期刊
CELL
卷 185, 期 8, 页码 1356-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2022.02.027
关键词
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资金
- National Natural Science Foundation of China (NSFC) [32170803, 81872405]
- Westlake Edu-cation Foundation
Tumor-resident intracellular microbiota plays an important role in promoting cancer metastasis, enhancing host-cell survival by increasing resistance to fluid shear stress. Furthermore, administration of intratumor bacteria can also promote tumor metastasis.
Tumor-resident intracellular microbiota is an emerging tumor component that has been documented for a variety of cancer types with unclear biological functions. Here, we explored the functional significance of these intratumor bacteria, primarily using a murine spontaneous breast-tumor model MMTV-PyMT. We found that depletion of intratumor bacteria significantly reduced lung metastasis without affecting primary tumor growth. During metastatic colonization, intratumor bacteria carried by circulating tumor cells promoted host-cell survival by enhancing resistance to fluid shear stress by reorganizing actin cytoskeleton. We further showed that intratumor administration of selected bacteria strains isolated from tumor-resident microbiota promoted metastasis in two murine tumor models with significantly different levels of metastasis potential. Our findings suggest that tumor-resident microbiota, albeit at low biomass, play an important role in promoting cancer metastasis, intervention of which might therefore be worth exploring for advancing oncology care.
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