Article
Clinical Neurology
Claire Olivier, Jean-Charles Lamy, Zuzana Kosutzka, Angele Van Hamme, Saoussen Cherif, Brian Lau, Marie Vidailhet, Carine Karachi, Marie-Laure Welter
Summary: This study investigated the effects of high-frequency non-invasive cerebellar transcranial alternating current stimulation (tACS) on patients with severe essential tremor (ET) who had previously undergone deep brain stimulation (DBS). The results showed that active-tACS significantly improved tremor amplitude and severity in the VIM-DBS group, while sham-tACS had no effect. In the non-VIM-DBS group, active-tACS also improved tremor amplitude and severity. These findings support the safety and potential efficacy of high-frequency cerebellar tACS in reducing ET amplitude and severity.
Article
Neurosciences
Faraz Sadrzadeh-Afsharazar, Alexandre Douplik
Summary: This study investigated the use of Non-Invasive Transcranial Alternating Current Stimulation (NITACS) to induce and map phosphenes in healthy individuals. The study identified optimal stimulation parameters for reliable phosphene induction without skin irritation or pain. The findings suggest that NITACS can be a valuable tool for studying the relationship between facial stimulation location and phosphene localization, and raise questions about the origin of phosphenes generated through NITACS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychiatry
Jonas Rauh, Anne S. M. Mueller, Guido Nolte, Moritz Haaf, Marius Mussmann, Saskia Steinmann, Christoph Mulert, Gregor Leicht
Summary: This study investigated the effects of non-invasive brain stimulation on working memory performance. The results show that under specific conditions, using transcranial alternating current stimulation at a frequency of 5 Hz on the left dorsolateral prefrontal cortex can significantly improve working memory performance.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Jochen A. Mosbacher, Stefan Halverscheid, Kolja Pustelnik, Martina Danner, Christina Prassl, Clemens Brunner, Stephan E. Vogel, Michael A. Nitsche, Roland H. Grabner
Summary: The study found that frontal theta band tACS can reduce the repetitions needed to learn new facts, while both frontal and parietal theta band tACS can accelerate the decrease in calculation times in arithmetic learning problems. However, the effects on procedural learning and neurophysiological processes remain unclear.
Article
Clinical Neurology
Anna Latorre, Lorenzo Rocchi, Amit Batla, Alfredo Berardelli, John C. Rothwell, Kailash P. Bhatia
Summary: The study found that primary writing tremor and dystonic tremor syndrome share similar patterns of electrophysiological abnormalities, supporting the hypothesis of a common pathophysiology between them.
MOVEMENT DISORDERS
(2021)
Article
Engineering, Biomedical
Lei Zhang, Long Chen, Zhongpeng Wang, Xiuyun Liu, Dong Ming
Summary: This study investigated whether electrically stimulating frontal and parietal regions using dual-site tACS at mu frequency can modulate motor imagery (MI) performance. The results showed that anti-phase stimulation significantly improved event-related desynchronization (ERD) and classification accuracy during complex tasks, while also decreasing event-related functional connectivity within the frontoparietal network. However, no beneficial effects of anti-phase stimulation were found in the simple task.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Review
Neurosciences
Yuchen He, Shuang Liu, Long Chen, Yufeng Ke, Dong Ming
Summary: Neuronal oscillations are crucial for temporal coordination and brain functions, and transcranial alternating current stimulation (tACS) has shown potential in enhancing cognition. However, the variability and translatability of tACS results are challenging, and a thorough understanding of its mechanisms is essential. Animal models provide insights into tACS mechanisms, parameter optimization, and rational design, aiming to improve validity and reproducibility. This review discusses recent electrophysiological advances in tACS using animal models, addressing important issues for result coordination and translation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Asher Geffen, Nicholas Bland, Martin V. Sale
Summary: The study investigated the effects of slow oscillatory (SO) tACS on motor cortical excitability and found that tACS had a facilitatory effect on motor cortical excitability that outlasted stimulation. However, there was no evidence supporting entrainment of endogenous oscillations as the underlying mechanism.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Neurosciences
Bin Zhang, Feifei Huang, Jun Liu, Dingguo Zhang
Summary: Parkinsonian tremor, a common pathological tremor, affects over 6 million people worldwide. This research explored the immediate effect of bilateral transcranial direct current stimulation (tDCS) in suppressing Parkinsonian tremor and compared it with three other setups. The results showed that bilateral tDCS effectively suppressed Parkinsonian tremor with the optimal suppressive effect.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Hongxing Wang, Kun Wang, Qing Xue, Mao Peng, Lu Yin, Xuecun Gu, Haixia Leng, Juan Lu, Hongzhi Liu, Di Wang, Jin Xiao, Zhichao Sun, Ning Li, Kai Dong, Qian Zhang, Shuqin Zhan, Chunqiu Fan, Baoquan Min, Aihong Zhou, Yunyan Xie, Haiqing Song, Jing Ye, Aihua Liu, Ran Gao, Liyuan Huang, Lidong Jiao, Yang Song, Huiqing Dong, Zichen Tian, Tianmei Si, Xiangyang Zhang, Xinmin Li, Atsushi Kamiya, Fiammetta Cosci, Keming Gao, Yuping Wang
Summary: In a randomized, double-blind controlled trial, Wang et al. demonstrate that four weeks of treatment with transcranial alternating current stimulation (tACS) is more effective in reducing symptoms compared to sham stimulation in first-episode drug-naive patients with major depressive disorder.
Article
Clinical Neurology
Sreekari Vogeti, Maryam Faramarzi, Christoph S. Herrmann
Summary: This study examined the influence of phase and polarity of alpha and delta/theta oscillations on auditory perception. The results suggest that alpha tACS can modulate auditory perception, with a better effect observed in the positive phase of alpha oscillations.
Article
Multidisciplinary Sciences
Carsten Thiele, Tino Zaehle, Aiden Haghikia, Philipp Ruhnau
Summary: The study evaluated the effects of amplitude modulated transcranial alternating current stimulation (AM-tACS) on inducing phosphenes, finding that AM-tACS with a 50 Hz carrier frequency was able to induce phosphenes, while carrier frequencies of 200 Hz and 1000 Hz did not. The stimulation effects of AM-tACS were found to be independent of amplitude modulation and instead relied solely on the carrier frequency.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
David Haslacher, Khaled Nasr, Stephen E. Robinson, Christoph Braun, Surjo R. Soekadar
Summary: A real-time compatible artifact rejection algorithm (SASS) was introduced to overcome limitations in adapting stimulation parameters to ongoing brain oscillations. By using SASS, stimulation-specific signal components could be reliably removed while leaving physiological signal components unaffected. Results indicate that SASS can be used to establish adaptive AM-tACS, providing a potentially powerful tool to target various brain functions and investigate how AM-tACS interacts with electric brain oscillations.
Article
Multidisciplinary Sciences
Basil C. Preisig, Lars Riecke, Matthias J. Sjerps, Anne Kosem, Benjamin R. Kop, Bob Bramson, Peter Hagoort, Alexis Hervais-Adelman
Summary: Brain connectivity is crucial for encoding, transferring, and integrating sensory information, with neural oscillations synchronization playing a key role in perceptual integration. Interhemispheric oscillatory synchrony modulation affects binaural integration of dichotic acoustic features, and changes in intra- and interhemispheric connectivity induced by stimulation are correlated with changes in perceptual integration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geriatrics & Gerontology
Elisa Pelosin, Chiara Ponte, Martina Putzolu, Giovanna Lagravinese, Jeffrey M. Hausdorff, Alice Nieuwboer, Pieter Ginis, Lynn Rochester, Lisa Alcock, Bastiaan R. Bloem, Freek Nieuwhof, Andrea Cereatti, Ugo Della Croce, Anat Mirelman, Laura Avanzino
Summary: The study showed that longer TT + VR training leads to greater improvements in cognitive functions, especially those directly addressed by the virtual environment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neuroimaging
Freek Nieuwhof, Ivan Toni, Michiel F. Dirkx, Cecile Gallea, Marie Vidailhet, Arthur W. G. Buijink, Anne-Fleur van Rootselaar, Bart P. C. van de Warrenburg, Rick C. Helmich
Summary: This study investigates the role of the cerebello-thalamo-cortical circuit and the basal ganglia in dystonic tremor syndrome, linking tremor fluctuations to cerebral activity. Tremor-related activity was found in specific brain regions, with grey matter volume changes and altered effective connectivity indicating involvement of the cerebello-thalamo-cortical circuit and pallidum in the pathophysiology of dystonic tremor syndromes. Deficient input from the cerebellum to the thalamo-cortical circuit and thalamic hypertrophy may play a key role in the generation of dystonic tremor syndrome.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Renske M. J. Janssen, Renee Lustenhouwer, Edith H. C. Cup, Nens van Alfen, Jos Ijspeert, Rick C. Helmich, Ian G. M. Cameron, Alexander C. H. Geurts, Baziel G. M. van Engelen, Maud J. L. Graff, Jan T. Groothuis
Summary: This study compared the effects of multidisciplinary rehabilitation with usual care on the functional capability of the shoulder, arm, and hand in patients with neuralgic amyotrophy. The results showed that multidisciplinary rehabilitation was more effective in improving shoulder functional capability and reducing pain and fatigue.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Lotte Eijk, Marlou Rasenberg, Flavia Arnese, Mark Blokpoel, Mark Dingemanse, Christian F. Doeller, Mirjam Ernestus, Judith Holler, Branka Milivojevic, Asli Ozyurek, Wim Pouw, Iris van Rooij, Herbert Schriefers, Ivan Toni, James Trujillo, Sara Bogels
Summary: This dataset presents behavioral and fMRI observations of humans engaged in multimodal referential communication. The dataset includes audio/video, motion-tracking, and neural correlates data obtained during face-to-face communicative interactions. It provides a unique opportunity to investigate the relationship between communicative behaviors and the representational space shared by communicators. This dataset can be valuable for research in neuroscience, psychology, linguistics, and beyond.
Editorial Material
Clinical Neurology
Milan Beckers, Bastiaan R. Bloem, Rick C. Helmich
JOURNAL OF MOVEMENT DISORDERS
(2023)
Review
Neurosciences
Anouk Tosserams, Bastiaan R. Bloem, Kaylena Ehgoetz A. Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Summary: In stressful situations, individuals with Parkinson's disease (PD) may experience worsening of motor symptoms, including gait impairments. However, some patients report benefits from stressful or high-arousal situations. A study with 4324 PD patients shows that they use various mental strategies to cope with gait impairments, which can either increase or decrease overall sympathetic tone. This suggests that arousal can have both detrimental and alleviating effects on gait control in PD.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Neurosciences
Martin E. Johansson, Nina M. van Lier, Roy P. C. Kessels, Bastiaan R. Bloem, Rick C. Helmich
Summary: Heterogeneity in Parkinson's disease (PD) makes it difficult to understand the disease and develop treatments. Stratifying patients into subtypes based on clinical characteristics may help overcome this challenge. A recent study classified de novo PD patients into three subtypes and found that the diffuse-malignant subtype had more severe symptoms and faster progression compared to the mild-motor predominant subtype. These findings suggest different pathophysiological mechanisms underlie distinct PD subtypes.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Bart E. K. S. Swinnen, Rob M. A. de Bie, Mark Hallett, Rick C. Helmich, Arthur W. G. Buijink
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Arthur W. G. Buijink, Anke H. Snijders, Rick C. Helmich
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Steve Bates, Serge O. Dumoulin, Paul J. M. Folkers, Elia Formisano, Rainer Goebel, Aidin Haghnejad, Rick C. Helmich, Dennis Klomp, Anja G. van der Kolk, Yi Li, Aart Nederveen, David G. Norris, Natalia Petridou, Stefan Roell, Tom W. J. Scheenen, Menno M. Schoonheim, Ingmar Voogt, Andrew Webb
Summary: We propose a vision for a 14 Tesla MR system, which includes a novel whole-body magnet design using high temperature superconductor, a console and associated electronic equipment, an optimized radiofrequency coil setup for proton measurement in the brain, and a high-performance gradient set. This system has significant applications in neuroscience and medical research, allowing for fine-grained observation of neural activity and structural abnormalities.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Renee Lustenhouwer, Ian G. M. Cameron, Nens van Alfen, Ivan Toni, Alexander C. H. Geurts, Baziel G. M. van Engelen, Jan T. Groothuis, Rick C. Helmich
Summary: This study aimed to determine whether abnormal cerebral sensorimotor representations associated with peripheral nerve damage in neuralgic amyotrophy (NA) can be changed by specialized multidisciplinary outpatient rehabilitation. The results showed that the multidisciplinary rehabilitation group demonstrated significant clinical improvement on the Shoulder Rating Questionnaire, while both groups showed improvement in task performance and increased activity in visuomotor occipito-parietal brain areas specific to the affected upper extremity. This study suggests that abnormal cerebral sensorimotor representations can recover towards normality after peripheral nerve damage.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Clinical Neurology
M. J. Stam, B. C. M. van Wijk, P. Sharma, M. Beudel, D. A. Pina-Fuentes, R. M. A. de Bie, P. R. Schuurman, W. -j. Neumann, A. W. G. Buijink
Summary: ECG artifacts often interfere with the detection of disease-specific electrical brain activity in deep brain stimulation (DBS) recordings of local field potentials (LFPs). Three ECG suppression methods, QRS interpolation, template subtraction, and singular value decomposition (SVD), were evaluated in this study. LFPs were recorded in Parkinson's disease patients with the Medtronic PerceptTM PC system. The results showed that all ECG suppression methods reduced artifact-induced beta band power and recovered beta dynamics to some extent. The SVD method had the best trade-off between artifact cleaning and signal loss when its parameters were properly chosen.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neuroimaging
Hanneke M. Keijzer, Puck A. M. Lange, Frederick J. A. Meijer, Bart A. R. Tonino, Michiel J. Blans, Catharina J. M. Klijn, Cornelia W. E. Hoedemaekers, Jeannette Hofmeijer, Rick C. Helmich
Summary: The study found that early MRI markers of brain network integrity after cardiac arrest can be used to predict neurological outcome six months later. Patients with good outcomes showed higher functional connectivity and mean diffusivity levels compared to those with poor outcomes.
NEUROIMAGE-CLINICAL
(2022)
Review
Neurosciences
Robert Chen, Alfredo Berardelli, Amitabh Bhattacharya, Matteo Bologna, Kai-Hsiang Stanley Chen, Alfonso Fasano, Rick C. Helmich, William D. Hutchison, Nitish Kamble, Andrea A. Kuehn, Antonella Macerollo, Wolf-Julian Neumann, Pramod Kumar Pal, Giulia Paparella, Antonio Suppa, Kaviraja Udupa
Summary: This review article focuses on the clinical neurophysiology of Parkinson's disease and parkinsonism, including the pathophysiology, diagnosis, and treatment options.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2022)
Article
Clinical Neurology
Renee Lustenhouwer, Ian G. M. Cameron, Elze Wolfs, Nens van Alfen, Ivan Toni, Alexander C. H. Geurts, Baziel G. M. van Engelen, Jan T. Groothuis, Rick C. Helmich
Summary: Neuralgic amyotrophy is a common peripheral nerve disorder characterized by pain and weakness in the shoulder muscles. This study reveals that cerebral alterations in visuomotor brain areas contribute to residual motor dysfunction and persistent pain in neuralgic amyotrophy. These findings suggest that targeting visuomotor integration in rehabilitation interventions may help improve sensorimotor function in patients with this condition.
BRAIN COMMUNICATIONS
(2022)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)