Article
Environmental Sciences
Yi Zhang, Pai Zheng, Jiaqi Shi, Ying Ma, Zhangjian Chen, Tiancheng Wang, Guang Jia
Summary: This study aimed to investigate the association of ambient temperature with creatine kinase MB (CK-MB) and creatine kinase (CK). The results showed a V-shaped relationship between CK-MB and ambient temperature, and a linear relationship between CK and ambient temperature. Cold exposure was associated with increased levels of CK-MB and CK, while no heat-related elevation was observed. These findings suggest a possible adverse effect of cold exposure on myocardial injury.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Mengmeng Chen, Yu Wang, Xudong Zhao, Jingyang Zhang, Yuan Peng, Jialei Bai, Shuang Li, Dianpeng Han, Shuyue Ren, Kang Qin, Sen Li, Tie Han, Zhixian Gao
Summary: A portable visual quantitative assay for CK-MB was developed by combining target-responsive DNA hydrogel and a microfluidic chip. This method has the potential for quantitative point-of-care testing in resource-constrained settings.
Article
Medicine, General & Internal
David Zahler, Keren-Lee Rozenfeld, Ilan Merdler, Tamar Itach, Samuel Morgan, Dana Levit, Shmuel Banai, Yacov Shacham
Summary: This study evaluated the relationship between serum CPK levels and the occurrence of acute kidney injury in patients with severe ST-elevation myocardial infarction. The results showed that elevated CPK levels were independently associated with acute kidney injury.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Wen Wei, Lingyu Zhang, Yunhan Zhang, Ronghui Tang, Miao Zhao, Zhidong Huang, Jin Liu, Danyuan Xu, Yibo He, Bo Wang, Haozhang Huang, Qiang Li, Mengfei Lin, Yong Liu, Kaihong Chen, Shiqun Chen
Summary: This study evaluated the predictive value of CK-MB for CI-AKI among MI patients, finding that CK-MB was independently associated with CI-AKI. Additionally, integrating CK-MB with ACEF score, Mehran score A, and Mehran score B resulted in increased C-statistics. Internal validation showed consistent results, and external validation demonstrated good discrimination and calibration.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Medicine, General & Internal
Peng Gu, Shengjin Han, Zhengwu Zhou, Jianzhong Ma
Summary: The objective of this study was to investigate the changes to the myocardial enzyme profile and its clinical value in patients with different degrees of spleen injury. The results showed that the increase in myocardial enzyme spectrum was positively correlated with the severity of spleen injury, suggesting that patients may have myocardial damage in the early stage of traumatic spleen injury and should be treated as soon as possible.
Article
Cardiac & Cardiovascular Systems
Jaihoon Amon, Graham C. Wong, Terry Lee, Joel Singer, John Cairns, Jay S. Shavadia, Christopher Granger, Kenneth Gin, Tracy Y. Wang, Sean van Diepen, Christopher B. Fordyce
Summary: The aim of this study was to identify factors associated with in-hospital adverse events in stable patients with STEMI who received pPCI. The results showed that only 1 in 20 stable STEMI patients developed an adverse event after receiving pPCI. Moderate to severe chronic kidney disease was identified as a predictor of future adverse events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Chemistry, Analytical
Mengke Wang, Junyang Chen, Shan Jiang, Yixin Nie, Xingguang Su
Summary: A novel fluorescent method for polynucleotide kinase (PNK) activity analysis was developed using gold nanoclusters and dsDNA-intercalating dye, presenting a sensitive and simple ratio fluorescent strategy for PNK determination.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Alhussain H. Aodah, Sushma Devi, Faisal K. Alkholifi, Hasan S. Yusufoglu, Ahmed I. Foudah, Aftab Alam
Summary: Myocardial infarction (MI) remains a significant issue in healthcare systems worldwide, leading to high rates of morbidity and mortality. Despite ongoing efforts, addressing the challenges posed by MI remains difficult. However, recent research has investigated the potential cardioprotective effects of taraxerol in an ISO-induced cardiotoxicity model in rats.
Article
Emergency Medicine
Guang-mei Wang, Yong Li, Shuo Wu, Wen Zheng, Jing-jing Ma, Feng Xu, Jia-qi Zheng, He Zhang, Jia-li Wang, Yu-guo Chen
Summary: The combination of CK-MB and POC-cTn or c-cTn may be valuable for the early diagnosis of AMI, especially when hs-cTn is not available.
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Nutrition & Dietetics
Sergej M. Ostojic, Tonje Holte Stea, Dagrun Engeset
Summary: Male fertility decline is a global public health problem, and finding efficient biomarkers and interventions to enhance fertility is of utmost importance. Creatine, due to its role in sperm energy metabolism, has been recognized as a potential candidate for promoting male fertility.
Article
Multidisciplinary Sciences
Sergey V. V. Stovbun, Dmitry V. V. Zlenko, Alexander A. A. Bukhvostov, Alexander S. S. Vedenkin, Alexey A. A. Skoblin, Dmitry A. A. Kuznetsov, Anatoly L. L. Buchachenko
Summary: The rate of a chemical reaction can be influenced by the isotope composition of the reactants, resulting in sensitivity to the external magnetic field. This study demonstrates the impact of the external magnetic field on enzymatic DNA synthesis, as well as the effect of spin-bearing magnesium ions. The rate of DNA synthesis decreases steadily with increasing magnetic field induction in the presence of zero-spin magnesium ions. However, in the presence of spin-bearing magnesium ions, the dependence of the reaction rate on magnetic field induction is non-monotonic with a distinct minimum at 80-100 mT. A proposed chemical scheme and biophysical mechanism explain this observed effect by considering the competition between Zeeman and Fermi interactions in the external magnetic field.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Seokjoon Kim, Eun Sung Lee, Byung Seok Cha, Ki Soo Park
Summary: In this study, DNA-templated copper nanoclusters with improved fluorescence stability were prepared by introducing fructose into the synthesis process. The inclusion of fructose significantly increased the operating lifetime of the CuNCs and improved their stability against various conditions. Moreover, the fluorescence signal of CuNCs was maintained for a longer time when stored at low temperatures. These findings provide a basis for improving the stability of copper nanoclusters for various applications.
Article
Chemistry, Physical
Junsheng Chen, Ajeet Kumar, Cecilia Cerretani, Tom Vosch, Donatas Zigmantas, Erling Thyrhaug
Summary: Due to desirable optical properties, such as efficient luminescence and large Stokes shift, DNA-templated silver nanoclusters (DNA-AgNCs) have received significant attention over the past decade. In this study, we investigate the early time relaxation dynamics of a 16-atom silver cluster (DNA-Ag16NC) with NIR emission and an unusually large Stokes shift. By using ultrafast optical spectroscopy, we extract a kinetic model to clarify the physical picture of the photoinduced dynamics, which can guide further research on the electronic structure and dynamics of these novel objects and their potential applications.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Cardiac & Cardiovascular Systems
Mahon L. Maguire, Debra J. McAndrew, Hannah A. Lake, Philip J. Ostrowski, Sevasti Zervou, Stefan Neubauer, Craig A. Lygate, Jurgen E. Schneider
Summary: This study developed an improved P-31-CMRS technique for evaluating myocardial energetics in mice. The results showed that overexpression of creatine and creatine kinase in the heart significantly increased the ratio of phosphocreatine to adenosine triphosphate, indicating an augmented energetic status.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Multidisciplinary Sciences
Shengwei Wu, Yufang Zhou, Zhengzheng Xuan, Linghui Xiong, Xinyu Ge, Junrong Ye, Yun Liu, Lexin Yuan, Yan Xu, Guoan Ding, Aixiang Xiao, Jianxiong Guo, Lin Yu
Summary: This study found that patients, especially females, who had previously used SSRI antidepressants were more likely to have elevated CK and CK-MB levels, indicators of myocardial muscle injury.
SCIENTIFIC REPORTS
(2021)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)