期刊
CLINICAL IMMUNOLOGY
卷 238, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2022.109013
关键词
SCFAs; CVD; NLRP3 inflammasome; Angiogenesis
类别
资金
- Open Project Foundation of Xinjiang key laboratory [2020D04020]
- National Natural Science Foundation of China [81973509]
- Xinjiang High-level Talents Introduction Tian-chi Plan
- Joint Laboratory Project of Jiangsu University International Cooperation
This review summarizes the impact of short-chain fatty acids (SCFAs) on cardiovascular disease (CVD) and highlights the interaction between SCFAs and CVD, NLRP3 inflammasome, and angiogenesis.
Short-chain fatty acids (SCFAs), metabolites of intestinal microorganisms, have been linked to the occurrence and development of a variety of disorders, including cardiovascular disease (CVD), which is frequently accompanied by a sustaining inflammatory response and aberrant angiogenesis. Accumulating evidence from the study emphasizes that SCFAs are closely connected with the activation of the NLRP3 inflammasome (NACHT, LRR, and PYD domains-containing protein 3) and the process of angiogenesis. This review summarizes emerging literature on the impact of SCFAs on various physiological processes, with a subtle attention on the interaction between SCFAs and CVD (especially atherosclerosis, myocardial infarction, and hypertension), SCFAs and NLRP3 inflammasome, as well as SCFAs and angiogenesis. As a result, we speculate that it is convincing that SCFAs play a mediating role in the microbiota-inflammasome-angiogenesis-CVD axis, opening up a new horizon to investigate the function or level of SCFAs as a therapeutic strategy for CVD.
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