Review
Engineering, Biomedical
Jinyuan Zhang, Jian Xu, Jongcheon Lim, James K. Nolan, Hyowon Lee, Chi Hwan Lee
Summary: The emerging trends in wearable glucose monitoring and implantable insulin delivery technologies have opened new possibilities for diabetes management, enabling closed-loop care. These technologies, with advanced materials and construction, allow real-time monitoring of glucose excursions and self-regulating drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Biagio Todaro, Filippo Begarani, Federica Sartori, Stefano Luin
Summary: Diabetes management is critical due to lack of well-established cure. Developing blood glucose-monitoring devices that are non-invasive, continuous, user-friendly and reliable is essential. However, most current alternatives to fingerstick tests are not reliable, user-friendly or affordable, requiring in-depth analysis and research.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yasin Cotur, Selin Olenik, Tarek Asfour, Michael Bruyns-Haylett, Michael Kasimatis, Ugur Tanriverdi, Laura Gonzalez-Macia, Hong Seok Lee, Andrei S. Kozlov, Firat Guder
Summary: This article introduces a continuous wearable respiration sensor inspired by the lateral line system of fish, capable of detecting mechanical disturbances in water. The sensor continuously measures respiratory activity by sensing the force applied to an air channel embedded in silicone-based elastomeric material, potentially enabling early detection of disorders resulting in altered respiratory patterns.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Yan Wang, Hossam Haick, Shuyang Guo, Chunya Wang, Sunghoon Lee, Tomoyuki Yokota, Takao Someya
Summary: Skin bioelectronics, with its unique characteristics, have been widely applied in healthcare and precision medicine, especially in long-term, continuous health monitoring. It can effectively analyze a wide range of health conditions, providing an effective pathway for early disease diagnosis and treatment.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Materials Science, Multidisciplinary
Ashwin Aggarwal, Manik Dautta, Luis Fernando Ayala-Cardona, Aalaya Wudaru, Ali Javey
Summary: The rapid advancements in wearable technologies have enabled the development of personal monitoring systems for core bodily metrics. Current smartwatches accurately monitor physical signals like heart rate and respiratory rate, but they are unable to track several important physiological parameters, including sweat rate. This study presents a new wearable device that can track sweat rate using an off-the-shelf humidity sensor. The device features a 3D-printed chamber with a humidity sensor and microheater, and it interfaces with the skin using a malleable and concave sweat collector. Through experiments, the authors aim to understand the relationship between sweat-induced humidity and the amount of sweat secreted. Compared to existing sweat rate sensing devices, this hygrometer-based device is more comfortable for extended wear and can be used alongside microfluidic-based sweat rate devices.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Public, Environmental & Occupational Health
Olena Litvinova, Magdalena Eitenberger, Aylin Bilir, Andy Wai Kan Yeung, Emil D. D. Parvanov, ArunSundar MohanaSundaram, Jaroslaw Olav Horbanczuk, Atanas G. G. Atanasov, Harald Willschke
Summary: There is a high demand for digital sensors for continuous glucose monitoring in diabetes management. Many sensors have been patented and proven effective in clinical practice. Non-invasive glucose monitoring methods can also benefit non-diabetic individuals.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Multidisciplinary
Md Abu Zahed, Dong Kyun Kim, Seong Hoon Jeong, Md Selim Reza, Md Sharifuzzaman, Gagan Bahadur Pradhan, Hyesu Song, Md Asaduzzaman, Jae Yeong Park
Summary: In this study, a flexible patch-based wireless system integrating multimodal biosensing and microfluidic channels is developed for real-time and continuous monitoring. The system accurately monitors sweat glucose and electrocardiogram (ECG) during physical exercise. The sensors show good sensitivity and stability, and the electrodes exhibit high-quality electrophysiological signals.
Review
Materials Science, Multidisciplinary
Le Minh Tu Phan, Thuy Anh Thu Vo, Thi Xoan Hoang, Sathish Panneer Selvam, Hoang Lan Pham, Jae Young Kim, Sungbo Cho
Summary: During the COVID-19 pandemic, continuous glucose monitoring is essential for diabetes management, reducing the risk of virus exposure and ensuring reliable results for patients.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Chemistry, Multidisciplinary
Rosalia Moreddu, Vahid Nasrollahi, Panagiotis Kassanos, Stefan Dimov, Daniele Vigolo, Ali K. Yetisen
Summary: In this article, femtosecond laser writing is used to engrave microfluidic networks into commercial contact lenses, achieving rapid and precise processing. The ablation process and tear flow within microfluidic structures are evaluated experimentally and computationally. Functional microfluidic components such as flow valves, resistors, and two applications, a tear volume sensor and a tear uric acid sensor, are introduced, providing painless alternatives with reduced contamination risks.
Article
Materials Science, Multidisciplinary
Israr Ahmed, Mohamed Elsherif, Murad Ali, Amal Al Ghaferi, Baker Mohammad, Haider Butt
Summary: Diabetes is a leading cause of death worldwide. Developing low-cost, rapid, and reusable sensors can provide a solution for continuous glucose monitoring to reduce the potentially fatal complications of diabetes. In this study, Phenylboronic acid (PBA)-based hydrogel sensors with embedded photonic nanostructures were developed for rapid and continuous glucose quantification within the physiological range.
MATERIALS & DESIGN
(2023)
Review
Engineering, Electrical & Electronic
Kan Kan Yeung, Ting Huang, Yunzhi Hua, Kai Zhang, Matthew M. F. Yuen, Zhaoli Gao
Summary: This review highlights the recent progress in the development and application of electrochemical sweat sensors and self-powered systems for wearable applications, including various types of sensors and novel functional nanomaterials. The advancement of battery-free wearable devices, such as self-powered biofuel cells and energy harvesting from novel materials, are also discussed, along with the challenges and opportunities in developing sweat sensor-based wearable systems for future directions.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Physical
Yansong Gai, Engui Wang, Minghao Liu, Lirong Xie, Yuan Bai, Yuan Yang, Jiangtao Xue, Xuecheng Qu, Yuan Xi, Linlin Li, Dan Luo, Zhou Li
Summary: This article presents the design of a wireless self-powered wearable sweat analysis system that converts mechanical energy into electricity for power supply. It enables real-time selective monitoring of biomarkers in sweat and wireless transmission of data.
Article
Chemistry, Analytical
Yiqun Liu, Li Yang, Yue Cui
Summary: Diabetes is a prevalent and chronic metabolic disease, and continuous monitoring is crucial for its management. Transdermal glucose biosensors offer accurate monitoring, but face challenges in biosensing principles, device configuration, and material integration. This review aims to address these questions and explore the practical applications of transdermal glucose biosensors.
Article
Biophysics
Artur Polinski
Summary: The objective of the study is to investigate the effect of signal sampling frequency and low-pass filtering on the accuracy of localizing fiducial points in the photoplethysmographic signal (PPG) and the estimation of blood pressure. Statistical analysis was performed on 3,799 data samples from a publicly available database. Results show that for noise-free data, cubic spline interpolation has limited influence on the localization of fiducial points within the considered sampling frequency range of 62.5-500 Hz. The pulse transit time (PTT) approach yields better results than the pulse arrival time (PAT) approach, with the tangent fiducial point producing the best results. The findings have significance in determining the minimum requirements for sampling frequency and filtering of PPG signals for reliable blood pressure estimation.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Biophysics
Inyoung Lee, David Probst, David Klonoff, Koji Sode
Summary: Diabetes mellitus is a chronic illness in the United States with approximately 120 million affected adults. Tight glycemic control is essential for managing diabetes and reducing the risk of complications. Continuous glucose monitoring systems are recognized as the ideal monitoring systems for diabetic patients.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Hadi Mirzajani, Cheng Cheng, Reza Hadjiaghaie Vafaie, Jayne Wu, Jiangang Chen, Shigotoshi Eda, Esmaeil Najafi Aghdam, Habib Badri Ghavifekr
Summary: A low-cost and easy-to-use capacitive biosensor was developed using PCB technology, demonstrating fast, accurate, and highly sensitive detection of BPA with a wide detection range and low LOD. The biosensor has the potential for on-site detection of bisphenol A in low-resource settings.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Hadi Mirzajani, Fariborz Mirlou, Emin Istif, Rahul Singh, Levent Beker
Summary: Smart contact lenses, utilizing tear as a convenient biological interface, have become a noninvasive and continuous wearable medical device for out-of-hospital and self-monitoring applications. Recent advancements in integrated circuits and biosensors, along with wireless data communication techniques, enable smart contact lenses to continuously sample tear fluid, analyze physiological conditions, and wirelessly transmit data to electronic devices for further healthcare monitoring. Despite the limitations in power supply due to limited space, various power delivery techniques, including wireless power transmission, biofuel cells, supercapacitors, flexible batteries, wired connections, and hybrid methods, are being explored to enhance the functionality of self-sustainable contact lens biosensors.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Materials Science, Multidisciplinary
Hadi Mirzajani, Emin Istif, Taher Abbasiasl, Fariborz Mirlou, Ecem Ezgi Ozkahraman, Murat Hasanreisoglu, Levent Beker
Summary: This study uses the femtosecond laser ablation technique to fabricate annular ring antennas on smart contact lenses, allowing for wireless monitoring of glucose concentration. The antenna has a small footprint and has been tested for aging and bending. The device has low interference response and successfully detects biologically relevant glucose concentrations.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Mohammad Javad Bathaei, Rahul Singh, Hadi Mirzajani, Emin Istif, Muhammad Junaid Akhtar, Taher Abbasiasl, Levent Beker
Summary: Biodegradable sensors based on integrating conductive layers with polymeric materials in flexible and stretchable forms have been successfully fabricated using a photolithography-based microfabrication approach. Up to 1600 devices with high device yield and density are fabricated on flexible and stretchable substrates. Various biodegradable passive electrical components, mechanical sensors, and chemical sensors have been demonstrated on these substrates, proving the versatility and scalability of the proposed fabrication method.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Cyril Routier, Lorenzo Vallan, Yohann Daguerre, Marta Juvany, Emin Istif, Daniele Mantione, Cyril Brochon, Georges Hadziioannou, Asa Strand, Torgny N. Nasholm, Eric Cloutet, Eleni Pavlopoulou, Eleni Stavrinidou
Summary: Increasing plants' photosynthetic efficiency is crucial for meeting the growing food demands of the population. In this study, we developed polyethyleneimine-based nanoparticles that can capture CO2 and enhance the carboxylation reaction in photosynthesis. These nanoparticles can be introduced to plants via leaf infiltration and do not have any toxic effects. Our results contribute to the development of a nanomaterials-based CO2-concentrating mechanism in plants that can potentially increase photosynthetic efficiency and overall CO2 storage.
Article
Food Science & Technology
Emin Istif, Hadi Mirzajani, Cagdas Dag, Fariborz Mirlou, Elif Yaren Ozuaciksoz, Cengiz Cakir, Hatice Ceylan Koydemir, Iskender Yilgor, Emel Yilgor, Levent Beker
Summary: Food spoilage leads to waste and diseases. A miniature sensor based on poly(styrene-co-maleic anhydride) was developed for on-demand spoilage analysis via mobile phones. The sensor was embedded in packaged chicken and beef to monitor spoilage. This low-cost, miniature wireless sensor can help consumers and suppliers detect spoilage of protein-rich foods and prevent food waste and food-borne diseases.
Article
Chemistry, Multidisciplinary
Taher Abbasiasl, Fariborz Mirlou, Hadi Mirzajani, Mohammad Javad Bathaei, Emin Istif, Narges Shomalizadeh, Ruemeysa Emine Cebecioglu, Ecem Ezgi Ozkahraman, Umut Can Yener, Levent Beker
Summary: Dermal interstitial fluid (ISF) is a valuable source of biomarkers, but extracting it has been challenging. A microneedle-based wearable device has been developed to extract and sense dermal ISF in a pain-free and easy-to-use way. The device can generate and maintain the required vacuum pressure for ISF collection, and has the capability for continuous health monitoring.
ADVANCED MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Berkay Kullukcu, Mohammad J. Bathaei, Muhammad Awais, Hadi Mirzajani, Levent Beker
Summary: This study presents a piezoelectric energy harvester made of PVDF-TrFE/PET for structural health monitoring applications. The device was characterized by measuring its output voltage and current, and was found to be capable of powering a MEMS pressure sensor.
INTEGRATED FERROELECTRICS
(2023)
Review
Engineering, Electrical & Electronic
Fariborz Mirlou, Levent Beker
Summary: Wearable devices and biosensors have the potential to continuously monitor biomarkers in human body biofluids and provide real-time feedback to users. Advances have been made in non-invasive measurements of desired biomarkers using electrochemical devices. Integrating multiplexed human health monitoring, biosensors, and wireless systems has been achieved and miniaturized. The precise monitoring through wearable devices can significantly improve life quality by providing critical health-related information in real-time.
IEEE TRANSACTIONS ON MOLECULAR BIOLOGICAL AND MULTI-SCALE COMMUNICATIONS
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
