Article
Engineering, Biomedical
Zhaoyuan Guo, Zhuangzhuang Zhang, Nan Zhang, Wenxia Gao, Jing Li, Yuji Pu, Bin He, Jing Xie
Summary: In this study, a composite antibacterial hydrogel PDA-PAM/Mg2+ was developed for accelerated wound healing. This hydrogel showed excellent self-healing and tissue adhesive properties, as well as photothermal antibacterial functions. It demonstrated efficient bacteria inhibition and enhanced wound healing in a rat model.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Physical
Liang Liu, Chunxia Zhao, Min Guo, Yunxin Chen, Yuanpeng Wu, Zhenyu Li, Yuntao Li, Dong Xiang, Hui Li, Li Wang
Summary: In this study, a spider web-inspired conductive hydrogel was synthesized, which exhibits good mechanical strength, high stretchability, strong adhesiveness, high conductivity, injectability, and rapid self-healing performance. The hydrogel can be easily reprocessed multiple times without losing its intrinsic characteristics. It also shows high strain sensitivity and the ability to monitor real-time human motions. Furthermore, a sensing array assembled via injectable behavior can detect the mass and contact shape of the target. This study will significantly broaden the practical applications of hydrogel-based wearable strain sensors.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Materials Science, Biomaterials
Yajun Chen, Qingqing Wang, Dawei Li, Alfred Mensah, Yuyu Qiu, Huizhen Ke, Qufu Wei
Summary: The study demonstrates that multifunctional hydrogels based on quaternized chitosan and polyacrylamide, with appropriate dopamine and quaternized chitosan content, exhibit excellent mechanical properties, tissue adhesiveness, and self-healing capability. Furthermore, these hydrogels show strong adhesion to porcine skin and effective antibacterial properties against S. aureus and E. coli.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Polymer Science
Mengyuan Zhang, Peiling Lin, Xiaofan Song, Kun Chen, Yuxuan Yang, Yongliang Xu, Qiang Zhang, Youshen Wu, Yanfeng Zhang, Yilong Cheng
Summary: This study successfully prepared multi-functional hydrogel dressings with excellent self-healing ability, tissue adhesion, and antibacterial activity. The hydrogel can effectively treat infected wounds and provide a new strategy for the treatment of infected wounds.
JOURNAL OF POLYMER SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Pengfei Yin, Yang Liu, Dan Huang, Chao Zhang
Summary: A new type of polyampholyte with unique viscoelastic properties can be easily synthesized by copolymerizing butyl acrylate with dimethylaminoethyl methacrylate and acid acrylate. The elastic modulus of the polyampholyte can be adjusted by changing the ratio of butyl acrylate to ionic monomers. The as-prepared polyampholyte shows good conformal compliance, energy dissipation, self-recovery, self-healing, and tough adhesiveness on various substrates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Shih-Ho Lin, Christine M. Papadakis, Jia-Jhen Kang, Jhih-Min Lin, Shan-hui Hsu
Summary: The biodegradable self-healing hydrogel synthesized in this study showed multifunctionalities, benefiting from micellar architectures and phenolic modification. The investigation into the corresponding hierarchical structure helps to gain insights into the multiscale designs of next-generation self-healing hydrogels for biomedical applications.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Applied
Mengying Zhang, Yijing Huang, Wenhao Pan, Xianqin Tong, Qiankun Zeng, Ting Su, Xiaoliang Qi, Jianliang Shen
Summary: The study introduces an effective method for fabricating polysaccharide hydrogels for controlled release of antibiotics, with promising biocompatibility and antibacterial properties. By systematically evaluating the physicochemical properties, the hydrogels exhibited good biocompatibility and antibacterial performance. The properties of the hydrogels can be controlled by adjusting the composition ratio.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Wenjuan Ma, Xiaoxuan Zhang, Yuxiao Liu, Lu Fan, Jingjing Gan, Weilin Liu, Yuanjin Zhao, Lingyun Sun
Summary: This study presents a novel wound dressing that combines antioxidation, antiinflammation, and efficient angiogenesis induction capacities, and demonstrates its excellent effect on diabetic wound healing in vivo.
Article
Materials Science, Multidisciplinary
Li Zhao, Tao Ke, Qiangjun Ling, Jiachang Liu, Zhengjun Li, Haibin Gu
Summary: Hydrogel-based sensors have great potential in various applications, but the challenge lies in fabricating conductive hydrogel sensors with multiple desirable properties. Researchers have developed a multifunctional ionic conductive double-network hydrogel to address this challenge, which exhibits self-healing behavior, self-adhesiveness, and other excellent properties, making it suitable for monitoring human movements and object deformations.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Yuxuan Pang, Lin Guan, Yanlin Zhu, Ruijuan Niu, Song Zhu, Quan Lin
Summary: A composite hydrogel, CGH/PDA@HAP, with excellent mechanical properties and enhanced cellular affinity was synthesized. The introduction of PDA@HAP promoted the differentiation of BMSCs into osteoblasts, leading to enhanced bone regeneration. Moreover, the grafting of gallic acid onto chitosan effectively inhibited the growth of bacteria.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wenda Wang, Zicheng Zeng, Li Xiang, Cong Liu, Diana Diaz-Dussan, Zunguo Du, Anika B. Asha, Wenshuai Yang, Yi-Yang Peng, Mingfei Pan, Ravin Narain, Jifang Liu, Hongbo Zeng
Summary: An injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly has been developed for gastric perforation healing. The hydrogel dressing possesses sensitive thermo-responsibility, injectability, antibiofouling property, simplifying surgical procedures, reducing postoperative complications, and enhancing the healing process. This work provides valuable insights for the development of biological environment-adaptive functional materials for biomedical applications.
Article
Chemistry, Applied
Rixiang Su, Peiyuan Li, Ying Zhang, Yingbin Lv, Fangzhou Wen, Wei Su
Summary: Researchers have successfully developed an in situ-formed antibacterial wound dressing with temperature stimulation and near-infrared radiation (NIR) responsive ability. The dressing, called PTCPP, possesses injectability, photothermal stability, sustained release properties, and cytocompatibility. In vitro and in vivo experiments demonstrated its high antibacterial efficacy against Staphylococcus aureus and Escherichia coli, as well as its ability to adapt to wound shape and promote wound healing in bacterial infections.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Xiaoliang Qi, Wenhao Pan, Xianqin Tong, Teng Gao, Yajing Xiang, Shengye You, Ruiting Mao, Jun Chi, Rongdang Hu, Wenzhen Zhang, Hui Deng, Jianliang Shen
Summary: A new hydrogel dressing with robust and stable photothermal performance was constructed by introducing e-Polylysine (e-PL) into agarose/PDA matrix, efficiently locking PDA. The hybrid agarose/PDA/e-PL hydrogel (ADPH) achieved stable photothermal functionality and desirable physicochemical properties, showing satisfactory microbicidal efficacy in vivo for treating bacterial-infected skin wounds.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Areetha D'Souza, Liam R. Marshall, Jennifer Yoon, Alona Kulesha, Dona I. U. Edirisinghe, Siddarth Chandrasekaran, Parth Rathee, Rajeev Prabhakar, Olga V. Makhlynets
Summary: We have successfully designed a metallohydrogel that can respond to reducing agents and possess antimicrobial properties. The gel demonstrates remarkable self-healing capability and undergoes a 160-fold change in stiffness upon reduction by ascorbate under physiological conditions. Computational modeling explains the significant difference in gelation properties of peptides with metal ions when the nitrogen position in the non-natural amino acid pyridyl-alanine is altered. This newly designed hydrogel shows potential for removable wound dressing application, addressing a major unmet need in clinical care.
Article
Nanoscience & Nanotechnology
Chaoming Xie, Jiaqing Luo, Yongjie Luo, Jie Zhou, Xiaochuan Guo, Xiong Lu
Summary: This study reports a mussel-inspired approach to design a near-infrared light-responsive antibacterial hydrogel wound dressing. The hydrogel dressing possesses on-demand antibacterial and excellent wound repair properties, as well as conductivity and cell affinity. In vitro and in vivo studies demonstrated its strong tissue repair activity under near-infrared light irradiation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)