Review
Biochemistry & Molecular Biology
Valentin L'Hote, Carl Mann, Jean-Yves Thuret
Summary: Senescence is a cellular stress response that can lead to chronic inflammation and tissue dysfunction. Senolytic drugs selectively induce death in senescent cells and have shown therapeutic potential in models of age-related diseases. By classifying senolytic drugs based on their target level in senescent cells, the study highlights the diversity of senescent cells and suggests avenues for developing more selective senolytics.
Review
Pharmacology & Pharmacy
Paul D. Robbins, Diana Jurk, Sundeep Khosla, James L. Kirkland, Nathan K. LeBrasseur, Jordan D. Miller, Joao F. Passos, Robert J. Pignolo, Tamar Tchkonia, Laura J. Niedernhofer
Summary: Senescence is a signaling mechanism activated in stressed cells to prevent proliferation of damaged cells, leading to chronic sterile inflammation and age-related diseases. Senescent cells accumulate with age and in diseased anatomical sites, making them a logical therapeutic target. Senotherapeutics, a new class of drugs, selectively kill senescent cells or suppress their disease-causing phenotypes, showing promising results in preclinical studies and clinical trials.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Cell Biology
Mikolaj Ogrodnik, Shane A. Evans, Edward Fielder, Stella Victorelli, Patrick Kruger, Hanna Salmonowicz, Bettina M. Weigand, Ayush D. Patel, Tamar Pirtskhalava, Christine L. Inman, Kurt O. Johnson, Stephanie L. Dickinson, Azucena Rocha, Marissa J. Schafer, Yi Zhu, David B. Allison, Thomas von Zglinicki, Nathan K. LeBrasseur, Tamar Tchkonia, Nicola Neretti, Joao F. Passos, James L. Kirkland, Diana Jurk
Summary: Clearing senescent cells, either through drug treatment or senolytic cocktail, has been shown to improve cognitive function, providing proof-of-concept for senolytic interventions as a potential therapeutic avenue for alleviating age-associated cognitive impairment.
Article
Medicine, General & Internal
Hillary H. Le, Suleyman S. Cinaroglu, Elise C. Manalo, Aysegul Ors, Michelle M. Gomes, Burcin Duan Sahbaz, Karla Bonic, Carlos A. Origel Marmolejo, Arnaud Quentel, Justin S. Plaut, Taryn E. Kawashima, E. Sila Ozdemir, Sanjay Malhotra, Yavuz Ahiska, Ugur Sezerman, Gunseli Bayram Akcapinar, Joshua C. Saldivar, Emel Timucin, Jared M. Fischer
Summary: The study demonstrates that newly developed peptides can target and eliminate senescent cancer cells, reducing cancer recurrence and improving survival rates. These peptides exhibit significant apoptosis and survival advantages in vivo, with minimal toxicity in older mice.
Review
Cell Biology
Li Hu, Huiqin Li, Meiting Zi, Wen Li, Jing Liu, Yang Yang, Daohong Zhou, Qing-Peng Kong, Yunxia Zhang, Yonghan He
Summary: Cellular senescence is an irreversible process of cell growth arrest caused by various stresses, and elimination of senescent cells may have significant implications for delaying aging and treating age-related diseases. However, senescent cells exhibit resistance to apoptosis, highlighting the importance of studying the underlying mechanisms of apoptotic resistance for the development of targeted therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Jessica D. Hense, Driele N. Garcia, Jose Isola, Joao A. Alvarado-Rincon, Bianka M. Zanini, Juliane B. Prosczek, Michael B. Stout, Jeffrey B. Mason, Patrick T. Walsh, Miguel A. Brieno-Enriquez, Ines Schadock, Carlos C. Barros, Michal M. Masternak, Augusto Schneider
Summary: Senescent cells accumulate in the ovaries of obese mice but can be reduced by treatment with senolytic drugs. However, neither obesity nor drug treatment affects the ovarian reserve.
Article
Cell Biology
Fernanda Hernandez-Gonzalez, Neus Prats, Valentina Ramponi, Jose Alberto Lopez-Dominguez, Kathleen Meyer, Monica Aguilera, Maria Isabel Munoz Martin, Daniel Martinez, Alvar Agusti, Rosa Faner, Jacobo Sellares, Federico Pietrocola, Manuel Serrano
Summary: Cell senescence has emerged as a potential mechanism in fibrosing interstitial lung diseases, and senescent human fibroblasts can trigger progressive fibrogenic reaction in the lungs. The secretome of senescent fibroblasts is pro-senescence and pro-fibrotic, while non-senescent fibroblasts lack these activities. Drugs like navitoclax, nintedanib, and pirfenidone can ameliorate lung fibrosis induced by senescent fibroblasts in mice.
Article
Cell & Tissue Engineering
Seokhyeong Go, Mikyung Kang, Sung Pil Kwon, Mungyo Jung, Ok Hee Jeon, Byung-Soo Kim
Summary: The study demonstrates that JQ1 can selectively eliminate senescent cells, reduce SASP expression, decrease ferroptosis-resistance genes in senescent cells, and induce lipid peroxidation in senescent cells. This suggests ferroptosis as a new mechanism of senolytic therapy.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yanghuan Zhang, Dongxiao Gao, Yang Yuan, Runzi Zheng, Manting Sun, Shuting Jia, Jing Liu
Summary: Accumulating evidence suggests that senescent cells (SCs) have a significant impact on age-related diseases in aged organisms. In this study, cycloastragenol (CAG) was found to delay age-related symptoms in mice by selectively killing SCs through apoptosis induction and inhibiting the Bcl-2 antiapoptotic family proteins and the PI3K/AKT/mTOR pathway. CAG treatment also suppressed the development of senescence-associated secretory phenotype (SASP) and improved age-related physical dysfunction in mice with irradiation-induced aging. These findings demonstrate that CAG has the potential to be a novel senolytic agent for the treatment of age-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Dror Kolodkin-Gal, Lior Roitman, Yossi Ovadya, Narmen Azazmeh, Benjamin Assouline, Yehuda Schlesinger, Rachel Kalifa, Shaul Horwitz, Yonatan Khalatnik, Anna Hochner-Ger, Ashraf Imam, Jonathan Abraham Demma, Eitan Winter, Hadar Benyamini, Sharona Elgavish, Areej A. S. Khatib, Karen Meir, Karine Atlan, Eli Pikarsky, Oren Parnas, Yuval Dor, Gideon Zamir, Ittai Ben-Porath, Valery Krizhanovsky
Summary: Cellular senescence limits tumourigenesis by blocking cell proliferation, but senescent cells can also promote tumour growth through paracrine effects. Senescent cells in early pancreatic lesions express a proinflammatory signature, and targeting these cells with the senolytic drug ABT-737 can reduce PanIN development and progression to pancreatic ductal adenocarcinoma. These findings suggest that eliminating senescent cells may be an effective preventive therapy for precancerous lesions.
Review
Biotechnology & Applied Microbiology
Yuhao Wu, Shiwei Shen, Yifeng Shi, Naifeng Tian, Yifei Zhou, Xiaolei Zhang
Summary: In this article, the involvement of senescence in intervertebral disc degeneration (IVDD) is reviewed, and the potential of senolytics in eliminating senescent disc cells and alleviating IVDD is discussed. A table listing potential drugs for IVDD therapy is also provided.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Hang Lin
Summary: ACI is a procedure used to treat articular cartilage injuries, and in vitro expansion of chondrocytes for ACI can result in the generation of senescent cells. FOXO4-DRI has been shown to selectively kill senescent fibroblasts, and in this study, it was found to reduce senescence in expanded chondrocytes. However, further investigation is needed to determine its potential in promoting cartilage formation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Mingxia Ge, Li Hu, Hongshun Ao, Meiting Zi, Qingpeng Kong, Yonghan He
Summary: Senescent cells (SCs) accumulate with age and contribute to age-related diseases. Clearing SCs can delay aging, treat age-related diseases, and extend healthspan. Targeting the proteins in the SC anti-apoptotic pathways with small molecules can selectively kill SCs, but current senolytics still have limitations in terms of safety, specificity, and broad-spectrum activity. New strategies such as PROTAC technology, CAR T cells, and ?-galactosidase-modified prodrugs have shown promising potential in clearing SCs.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Medicine, Research & Experimental
Young Joon Park, Jin Cheol Kim, Yeongeun Kim, Yul Hee Kim, Soon Sang Park, Charlotte Muther, Agnes Tessier, Gimyung Lee, Gaelle Gendronneau, Sandra Forestier, Youcef Ben-Khalifa, Tae Jun Park, Hee Young Kang
Summary: The accumulation of senescent melanocytes is closely related to skin aging. An in vitro model of senescence in melanocytes was developed using UV irradiation, and the functional characteristics and molecular mechanisms underlying senescence were investigated. Senescent melanocytes were found to have dysfunctional melanosome transport and melanin accumulation. Single-cell transcriptomic analysis revealed upregulation of the glycolytic metabolism pathway in most senescent phenotypes. Inhibition of glycolysis mitigated the pro-aging effects of melanocyte senescence, suggesting that alterations in cellular glucose metabolism drive senescence in melanocytes.
Article
Medicine, Research & Experimental
Dawei Yang, Xiaoyu Tian, Yuchen Ye, Yin Liang, Jie Zhao, Tao Wu, Na Lu
Summary: The study demonstrated that GL-V9 can eliminate senescent cancer cells and induce apoptosis, potentially improving the outcome of cancer chemotherapy.
Article
Biochemistry & Molecular Biology
Jin Hyung Kim, Hae Dong Jeong, Min Ji Song, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee
Summary: SOD3 plays a role in reducing oxidative stress and promoting collagen synthesis in skin aging.
Article
Dermatology
J. Ahn, D. H. Lee, C. H. Na, D. H. Shim, Y. S. Choi, H. J. Jung, E. L. Simpson
Summary: This study described the clinical features, morphology, and causes of facial dermatitis in patients treated with dupilumab for atopic dermatitis. The majority of patients experienced improvement in their facial dermatitis with dupilumab therapy, but a small proportion of patients had new onset or exacerbation.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Allergy
Hye Yung Yum, Ji Su Lee, Jung Min Bae, Sooyoung Lee, Yun Hee Kim, Myongsoon Sung, Song - Yang, Jeongmin Lee, Mi-Hee Lee, Dong Hun Lee
Summary: A cluster study classified childhood atopic dermatitis (AD) into 4 clusters based on allergic sensitization, each cluster showing different clinical phenotypes and treatment strategies.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Review
Medicine, General & Internal
Yoon Sun Cho, Hye One Kim, Seung Man Woo, Dong Hun Lee
Summary: This review article systematically evaluated the latest evidence on the use of dexpanthenol in the treatment of atopic dermatitis (AD), and found that dexpanthenol has good efficacy and tolerability. It can improve skin function, reduce acute flares, and spare the use of topical corticosteroids.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Allergy
Hanjae Lee, Soo Ick Cho, Min-Suk Yang, Soo-Jeong Cho, Dong Hun Lee
Article
Medicine, Research & Experimental
Hye-Sun Lim, Seung Hoon Lee, Huiyun Seo, Hwi-Ho Lee, Kyeongno Yoon, Yong-ung Kim, Moon-Ki Park, Jin Ho Chung, Yong-Seok Lee, Dong Hun Lee, Gunhyuk Park
Summary: UV rays are an important environmental factor that affects the homeostasis of the skin, adrenal glands, and brain. Psychological stress during early UVB irradiation inhibits collagen production, leading to skin aging. Increased levels of corticosterone during UV irradiation are caused by enhanced CYP11B1/2 levels. Inhibiting CYP11B1/2 with osilodrostat preserves skin collagen and suppresses skin aging.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Jin-Cheol Kim, Won-Sik Shim, In-Suk Kwak, Dong-Hun Lee, Jin-Seo Park, So-Yeon Lee, Seok-Young Kang, Bo-Young Chung, Chun-Wook Park, Hye-One Kim
Summary: This article summarizes the causes, pathophysiology, and appropriate treatments of pruritus caused by systemic diseases, with a focus on chronic kidney disease and cholestatic liver disease. It contributes to improving the quality of life for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Information Systems
Soo Ick Cho, Dongheon Lee, Byeol Han, Ji Su Lee, Ji Yeon Hong, Jin Ho Chung, Dong Hun Lee, Jung-Im Na
Summary: This study investigated the performance of convolutional neural networks (CNN) models in grading the severity of atopic dermatitis (AD) through evaluation by multiple dermatologists. Two best models were selected based on AUROC and F1-score, using labeled dataset from multiple evaluators, soft-label, and train-set pruning. The CNN models trained by a multi-evaluator dataset showed improved performance for AD.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Computer Science, Information Systems
Kyungsu Lee, T. C. Cavalcanti, Sewoong Kim, Hah Min Lew, Dae Hun Suh, Dong Hun Lee, Jae Youn Hwang
Summary: Fluorescence imaging-based diagnostic systems have been widely used for diagnosing skin diseases due to their ability to provide detailed molecular information about the skin. Recent advancements in smartphones have enabled the development of smartphone-based optical imaging systems for mobile healthcare. However, advanced analysis algorithms are needed to improve the accuracy of diagnosis.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Correction
Immunology
Youngae Lee, Jang-Hee Oh, Na Li, Hyun-Jae Jang, Kyung-Seop Ahn, Sei-Ryang Oh, Dong Hun Lee, Jin Ho Chung
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Je-Young Park, Ji Su Lee, Soo Ran Lee, Dong Hun Lee
Summary: Combined treatment with superficial micro-focused ultrasound and intradermal incobotulinumtoxin-A can effectively and safely reduce enlarged facial pores, with sustained improvement for up to 24 weeks.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Cell Biology
Min Ji Song, Chi-Hyun Park, Haesoo Kim, Sangbum Han, Si Hyung Lee, Dong Hun Lee, Jin Ho Chung
Summary: Aging is characterized by impaired mitochondrial function and cellular senescence. This study reveals a novel role of carnitine acetyltransferase (CRAT) in the development of mitochondrial dysfunction and cellular senescence. CRAT deficiency induces mitochondrial damage, leading to the secretion of senescence-associated secretory phenotype (SASP) and the initiation of aging.
Review
Dermatology
Qing-Ling Quan, Kyeong-No Yoon, Ji Su Lee, Eun Ju Kim, Dong Hun Lee
Summary: UV radiation has both harmful and beneficial effects on human skin and health. It can cause skin damage and cancer, but also provides vitamin D and has protective effects on several cardiovascular and metabolic disorders. However, the mechanisms of UV protection against these diseases have yet to be fully understood.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Meeting Abstract
Dermatology
Kyungchun Lee, Yoon Ji Bang, Ji Su Lee, Chung-Gyu Park, Kyu Han Kim, Hyun Je Kim, Seunghee Hong, Dong Hun Lee
ACTA DERMATO-VENEREOLOGICA
(2022)
Meeting Abstract
Dermatology
Gi Ung Ha, Ji Hoon Ryoo, Seon Hwa Lee, Dae-Lyong Ha, Kyung Duck Park, Jaehee Rho, Gyeong-Hun Park, Byung-Soo Kim, Kapsok Li, Chang Ook Park, Hye One Kim, Hei Sung Kim, Min Soo Jang, Dong Hun Lee, Yang Won Lee, Do Won Kim, Yong Hyun Jang, Seong-Jin Kim
ACTA DERMATO-VENEREOLOGICA
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)