Article
Cell Biology
Zhuoqi Li, Xuehong Zhang, Wenjie Weng, Ge Zhang, Qianwen Ren, Yuan Tian
Summary: RNA modifications, TME, and cancer stemness have significant roles in tumor development and immunotherapy of gastric cancer (GC). This study identified four RNA modification patterns with diverse survival and TME features. The WM_Score model was constructed to evaluate the RNA modification-related subtypes and showed predictive value in immunotherapy, with low WM_Score associated with enhanced efficacy of anti-PD-1/L1 immunotherapy.
Article
Immunology
Wenzhe Gao, Dongjie Chen, Jixing Liu, Longjun Zang, Tijun Xiao, Xianlin Zhang, Zheng Li, Hongwei Zhu, Xiao Yu
Summary: This study reveals the interplay network of four RNA modifications in pancreatic cancer. The WM_Score model demonstrates powerful predictive capacity in epigenetic, immunological, and biological landscape, providing a theoretical basis for future clinical judgments in pancreatic cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huifang Chen, Jiameng Yao, Rujuan Bao, Yu Dong, Ting Zhang, Yanhua Du, Gaoyang Wang, Duan Ni, Zhenzhen Xun, Xiaoyin Niu, Youqiong Ye, Hua-Bing Li
Summary: Our study provides a comprehensive analysis of four RNA modifications in CRC and reveals the potential functions of these writers in TME, transcriptional and post-transcriptional events. The study also identifies the therapeutic implications of targeting these writers in cancer therapy, highlighting their potential clinical utility in targeted therapy and immunotherapy.
Article
Immunology
Yao Zhang, Ying Chen, Wen Wen
Summary: This study identified novel RNA modification writers in bladder cancer (BLCA) and developed a quantitative indicator called WriterScore. The WriterScore was found to be strongly associated with immunological characteristics, molecular subtypes, clinicopathologic features, and treatment options in BLCA. Moreover, the WriterScore can accurately predict clinical outcomes and immunotherapy effectiveness in BLCA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Shichao Zhang, Yu Xiong, Chaochao Zheng, Jinhua Long, Houming Zhou, Zhu Zeng, Yan Ouyang, Fuzhou Tang
Summary: This study systematically analyzes the role of four types of A-related RNA modifications in SKCM, revealing their significance in the complexity and diversity of the tumor microenvironment. By evaluating the RNA modification patterns in individual tumors, personalized immunotherapy strategies can be developed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Wan He, Gengpeng Lin, Chaohu Pan, Wenwen Li, Jing Shen, Yangli Liu, Hui Li, Dongfang Wu, Xuejia Lin
Summary: This study investigates the role of RNA modification patterns in tumor microenvironment (TME), genetic variation, targeted inhibitor therapy, and immunotherapy in lung adenocarcinoma (LUAD) patients. The findings provide insights into the characteristics of TME in LUAD and may contribute to the development of immunotherapy strategies.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Pu Zhang, Zijian Liu, Decai Wang, Yunxue Li, Yifei Xing, Yajun Xiao
Summary: This study comprehensively described alterations of 26 RNA modification writer genes in BLCA and constructed a ten-gene signature with predictive and prognostic value for BLCA patients' overall survival. The writer-related gene signature was also associated with EMT-related pathways and immune characteristics, indicating its potential role in predicting patients who will benefit from immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mateja Condic, Damian J. Ralser, Niklas Kluemper, Joerg Ellinger, Maryam Qureischi, Eva K. Egger, Glen Kristiansen, Alexander Mustea, Thore Thiesler
Summary: There is growing evidence for the important role of post-transcriptional RNA modifications in cancer development and progression. This study examined the expression levels of m6A writers, readers, and erasers in cervical cancer cohorts and found that high protein expression levels of certain factors were associated with shorter overall survival. m6A may serve as a promising prognostic biomarker and therapeutic target in cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Qiangan Jing, Hongfeng Yao, Huanjuan Li, Chen Yuan, Jiayu Hu, Ping Zhang, Yunyi Wu, Yi Zhou, Xueying Ren, Chen Yang, Guojie Lei, Jing Du, Xia Ke, Jun Xia, Xiangmin Tong
Summary: This study reveals the important role of RNA modification in gastric cancer by analyzing cancer genomics and gene expression databases. Three distinct RNA modification clusters were identified, which were found to participate in different biological pathways and correlate with clinicopathological characteristics, immune cell infiltration, and prognosis of gastric cancer patients. Furthermore, a RM_Score system was developed to quantify and predict the prognostic value of RNA modification in gastric cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemical Research Methods
Peng Song, Sheng Zhou, Xiaoyang Qi, Yuwen Jiao, Yu Gong, Jie Zhao, Haojun Yang, Zhifen Qian, Jun Qian, Liming Tang
Summary: RNA adenosine modifications are closely associated with tumor microenvironment, clinical prognosis, and treatment effectiveness. The WM_scoring system quantifies RNA modifications in gastric cancer patients, aiding in predicting clinical outcomes.
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Bolun Zhou, Fenglong Bie, Ruochuan Zang, Moyan Zhang, Peng Song, Lei Liu, Guangyu Bai, Jun Zhao, Shugeng Gao
Summary: This study analyzed four types of RNA modifications and constructed a scoring system to guide neoadjuvant immunotherapy in NSCLC, highlighting the writers' roles in post-transcriptional events, TME, and neoadjuvant immunotherapy.
Review
Oncology
Qian Sun, Liangliang Wang, Cong Zhang, Zhenya Hong, Zhiqiang Han
Summary: Cervical cancer heterogeneity is crucial for effective prevention and treatment, involving aspects such as immune clearance of viruses, tumorigenesis, metastasis, and drug resistance. The combination of cervical cancer therapeutic vaccine and immune checkpoint inhibitors is an effective strategy to address treatment heterogeneity. Understanding global vaccination rates, screening rates, incidence, and mortality, as well as genomic factors, is important for cervical cancer prevention and control.
BIOMARKER RESEARCH
(2022)
Article
Genetics & Heredity
Xu Cheng, Xuanzi Yi
Summary: This study describes 26 RNA writers that mediate gene expression and genetic mutation in prostate cancer and evaluates their expression patterns in 948 prostate cancer samples. The RM Score, developed using principal component analysis algorithms, quantifies the RNA modification patterns of specific tumors. Analysis shows significant differences in prognosis between two categories determined by unsupervised clustering methods. The study also examines the relationship between the RM Score and clinical characteristics, immune infiltration level, drug response, and efficacy of chemotherapy and immunotherapy.
FRONTIERS IN GENETICS
(2023)
Article
Genetics & Heredity
Xujia Li, Yixin Zhou, Qi Jiang, Jinsheng Huang, Zexian Liu, Yongqiang Li, Guifang Guo
Summary: We constructed a scoring model called WRM_Score to quantify RNA modification subtypes in gastric cancer patients by analyzing RNA modification writers in multiple samples. Our findings revealed the relationship between WRM_Score and various factors such as transcriptional regulation, tumor microenvironment, clinical features, and molecular subtypes. The WRM score can serve as a reliable predictor for prognosis and therapeutic efficacy of immune checkpoint inhibitors in gastric cancer.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Oncology
Ziena Abdulrahman, Natasja Hendriks, Arnold J. Kruse, Antonios Somarakis, Anna J. M. van de Sande, Heleen J. van Beekhuizen, Jurgen M. J. Piek, Noel F. C. C. de Miranda, Loes F. S. Kooreman, Brigitte F. M. Slangen, Sjoerd H. van der Burg, Peggy J. de Vos van Steenwijk, Edith M. G. van Esch
Summary: The response of cHSIL patients to imiquimod immunotherapy is associated with the pre-existing immune microenvironment, characterized by infiltration of T helper cells, M1-like macrophages, and dendritic cells in complete responders. Non-responders, on the other hand, have a high infiltration of regulatory T cells. After 10 weeks of imiquimod treatment, complete responders show a significant increase in CD4(+) T cell infiltration, while the macrophage count decreases in both complete responders and non-responders. Using the pre-existing immune composition differences, a quantitative simplified immunohistochemical biomarker, CIBI, was developed, which has a strong predictive capacity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
