Implications of enigmatic transglutaminase 2 (TG2) in cardiac diseases and therapeutic developments
出版年份 2022 全文链接
标题
Implications of enigmatic transglutaminase 2 (TG2) in cardiac diseases and therapeutic developments
作者
关键词
Tissue transglutaminase, Enzymatic cross-linking, Signaling functions, Cardiac fibrosis, Extracellular matrix, Heart failure, TG2 inhibitors
出版物
BIOCHEMICAL PHARMACOLOGY
Volume -, Issue -, Pages 115104
出版商
Elsevier BV
发表日期
2022-05-23
DOI
10.1016/j.bcp.2022.115104
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Roles and potential clinical implications of tissue transglutaminase in cardiovascular diseases
- (2022) Shiqi Chen et al. PHARMACOLOGICAL RESEARCH
- A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease
- (2021) Detlef Schuppan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alternative Splicing in Cardiovascular Disease—A Survey of Recent Findings
- (2021) Ena Hasimbegovic et al. Genes
- Role of Transglutaminase 2 in Cell Death, Survival, and Fibrosis
- (2021) Hideki Tatsukawa et al. Cells
- Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction
- (2021) Fabio Da Silva et al. eLife
- Transglutaminases: part I—origins, sources, and biotechnological characteristics
- (2020) Lovaine Duarte et al. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
- Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries
- (2020) Estéfano Pinilla et al. HYPERTENSION
- Tissue Transglutaminase-Mediated AT1 Receptor Sensitization Underlies Pro-inflammatory Cytokine LIGHT-Induced Hypertension
- (2019) Chen Liu et al. AMERICAN JOURNAL OF HYPERTENSION
- Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling
- (2019) Chinmayee D. Bhedi et al. FASEB JOURNAL
- Transglutaminase 2 limits the extravasation and the resultant myocardial fibrosis associated with factor XIII-A deficiency
- (2019) Kathryn J. Griffin et al. ATHEROSCLEROSIS
- Spotlight on the transglutaminase 2 gene: a focus on genomic and transcriptional aspects
- (2018) Nicoletta Bianchi et al. BIOCHEMICAL JOURNAL
- Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism
- (2018) Brad A. Palanski et al. BIOCHEMISTRY
- Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload
- (2018) Arti V. Shinde et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
- (2018) Marsha C. Lampi et al. Science Translational Medicine
- Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor
- (2018) Zhuo Wang et al. Cell Death & Disease
- Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis
- (2018) Hideki Tatsukawa et al. Scientific Reports
- The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
- (2018) Kine Andenæs et al. PLoS One
- β 2 -adrenoceptor-induced modulation of transglutaminase 2 transamidase activity in cardiomyoblasts
- (2017) Falguni S. Vyas et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Phenotyping of myocardial fibrosis in hypertensive patients with heart failure. Influence on clinical outcome
- (2017) Susana Ravassa et al. JOURNAL OF HYPERTENSION
- Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking‐Dependent and Crosslinking‐Independent Functions
- (2017) Jochen Steppan et al. Journal of the American Heart Association
- The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis
- (2017) Lucy A. Murtha et al. Frontiers in Physiology
- Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases
- (2016) Mei-qing Liu et al. ACTA PHARMACOLOGICA SINICA
- Role of tissue transglutaminase in age-associated ventricular stiffness
- (2016) Young Jun Oh et al. AMINO ACIDS
- Role of tissue transglutaminase-2 (TG2)-mediated aminylation in biological processes
- (2016) Thung-S. Lai et al. AMINO ACIDS
- A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: A role in cell survival
- (2016) Falguni S. Vyas et al. BIOCHEMICAL PHARMACOLOGY
- Vascular Fibrosis in Aging and Hypertension: Molecular Mechanisms and Clinical Implications
- (2016) Adam Harvey et al. CANADIAN JOURNAL OF CARDIOLOGY
- Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial HypertensionClinical Perspective
- (2016) Silvia Rain et al. Circulation-Heart Failure
- Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer
- (2016) Philip C. Trackman EXPERT OPINION ON THERAPEUTIC TARGETS
- Simultaneous analysis of enzyme structure and activity by kinetic capillary electrophoresis–MS
- (2016) Gleb G Mironov et al. Nature Chemical Biology
- Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death
- (2016) H Tatsukawa et al. Cell Death & Disease
- Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice†
- (2015) Biljana Skrbic et al. CARDIOVASCULAR RESEARCH
- Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions
- (2015) Eduard Badarau et al. CHEMISTRY & BIOLOGY
- Cross-linking of collagen I by tissue transglutaminase provides a promising biomaterial for promoting bone healing
- (2014) Dario Fortunati et al. AMINO ACIDS
- Distribution of Transglutaminase 6 in the Central Nervous System of Adult Mice
- (2014) Yu-Tao Liu et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- Modulation of transglutaminase 2 activity in H9c2 cells by PKC and PKA signalling: a role for transglutaminase 2 in cytoprotection
- (2014) Ibtesam Almami et al. BRITISH JOURNAL OF PHARMACOLOGY
- Transglutaminase Regulation of Cell Function
- (2014) Richard L. Eckert et al. PHYSIOLOGICAL REVIEWS
- Elevated Transglutaminase 2 Activity Is Associated with Hypoxia-Induced Experimental Pulmonary Hypertension in Mice
- (2013) Thomas R. DiRaimondo et al. ACS Chemical Biology
- Topical Enzyme-Replacement Therapy Restores Transglutaminase 1 Activity and Corrects Architecture of Transglutaminase-1-Deficient Skin Grafts
- (2013) Karin Aufenvenne et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Inhibition of Transglutaminase 2, a Novel Target for Pulmonary Fibrosis, by Two Small Electrophilic Molecules
- (2013) Keith C. Olsen et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The pathogenesis of cardiac fibrosis
- (2013) Ping Kong et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- TGM2 and implications for human disease: role of alternative splicing
- (2013) Charles Greenberg Frontiers in Bioscience-Landmark
- Tissue Transglutaminase Contributes to the Pathogenesis of Preeclampsia and Stabilizes Placental Angiotensin Receptor Type 1 by Ubiquitination-Preventing Isopeptide Modification
- (2013) Chen Liu et al. HYPERTENSION
- Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts
- (2013) Katarzyna A. Cieslik et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Cystamine ameliorates ventricular hypertrophy associated with modulation of IL-6-mediated signaling in lupus-prone mice
- (2013) Bor-Show Tzang et al. LIFE SCIENCES
- Cellular Mechanisms of Tissue Fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression
- (2012) Edie C. Goldsmith et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Collagen Cross-Linking But Not Collagen Amount Associates With Elevated Filling Pressures in Hypertensive Patients With Stage C Heart Failure
- (2012) Begoña López et al. HYPERTENSION
- Transglutaminase-2 Interaction with Heparin
- (2012) Hugues Lortat-Jacob et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The myofibroblast matrix: implications for tissue repair and fibrosis
- (2012) Franco Klingberg et al. JOURNAL OF PATHOLOGY
- Matricellular Proteins in Cardiac Adaptation and Disease
- (2012) Nikolaos G. Frangogiannis PHYSIOLOGICAL REVIEWS
- TG2, a novel extracellular protein with multiple functions
- (2011) Zhuo Wang et al. AMINO ACIDS
- Transglutaminase 2: A molecular Swiss army knife
- (2011) Soner Gundemir et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Prostate transglutaminase: a unique transglutaminase and its role in prostate cancer
- (2011) Wen G Jiang et al. Biomarkers in Medicine
- Extracellular TG2: emerging functions and regulation
- (2011) Alexey M. Belkin FEBS Journal
- Cystamine attenuates lupus-associated apoptosis of ventricular tissue by suppressing both intrinsic and extrinsic pathways
- (2011) Bor-Show Tzang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice
- (2011) Keunhee Oh et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Diastolic Tissue Doppler Indexes Correlate With the Degree of Collagen Expression and Cross-Linking in Heart Failure and Normal Ejection Fraction
- (2011) Mario Kasner et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2
- (2011) Jiri Petrak et al. Proteome Science
- Transglutaminase 2: a multi-functional protein in multiple subcellular compartments
- (2010) Donghyun Park et al. AMINO ACIDS
- Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness
- (2010) Lakshmi Santhanam et al. CIRCULATION RESEARCH
- Potential of transglutaminase 2 as a therapeutic target
- (2010) Daniela Caccamo et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Redox Regulation of Transglutaminase 2 Activity
- (2010) Jorunn Stamnaes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tissue transglutaminase 2 promotes apoptosis of rat neonatal cardiomyocytes under oxidative stress
- (2010) Heesang Song et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel disease
- (2010) Luca Elli et al. LABORATORY INVESTIGATION
- The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis
- (2009) W Malorni et al. CELL DEATH AND DIFFERENTIATION
- Involvement of Tissue Transglutaminase in Endothelin 1–Induced Hypertrophy in Cultured Neonatal Rat Cardiomyocytes
- (2009) Xin Li et al. HYPERTENSION
- Increased TG2 Expression Can Result in Induction of Transforming Growth Factor β1, Causing Increased Synthesis and Deposition of Matrix Proteins, Which Can Be Regulated by Nitric Oxide
- (2009) Dilek Telci et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism
- (2009) John T. Pinto et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Transglutaminase 2 Deficiency Decreases Plaque Fibrosis and Increases Plaque Inflammation in Apolipoprotein-E-Deficient Mice
- (2009) Jozef L. Van Herck et al. JOURNAL OF VASCULAR RESEARCH
- Transglutaminases and Disease: Lessons From Genetically Engineered Mouse Models and Inherited Disorders
- (2009) Siiri E. Iismaa et al. PHYSIOLOGICAL REVIEWS
- Transglutaminases and their substrates in biology and human diseases: 50 years of growing
- (2008) Angelo Facchiano et al. AMINO ACIDS
- Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction
- (2008) Matthias Nahrendorf et al. EUROPEAN HEART JOURNAL
- Beneficial effects of treatment with cystamine on brain in NZB/W F1 mice
- (2008) Tsai-Ching Hsu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Fibronectin-Tissue Transglutaminase Matrix Rescues RGD-impaired Cell Adhesion through Syndecan-4 and β1Integrin Co-signaling
- (2008) Dilek Telci et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tackling heart failure in the twenty-first century
- (2008) James O. Mudd et al. NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now