Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

(2019) Philipp Kirchner et al.   PLOS BIOLOGY

MK5 Regulates YAP Stability and Is a Molecular Target in YAP-Driven Cancers

(2019) Jimyung Seo et al.   CANCER RESEARCH

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer

(2019) Beiqing Pan et al.   Protein & Cell

CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus

(2019) Yong Suk Cho et al.   GENES & DEVELOPMENT

Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment

(2018) Pasquale Agosti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aberrant regulation of autophagy in mammalian diseases

(2018) Wei Xie et al.   Biology Letters

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

(2017) Kumsal Tekirdag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Humanin is an endogenous activator of chaperone-mediated autophagy

(2017) Zhenwei Gong et al.   JOURNAL OF CELL BIOLOGY

Chaperone-mediated autophagy substrate proteins in cancer

(2017) Ying Tang et al.   Oncotarget

Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition

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YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells

(2016) Yu Shi et al.   CELL DEATH AND DIFFERENTIATION

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

(2016) Ines Jeric et al.   Nature Communications

The interplay between autophagy and the ubiquitin–proteasome system in cardiac proteotoxicity

(2015) Changhua Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

(2015) Hong-guang Xia et al.   JOURNAL OF CELL BIOLOGY

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

(2015) M Hatting et al.   Cell Death & Disease

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

(2015) Caroline Park et al.   Nature Communications

Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation

(2014) Jaime L. Schneider et al.   Cell Metabolism

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

(2014) Ning Liang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Humanin and Age-Related Diseases: A New Link?

(2014) Zhenwei Gong et al.   Frontiers in Endocrinology

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

(2013) Jaime Anguiano et al.   Nature Chemical Biology

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Chaperone-Mediated Autophagy Is Required for Tumor Growth

(2011) M. Kon et al.   Science Translational Medicine

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Cancer gene discovery in hepatocellular carcinoma

(2010) Lars Zender et al.   JOURNAL OF HEPATOLOGY

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)

(2008) Tsutomu Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE