Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Cai, Natthaya Triphuridet, Yeqing Zhu, Nan You, Rowena Yip, David F. Yankelevitz, Claudia Henschke
Summary: Bronchiectasis is prevalent in smokers undergoing low-dose CT screening, and the occurrence of respiratory symptoms and acute events increases with the severity of the Early Lung and Cardiac Action Program Bronchiectasis score.
Review
Oncology
J. L. Dickson, C. Horst, A. Nair, S. Tisi, R. Prendecki, S. M. Janes
Summary: Lung cancer is the leading cause of cancer death worldwide, with early detection playing a crucial role in improving survival rates. Studies have shown that low-dose computed tomography can significantly reduce lung cancer-specific mortality. Despite some barriers and concerns, this screening method should still be widely promoted.
ANNALS OF ONCOLOGY
(2022)
Article
Critical Care Medicine
Paul Pinsky, Eric Miller, Nick Faris, Raymond Osarogiagbon
Summary: This study explores the relationship between pulmonary nodules and lung cancer, assessing the commonness of nodules in the Medicare population and the rate of lung cancer after their detection. The study finds that pulmonary nodules are relatively common and are associated with a higher occurrence of lung cancer. It also suggests that a larger proportion of early-stage lung cancer is diagnosed through reporting of nodules compared to low-dose CT scan screening.
Article
Medicine, General & Internal
Lisa Jungblut, Harry Etienne, Caroline Zellweger, Alessandra Matter, Miriam Patella, Thomas Frauenfelder, Isabelle Opitz
Summary: This pilot study in Switzerland assesses the implementation and performance of low-dose CT lung cancer screening and explores its potential impact on reducing mortality rates. The study enrolls participants meeting specific criteria and uses LDCT scans for assessment. Preliminary results suggest the feasibility of LDCT lung cancer screening in Switzerland.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Jennifer L. Dickson, Helen Hall, Carolyn Horst, Sophie Tisi, Priyam Verghese, Anne-Marie Mullin, Jonathan Teague, Laura Farrelly, Vicky Bowyer, Kylie Gyertson, Fanta Bojang, Claire Levermore, Tania Anastasiadis, Karen Sennett, John McCabe, Anand Devaraj, Arjun Nair, Neal Navani, Matthew E. J. Callister, Allan Hackshaw, Samantha L. Quaife, Sam M. Janes
Summary: Telephone-based risk assessment is an efficient method to optimize selection for lung cancer screening appointments, but further adjustments are needed to ensure fairness, especially for younger individuals and minority ethnic groups.
Review
Critical Care Medicine
Deepti Singhvi, Jessica Bon
Summary: Comorbidities significantly impact COPD patients, and targeted early screening and treatment may have a significant effect on COPD outcomes. Recent studies suggest that certain radiographic features can serve as surrogate markers for comorbid disease in COPD patients.
Article
Oncology
Eric W. Zhang, Jo-Anne O. Shepard, Anderson Kuo, Wariya Chintanapakdee, Florence Keane, Justin F. Gainor, Mari Mino-Kenudson, Michael Lanuti, Inga T. Lennes, Subba R. Digumarthy
Summary: The study investigated the characteristics and outcomes of screening-detected lung cancers, and found that LCS implementation achieved a higher cancer detection rate, detection of early-stage cancers, and more multifocal lung cancers compared with the NLST, with low complications and mortality.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Jaeyoun Yi, Yeol Kim
Summary: Elevating the diameter threshold for solid nodules from 6 to 9 mm may lead to a substantial reduction in unnecessary follow-up LDCTs with a small proportion of diagnostic delay of lung cancers.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Anil Vachani, Nikki M. Carroll, Michael J. Simoff, Christine Neslund-Dudas, Stacey Honda, Robert T. Greenlee, Katharine A. Rendle, Andrea Burnett-Hartman, Debra P. Ritzwoller
Summary: Despite evidence from clinical trials, the effectiveness of lung cancer screening (LCS) in clinical practice has not been clearly revealed. A multicenter cohort study showed that implementation of LCS at four diverse health care systems resulted in an increase in the incidence of early-stage lung cancer and a decrease in late-stage lung cancer, but overall lung cancer incidence did not significantly increase, suggesting limited impact of overdiagnosis.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Critical Care Medicine
Lynn T. Tanoue, Polly Sather, Isabel Cortopassi, Demetrius Dicks, Anne Curtis, Gaetane Michaud, Anna Bader, Christopher Gange, Frank Detterbeck, Jonathan Killam
Summary: Standardization of reporting positive findings on low-dose CT scans is crucial for high-quality lung cancer screening. Developing a structured system for standardized reporting can help reduce the risk of variability in reporting and unnecessary evaluations.
Article
Medicine, General & Internal
Elke A. Nekolla, Gunnar Brix, Juergen Griebel
Summary: Recent studies have shown that low-dose computed tomography (LDCT) screening can significantly reduce lung cancer mortality in heavy smokers or ex-smokers. However, LDCT screening is associated with radiation risks, and the benefits and risks need to be carefully considered.
Article
Oncology
Cherie P. Erkmen, Farouk Dako, Ryan Moore, Chandra Dass, Mark G. Weiner, Larry R. Kaiser, Grace X. Ma
Summary: The study enrolled 505 patients of diverse backgrounds, with most participants undergoing SDM and LDCT, mainly due to result discussions and follow-up recommendations. Ultimately, the findings suggest that an integrated lung cancer screening program can be safely implemented in a diverse population, but adherence to annual screening is poor.
CANCER CAUSES & CONTROL
(2021)
Review
Medicine, General & Internal
Theresa Hunger, Eva Wanka-Pail, Gunnar Brix, Juergen Griebel
Summary: The review found that screening for lung cancer in (former) smokers with low-dose computed tomography (LDCT) can significantly reduce disease-specific mortality. However, the screening may have a high false positive rate and carries the risk of overdiagnosis.
Article
Gastroenterology & Hepatology
Meylin Caballeros Lam, Paula Pujols, Ana Ezponda Casajus, Fernando Guillen Valderrama, Maria Jose Garcia Velloso, Alejandra Wyss, Loreto Garcia del Barrio, Javier Larrache Latasa, Jesus Pueyo Villoslada, Maria Dolores Lozano Escario, Juan P. de-Torres, Ana Belen Alcaide Ocana, Aranzazu Campo Ezquibela, Luis Seijo Maceiras, Luis Montuenga Badia, Javier Zulueta, Mercedes Inarrairaegui Bastarrica, Ignacio Herrero Santos, Gorka Bastarrika Aleman
Summary: In this study, a lung cancer screening program was implemented in liver transplant recipients (LTR) using low-dose CT and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET). The results showed that 9.7% of the LTR were diagnosed with lung cancer, most of which were non-small cell subtype. The majority of lung cancers (82.3%) were diagnosed at stage I, indicating the effectiveness of the screening program in detecting early-stage lung cancer.
LIVER TRANSPLANTATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Giulia Picozzi, Nicola Sverzellati, Sandra Anglesio, Maurizio Bartolucci, Edoardo Cavigli, Annalisa Deliperi, Massimo Falchini, Fabio Falaschi, Domenico Ghio, Paola Gollini, Anna Rita Larici, Alfonso Marchiano, Stefano Palmucci, Lorenzo Preda, Chiara Romei, Carlo Tessa, Cristiano Rampinelli, Mario Mascalchi
Summary: Smoking is the main risk factor for lung cancer, and low dose computed tomography (LDCT) screening has been proven to reduce lung cancer mortality, especially in women. Several Italian initiatives are currently offering LDCT screening and smoking cessation to high-risk individuals, with the aim of implementing a population-based screening program. This position paper provides recommendations for LDCT scan protocol, nodule classification, and management based on international guidelines.