Review
Medicine, Research & Experimental
Zhenzhen Li, Chanjun Sun, Zhihai Qin
Summary: Cancer cells adapt their metabolism to proliferate and survive in harsh environments, with a close relationship between tumor microenvironment and cancer-associated fibroblasts (CAFs) playing key roles in tumor growth and metastasis. CAFs act as major regulators in shaping tumor metabolism, especially through dysregulation of metabolic pathways, influencing cancer cell behavior and response to therapy. The interaction and crosstalk between cancer cells and CAFs contribute to metabolic reprogramming that impacts cancer cell growth and progression.
Review
Biochemistry & Molecular Biology
Liang Yan, Yanlian Tan, Guo Chen, Jun Fan, Jun Zhang
Summary: Metabolic reprogramming plays a critical role in cancer and immune cell function, particularly within the tumor microenvironment. Understanding the impact of metabolic reprogramming on both tumor and immune cells and their interaction is essential for effectively modulating the tumor immune microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Zhiwei Cai, Yang Li, Mingjian Ma, Longxiang Wang, Hongwei Wang, Meng Liu, Chongyi Jiang
Summary: It was found that adipocytes promote tumor progression in locally advanced and metastatic pancreatic cancer through an intricate metabolic network with cancer cells. The coculture of cancer cells with adipocytes leads to activated hypoxia signaling, elevated STAT3 activity, and an insulin-resistant phenotype in adipocytes. Additionally, enhanced fatty acid oxidation and increased lipid droplets were observed in cancer cells, while downregulated lipid metabolism and decreased lipid droplets were found in adipocytes. The increase in lipid droplets contributes to the increased metastatic capacity of the cancer cells. Interrupting the mechanisms of lipid uptake from adipocytes may offer a potential strategy for attenuating pancreatic cancer metastasis.
Article
Endocrinology & Metabolism
R. Aird, J. Wills, K. F. Roby, C. Benezech, R. H. Stimson, M. Wabitsch, J. W. Pollard, A. Finch, Z. Michailidou
Summary: This study found that hypoxia in the adipose-tumour microenvironment promotes lipid uptake in cancer cells, leading to increased proliferation. Additionally, hypoxia alters the metabolome of adipocytes and drives proliferation of non-malignant cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gyongyi Munkacsy, Libero Santarpia, Balazs Gyorffy
Summary: Triple-negative breast cancer is the most aggressive subtype of breast cancer, characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth receptor 2 expression. It has genomic and transcriptional heterogeneity and an immunosuppressive tumor microenvironment with high levels of tumor-infiltrating lymphocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Maurice Zaoui, Mehdi Morel, Lila Louadj, Nathalie Ferrand, Antonin Lamaziere, Catherine Uzan, Geoffroy Canlorbe, Michael Atlan, Michele Sabbah
Summary: This study focused on the effects of adipose stem cells derived from breast of healthy women and cancer patients on normal or tumor breast cells. The study found that adipocyte conditioned media from tumor tissues contain a higher level of arachidonic acid. Leptin secretion in adipose tissues from tumor free is twice as much as those from proximal or distal to the tumor. The conditioned media from adipose cells promote proliferation and invasion of SUM159 cells compared to MCF-7 and HMEC cells.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Ying Wang, Dan Wang, Li Yang, Yi Zhang
Summary: Tumor-associated macrophages (TAMs) play a crucial role in the tumor immune microenvironment and have immunosuppressive functions. The metabolic reprogramming of TAMs has a significant impact on their function and phenotype, and targeting metabolism-related pathways shows potential as an anti-tumor therapy.
CHINESE MEDICAL JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Melissa Garcia-Caballero, Liliana Sokol, Anne Cuypers, Peter Carmeliet
Summary: The dynamic crosstalk between different components of the tumor microenvironment plays a critical role in cancer progression and metastasis. Angiogenesis is crucial for tumor growth, but abnormal blood vessels can lead to hypoxia and acidosis in the tumor microenvironment. Cancer and stromal cells can alter their metabolism to meet high energy demands and promote tumor proliferation. Recent studies have shown that the metabolism of tumor endothelial cells is reprogrammed and targeting these metabolic pathways can affect blood vessel formation. Therefore, metabolic antiangiogenic therapies combined with immunotherapies offer a clinical opportunity for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Adriana Grigoras, Cornelia Amalinei
Summary: Colorectal cancer (CRC) is a common type of cancer, particularly in obese patients, and is a leading cause of cancer-related death. Cancer-associated adipocytes (CAAs) play a crucial role in the tumor microenvironment (TME) of CRC, aiding in cancer cell development through the release of metabolites, growth factors, and inflammatory adipokines. CAAs also affect the immune response, metabolic reprogramming, and chemotherapeutic resistance in colon cancer cells.
Review
Medicine, Research & Experimental
Lunxu Li, Yu Tian
Summary: Macrophages in the tumor micro-environment (TME) play a significant role in innate immunity and have dual effects. Tumor-associated macrophages (TAMs) are a major component of immune cells in the TME. TAMs, like M1/M2 macrophages, are highly adaptable and their functions are influenced by cytokines, chemokines, and other TME factors. Metabolic changes in TAMs are closely associated with their polarization towards promoting or suppressing tumor growth. The metabolic reprogramming of TAMs generates metabolites that contribute to tumor progression and immune evasion. This review examines the metabolic reprogramming of TAMs in terms of energy, amino acid, and fatty acid metabolism, and explores their potential roles in immune suppression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Yu-Ling Bin, Hong-Sai Hu, Feng Tian, Zhen-Hua Wen, Mei-Feng Yang, Ben-Hua Wu, Li-Sheng Wang, Jun Yao, De-Feng Li
Summary: This review summarizes the impact of metabolic reprogramming on the tumor microenvironment and overcoming drug resistance in gastric cancer, and discusses clinical studies on combination treatments with conventional chemotherapy or molecular targeted therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Physiology
Ying Kang, Emmanuel Boadi Amoafo, Philomena Entsie, Gregory L. Beatty, Elisabetta Liverani
Summary: Cancer incidence and mortality are increasing worldwide, and there is a need for new treatment strategies. The immune system can be utilized to target cancer cells, but the tumor microenvironment (TME) often suppresses immune response. Macrophages play a major role in regulating tumor growth within the TME and can be a potential therapeutic target. Platelets also contribute to cancer growth and immune suppression, and modulating platelet-macrophage interaction may be a novel strategy for cancer treatment.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Oncology
Chenghui Wu, Shuwen Dong, Renhong Huang, Xiaosong Chen
Summary: This review summarizes the complex bidirectional regulation between breast cancer and adjacent cancer-associated adipocytes, as well as the effect of cancer-associated adipocytes on the tumorigenesis, progression, and metastasis of breast cancer. It focuses on the therapeutic resistance caused by cancer-associated adipocytes and potential strategies for targeting them in breast cancer treatment.
Article
Oncology
Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue, Long Chen, Yuan Su, Qiong Zhou
Summary: This study reveals the immune suppressive mechanism of C1q(+) TAMs and suggests that targeting C1q(+) TAMs effectively alleviates immunosuppression and enhances the efficacy of immune checkpoint blockade (ICB) therapy. The researchers also found that inhibition of FABP5 can weaken the anti-tumor effects of TAMs and improve the effectiveness of ICB therapy, indicating that C1q(+) TAMs have great potential as a therapeutic target for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Yujia Xia, Zachary J. Brown, Hai Huang, Allan Tsung
Summary: HCC is an inflammation-induced cancer with a complex interaction between immune cells in the tumor microenvironment and tumor development. Metabolic reprogramming is crucial for the differentiation and function of immune cells in HCC progression.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
