Kinesin-5 Eg5 mediates centrosome separation to control spindle assembly in spermatocytes

Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes

(2020) Zhen-Yu She et al.   Cell Division

Prophase-Specific Perinuclear Actin Coordinates Centrosome Separation and Positioning to Ensure Accurate Chromosome Segregation

(2020) Tom Stiff et al.   Cell Reports

Mechanically Distinct Microtubule Arrays Determine the Length and Force Response of the Meiotic Spindle

(2019) Jun Takagi et al.   DEVELOPMENTAL CELL

The molecular architecture of the meiotic spindle is remodeled during metaphase arrest in oocytes

(2019) Mariana F.A. Costa et al.   JOURNAL OF CELL BIOLOGY

KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections

(2019) Miki Hara-Yokoyama et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The balance of forces generated by kinesins controls spindle polarity and chromosomal heterogeneity in tetraploid cells

(2019) Sei Shu et al.   JOURNAL OF CELL SCIENCE

Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles

(2018) Sudhir Kumar Singh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Silica nanoparticles induce abnormal mitosis and apoptosis via PKC-δ mediated negative signaling pathway in GC-2 cells of mice

(2018) Jin Zhang et al.   CHEMOSPHERE

Cooperative Accumulation of Dynein-Dynactin at Microtubule Minus-Ends Drives Microtubule Network Reorganization

(2018) Ruensern Tan et al.   DEVELOPMENTAL CELL

The nonmotor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of chromosome segregation

(2018) Helen Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Eg5 orchestrates porcine oocyte maturational progression by maintaining meiotic organelle arrangement

(2018) Yan Xie et al.   Cell Division

Meiotic arrest and spindle defects are associated with altered KIF11 expression in porcine oocytes-

(2018) Xiang Wan et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Kinesin-5 Regulation and Function in Mitosis

(2018) Barbara J. Mann et al.   TRENDS IN CELL BIOLOGY

The mitotic spindle is chiral due to torques within microtubule bundles

(2018) Maja Novak et al.   Nature Communications

Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe

(2018) Masashi Yukawa et al.   G3-Genes Genomes Genetics

Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation

(2017) Zhen-Yu She et al.   JOURNAL OF CELL SCIENCE

Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

(2017) Sergio A. Rincon et al.   Nature Communications

Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast

(2017) Robert Blackwell et al.   Science Advances

In Vitro Maturation of Mouse Oocytes Increases the Level of Kif11/Eg5 on Meiosis II Spindles

(2016) K. Kovacovicova et al.   BIOLOGY OF REPRODUCTION

Kinesin-5 inhibitor resistance is driven by kinesin-12

(2016) Emma G. Sturgill et al.   JOURNAL OF CELL BIOLOGY

Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules

(2015) Yuta Shimamoto et al.   DEVELOPMENTAL CELL

Regulatory mechanisms that control mitotic kinesins

(2015) Amber L. Yount et al.   EXPERIMENTAL CELL RESEARCH

Physical limits on kinesin-5–mediated chromosome congression in the smallest mitotic spindles

(2015) Kelsey M. McCoy et al.   MOLECULAR BIOLOGY OF THE CELL

Mitotic Slippage and Expression of Survivin Are Linked to Differential Sensitivity of Human Cancer Cell-Lines to the Kinesin-5 Inhibitor Monastrol

(2015) Hila Asraf et al.   PLoS One

Modulation of Eg5 activity contributes to mitotic spindle checkpoint activation and Tat-mediated apoptosis in CD4-positive T-lymphocytes

(2014) Min Liu et al.   JOURNAL OF PATHOLOGY

Kinetochore-microtubule stability governs the metaphase requirement for Eg5

(2014) A. Sophia Gayek et al.   MOLECULAR BIOLOGY OF THE CELL

Separate to operate: control of centrosome positioning and separation

(2014) F. G. Agircan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Balanced Activity of Three Mitotic Motors Is Required for Bipolar Spindle Assembly and Chromosome Segregation

(2014) Roy G.H.P. van Heesbeen et al.   Cell Reports

Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

(2014) Jessica E Scholey et al.   eLife

Interaction of NuMA protein with the kinesin Eg5: its possible role in bipolar spindle assembly and chromosome alignment

(2013) Yuko Iwakiri et al.   BIOCHEMICAL JOURNAL

Kinesin-12 Differentially Affects Spindle Assembly Depending on Its Microtubule Substrate

(2013) Emma G. Sturgill et al.   CURRENT BIOLOGY

Eg5 restricts anaphase B spindle elongation in mammalian cells

(2013) Elizabeth Collins et al.   Cytoskeleton

Nonautonomous Movement of Chromosomes in Mitosis

(2013) Elina Vladimirou et al.   DEVELOPMENTAL CELL

Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation

(2012) Jonne A Raaijmakers et al.   EMBO JOURNAL

CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia

(2012) Hao Chen et al.   HUMAN REPRODUCTION

17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line

(2012) Adele Chimento et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chromosome passenger complexes control anaphase duration and spindle elongation via a kinesin-5 brake

(2011) Daniel K. Rozelle et al.   JOURNAL OF CELL BIOLOGY

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

(2011) Nan Ma et al.   JOURNAL OF CELL BIOLOGY

Directional Switching of the Kinesin Cin8 Through Motor Coupling

(2011) J. Roostalu et al.   SCIENCE

Biochemical analysis of cellular target of S-trityl-l-cysteine derivatives using affinity matrix

(2010) Makiko Shimizu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms of Centrosome Separation and Bipolar Spindle Assembly

(2010) Marvin E. Tanenbaum et al.   DEVELOPMENTAL CELL

Microtubule organization by the antagonistic mitotic motors kinesin-5 and kinesin-14

(2010) Christian Hentrich et al.   JOURNAL OF CELL BIOLOGY

Mitotic functions of kinesin-5

(2010) Nick P. Ferenz et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

An allosteric transition trapped in an intermediate state of a new kinesin–inhibitor complex

(2009) Hung Yi Kristal Kaan et al.   BIOCHEMICAL JOURNAL

Kif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly

(2009) Marvin E. Tanenbaum et al.   CURRENT BIOLOGY

The Role of Hklp2 in the Stabilization and Maintenance of Spindle Bipolarity

(2009) David Vanneste et al.   CURRENT BIOLOGY

Dynein Antagonizes Eg5 by Crosslinking and Sliding Antiparallel Microtubules

(2009) Nick P. Ferenz et al.   CURRENT BIOLOGY

Kinesin-5–dependent Poleward Flux and Spindle Length Control in Drosophila Embryo Mitosis

(2009) Ingrid Brust-Mascher et al.   MOLECULAR BIOLOGY OF THE CELL

The mitotic kinesin-14 Ncd drives directional microtubule–microtubule sliding

(2009) Gero Fink et al.   NATURE CELL BIOLOGY

Disruption of the mitotic kinesin Eg5 gene (Knsl1) results in early embryonic lethality

(2008) Muriel Chauvière et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chromosome Congression by Kinesin-5 Motor-Mediated Disassembly of Longer Kinetochore Microtubules

(2008) Melissa K. Gardner et al.   CELL

Mid-anaphase arrest in S. cerevisiae cells eliminated for the function of Cin8 and dynein

(2008) A. Gerson-Gurwitz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells

(2008) N. Movshovich et al.   JOURNAL OF CELL SCIENCE

Kinesin-5 is not essential for mitotic spindle elongation in Dictyostelium

(2008) Irina Tikhonenko et al.   CELL MOTILITY AND THE CYTOSKELETON