Article
Urology & Nephrology
Soshiro Ogata, Yuumi Akashi, Takaya Sakusabe, Shigehito Yoshizaki, Yuko Maeda, Kunihiro Nishimura, Kenji Maeda, Shigeru Nakai
Summary: This study found that there is an association between kidney function decline in patients with chronic kidney disease and sodium and potassium intake. Higher sodium intake was positively correlated, while higher potassium intake was negatively correlated with kidney function decline. Higher sodium intake but lower potassium intake was associated with more severe decline in kidney function.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Johannes Ruhe, Jennifer Nadal, Barbara Barthlein, Heike Meiselbach, Ulla T. Schultheiss, Fruzsina Kotsis, Helena Stockmann, Vera Krane, Claudia Sommerer, Ivonne Loeffler, Turgay Saritas, Jan T. Kielstein, Thomas Sitter, Markus P. Schneider, Matthias Schmid, Christoph Wanner, Kai-Uwe Eckardt, Gunter Wolf, Martin Busch
Summary: Diabetes mellitus (DM) and chronic kidney disease (CKD) are known risk factors for cardiovascular disease and mortality. This study found that DM significantly increased the risk of cardiovascular and non-cardiovascular death, major adverse cardiovascular events, and hospitalization for heart failure in patients with moderate to severe CKD. The increased risk was similar in patients with CKD caused by cardiovascular/metabolic diseases and those with genuine CKD. Patients with DM and CKD caused by cardiovascular/metabolic diseases were particularly susceptible to heart failure.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Ya-Lien Cheng, Shu-Chun Huang, Ming-Yun Ho, Yan-Rong Li, Chieh-Li Yen, Kuan-Hsing Chen, Wei-Chiao Sun, Pei-Yi Fan, Jung-Sheng Chen, Chihung Lin, Ching-Chung Hsiao
Summary: Metabolic acidosis is a common complication in chronic kidney disease (CKD) patients. This study found that the use of sodium bicarbonate in patients with advanced CKD was associated with similar risk of dialysis initiation but significantly lower risks of major adverse cardiovascular events (MACE) and mortality. The findings highlight the benefits of sodium bicarbonate therapy in the CKD population.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Urology & Nephrology
Joshua D. Bundy, Mahboob Rahman, Kunihiro Matsushita, Byron C. Jaeger, Jordana B. Cohen, Jing Chen, Rajat Deo, Mirela A. Dobre, Harold I. Feldman, John Flack, Radhakrishna R. Kallem, James P. Lash, Stephen Seliger, Tariq Shafi, Shoshana J. Weiner, Myles Wolf, Wei Yang, Norrina B. Allen, Nisha Bansal, Jiang He, CRIC Study Investigators
Summary: This study developed 10-year ASCVD risk prediction models in patients with CKD, including novel biomarkers, which performed better than models using only traditional risk factors developed for the general population.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Demetria Hubbard, Lisandro D. Colantonio, Robert S. Rosenson, Todd M. Brown, Elizabeth A. Jackson, Lei Huang, Kate K. Orroth, Stephanie Reading, Mark Woodward, Vera Bittner, Orlando M. Gutierrez, Monika M. Safford, Michael E. Farkouh, Paul Muntner
Summary: This study compared the risk for recurrent cardiovascular disease events among patients with a history of CVD and different levels of diabetes and CKD. The findings suggest that adults with both diabetes and CKD after a myocardial infarction have a higher risk for recurrent CVD events compared to those with prior CVD without diabetes or CKD.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Urology & Nephrology
Vera Jankowski, Turgay Saritas, Mads Kjolby, Juliane Hermann, Thimoteus Speer, Anika Himmelsbach, Kerstin Mahr, Marina Augusto Heuschkel, Stefan J. Schunk, Soren Thirup, Simon Winther, Morten Bottcher, Mette Nyegard, Anders Nykjaer, Rafael Kramann, Nadine Kaesler, Joachim Jankowski, Juergen Floege, Nikolaus Marx, Claudia Goettsch
Summary: Sortilin carbamylation is associated with cardiovascular calcification in patients with chronic kidney disease (CKD). Carbamylated sortilin alters ligand binding and accelerates vascular calcification. Patients with carbamylated sortilin exhibit faster progression of coronary artery calcification. Therefore, carbamylated sortilin may be an important risk factor for cardiovascular complications in CKD patients.
KIDNEY INTERNATIONAL
(2022)
Article
Transplantation
Hirohito Goto, Ken Iseri, Noriko Hida
Summary: This nested case-control study investigated the efficacy of fibrates on the risk of major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD). The results showed that recent and current use of fibrates, especially pemafibrate, was associated with a reduced risk of MACE in CKD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Adi-Lukas Kurniawan, Ya-Lan Yang, Mei-Yun Chin, Chien-Yeh Hsu, Rathi Paramastri, Hsiu-An Lee, Po-Yuan Ni, Jane Chao
Summary: The study showed that chronic kidney disease (CKD) patients can benefit from nutrition education (NE) and lifestyle adjustments in improving kidney function and cardiovascular risk factors, particularly for patients who smoke or have inactive physical activity. Nutrition education may play a positive role in enhancing kidney function and improving cardiovascular risk factors.
Article
Endocrinology & Metabolism
Jing Liu, Maria Clarissa Tio, Ashish Verma, Insa M. Schmidt, Titilayo O. Ilori, Felix Knauf, Finnian R. Mc Causland, Sushrut S. Waikar
Summary: This study aimed to investigate predictors of urinary calcium excretion and its association with adverse clinical outcomes in chronic kidney disease (CKD). The results showed that estimated glomerular filtration rate (eGFR) was positively correlated with 24-hour urinary calcium excretion. The determinants of urinary calcium excretion differed between sexes and levels of CKD. Lower urinary calcium excretion was associated with higher risks of adverse outcomes, but these associations were greatly attenuated or nullified after adjustment for baseline eGFR.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Joshua Solomon, Maria Carolina Festa, Yiannis S. Chatzizisis, Ratna Samanta, Rita S. Suri, Thomas A. Mavrakanas
Summary: Diabetes leads to an increasing burden of cardiovascular and renal diseases globally, driving the search for new hypoglycemic agents that provide cardiac and renal protective effects. Sodium-glucose co-transporter 2 (SGLT-2) inhibitors, originally developed as hypoglycemic agents, have shown efficacy and safety in patients with chronic kidney disease (CKD) due to their complex mechanisms of action. This review focuses on the pharmacology and pathophysiology of SGLT-2 inhibitors in CKD patients, as well as their cardiovascular and renal effects in this population.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Urology & Nephrology
Cecilia Malheiro Cury, Vanessa Burgugi Banin, Pamela Falbo dos Reis, Jacqueline Costa Teixeira Caramori, Pasqual Barretti, Luis Gustavo Modelli de Andrade, Luis Cuadrado Martin
Summary: Moderate sodium intake is associated with a lower risk of renal failure, but not with mortality.
Article
Cell Biology
Katarzyna Romejko, Aleksandra Rymarz, Katarzyna Szamotulska, Zbigniew Bartoszewicz, Tomasz Rozmyslowicz, Stanislaw Niemczyk
Summary: This study investigated the relationship between resistin and cardiovascular risk in men with chronic kidney disease (CKD) not treated with dialysis. The results showed that resistin concentrations were significantly higher in CKD patients and resistin may contribute to the progression of cardiovascular risk in this group of patients. Additionally, the relationship between resistin and CV risk is modified by PAI-1 concentrations.
Article
Peripheral Vascular Disease
Yuta Matsukuma, Masaru Nakayama, Susumu Tsuda, Akiko Fukui, Ryota Yoshitomi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
Summary: This study found that a higher UNa/K ratio was independently associated with poor renal outcomes in patients with chronic kidney disease.
HYPERTENSION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Chia-Ter Chao, Szu-Ying Lee, Jui Wang, Kuo-Liong Chien, Kuan-Yu Hung
Summary: Patients with incident diabetes and subsequently developed chronic kidney disease had a significantly higher risk of mortality, heart failure, acute myocardial infarction, and peripheral vascular disease compared to those without CKD. The risk of mortality, heart failure, and acute myocardial infarction associated with CKD became significant soon after diabetes occurred and remained significant throughout follow-up, indicating the need for early cardiovascular care strategies for newly diagnosed diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rajat Deo, Ruth F. Dubin, Yue Ren, Ashwin C. Murthy, Jianqiao Wang, Haotian Zheng, Zihe Zheng, Harold Feldman, Haochang Shou, Josef Coresh, Morgan Grams, Aditya L. Surapaneni, Zeenat Bhat, Jordana B. Cohen, Mahboob Rahman, Jiang He, Santosh L. Saraf, Alan S. Go, Paul L. Kimmel, Ramachandran S. Vasan, Mark R. Segal, Hongzhe Li, Peter Ganz
Summary: Through large-scale proteomics discovery, this study aimed to create more accurate cardiovascular risk models for patients with chronic kidney disease (CKD). The proteomic risk model outperformed traditional clinical models in predicting cardiovascular risk and provided new biological insights for the development of cardiovascular risk management strategies in CKD patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Urology & Nephrology
Insa M. Schmidt, Anand Srivastava, Venkata Sabbisetti, Gearoid M. McMahon, Jiang He, Jing Chen, John W. Kusek, Jonathan Taliercio, Ana C. Ricardo, Chi-yuan Hsu, Paul L. Kimmel, Kathleen D. Liu, Theodore E. Miff, Robert G. Nelson, Ramachandran S. Vasan, Dawei Xie, Xiaoming Zhang, Ragnar Palsson, Isaac E. Stillman, Helmut G. Rennke, Harold I. Feldman, Joseph V. Bonventre, Sushrut S. Waikar
Summary: Plasma KIM-1 levels are associated with clinical outcomes and pathological lesions in various kidney diseases, with higher levels of plasma KIM-1 being linked to an increased risk of kidney failure.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Urology & Nephrology
Manjula Kurella Tamura, Sarah Gaussoin, Nicholas M. Pajewski, Greg Zaharchuk, Barry Freedman, Stephen R. Rapp, Alexander P. Auchus, William E. Haley, Suzanne Oparil, Jessica Kendrick, Christianne L. Roumie, Srinivasan Beddhu, Alfred K. Cheung, Jeff D. Williamson, John A. Detre, Sudipto Dolui, R. Nick Bryan, Ilya M. Nasrallah
Summary: This study aimed to investigate the effects of intensive blood pressure control on cerebral perfusion and structure in individuals with and without chronic kidney disease (CKD). The findings suggest that intensive blood pressure treatment in adults with early kidney disease does not appear to have a detrimental effect on brain perfusion or structure.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Yuhan Zang, Zhengbao Zhu, Mengyao Shi, Aili Wang, Xuewei Xie, Tan Xu, Yanbo Peng, Pinni Yang, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Liping Liu, Yonghong Zhang, Jiang He
Summary: This study investigated the association between annual household income and prognosis of ischaemic stroke. The findings indicated that low annual household income was significantly associated with increased risks of adverse clinical outcomes after ischaemic stroke. Further studies are needed to replicate these findings in other samples.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Clinical Neurology
Kaixin Zhang, Zhengbao Zhu, Bizhong Che, Xiaoqing Bu, Tian Xu, Chongke Zhong, Aili Wang, Hao Peng, Daoxia Guo, Xiaowei Zheng, Tan Xu, Jing Chen, Yonghong Zhang, Jiang He
Summary: The study found that among Chinese patients with ischemic stroke, the ASTRAL score had the best accuracy for predicting 2-year prognosis. The ASTRAL score showed good fit and higher efficacy compared to other prognostic scores such as SPAN-100 and THRIVE, making it a valuable risk assessment tool for the 2-year prognosis of these patients.
NEUROLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Antoine H. Chaanine, LeeAnn Higgins, Todd Markowski, Jarrod Harman, Maureen Kachman, Charles Burant, L. Gabriel Navar, David Busija, Patrice Delafontaine
Summary: Metabolic remodeling plays a significant role in the pathophysiology of heart failure, and the crosstalk between PKA and AMPK signaling governs metabolic remodeling in myocardial remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Adrianna Westbrook, Ruiyuan Zhang, Mengyao Shi, Alexander C. Razavi, Zhijie Huang, Jing Chen, Jiang He, Tanika Kelly, Ye Shen, Changwei Li
Summary: This study aimed to evaluate the association between baseline telomere length and kidney function. The results showed that participants with longer telomere length were more likely to have consistently normal kidney function, while it was not associated with the rate of eGFR change.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kirsten S. Dorans, Lydia A. Bazzano, Xingyan Li, Joshua D. Bundy, Ling Tian, Jiang He
Summary: This study compared cardiometabolic risk factors among parous women aged 20-44 in the United States with and without a history of gestational diabetes mellitus (GDM). The results showed that women with a history of GDM had less favorable cardiometabolic risk factor profiles, highlighting the importance of developing interventions to improve cardiovascular health in women with a history of GDM.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Yuhan Zang, Zhengbao Zhu, Yi Xie, Zhen Liu, Jieyun Yin, Pinni Yang, Kaixin Zhang, Xiaoqing Bu, Aili Wang, Jing Chen, Yonghong Zhang, Jiang He
Summary: This study found that elevated serum GDF-15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF-15 may be a valuable prognostic biomarker for PSD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Deying Liu, Yan Huang, Chensihan Huang, Shunyu Yang, Xueyun Wei, Peizhen Zhang, Dan Guo, Jiayang Lin, Bingyan Xu, Changwei Li, Hua He, Jiang He, Shiqun Liu, Linna Shi, Yaoming Xue, Huijie Zhang
Summary: Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Mengyao Shi, Jiang He, Changwei Li, Xiangfeng Lu, William J. He, Jie Cao, Jing Chen, Ji-Chun Chen, Lydia A. Bazzano, Jian-Xin Li, Hua He, Dongfeng Gu, Tanika N. Kelly
Summary: The study identified metabolite associations with salt sensitivity and hypertension, with 15 metabolites linked to hypertension. Changes in these metabolites predicted the occurrence of hypertension, providing insights into the biological mechanisms underlying salt-sensitive hypertension.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Pinni Yang, Zhengbao Zhu, Mengyao Shi, Jieyun Yin, Yuhan Zang, Chongke Zhong, Aili Wang, Hao Peng, Tian Xu, Daoxia Guo, Tan Xu, Jing Chen, Yonghong Zhang, Jiang He
Summary: The association between GDF-15 levels and stroke prognosis differs based on diabetes status, with a significant association found in patients with diabetes but not in those without diabetes. Elevated serum GDF-15 levels may serve as an important prognostic factor for ischemic stroke in patients with diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cell Biology
Antoine H. Chaanine, LeeAnn Higgins, Lothar Lauterboeck, Todd Markowski, Qinglin Yang, Patrice Delafontaine
Summary: The study utilizes a multiomics approach to uncover the molecular mechanisms of BNIP3 in the pathogenesis of HFrEF, revealing its role in modulating various pathobiological processes. The findings suggest that BNIP3 could be a potential therapeutic target for HFrEF.
Letter
Cardiac & Cardiovascular Systems
Emilie K. Frimodt-Moller, John S. Gottdiener, Elsayed Z. Soliman, Jorge R. Kizer, Eric Vittinghoff, Bruce M. Psaty, Tor Biering-Sorensen, Gregory M. Marcus
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Imtiaz Ahmad, Mai Z. Soliman, Elsayed Z. Soliman
Summary: The presence of premature ventricular complexes (PVCs) is associated with an increased risk of stroke mortality, particularly in individuals with coronary heart disease (CHD). Prospective studies are needed to investigate whether improved hospital care or modification of PVCs could improve outcomes.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Linzi Li, Pamela L. Lutsey, Lin Yee Chen, Elsayed Z. Soliman, Mary R. Rooney, Alvaro Alonso
Summary: Higher serum magnesium is associated with a lower risk of cardiovascular events, especially myocardial infarction, in patients with atrial fibrillation.