Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Kepeng Hu, Erna Jia, Qimeng Zhang, Wei Zheng, Rongjiao Sun, Mengao Qian, Ying Tan, Wanle Hu
Summary: Tea tree oil (TTO) is encapsulated into the hydrogel network via a previous emulsification process, and a tough and antibacterial injectable hydrogel is synthesized by the Schiff base reaction between carboxymethyl chitosan (CMCS) and genipin (GP). The obtained hydrogels exhibit high adhesive strength (about 162.75 kPa), excellent antibacterial properties (over 90%), and great biocompatibility. The heterogeneous hydrogel shows good slow-release properties of TTO for accelerated healing of complex anal fistula wounds according to an anal fistula-like wound healing experiment.
CARBOHYDRATE POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Zilong Fang, Tao Lin, Shuai Fan, Xing Qiu, Ziqing Zhong, Ganghua Yang, Jianqiu Yang, Guoqing Zhang, Yang Feng, Fanrong Ai, Qingming Shi, Wenbing Wan
Summary: This study discovered and constructed a novel injectable hydrogel wound dressing based on carboxymethyl chitosan (CMCS) and polyethylenimine (PEI). The hydrogel has good injectability, biocompatibility, antibacterial properties, and certain adhesion properties, which can promote wound healing and cell repair with broad application prospects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Qingcong Wei, Yaxing Wang, Huan Wang, Li Qiao, Yuqin Jiang, Guanglei Ma, Weiwei Zhang, Zhiguo Hu
Summary: Designing adhesive hydrogel wound dressings with inherent antibacterial and antioxidant properties is desirable for clinical care. In this study, a series of photo-induced Schiff base crosslinking-based adhesive hydrogels with promising traits were designed and prepared. The hydrogels exhibited excellent antibacterial and antioxidant properties, as well as adhesiveness and hemostatic property. In vivo experiments on mice showed that the hydrogels can effectively improve wound healing.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Yikun Ren, Dan Zhang, Yuanmeng He, Rong Chang, Shen Guo, Shanshan Ma, Minghao Yao, Fangxia Guan
Summary: Hydrogels with injectable and antioxidant properties, such as the HT/QGA hydrogel prepared in this study, show promising qualities for wound healing. The hydrogel exhibited excellent injectability, favorable antioxidant activity, and good biocompatibility, and showed potential application in wound healing in a full-thickness skin injury model.
Article
Chemistry, Applied
Guozhu Chang, Qifeng Dang, Chengsheng Liu, Xiaoyu Wang, Hao Song, Hong Gao, Hantian Sun, Bonian Zhang, Dongsu Cha
Summary: A new dual drug delivery system CMCSH was designed to promote diabetic wound healing effectively. This system improved drug availability, promoted cell proliferation, and reduced inflammation.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Bin Kong, Rui Liu, Yi Cheng, Xiaodong Cai, Junying Liu, Dagan Zhang, Hui Tan, Yuanjin Zhao
Summary: This paper presents a biocompatible and multifunctional adhesive hydrogel based on oxidized guar gum and carboxymethyl chitosan for promoting wound healing. The hydrogel has self-healing ability and shear thinning behavior, allowing it to be easily injected. Its physiochemical properties can be controlled by regulating the concentrations of the hydrogel components. Additionally, the hydrogel exhibits strong adhesion to tissues at physiological temperature.
Article
Chemistry, Physical
Bin Kong, Rui Liu, Yi Cheng, Xiaodong Cai, Junying Liu, Dagan Zhang, Hui Tan, Yuanjin Zhao
Summary: Developing a biocompatible and multifunctional adhesive hydrogel for wound healing is a highly anticipated clinical application. In this paper, a novel natural biopolymer-derived hydrogel based on aldehyde-modified oxidized guar gum (OGG) and carboxymethyl chitosan (CMCS) is presented. The hydrogel has excellent self-healing ability and shear thinning behavior, and can be injected conveniently through a needle. The physiochemical properties of the hydrogel can be controlled by regulating the concentrations of OGG. In addition, the hydrogel can adhere tightly to tissues and promote wound repair by encapsulating vascular endothelial growth factor (VEGF).
Article
Nanoscience & Nanotechnology
Jiahui He, Zixi Zhang, Yutong Yang, Fenggang Ren, Jipeng Li, Shaojun Zhu, Feng Ma, Rongqian Wu, Yi Lv, Gang He, Baolin Guo, Dake Chu
Summary: A series of injectable pH-responsive self-healing adhesive hydrogels have been developed for treating gastric bleeding and wound healing after endoscopic treatment. These hydrogels show great potential as endoscopic sprayable bioadhesive materials, with good hemostatic properties and enhanced wound healing effects in animal models.
NANO-MICRO LETTERS
(2021)
Article
Biophysics
Xiaoshuang Yu, Can Cheng, Xu Peng, Kaixuan Zhang, Xixun Yu
Summary: In this study, a multifunctional hydrogel was successfully prepared by modifying guar gum with quaternization and oxidation, showing properties such as antibacterial, hemostatic, self-repairing, and injectable capabilities. The hydrogel exhibited excellent biocompatibility and demonstrated potential in promoting wound healing in a rat wound model infected with S. aureus.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Cheng Yang, Yuhui Chen, Hai Huang, Shicai Fan, Chengliang Yang, Liping Wang, Wenqiang Li, Wenxin Niu, Jianwen Liao
Summary: The ROS-sensitive hydrogel prepared in this study showed strong free radical scavenging ability, accelerated wound healing, and promoted tissue regeneration in experiments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Pengpeng Deng, Lichao Yao, Juanjuan Chen, Zhigang Tang, Jinping Zhou
Summary: AC hydrogels can accelerate wound healing, with self-healing, low swelling rate, biocompatibility, and excellent hemostatic effect. They also show outstanding antibacterial activity and can be used for designing multifunctional dressings.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Kummara Madhusudana Rao, Kannan Badri Narayanan, Uluvangada Thammaiah Uthappa, Pil-Hoon Park, Inho Choi, Sung Soo Han
Summary: In this study, multifunctional fungal mushroom-derived hydrogels were developed for wound dressing applications, with tissue adhesive, hemostasis, self-healing, and antibacterial properties. The hydrogels exhibited good swelling ratio, biodegradability, mechanical properties, and high adhesion strength to porcine skin. Additionally, they showed excellent antibacterial properties and promoted cell viability and attachment, making them a promising material for wound healing.
Article
Biochemistry & Molecular Biology
Zheng Chen, Jinpeng Yao, Jiulong Zhao, Shige Wang
Summary: In this study, a multifunctional COP hydrogel composed of CMCS, OD, and γ-PGA was prepared for antimicrobial and hemostasis of diffuse wounds. The COP hydrogel exhibited significant antibacterial effects, inhibited bacterial growth, and promoted wound healing. It also showed superior hemostasis ability in a rat tail diffuse hemorrhage wound model. Therefore, the multifunctional COP hydrogel is expected to have important applications in wound hemostasis and healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Aayushi Randhawa, Sayan Deb Dutta, Keya Ganguly, Dinesh K. Patel, Tejal Patil, Ki-Taek Lim
Summary: Photopolymerization is the process of converting liquid resin into solid structures using specific wavelengths of light. In recent years, photopolymerization-based 3D printing has gained attention for constructing tissue-specific structures. However, the lack of suitable bio-based photopolymers, effective crosslinking strategies, and optimal printing conditions hinder the widespread application of 3D printed materials.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Keya Ganguly, Sayan Deb Dutta, Aayushi Randhawa, Dinesh K. Patel, Tejal V. Patil, Ki-Taek Lim
Summary: This study investigates the differentiation of human bone-marrow-derived mesenchymal stem cells (hBMSCs) into early osteoblasts on a remarkably soft 3D hydrogel. Pulsatile pressure stimulation (PPS) of 5-20 kPa for 7 days stimulates cellular processes such as mechanotransduction, cytoskeletal distribution, calcium homeostasis, and osteogenic marker gene expression. The involvement of Piezo 1 in mechanotransduction is identified as the main ion channel. RNA-sequencing results reveal differential gene expression related to osteogenesis, bone mineralization, ion channel activity, and focal adhesion.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Keya Ganguly, Maria Mercedes Espinal, Sayan Deb Dutta, Dinesh K. Patel, Tejal V. Patil, Rachmi Luthfikasari, Ki-Tae Lim
Summary: This review provides an overview of the application of three-dimensional hemostatic platforms in rapid wound healing. The critical role of micro/nano-3D topography and biomaterial properties in mediating rapid blood clots and healing at the hemostat-biointerface is discussed. The advantages and limitations of the designed 3D hemostats are highlighted. This review is anticipated to guide the fabrication of smart hemostats for tissue engineering applications in the future.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Chemistry, Physical
Tejal V. Patil, Sayan Deb Dutta, Dinesh K. Patel, Keya Ganguly, Ki-Taek Lim
Summary: Near infra-red (NIR) responsive photothermal agents (PTAs) have shown potential in combating bacterial infections. This study introduces a mussel-inspired NIR-responsive unzipped CNT (uCNT)-based nanocomposite for antibacterial applications.
APPLIED SURFACE SCIENCE
(2023)
Article
Engineering, Biomedical
Sayan Deb Dutta, Keya Ganguly, Aayushi Randhawa, Tejal Patil, Dinesh K. Patel, Ki-Taek Lim
Summary: In recent years, significant progress has been made in the fabrication of high-resolution biomimetic structures using three-dimensional (3D) bioprinting of conductive hydrogels. However, the development of cell-laden constructs using extrusion-based 3D printing of conductive polymers remains a challenge due to the lack of an effective cross-linking strategy and suitable shear-thinning properties. In this study, a highly stable and conductive bioink based on polypyrrole-grafted gelatin methacryloyl (GelMA-PPy) was developed, which demonstrated excellent shear-thinning properties and enhanced shape fidelity and structural stability during 3D printing. The bioprinted GelMA-PPy-Fe hydrogel showed high cytocompatibility and the ability to support the differentiation of human bone mesenchymal stem cells (hBMSCs) with microcurrent stimulation.
Article
Chemistry, Applied
Dinesh K. Patel, Keya Ganguly, Sayan Deb Dutta, Tejal Patil, Ki-Taek Lim
Summary: The application of nanocellulose has been increasing due to its excellent physicochemical properties. It is important to monitor the crystallinity, surface topography, and reactivity of nanocellulose for efficient tissue engineering. This study investigated the effects of shape-regulated nanocellulose on macrophage polarization and found that the shape and incubation time of nanocellulose profoundly affected macrophage polarization. The findings suggest that macrophage polarization can be controlled by selecting suitable nanocellulose shape and incubation time.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Sayan Deb Dutta, Keya Ganguly, Jin Hexiu, Aayushi Randhawa, Md Moniruzzaman, Ki-Taek Lim
Summary: A 3D printable hydrogel composed of GelMA and CQDs was developed for angiogenesis, bone regeneration, and anti-tumor therapy. The hydrogel showed M2 polarization of macrophage cells and induced angiogenesis and osteogenesis of human bone mesenchymal stem cells. The hydrogel also exhibited NIR responsive properties and controlled release of antitumor drugs.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Engineering, Biomedical
Sayan Deb Dutta, Tejal V. Patil, Keya Ganguly, Aayushi Randhawa, Ki-Taek Lim
Summary: Macrophage-assisted immunomodulation is a strategy used in tissue engineering to determine the fate of healing or inflammation by the interplay between pro-inflammatory and anti-inflammatory macrophage cells and body cells. This review focuses on the necessity of 3D immunomodulatory scaffolds and nanomaterials, their interaction with macrophages, and the challenges and future necessity of 3D bioprinted immunomodulatory materials for tissue engineering.
BIOACTIVE MATERIALS
(2023)
Review
Engineering, Biomedical
Rumi Acharya, Sayan Deb Dutta, Tejal Patil, Keya Ganguly, Aayushi Randhawa, Ki-Taek Lim
Summary: Electroactive polymer-metal composites (EAPMCs) have significant mechanical and electrical properties in tissue engineering. By selecting appropriate metal and polymer materials, and applying interface engineering and surface modification techniques, the adhesion and biocompatibility of the composites can be enhanced. Based on their ability to promote cellular responses through electrical stimulation, these composites can mimic natural electrical signals and aid tissue regeneration.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Engineering, Biomedical
Jieun Lee, Sayan Deb Dutta, Rumi Acharya, Hyeonseo Park, Hojin Kim, Aayushi Randhawa, Tejal V. Patil, Keya Ganguly, Rachmi Luthfikasari, Ki-Taek Lim
Summary: Conductive hydrogels have shown promising potential in biomedical engineering for electrical stimulation of cells and tissues. This review summarizes recent advances in 3D printable conductive hydrogels for wound healing and their effect on macrophage polarization, and discusses the properties of various conductive materials and the challenges for future material discovery.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
