Article
Neurosciences
Yi-Tien Li, Duen-Pang Kuo, Philip Tseng, Yung-Chieh Chen, Sho-Jen Cheng, Changwei W. Wu, Li-Chun Hsieh, Yung-Hsiao Chiang, Hsiao-Wen Chung, Yvonne W. Lui, Cheng-Yu Chen
Summary: The pathogenetic mechanism of persistent post-concussive symptoms (PCS) following concussion remains unclear. Thalamic damage is known to play a role in PCS prolongation while the evidence and biomarkers that trigger persistent PCS have never been elucidated. We collected longitudinal neuroimaging and behavior data from patients and rodents to unravel the early biomarkers of persistent PCS. Diffusion tensor imaging (DTI) and resting-state functional MRI were used to investigate thalamic damage and thalamocortical functioning, respectively. Abnormal DTI-derived indices at the boundaries of bilateral thalami were observed in patients with prolonged symptoms. Enhanced thalamocortical coherence between different thalamocortical circuits was found in both patients and rats with persistent symptoms, disrupting thalamocortical multifunctionality. The DTI abnormalities in thalamic reticular nucleus (TRN) were validated and correlated with enhanced thalamocortical coherence in rodents. The predictive power of these coherence biomarkers for long-term PCS was also confirmed using another patient cohort. Postconcussive events may begin with persistent TRN injury, followed by disrupted thalamocortical coherence and prolonged PCS. Functional MRI-based coherence measures can be surrogate biomarkers for early prediction of long-term PCS.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Orthopedics
Shane M. Miller, Tamara C. Valovich McLeod, Tracy L. Zaslow, Julie C. Wilson, Christina L. Master, Traci R. Snedden, Mark E. Halstead, Matthew F. Grady, Matthew L. Fazekas, Jonathan A. Santana, Rachel A. Coel, David R. Howell
Summary: The use of a clinical risk prediction tool accurately predicts the risk of persistent postconcussive symptoms (PPCSs) in youth athletes.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Neurosciences
Jacob I. McPherson, Mohammad N. Haider, Theresa Miyashita, Lacey Bromley, Benjamin Mazur, Barry Willer, John Leddy
Summary: Individuals with persistent post-concussive symptoms (PPCS) may experience various physical symptoms. Limited research has compared the examination findings among PPCS patients from different age groups. A retrospective study found that all PPCS groups had higher rates of abnormal oculomotor findings compared to age-matched controls, and differences were observed in cervical and vestibular/balance findings among patients of different age groups.
Review
Sport Sciences
Mohammad Nadir Haider, Itai Bezherano, Alex Wertheimer, Akas H. Siddiqui, Emily C. Horn, Barry S. Willer, John J. Leddy
Summary: Aerobic exercise is safe and effective for treating SRC and PPCS, speeding up recovery and reducing symptoms. Early assessment of exercise tolerance can help with diagnosis and prognosis.
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2021)
Article
Clinical Neurology
Andrew R. Mayer, Timothy B. Meier, Andrew B. Dodd, David D. Stephenson, Cidney R. Robertson-Benta, Josef M. Ling, Sharvani Pabbathi Reddy, Vadim Zotev, Kishore Vakamudi, Richard A. Campbell, Robert E. Sapien, Erik B. Erhardt, John P. Phillips, Andrei A. Vakhtin
Summary: The study aims to investigate the recovery process after pediatric mild traumatic brain injury (pmTBI) by examining the changes in brain structure and the age-at-injury effects. It is hypothesized that there will be reduced cortical thickness and hippocampal volumes up to 4 months postinjury, and these changes will be influenced by the age at injury.
Article
Clinical Neurology
Andrew R. Mayer, Timothy B. Meier, Andrew B. Dodd, David D. Stephenson, Cidney R. Robertson-Benta, Josef M. Ling, Sharvani Pabbathi Reddy, Vadim Zotev, Kishore Vakamudi, Richard A. Campbell, Robert E. Sapien, Erik B. Erhardt, John P. Phillips, Andrei A. Vakhtin
Summary: This study aimed to examine the structural brain changes and age-at-injury effects in pediatric patients with mild traumatic brain injury (pmTBI). The results showed reduced cortical thickness and hippocampal volumes in pmTBI patients, but these changes were not associated with age at injury. The study also found that postconcussive symptoms and cognitive deficits were observed in these patients.
Article
Pediatrics
Molly Cairncross, Keith Owen Yeates, Ken Tang, Sheri Madigan, Miriam H. Beauchamp, William Craig, Quynh Doan, Roger Zemek, Kristina Kowalski, Noah D. Silverberg
Summary: This study aims to determine the association between early screen time and postconcussion symptom severity in children and adolescents, and compare it with orthopedic injury.
Article
Clinical Neurology
Hamna Atif, Brianne Morgan, Kyle Tuohy, Monica Zukowski, Zachary Foster, Andrea Loeffert, Keith O. Yeates, Steven D. Hicks
Summary: The study aimed to determine whether adolescents with persistent postconcussion symptoms differ from healthy peers in personality traits and social supports. The findings showed that adolescents with persistent postconcussion symptoms had higher neuroticism scores and reported lower social support from teachers and classmates compared to their healthy peers.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Medicine, General & Internal
Carolyn A. McCarty, Douglas F. Zatzick, Lyscha A. Marcynyszyn, Jin Wang, Robert Hilt, Thomas Jinguji, Celeste Quitiquit, Sara P. D. Chrisman, Frederick P. Rivara
Summary: This randomized clinical trial examined the effectiveness of collaborative care treatment for adolescents with persistent postconcussive symptoms in improving symptoms, quality of life, anxiety, and depressive symptoms over 1 year compared to usual care. The findings suggest that collaborative care intervention led to fewer symptoms and better quality of life for adolescents over the course of 1 year. Additionally, delivering the intervention through telehealth broadened the reach of treatment.
Article
Sport Sciences
Mohammad Nadir Haider, Adam Cunningham, Scott Darling, Heidi N. Suffoletto, Michael S. Freitas, Rajiv K. Jain, Barry Willer, John J. Leddy
Summary: The study aimed to analyze a larger sample using the BCPE and develop a scoring system to identify children at risk for Persistent Post-Concussive Symptoms (PPCS). By using logistic regression, a scoring metric was derived that was 85% accurate in identifying children with different risk levels for PPCS.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Brian T. Vernau, Mohammad N. Haider, Alexander Fleming, John J. Leddy, Barry S. Willer, Eileen P. Storey, Matthew F. Grady, Rebekah Mannix, William Meehan, Christina L. Master
Summary: This study aimed to investigate the association between exercise-induced vision dysfunction and persistent post-concussive symptoms (PPCS) in adolescents early after sport-related concussion. The study found that adolescents with exercise-induced vision dysfunction had a 3-fold greater relative risk of developing PPCS compared to those without exercise-induced vision dysfunction.
CLINICAL JOURNAL OF SPORT MEDICINE
(2023)
Article
Neurosciences
Sowjanya Gowrisankaran, Ankoor S. Shah, Tawna L. Roberts, Emily Wiecek, Ryan N. Chinn, Karameh K. Hawash, Michael J. O'Brien, David R. Howell, William P. Meehan, Aparna Raghuram
Summary: This study found that high PCSS scores may indicate accommodation deficits and prompt an oculomotor assessment in patients following a concussion. Using the CISS and a detailed oculomotor assessment may reveal underlying oculomotor deficits, which may benefit from treatment.
Article
Public, Environmental & Occupational Health
Guijun Chi, Lei Wang
Summary: There is growing evidence that physical activity is negatively associated with depression and anxiety in adolescents. This study investigated the associations between sports participation and depression and anxiety among Chinese adolescents. The results showed that adolescents with less participation in sport-related activities were more likely to report depressive symptoms and anxiety disorders.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Rehabilitation
Brian M. Moore, Rachel K. Stark, Elisabeth C. D'Angelo
Summary: This study aimed to systematically assess the effectiveness of multidisciplinary care for patients with persistent post-concussion symptoms (PPCS). Eight studies were included, which varied in patient populations, care delivery systems, healthcare providers, treatment approaches, and outcomes. The findings suggest that multidisciplinary care using a needs-based approach may be more beneficial than usual care in reducing symptom complaints and improving quality of life in adolescents with sports-related concussion (SRC) and young, primarily female, adults with non-SRC. Future studies should prioritize the inclusion of objective measures to assess outcomes and clearly describe the decision-making processes used in care delivery.
DISABILITY AND REHABILITATION
(2023)
Review
Sport Sciences
Keith Owen Yeates, Anu M. Raisanen, Zahra Premji, Chantel T. Debert, Pierre Fremont, Sidney Hinds, Jonathan D. Smirl, Karen Barlow, Gavin A. Davis, Ruben J. Echemendia, Nina Feddermann-Demont, Colm Fuller, Isabelle Gagnon, Christopher C. Giza, Grant L. Iverson, Michael Makdissi, Kathryn J. Schneider
Summary: This systematic literature review aimed to determine the accurate tests and measures for diagnosing persisting post-concussive symptoms (PPCS) in children, adolescents, and adults following sport-related concussion (SRC). The results showed that the diagnosis of PPCS still relies on symptom report, preferably using standardized symptom rating scales. No specific tool or measure has been found to have satisfactory accuracy for clinical diagnosis.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Letter
Emergency Medicine
Laura Simone, Roger Zemek, Damian Roland, Mark D. Lyttle, Simon Craig, Stuart R. Dalziel, Jocelyn Gravel, Yaron Finkelstein, Sarah Curtis, Stephen B. Freedman, Amy C. Plint, Suzanne Schuh
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Neurosciences
Eda Cinar, Bradford J. J. McFadyen, Isabelle Gagnon
Summary: This study investigated the role of resource conflict in the dual-task effects on gait and concurrent tasks in children and adolescents. Gait was evaluated with different concurrent tasks, and the effects of condition and type of task on dual-task performance were analyzed. The results showed significant changes in gait parameters and concurrent task performance between single and dual-task conditions, indicating that resource conflict plays a role in dual-task performance.
JOURNAL OF MOTOR BEHAVIOR
(2023)
Article
Gastroenterology & Hepatology
Keon Ma, Samina Ali, Jianling Xie, Claudia Maki, Bonita Lee, Linda Chui, Xiao-Li Pang, Ran Zhuo, Brendon Parsons, Otto Vanderkooi, Naveen Poonai, Shannon E. MacDonald, Phillip Tarr, Stephen B. Freedman
Summary: This study aimed to explore the correlation between pain severity and specific enteropathogens in children with acute gastroenteritis (AGE). The study found that patients with bacterial infections had higher pain scores compared to those with single virus infections or negative stool tests, both before and during the emergency department visit. The study also found that age and fever had a greater impact on children's pain experiences than etiologic pathogens.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Letter
Pediatrics
Francesca del Giorgio, Merieme Habti, Joanna Merckx, Jay S. Kaufman, Jocelyn Gravel, Nelson Piche, Esli Osmanlliu, Olivier Drouin
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Emergency Medicine
Sriram Ramgopal, Jonathan Rodean, Elizabeth R. Alpern, Matt Hall, Pradip P. Chaudhari, Jennifer R. Marin, Samir S. Shah, Stephen B. Freedman, Mohamed Eltorki, Oluwakemi Badaki-Makun, Daniel J. Shapiro, Tara Rhine, Rustin B. Morse, Mark I. Neuman
Summary: This study found that one-fifth of children discharged from the emergency department had an ambulatory follow-up visit within 7 days, and this follow-up was associated with higher subsequent healthcare utilization. These findings highlight the need for further research on the role and costs of routine post-ED visit follow-up.
ACADEMIC EMERGENCY MEDICINE
(2023)
Review
Sport Sciences
Kathryn J. Schneider, Meghan L. Critchley, Vicki Anderson, Gavin A. Davis, Chantel T. Debert, Nina Feddermann-Demont, Isabelle Gagnon, Kevin M. Guskiewicz, K. Alix Hayden, Stanley Herring, Corson Johnstone, Michael Makdissi, Christina L. Master, Rosemarie Scolaro Moser, Jon S. Patricios, Johna K. Register-Mihalik, Paul E. Ronksley, Noah D. Silverberg, Keith Owen Yeates
Summary: This systematic review evaluated interventions for recovery in children, adolescents, and adults with a sport-related concussion (SRC). The results suggest that individualized cervicovestibular rehabilitation may decrease the time to return to sport for adolescents and adults with dizziness, neck pain, and/or headaches lasting more than 10 days. Vestibular rehabilitation may decrease the time to medical clearance for adolescents with vestibular symptoms/impairments. Active rehabilitation and collaborative care may decrease symptoms for adolescents with persisting symptoms lasting more than 30 days.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Editorial Material
Sport Sciences
Kathryn J. Schneider, Jon S. Patricios
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Emergency Medicine
Teresa Lightbody, Jennifer Thull-Freedman, Stephen B. Freedman, Bruce Wright, Nicole Finseth, Angela Coulombe, Matthew Morrissette, Amanda DeGuerre, Stephanie McConnell, Karen Bozocea, Shelley Groves-Johnston, Jennifer Woods, Amanda Newton
Summary: We implemented a care bundle for children with mental health concerns in a pediatric emergency department using quality improvement methods. The bundle included standardized risk assessment, brief mental health assessments, and an alternative option for low-risk patients to be assessed in a partnered clinic. Our primary aim was to establish successful implementation of the bundle before studying its impact.
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Emergency Medicine
Conne Lategan, Amanda S. Newton, Jennifer Thull-Freedman, Antonia Stang, Eddy Lang, Paul Arnold, Michael Stubbs, Stephen B. Freedman
Summary: This study aimed to evaluate satisfaction with ED mental health care delivery and explore the factors associated with overall satisfaction, as well as patient and ED visit characteristics related to satisfaction and reported care experience. The majority of patients were satisfied with confidentiality and respect in the ED, but less satisfied with how ED services helped reduce symptoms and/or problems. General satisfaction was associated with the perceived amount of help received in the ED and satisfaction with evaluation by mental health team members and psychiatrist consultation. There is a need to improve ED mental health care delivery, particularly in terms of timely access to mental health providers and the availability of outpatient/community-based mental health care.
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marie-Eve Bolduc, Janet E. Rennick, Isabelle Gagnon, Eva Sokol, Annette Majnemer, Marie Brossard-Racine
Summary: This study aimed to explore the perspectives of parents of children and adolescents with complex CHD in Canada regarding developmental follow-up. The results revealed that the current developmental follow-up practices may not timely identify challenges, leading to additional burden on parents and affecting parent-child relationships. Parents emphasized the importance of implementing a universal and systematic approach to developmental follow-up to enable timely identification of challenges and promote positive parent-child relationships.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Medicine, Research & Experimental
Stephen Freedman, David Schnadower, Myka Estes, T. Charles Casper, Stuart L. Goldstein, Silviu Grisaru, Andrew T. Pavia, Benjamin Wilfond, Melissa Metheney, Kadyn Kimball, Phillip I. Tarr
Summary: This study aims to determine whether hyperhydration can improve outcomes for children with high-risk STEC infections. A randomized controlled trial will be conducted in 26 pediatric institutions involving 1040 children, with the primary outcome being major adverse kidney events within 30 days. This study is of great importance in determining the efficacy of hyperhydration therapy in reducing complications associated with HUS.
Article
Microbiology
Jianling Xie, Kelly Kim, Byron M. Berenger, Linda Chui, Otto G. Vanderkooi, Silviu Grisaru, Stephen B. Freedman
Summary: Advances in diagnostic microbiology have led to faster identification of enteropathogens, which can reduce testing and provide care. This study compared routine microbiologic approaches with the use of the BioFire FilmArray gastrointestinal panel in pediatric patients with acute bloody diarrhea. The BioFire FilmArray group had a significantly shorter time to test result availability (median 3.0 h) compared to the standard-of-care group (median 42.0 h). The use of BioFire FilmArray did not lead to significant improvements in healthcare utilization or outcomes.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medical Laboratory Technology
Madeleine W. Sumner, Todd A. Florin, Nathan Kuppermann, Jianling Xie, Daniel J. Tancredi, Stephen B. Freedman
Summary: This study aimed to evaluate the relationship between SARS-CoV-2 infection and liver injury by comparing transaminase concentrations among children tested for SARS-CoV-2 and other respiratory viruses. The results showed no significant difference in transaminase concentrations between SARS-CoV-2-positive children and those with a negative respiratory viral panel.
CLINICAL BIOCHEMISTRY
(2023)
Article
Virology
Yuanyuan Qiu, Stephen B. Freedman, Sarah Williamson-Urquhart, Ken J. Farion, Serge Gouin, Naveen Poonai, Suzanne Schuh, Yaron Finkelstein, Jianling Xie, Bonita E. Lee, Linda Chui, Xiaoli Pang
Summary: Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children under 5 years of age worldwide. Norovirus, rotavirus, and enteric adenovirus are leading viral causes of pediatric AGE. This study found that norovirus had a significantly lower viral load compared to rotavirus and adenovirus on the day of enrollment, but had a higher viral load on days 5 and 28. Norovirus was detected in the stool for the longest duration compared to rotavirus and adenovirus.
Article
Critical Care Medicine
Mohammad M. Banoei, Chel Hee Lee, James Hutchison, William Panenka, Cheryl Wellington, David S. Wishart, Brent W. Winston
Summary: Prognostication in the early management of severe traumatic brain injury remains challenging. This study demonstrates that early measurement of serum metabolomic profiles can be a useful tool for predicting outcomes in individuals with severe TBI.