Alginate oligosaccharides: The structure-function relationships and the directional preparation for application

Alginate oligosaccharides (AOS) are degradation products of alginate extracted from brown algae. With low molecular weight, high water solubility, and good biological activity, AOS present anti-inflammatory, antimi-crobial, antioxidant, and antitumor properties. They also exert growth-promoting effects in animals and plants. Three types of AOS, mannuronate oligosaccharides (MAOS), guluronate oligosaccharides (GAOS), and hetero-zygous mannuronate and guluronate oligosaccharides (HAOS), can be produced from alginate by enzymatic hydrolysis. Thus far, most studies on the applications and biological activities of AOS have been based mainly on a hybrid form of HAOS. To improve the directional production of AOS for practical applications, systematic studies on the structures and related biological activities of AOS are needed. This review provides a summary of current understanding of structure-function relationships and advances in the production of AOS. The current challenges and opportunities in the application of AOS is suggested to guide the precise application of AOS in practice.

Automated summary

Alginate oligosaccharides (AOS), degradation products of brown algae, have diverse biological activities including anti-inflammatory, antimicrobial, antioxidant, and antitumor properties. Enzymatic hydrolysis of alginate produces different types of AOS, with the hybrid form HAOS being the most extensively studied. Systematic studies on the structures and biological activities of AOS are necessary for precise application.