Review
Nanoscience & Nanotechnology
Xi Luo, Sudan Wu, Meng Xiao, Huan Gu, Huan Zhang, Jianping Chen, Yang Liu, Chen Zhang, Jinming Zhang
Summary: Zein, derived from corn, is recognized as one of the safest biological materials by the US FDA. It has valuable characteristics that make it popular for preparing drug carriers to improve the therapeutic effect of antitumor drugs. However, the clinical translation of drug-loaded zein-based carriers is challenging due to insufficient research and strong hydrophobicity. This paper aims to introduce the interactions between loaded drugs and zein, administration routes, and the functionalization of zein-based drug delivery systems, demonstrating its potential and promoting further application.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Alessandro Parodi, Dmitry Kostyushev, Sergey Brezgin, Anastasiya Kostyusheva, Tatiana Borodina, Roman Akasov, Anastasia Frolova, Vladimir Chulanov, Andrey A. Zamyatnin Jr
Summary: In order to increase the accumulation of drugs in tumors, various nanocarriers have been designed. The development of biomimetic nanomedicine allows the generation of nanoparticles with the same characteristics as cells that naturally infiltrate tumors. Moreover, strategies such as cell membrane transfer and biomimetic targeting can enhance the targeting efficiency of drugs in tumors.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Mengyu Guo, Chenjie Xia, Yu Wu, Nong Zhou, Zhipeng Chen, Weidong Li
Summary: Cell membrane-coated biomimetic nanoplatforms have inherent properties that enhance drug delivery efficiency. Research progress on cell membrane biomimetic technology reveals broad prospects for biomedical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jing Liu, Si Si Liew, Jun Wang, Kanyi Pu
Summary: Cancer vaccines aim to stimulate tumor-specific immune responses while sparing normal tissues, with bioinspired materials and technologies playing a role in reshaping the field of cancer nanomedicine. By mimicking desirable properties in nature, bioinspired engineering of cancer vaccine delivery platforms can enhance therapeutic efficacy and safety profiles for clinical translation.
ADVANCED MATERIALS
(2022)
Article
Biophysics
Bhavya Surekha, Naga Sreenu Kommana, Sunil Kumar Dubey, A. V. Pavan Kumar, Rahul Shukla, Prashant Kesharwani
Summary: PAMAM dendrimers are novel polymeric structures with defined nano-size and multiple active functional groups, ideal for cancer therapy. Their modifiable surface functionalities and high drug encapsulation rate make them widely used in drug delivery and gene therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Carla Jimenez-Jimenez, Almudena Moreno-Borrallo, Bianca Dumontel, Miguel Manzano, Maria Vallet-Regi
Summary: Nanotechnology has revolutionized potential disease treatments, but immune clearance and poor biocompatibility limit the use of nanoparticles for drug delivery. Coating nanoparticles with cell membranes is a hypothesis to overcome rejection and enhance biocompatibility. Here, we show that coating mesoporous silica nanoparticles with membranes from preosteoblastic cells can be used for potential bone disease treatments. Our results demonstrate the cellular selectivity and migration capability of camouflaged nanocarriers, which inspire future treatments.
ACTA BIOMATERIALIA
(2023)
Review
Nanoscience & Nanotechnology
Yukun Chen, Zhenzhi Wang, Xiaofan Wang, Mingliang Su, Fan Xu, Lian Yang, Lijun Jia, Zhanxia Zhang
Summary: Nano drug delivery systems have been developed to improve the stability and water solubility of HCPT, thus enhancing its anticancer effect. Current research on HCPT nanomedicines has made progress, but there are still limitations.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Riccardo Rampado, Paolo Caliceti, Marco Agostini
Summary: In recent years, biomimetic materials have emerged as an alternative design approach for the development of innovative nanovectors. These materials use cell-derived components and coatings to endow nanomaterials with biological properties and functions.
Review
Polymer Science
Senbin Chen, Yanggui Wu, Frederic Lortie, Julien Bernard, Wolfgang H. Binder, Jintao Zhu
Summary: Diagnosis, complete cure, and healing of cancers are challenging due to the complexity of the disease. Supramolecular interactions, such as hydrogen-bonds, offer new possibilities for designing biomedical materials with remarkable properties. H-bonding (macro)molecules can be used as supramolecular motifs to create drug- and diagnostic carriers with assembled nanoplatforms and the responsiveness of H-bonds. H-bonded nanomedicine shows promise in early-stage diagnosis and therapy, with potential clinical translations.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Lili Ai, Tianhuan Peng, Yingying Li, Hailan Kuai, Yingyu Sima, Minhui Su, Dan Wang, Qiuxia Yang, Xue-Qiang Wang, Weihong Tan
Summary: This study describes the development of a novel dual-targeting circular aptamer that can recognize two different biomarkers on living cells, enhancing the recognition of target cells. This improvement not only boosts the binding and internalization abilities of the aptamer, but also expands its recognition spectrum to different leukemia cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Hongyue Yu, Yan Yu, Runfeng Lin, Minchao Liu, Qiaoyu Zhou, Mengli Liu, Liang Chen, Wenxing Wang, Ahmed A. Elzatahry, Dongyuan Zhao, Xiaomin Li
Summary: A camouflaged virus-like nanocarrier with a transformable rough surface composed of a mesoporous SiO2 nanoparticle and an acid-responsive polymer is reported. Under normal pH conditions, the spikes on the nanocarrier are hidden by the polymer shell, inhibiting non-specific strong nano-bio interactions. In an acidic tumor microenvironment, the nanocarrier sheds the polymer camouflage to expose its rough surface, improving retention ability and endocytosis efficiency. The rationally designed nanocarrier exhibits extended blood circulation time and enhanced tumor accumulation due to its dynamically variable rough surface.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Pharmacology & Pharmacy
Xiaoqiu Xu, Tong Li, Ke Jin
Summary: Nanomedicines offer alternative strategies for tumor-targeted therapy due to their nanoscale size and tunable surface features. Biomimetic nanomedicines show promising potential in maximizing anti-tumor efficacy with minimal adverse effects due to their good biocompatibility and high accumulation abilities.
Article
Engineering, Biomedical
Xiao Xu, Limei Xu, Caining Wen, Jiang Xia, Yuanmin Zhang, Yujie Liang
Summary: Exosomes, as a cell-free therapeutic approach, hold great promise. However, before clinical use, challenges in large-scale production, quality control, and heterogeneity need to be addressed. Biomimetic exosomes, called exosome-mimetics (EMs), have been created through various methods, such as extrusion, artificial synthesis, and liposome fusion, to overcome these limitations. EMs possess similar morphology and function to natural exosomes, but offer higher yields, faster large-scale production, and similar size. This article provides an overview of the chemical and biological properties of synthetic exosome systems, highlighting recent advances in production and applications, and discussing advantages, limitations, and potential clinical applications of EMs.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Mohamed Haider, Amr Elsherbeny, Valeria Pittala, Valeria Consoli, Maha Ali Alghamdi, Zahid Hussain, Ghalia Khoder, Khaled Greish
Summary: Lung cancer is a major cause of cancer occurrence and mortality worldwide. Drug resistance is a complex process in lung cancer, and nanomedicine provides promising tools for reversing resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Assaf Zinger
Summary: In this paper, the author presents design strategies for the two main biomimetic nanoparticles (BNP) groups: BNP composed of isolated cell membrane proteins, and BNP composed of the native cell membrane. The author also describes BNP fabrication methods and analyzes their advantages and challenges. Finally, future therapeutic applications of each BNP group are suggested and a new revolutionary concept for their use is proposed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Wenyan Yu, Cuiping Xuan, Bingbing Liu, Lei Zhou, Na Yin, Enpeng Gong, Zhenzhong Zhang, Yinchao Li, Kaixiang Zhang, Jinjin Shi
Summary: A carrier-free programmed spherical nucleic acid nanostructure has been developed, which showed efficient blood-brain barrier penetration capability and satisfactory caspase-3 silencing effect, significantly improving the therapeutic efficacy of ischemic stroke.
Article
Chemistry, Analytical
Yanan Li, Di Huang, Yiran Pei, Fenglei Quan, Hua Gao, Junli Zhang, Hongwei Hou, Kaixiang Zhang, Jinghong Li
Summary: Site-specific imaging of target genes using CRISPR probes is crucial for understanding gene function and developing tools for gene manipulation. The CasSABER probe allows programmable in situ imaging of low and nonrepetitive regions of a gene. It can specifically light up gene loci bound by dCas9/sgRNA, enabling high-specificity and high-signal-to-noise ratio imaging of fixed cellular gene loci. The CasSABER system also enables adjustable signal amplification, allowing simultaneous visualization of multicopy and single-copy gene loci with similar fluorescence intensity.
ANALYTICAL CHEMISTRY
(2023)
Review
Engineering, Biomedical
Danyu Wang, Jie Duan, Jingwen Liu, Hua Yi, Zhenzhong Zhang, Haiwei Song, Yinchao Li, Kaixiang Zhang
Summary: DNA hydrogels are increasingly important in biomedical and bioanalysis applications. They are highly programmable, multifunctional, and biocompatible, making them effective carriers for drugs and bioactive cargoes. However, the stability of DNA hydrogels hinders rapid release of cargoes. Stimulus-responsive DNA hydrogels have been designed to meet these requirements, switching from gel to solution for precision cargo delivery and bioanalysis. This review summarizes innovative methods for designing stimuli-responsive self-degradable DNA hydrogels and discusses their applications and challenges in the fields of bioanalysis and biomedicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Junli Zhang, Mengting Guan, Chihong Ma, Yingying Liu, Min Lv, Zhenzhong Zhang, Hua Gao, Kaixiang Zhang
Summary: Exosomal miRNAs have a critical role in cancer biology and may serve as potential biomarkers for cancer diagnosis. However, detecting disease-associated exosomal miRNAs in an easy-to-operate manner is challenging due to their low abundance. In this study, a liposome-mediated membrane fusion strategy (MFS) called MFS-CRISPR was used to directly measure exosomal miRNAs in plasma. The MFS-CRISPR platform exhibited a linear detection range from 10(4) to 10(8) particles/mL and could detect exosomal miR-21 at a low concentration of 1.2 x 10(3) particles/mL. The proposed method showed promising clinical potential for cancer diagnosis and treatment monitoring due to its high sensitivity and simplicity.
Article
Chemistry, Multidisciplinary
Yan Liang, Wenshuai Han, Chenlu Xu, Jinjin Wang, Jingge Zhang, Jingyi An, Wei Liu, Junjie Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang
Summary: A cascade-responsive oxidative stress amplifier, DR-TAF-pHT/FA, is proposed that can generate reactive oxygen species (ROS) on the lysosomal membrane of tumor cells and release Cas9/sgNrf2 RNPs for efficient gene disruption. The treatment significantly improves tumor ablation efficiency and extends median survival time in xenograft models.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shizhen Geng, Tingting Xiang, Yunya Zhang, Pengke Guo, Hongling Zhang, Zhenzhong Zhang, Mengchao Gu, Kaixiang Zhang, Haiwei Song, Jinjin Shi, Junjie Liu
Summary: Abundant CAFs in highly fibrotic breast cancer act as an immunosuppressive barrier and are linked to the failure of ICB. To overcome this, a strategy to transform immune-suppressed CAFs into immune-activated APCs is proposed. A photo-controlled gene expression nanosystem is developed to engineer CAFs as APCs and induce activation and proliferation of CD8+ T cells.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Yan Liang, Jinjin Wang, Chenlu Xu, Wenshuai Han, Sixuan Wu, Yonghua Wu, Jingge Zhang, Junjie Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang
Summary: This study developed a biomimetic nano-regulator (P-ZIF8-cirDNAzyme) that can affect collagen synthesis and degradation in the liver to reverse liver fibrosis. Zinc (II) interference inhibits collagen synthesis by inactivating proline 4 hydroxylase and affecting fibrosis-related signaling pathways. Zinc (II)-dependent circular DNAzymes silence tissue inhibitors of metalloproteinase-1, accelerating collagen degradation. The coated P-ZIF-8-cirDNAzyme targets activated hepatic stellate cells (aHSC) with inflammatory tropism and CD62p-CD44 interaction, showing a potent anti-fibrotic effect and restoring liver function in fibrotic mice.
Article
Chemistry, Multidisciplinary
Jiali Yang, Mengyun Peng, Shaochong Tan, Shengchan Ge, Li Xie, Tonghai Zhou, Wei Liu, Kaixiang Zhang, Zhenzhong Zhang, Junjie Liu, Jinjin Shi
Summary: Calcium tungstate microgel selectively disrupts the ecological niche occupied by abnormally expanded Enterobacteriaceae during colitis, promoting probiotic colonization. The use of a calcium tungste microgel-based oral probiotic delivery system improves the delivery and colonization of probiotics. The synergistic reduction of Enterobacteriaceae and increase in probiotic colonization results in effective treatment for colitis.
ACS CENTRAL SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Xianglin Zhu, Kaixiang Zhang, Xucong Teng, Xuhan Xia, Ruijie Deng, Jinghong Li
Summary: The gut microbiota is an important hidden organ closely related to human health. Emerging techniques such as spatially resolved sequencing and in vivo imaging enable the acquisition of spatial organizations and dynamic information of the gut microbiome, providing new insights into physiological activities, symbiotic functions, and spatial organization rearrangement under different physiological and pathological conditions, which have implications for diet and clinical treatment through gut microbiota management.
Article
Chemistry, Multidisciplinary
Xiu Zhao, Hui Cheng, Qiongwei Wang, Weimin Nie, Yue Yang, Xinyuan Yang, Kaixiang Zhang, Jinjin Shi, Junjie Liu
Summary: This study reports a photosensitizer metabolism-regulating strategy using ALA/DNAzyme-co-loaded nanoparticles (ALA & Dz@ZIF-PEG) for mitochondria-targeting photodynamic immunotherapy. The nanoparticles release zinc ions (Zn2+) in tumor cells, which promotes the conversion of ALA to PpIX and enhances the accumulation of PpIX in mitochondria, leading to improved photodynamic therapy outcomes.
Article
Chemistry, Multidisciplinary
Yan Liang, Jingge Zhang, Chenlu Xu, Jinjin Wang, Wenshuai Han, Jiali Yang, Sixuan Wu, Jingyi An, Junjie Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang
Summary: The researchers have developed an all-in-one biomimetic mineralized CRISPR/Cas9 RNA delivery system, which achieves efficient multiplex gene editing by editing multiple genomic loci. The system allows for precise control over the coencapsulation ratio between Cas9 mRNA and multiple sgRNAs, with a high RNA loading capacity. It also enhances the storage stability of RNA at 4°C and enables precise targeting of RNA nanoparticles in vivo. The system successfully achieved significant gene editing and inhibited tumor growth without off-target effects in liver tissue.
Correction
Chemistry, Multidisciplinary
Jingyi An, Kaixiang Zhang, Binghua Wang, Sixuan Wu, Yifei Wang, Hongling Zhang, Zhenzhong Zhang, Junjie Liu, Jinjin Shi
Article
Multidisciplinary Sciences
Danyu Wang, Jingwen Liu, Jie Duan, Hua Yi, Junjie Liu, Haiwei Song, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang
Summary: The authors developed a DNA hydrogel that can monitor tumor recurrence and prevent postoperative tumor recurrence and metastasis. The hydrogel contains PDL1 aptamers to capture and enrich relapsed tumor cells, increasing local ATP concentration and providing a timely warning signal. By triggering photodynamic therapy and releasing tumor-associated antigens, as well as promoting systemic antitumor immunotherapy, the hydrogel system effectively inhibits recurrent tumors and suppresses metastasis.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yanan Li, Ru Xu, Yonghua Wu, Jialing Guo, Fenglei Quan, Yiran Pei, Di Huang, Xiu Zhao, Hua Gao, Junjie Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang
Summary: This study presents a mutation-induced drug release system (MIDRS) that utilizes the single-nucleotide variation (SNV) recognition ability and trans-cleavage activity of Cas12a to convert tumor-specific mtDNA mutations into a regulatory switch for intracellular drug release, achieving precise tumor cell killing. The MIDRS system demonstrated excellent antitumor effects without affecting normal cells, leading to a stronger systemic antitumor immune response. This strategy shows promise for mutation-specific personalized tumor treatment approaches.
Correction
Chemistry, Multidisciplinary
Xiu Zhao, Hui Cheng, Qiongwei Wang, Weimin Nie, Yue Yang, Xinyuan Yang, Kaixiang Zhang, Jinjin Shi, Junjie Liu
