Article
Cardiac & Cardiovascular Systems
Andrew E. Arai, Jeanette Schulz-Menger, Dipan J. Shah, Yuchi Han, W. Patricia Bandettini, Arun Abraham, Pamela K. Woodard, Joseph B. Selvanayagam, Christian Hamilton-Craig, Ru-San Tan, James Carr, Lynette Teo, Christopher M. Kramer, Bernd J. Wintersperger, Mukesh G. Harisinghani, Scott D. Flamm, Matthias G. Friedrich, Igor Klem, Subha Raman, Daniel Haverstock, Zheyu Liu, Guenther Brueggenwerth, Marta Santiuste, Daniel S. Berman, Dudley J. Pennell
Summary: The study demonstrates that vasodilator stress perfusion cardiovascular magnetic resonance (CMR) performed with gadobutrol has superior diagnostic accuracy for the diagnosis and exclusion of significant coronary artery disease (CAD) compared to gated single-photon emission computed tomography (SPECT).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bao Liu, Wenji Yu, Feifei Zhang, Yunmei Shi, Le Yang, Qi Jiang, Yufeng Wang, Yuetao Wang
Summary: This study aimed to investigate the performance of rest-only gated SPECT MPI combined with CACS and cardiovascular risk factors in diagnosing obstructive CAD through machine learning. The results showed that Rpart, Naive Bayes, XGBoost, Logistic, and random forest algorithms all have high accuracy in diagnosing obstructive CAD.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Laurits Juhl Heinsen, Gokulan Pararajasingam, Thomas Rueskov Andersen, Soren Auscher, Hussam Mahmoud Sheta, Helle Precht, Jess Lambrechtsen, Kenneth Egstrup
Summary: This study found a high prevalence of HRP in asymptomatic T2D patients, with HRP detection associated with specific patient characteristics. HRP was not correlated with high CACS, as HRP could be found even in patients with zero CACS.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Martin Bodtker Mortensen, Omar Dzaye, Henrik Bodtker, Flemming Hald Steffensen, Hans Erik Botker, Jesper Moller Jensen, Niels Peter Ronnow Sand, Michael Maeng, Kevin Kris Warnakula Olesen, Henrik Toft Sorensen, Helle Kanstrup, Ron Blankstein, Michael J. Blaha, Bjarne Linde Norgaard
Summary: In young patients, there is a strong interaction between coronary artery calcium (CAC) and risk factors in predicting obstructive coronary artery disease (CAD) and future coronary heart disease (CHD) risk. Even with the presence of risk factors, a low CAC score can still be a high-risk marker. It is important to assess both risk factors and CAC simultaneously when evaluating risk in young patients.
JACC-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Giulia Vinco, Clementina Dugo, Marzia Rigolli, Cristina Dematte, Cristiana Giovanelli, Fabio Caruso, Alessandro Marinetti, Andrea Chiampan, Carmelo Ciccio, Carlo Cosimo Quattrocchi, Giulio Molon, Maurizio Del Greco
Summary: Stress cardiovascular magnetic resonance imaging has been extensively validated for the assessment of ischemic heart disease, providing detailed information on cardiac structure and function, as well as the presence and degree of myocardial ischemia and viability. It has demonstrated excellent sensitivity and specificity in detecting coronary artery stenosis and has strong prognostic value in clinical risk stratification.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Vasken Dilsizian, Henry Gewirtz, Thomas H. Marwick, Raymond Y. Kwong, Paolo Raggi, Mouaz H. Al-Mallah, Charles A. Herzog
Summary: Patients with chronic kidney disease (CKD) have a higher risk of cardiovascular complications and mortality compared to the general population, even after kidney transplantation. The evaluation of coronary artery disease (CAD) in CKD patients, as well as the use of non-nephrotoxic contrast agents, remains a topic of debate.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Bao Liu, Wenji Yu, Jianfeng Wang, Xiaoliang Shao, Feifei Zhang, Mingge Zhou, Yunmei Shi, Bing Wang, Yiduo Xu, Yuetao Wang
Summary: A prediction model based on rest-only ECG-gated SPECT MPI and cardiovascular risk factors has been developed and validated to effectively predict obstructive CAD in patients with suspected CAD and contraindications to stress MPI.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Yeela Talmor-Barkan, Noam Bar, Aviv A. Shaul, Nir Shahaf, Anastasia Godneva, Yuval Bussi, Maya Lotan-Pompan, Adina Weinberger, Alon Shechter, Chava Chezar-Azerrad, Ziad Arow, Yoav Hammer, Kanta Chechi, Sofia K. Forslund, Sebastien Fromentin, Marc-Emmanuel Dumas, S. Dusko Ehrlich, Oluf Pedersen, Ran Kornowski, Eran Segal
Summary: Multi-omic profiling of patients with coronary artery disease reveals links between alterations in the serum metabolome with genetics, diet, and the microbiome. The study found that these metabolomic alterations are associated with metabolic impairment preceding clinically overt coronary artery disease. The results highlight the importance of understanding risk-factor heterogeneity in coronary artery disease through the serum metabolome.
Review
Medicine, General & Internal
Lukas D. D. Weberling, Dirk Lossnitzer, Norbert Frey, Florian Andre
Summary: Coronary artery disease (CAD) is a global burden with increasing prevalence and recommendations for non-invasive imaging prior to invasive procedures. Both coronary computed tomography angiography (cCTA) and stress cardiac magnetic resonance imaging (CMR) are appropriate imaging modalities, offering high diagnostic accuracy and safety profiles. Advances in technology have improved the quality and functional assessment capabilities of both modalities, allowing for better risk stratification. This review compares the strengths and weaknesses of cCTA and CMR in assessing CAD, providing physicians with rationales for selecting the most appropriate modality for individual patients.
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Nestor Vasquez, Colby R. Ayers, Jaideep Patel, Ananya Hooda, Amit Khera, Roger S. Blumenthal, Michael D. Shapiro, Carlos J. Rodriguez, Michael Y. Tsai, Laurence S. Sperling, Salim S. Virani, Michael J. Blaha, Parag H. Joshi
Summary: Elevated lipoprotein(a) and coronary artery calcium are independently associated with ASCVD risk, and may be concurrently useful in guiding primary prevention therapy decisions, as demonstrated in the MESA and DHS cohorts.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Simon Winther, Samuel E. Schmidt, Borek Foldyna, Thomas Mayrhofer, Laust D. Rasmussen, Jonathan N. Dahl, Udo Hoffmann, Pamela S. Douglas, Juhani Knuuti, Morten Bottcher
Summary: The risk factor-weighted clinical likelihood (RF-CL) model and the coronary artery calcium score-weighted clinical likelihood (CACS-CL) model improve the identification of obstructive coronary artery disease (CAD) compared with basic pretest probability (PTP) models. These new models provide improved risk stratification for myocardial infarction and death.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jennifer M. Renaud, Alexis Poitrasson-Riviere, Jonathan B. Moody, Tomoe Hagio, Edward P. Ficaro, Venkatesh L. Murthy
Summary: By establishing normal databases, the diagnostic accuracy of PET MPI analysis can be improved. Normal databases built using 3D PET images have significant advantages in evaluating TPD in patients. The clinical application of these techniques should be considered to support accurate image interpretation.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Michael J. Blaha, Isaac N. Naazie, Miguel Cainzos-Achirica, Zeina A. Dardari, Andrew P. DeFilippis, Robyn L. McClelland, Mohammadhassan Mirbolouk, Olusola A. Orimoloye, Omar Dzaye, Khurram Nasir, John H. Page
Summary: The study introduced the concept of coronary age as a more effective way to communicate coronary heart disease (CHD) risk to patients. By calculating an individual's coronary age based on MESA 10-year CHD risk score equations and coronary artery calcium (CAC), the study found that coronary age had similar predictive ability to MESA CHD Risk Score and outperformed chronological age and CAC alone in predicting CHD events. The newly derived coronary age could potentially help in routine risk communication between patients and clinicians.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Medicine, General & Internal
Daan Ties, Paulien van Dorp, Gabija Pundziute, Erik Lipsic, Carlijn M. van der Aalst, Matthijs Oudkerk, Harry J. de Koning, Rozemarijn Vliegenthart, Pim van der Harst
Summary: Cardiovascular disease (CVD) remains a leading cause of death and disability worldwide. Acute myocardial infarction (AMI) causes irreversible damage and is a main driver of CVD mortality and morbidity. Improved strategies for prevention, including early detection of coronary artery disease and personalized treatment, are needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Michael J. Blaha, Seamus P. Whelton, Mahmoud Al Rifai, Zeina Dardari, Leslee J. Shaw, Mouaz H. Al-Mallah, Kunihiro Matsushita, Alan Rozanski, John A. Rumberger, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, Miguel Cainzos-Achirica
Summary: This study compared the risk discrimination for predicting CHD and CVD deaths between the Pooled Cohort Equations (PCE), the MESA Risk Score (with and without CAC), and the addition of CAC to the PCE. The results showed that adding CAC to the PCE improved risk discrimination, and the MESA Risk Score with CAC, as well as the PCE plus CAC, performed best among patients with 5% to 20% estimated risk. Additionally, CAC also modestly improved discrimination in low- and high-risk groups.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
C. Michael Gibson, Steven Steinhubl, Dhanunjaya Lakkireddy, Mintu P. Turakhia, Rod Passman, W. Schuyler Jones, T. Jared Bunch, Anne B. Curtis, Eric D. Peterson, Jeremy Ruskin, Leslie Saxon, Michael Tarino, Khaldoun G. Tarakji, Nassir Marrouche, Mithun Patel, Ante Harxhi, Simrati Kaul, Janeta Nikolovski, Stephanie Juan, Kevin Wildenhaus, C. V. Damaraju, John A. Spertus, Heartline Steering Committee Heartline Steering Committee
Summary: This study aims to evaluate the impact of using Apple Watch and application on timely detection of atrial fibrillation and improving clinical outcomes. Two groups of participants are included - those without a history of atrial fibrillation and aged over 65, and those diagnosed with atrial fibrillation and taking direct oral anticoagulant for more than 30 days. The study will determine if Apple Watch with application can improve the time to diagnose atrial fibrillation and cardiovascular outcomes.
AMERICAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Marina Del Rios, Brahmajee K. Nallamothu, Paul S. Chan
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Krishna K. Patel
JACC-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Stephen J. Greene, John A. Spertus, Wenxi Tang, Amiee Kang, Yue Zhong, Michael C. Myers, Sophie Shen, Jenny Jiang, Xuejun Liu, David R. Steffen, Marta G. Viola, G. Michael Felker
CIRCULATION-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Faiez Zannad, Jacqueline Alikhaani, Sadegh Alikhaani, Javed Butler, Jason Gordon, Klaus Jensen, Rani Khatib, Lorenzo Mantovani, Robin Martinez, Wanda F. Moore, Masahiro Murakami, Lothar Roessig, Norman Stockbridge, Harriette G. C. Van Spall, Clyde Yancy, John A. Spertus
Summary: There are numerous consequences of heart failure (HF), such as symptoms, impaired health-related quality of life (HRQoL), and physical and social limitations. Patient-reported outcomes (PROs) can effectively quantify patients' experiences of the disease and its treatment. Improving the use of PROs in HF trials, regulatory decisions, and patient care is crucial, and should involve patient, family, and caregiver involvement.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Adam C. Salisbury, J. Aaron Grantham, W. Morris Brown, William L. Ballard, Keith B. Allen, Ajay J. Kirtane, Michael Argenziano, Robert W. Yeh, Kamal Khabbaz, John Lasala, Puja Kachroo, Dimitri Karmpaliotis, Jeffrey Moses, William L. Lombardi, Karen Nugent, Ziad Ali, Kensey L. Gosch, John A. Spertus, David E. Kandzari
Summary: This study describes the characteristics, risk prediction utility, and outcomes of patients with left main or multivessel coronary artery disease ineligible for coronary bypass grafting (CABG) who underwent percutaneous coronary intervention (PCI). The short-term mortality rate after PCI was lower than estimated by surgeons but higher than predicted by the NCDR CathPCI model. Patients' health status significantly improved at 6 months.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Merrill Thomas, John A. Spertus, Adin-Cristian Andrei, Tingqing Wu, Stacy L. Farr, Anna Warzecha, Kathleen L. Grady
Summary: After LVAD implantation, caregivers may face increasing burden, but higher caregiver burden at baseline is not associated with patient recovery in the first year after LVAD implantation.
JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Mitsuaki Sawano, Yuan Lu, Cesar Caraballo, Shiwani Mahajan, Rachel Dreyer, Judith H. Lichtman, Gail D'Onofrio, Erica Spatz, Rohan Khera, Oyere Onuma, Karthik Murugiah, John A. Spertus, Harlan M. Krumholz
Summary: Younger women have poorer health outcomes than men after experiencing acute myocardial infarction (AMI), and it is unknown whether they have a higher risk for cardiovascular and noncardiovascular hospitalizations in the year after discharge. This study aimed to determine sex differences in causes and timing of 1-year outcomes after AMI in people aged 18 to 55 years. Analysis of data showed that young women with AMI had a higher rate of hospitalization in the year after discharge, with a sex disparity in both coronary-related and noncardiac hospitalizations.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Loba Alam, Alaa Mabrouk Salem Omar, Krishna K. K. Patel
Summary: This review compares positron emission tomography (PET) myocardial perfusion imaging with single photon emission computed tomography (SPECT) myocardial perfusion imaging, highlighting the advantages of PET in terms of diagnosis, prognosis, and clinical decision-making in patients with suspected coronary artery disease (CAD). PET offers better image quality, higher diagnostic accuracy, shorter testing time, and lower radiation dose compared to SPECT.
CURRENT CARDIOLOGY REPORTS
(2023)
Article
Social Sciences, Interdisciplinary
Theresa M. Coles, Li Lin, Kevin Weinfurt, Bryce B. Reeve, John A. Spertus, Robert J. Mentz, Ileana L. Pina, Fraser D. Bocell, Michelle E. Tarver, Anindita Saha, Brittany Caldwell
Summary: On average, women with heart failure have worse health-related quality of life than men. This could be due to differences in care or interpretation and responses to survey questions. A study on the Kansas City Cardiomyopathy Questionnaire found negligible gender-based differential item functioning in the Physical Limitations domain.
APPLIED RESEARCH IN QUALITY OF LIFE
(2023)
Article
Cardiac & Cardiovascular Systems
James A. Case, Staci A. Courter, AIain McGhie, Krishna K. Patel, Brett W. Sperry, Erin Moloney, Katrina O. Case, Eric V. Burgett, Timothy M. Bateman
Summary: Early post-injection stress-only imaging using CZT SPECT/CT appears promising with Tc-99m tetrofosmin, showing similar image quality, reader confidence, diagnosis, and need for a rest scan compared to standard delayed imaging.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Poghni A. Peri-Okonny, Krishna K. Patel, R. Angel Garcia, Merrill Thomas, A. Iain McGhie, Matthew C. Bunte, John A. Spertus, Randall C. Thompson, Timothy M. Bateman
Summary: This study found that coronary vascular dysfunction is common in patients with PAD and is associated with increased risk of death. The prevalence of coronary vascular dysfunction among patients with PAD and the prognostic impact when these two conditions present together have not been well studied.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Krishna K. Patel, A. Iain Mcghie, Kevin F. Kennedy, Randall C. Thompson, John A. Spertus, Brett W. Sperry, Leslee J. Shaw, Timothy M. Bateman
Summary: PET LVEF-R can be a significant predictor of prognosis in patients with cardiovascular disease. It can identify patients who benefit from revascularization within 90 days and improve survival, especially in the absence of prior myocardial infarction or revascularization.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Critical Care Medicine
Rayan S. El-Zein, Kevin F. Kennedy, Paul S. Chan
Summary: This study compared the impact of CPR initiated by first responders versus EMS on survival rates in patients with cardiac arrest. The results showed that patients who had CPR initiated by first responders had higher rates of survival to discharge, which was largely mediated by shorter response times.
Editorial Material
Cardiac & Cardiovascular Systems
Krishna K. Patel, Leslee J. Shaw