mark Kwaaitaal et al.   BIOCHEMICAL JOURNAL

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE