Article
Chemistry, Multidisciplinary
Qinrui Fu, Zhi Li, Fengfu Fu, Xiaoyuan Chen, Jibin Song, Huanghao Yang
Summary: This review provides an overview of the use of plasmonic nanoparticle assemblies functionalized with responsive molecules in biomedical applications and discusses future challenges regarding assembly/disassembly strategies and applications.
Review
Chemistry, Multidisciplinary
Patrycja Talarska, Maciej Boruczkowski, Jakub Zurawski
Summary: Silver and gold nanoparticles are widely used in various household products, raising concerns about their potential impact. Research is focusing on the effects of nanoparticles on cell function and environmentally friendly alternatives to chemically synthesized nanoparticles.
Review
Chemistry, Multidisciplinary
Rong Zhu, Juan Li, Lisen Lin, Jibin Song, Huanghao Yang
Summary: Plasmonic gold nanocrystals exhibit unique optical enhancement, catalytic activity, and photothermal properties, and when combined with DNA technology, novel functional Au nanomaterials can be created for biosensing, imaging, drug delivery, and therapy applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Physical
Jiamin Ye, Qiang Wen, Ying Wu, Qinrui Fu, Xuan Zhang, Jianmin Wang, Shi Gao, Jibin Song
Summary: Gold nanorods have attracted great interest in the field of biomedicine due to their unique optical properties and excellent biocompatibility. However, traditional single gold nanorods cannot deliver medicine to lesion regions, limiting their application in therapy. In recent years, researchers have modified the surface of gold nanorods to integrate diagnosis and treatment, enabling bioimaging and cancer therapy, among other biomedical applications.
Review
Biotechnology & Applied Microbiology
Qinyue Gao, Jingjing Zhang, Jie Gao, Zhengyang Zhang, Haitao Zhu, Dongqing Wang
Summary: Gold nanoparticles (AuNPs and GNPs) have been engineered to serve as targeted delivery vehicles and molecular probes in cancer therapy, owing to their easy surface modification, unique optical properties, and high biocompatibility. Their small size and surface characteristics enable them to access the tumor microenvironment (TME), offering a promising solution for highly effective treatments. Additionally, the stimuli-responsive properties of nanoparticles to TME allow for unrivaled control in the transport of therapeutic cargos.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yisu Wang, Zoltan Sztranyovszky, Attilio Zilli, Wiebke Albrecht, Sara Bals, Paola Borri, Wolfgang Langbein
Summary: This study presents a quantitative measurement and comparison of particle morphology and optical response by combining electron tomography and optical micro-spectroscopy. The presence of an oxide layer on the surface of pure silver particles, which cannot be observed in electron tomography, is indicated through numerical simulations. This research helps strengthen the link between particle morphology and optical response, supporting the design of plasmonic nanomaterials.
Review
Chemistry, Multidisciplinary
B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Mohammad Ali Abdullah Almoyad, Shadma Wahab, Waleed H. Almalki, Prashant Kesharwani
Summary: Nanosponges, with their unique sponge-like structure, offer a promising solution for drug delivery in cancer therapy. By utilizing their interconnected voids and mesh-like network, nanosponges enable efficient drug loading and controlled release, overcoming the limitations of conventional methods. They show potential in both cancer treatment and diagnosis, and are considered versatile carrier systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Navid Rabiee, Sepideh Ahmadi, Siavash Iravani, Rajender S. Varma
Summary: The functionalization of nanomaterials is an interesting strategy for designing nanosystems with suitable applicability and biocompatibility for biomedical applications. Research has been conducted in functionalizing silver and gold nanomaterials using suitable functional groups or agents to enhance their properties for biomedical purposes. Future studies should focus on designing novel functionalization tactics to improve these nanosystems and reduce their toxicity.
Article
Polymer Science
Meshal Alshamrani
Summary: This article discusses the application of nanomaterials in the field of medicine, focusing on the crucial role of nanoparticles in drug therapy. The article introduces different types of nanoparticles and their conjugation with biomolecules, and explores the application areas of nanomaterials in disease diagnosis and treatment, including bio-imaging, drug delivery, biosensing, and tissue engineering.
Review
Nanoscience & Nanotechnology
Mozhdeh Madadi, Sepideh Khoee
Summary: The advent of Janus nanoparticles has brought about a major breakthrough in the field of nanomaterials. These nanoparticles, with their asymmetric structures, have found wide applications in various fields, especially in biomedicine. Among them, magnetite Janus nanoparticles show great promise due to their magnetic controlling abilities, making them suitable for biomedical applications such as bioimaging, cancer therapies, and biosensing.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Andrea Ronavari, Nora Igaz, Dora I. Adamecz, Bettina Szerencses, Csaba Molnar, Zoltan Konya, Ilona Pfeiffer, Monika Kiricsi
Summary: The nanomaterial industry produces large quantities of metal-based nanomaterials for various applications, but the use of toxic chemicals for production burdens the environment. Green synthetic approaches have emerged to provide eco-friendly alternative methods and reduce the ecological footprint.
Article
Biochemistry & Molecular Biology
Chinmayee Priyadarsani Mandhata, Chita Ranjan Sahoo, Rabindra Nath Padhy
Summary: There is currently a strong interest in biologically synthesized nanoparticles as potential therapeutic agents. The drawbacks of conventional non-biological synthesis methods have led to a shift towards green syntheses of nanoparticles. Among noble metal nanoparticles, gold nanoparticles are widely used due to their unique physicochemical properties. AuNPs synthesized with biomolecules as reducing and stabilizing agents have potential therapeutic applications. The green synthesis method of AuNPs is simple, environmentally-friendly, non-toxic, and cost-effective.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Medicine, Research & Experimental
Huiqiao Liu, Xia Gao, Chen Xu, Dingbin Liu
Summary: Surface-enhanced Raman scattering (SERS) has become a valuable technique for molecular identification, with high sensitivity, excellent signal specificity, and photobleaching resistance. SERS tags, obtained by attaching organic molecules to plasmonic nanoparticles, show high-performance multiplexing capability for biosensing. In the past decade, SERS tags have made progress in liquid biopsy, bioimaging, and theranostics applications.
Article
Engineering, Biomedical
Zefeng Chen, Yaoxun Zeng, Niping Chen, Mingxia Zhang, Yakun Wang, Zhenxing Pan, Jiongpeng Yuan, Zhaoyi Ye, Xiaojing Li, Wangqing Bian, Haihong Li, Kun Zhang, Yan He, Xujie Liu
Summary: This study proposes a novel approach for the transport of metal ions using polyethylene glycol. By a simple synthesis method, 31 different metal ion-based nanoparticles were successfully synthesized and demonstrated their potential for cancer theranostics.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Chemical
Zhikai Liu, Mei Yang, Wang Yao, Tingting Wang, Guangwen Chen
Summary: A microfluidic ultrasound cavitation (MUC) approach was used to synthesize biomedical organic nanoparticles (NPs) with controllable and scalable properties. The NPs synthesized by MUC showed smaller sizes and more uniform distributions compared to traditional methods. The MUC approach can be used for continuous synthesis of lipopolymeric NPs with desired properties.
CHEMICAL ENGINEERING SCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Pemula Gowtham, Pragya Pallavi, Karthick Harini, Koyeli Girigoswami, Agnishwar Girigoswami
Summary: Hydrogels, consisting of water-absorbing hydrophilic polymers, are a three-dimensional network that can support tissue regeneration and release medication in a controlled manner. They are structurally similar to the extracellular matrix and have been widely used in biomedical applications and tissue engineering. Incorporating plant virus-mediated nanoparticles (VNPs) into hydrogels is a promising approach to create bioactive scaffolds that promote cell proliferation, adhesion, migration, and differentiation.
CURRENT NANOSCIENCE
(2023)
Article
Materials Science, Biomaterials
Govindharaj Poornima, Karthick Harini, Pragya Pallavi, Pemula Gowtham, Koyeli Girigoswami, Agnishwar Girigoswami
Summary: Significant progress has been made in using biomaterials as a medium for delivering pharmacologically active components to diseased cells in biomedical sciences. The therapeutic benefit is more related to drug formulation and administration routes than drug potency. Biomaterials play a vital role in formulating various pharmaceutical compounds and extending therapeutic release to overcome limitations of conventional therapies. This review discusses the history of biomaterials in drug delivery and the use of RNA as a therapeutic molecule to inhibit disease-causing protein synthesis resulting from misregulation.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Pharmacology & Pharmacy
Nagaraj Saraswathi, Koyeli Girigoswami, Kurunchi Chellapathi Divya, Subbaraj Gowtham Kumar, Agnishwar Girigoswami
Summary: Overuse and improper dosage of antibiotics have led to antimicrobial resistance worldwide. Silver nanoparticles have been identified as a promising option to overcome the infectious effect of multidrug-resistant organisms. Therefore, this study focuses on the development of gelatin-based polymeric hydrogel embedded with silver nanoparticles (G-AgNPs) for controlled bactericidal activity against multidrug-resistant Pseudomonas aeruginosa (PA) biofilms.
CURRENT DRUG DELIVERY
(2023)
Article
Nutrition & Dietetics
Gopikrishna Agraharam, Agnishwar Girigoswami, Koyeli Girigoswami
Summary: Oxidative stress is generated by endogenous cellular mechanisms and external factors, contributing to various disease pathologies. Chronic/acute exposure to oxidative stress can damage cellular integrity and lead to organ malfunctioning during aging. Mitochondrial respiration generates reactive oxygen species and free-radicals, which can cause damage to cellular organelles and biomolecules. Calorie restriction and extracellular ATP treatment, combined with advanced nanotechnology, can improve cellular integrity and enhance longevity by circumventing the mitochondrial pathway and alleviating oxidative stress.
CURRENT NUTRITION & FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Pragya Pallavi, Karthick Harini, Symone Crowder, Debanjana Ghosh, Pemula Gowtham, Koyeli Girigoswami, Agnishwar Girigoswami
Summary: Photodynamic therapy (PDT) is a promising clinical modality for cancer therapy and multidrug-resistant (MDR) infections. By using photosensitizers (PS) and specific wavelengths of light, reactive oxygen species (ROS) are generated to target cancer cells and pathogens. R6G-conjugated gold nanoparticles (AuNP) have shown higher ROS quantum yield and could be effective in treating cancer and MDR bacteria, as well as in medical imaging.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Pemula Gowtham, Karthick Harini, Anbazhagan Thirumalai, Pragya Pallavi, Koyeli Girigoswami, Agnishwar Girigoswami
Summary: Modern technologies have contributed greatly to addressing emerging issues, particularly in the field of nanomedicine, where the development of carbon dots technology at the atomic and nanoscale level has made significant strides. Researchers have focused on the unique properties of carbon dots, such as their easy surface modifications, excellent optical properties, low toxicity, and water solubility. Doping carbon dots with other elements has enhanced their potential for use in the medical sector.
Review
Oncology
Anbazhagan Thirumalai, Koyeli Girigoswami, Pragya Pallavi, Karthick Harini, Pemula Gowtham, Agnishwar Girigoswami
Summary: One of the primary threats in tumor treatment is the limited ability to penetrate tumor sites, which leads to reduced effectiveness. Recently, a novel peptide called iRGD has been discovered to have enhanced tumor-penetrating and inhibitory properties, targeting and penetrating tumors through specific receptors. Studies have shown that iRGD peptides can improve tumor tissue penetration and inhibit tumor metastasis effectively.
BULLETIN DU CANCER
(2023)
Article
Chemistry, Medicinal
M. K. Shurfa, Agnishwar Girigoswami, R. Sakthi Devi, Karthick Harini, Gopikrishna Agraharam, Balasubramanian Deepika, Pragya Pallavi, Koyeli Girigoswami
Summary: This study focused on the combinational effect of cerium oxide (CeO2) nanoparticles and doxorubicin (Dox) on melanoma cancer cells, both in vitro and in vivo. The results demonstrated that the combination of CeO2 and Dox had superior therapeutic efficiency in treating cancer cells compared to the individual drugs.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Pemula Gowtham, Vijaya Anand Arumugam, Karthick Harini, Pragya Pallavi, Anbazhagan Thirumalai, Koyeli Girigoswami, Agnishwar Girigoswami
Summary: Protein-based nanostructures have played a vital role in the advancement of nanomedicine in recent years. Due to their smaller size and larger surface area, protein nanoparticles have better interaction capabilities with other molecules, enabling efficient drug delivery to diseased tissues. These nanoparticles also possess attractive biocompatibility and biodegradability, as well as the ability to be modified on their surfaces. Various protein-based nanostructures can be fabricated using processes such as emulsification, desolvation, complex coacervation, and electrospray. By altering the internal and external interfaces of protein nanoparticles, they can be functionalized to encapsulate drugs, achieve controlled drug release, disassemble systematically, and target tumors.
BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS
(2023)
Review
Genetics & Heredity
Agnishwar Girigoswami, Koyeli Girigoswami
Summary: Lung cancer is typically treated using traditional methods like chemotherapy and radiation therapy, but they have limitations such as non-specific cell killing and drug solubility issues. Nanotechnology offers new solutions by utilizing nano-formulated drugs and particles to improve cancer cell killing and radiation sensitization. This review discusses conventional therapies for lung cancer inhibition and highlights the advancements made through the use of nanoparticles.
Review
Chemistry, Medicinal
Gopalarethinam Janani, Agnishwar Girigoswami, Koyeli Girigoswami
Summary: Chronic myelogenous leukemia (CML) is caused by the reciprocal translocation of the ABL gene and the BCR gene, and nanotechnology holds great potential in diagnosing and treating CML.
Review
Green & Sustainable Science & Technology
Sanmitro Bhattacharjee, Agnishwar Girigoswami, Moupriya Nag, Tanzil Rubab, Koyeli Girigoswami
Summary: This article focuses on the application of nanotechnology in sustainable development, particularly in the industrial field, to address environmental crises and protect ecological health.
ENVIRONMENTAL QUALITY MANAGEMENT
(2023)
Review
Engineering, Biomedical
Gopalarethinam Janani, Agnishwar Girigoswami, Koyeli Girigoswami
Summary: Leukemia is a type of blood cancer that mainly affects white blood cells, with acute myeloid leukemia being the most prevalent form in children. Traditional diagnostic and treatment methods have limitations, leading researchers to explore the use of nanotechnology for more effective treatment and diagnosis.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Chemistry, Multidisciplinary
Kunal Biswas, Gopalarethinam Janani, Saranya Udayakumar, Balasubramanian Deepika, Koyeli Girigoswami
Summary: In this study, reduced graphene oxide nanosheets (rGO) were synthesized using a modified Hummer's method. The optical and morphological characterizations of the as-synthesized graphene sheets were performed. The results showed that rGO exhibited robust anticancerous activities against cancer cells, but no antimicrobial activity at the selected doses.
RESULTS IN CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Koyeli Girigoswami, Pragya Pallavi, Agnishwar Girigoswami
Summary: Site-specific drug delivery can reduce side effects and dosage requirements. Nanoparticles are effective drug carriers that can achieve precise delivery through passive or active targeting.
