Synthesis of W‐Phos Ligand and Its Application in the Copper‐Catalyzed Enantioselective Addition of Linear Grignard Reagents to Ketones

Kinetic Resolution of Tertiary Benzyl Alcohols via Palladium/Chiral Norbornene Cooperative Catalysis

(2021) Yu Hua et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Enamide–Imine Tautomerism in the Kinetic Resolution of Tertiary Alcohols

(2021) Mengyao Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Overcoming the Naphthyl Requirement in Stereospecific Cross-Couplings to Form Quaternary Stereocenters

(2021) Jianyu Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Catalytic Dearomative Addition of Grignard Reagents to 4-Methoxypyridinium Ions

(2021) Yafei Guo et al.   ACS Catalysis

Axially Chiral Biaryl Monophosphine Oxides Enabled by Palladium/WJ-Phos-Catalyzed Asymmetric Suzuki–Miyaura Cross-coupling

(2020) Wangqin Ji et al.   ACS Catalysis

Regiodivergent Hydroborative Ring Opening of Epoxides via Selective C–O Bond Activation

(2020) Marc Magre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Dearomatization of Indole by Palladium/PC‐Phos‐Catalyzed Dynamic Kinetic Transformation

(2020) Haoke Chu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti‐Markovnikov Hydroamination of Racemic Allylic Alcohols to Access Chiral γ‐Amino Alcohols

(2020) Ruirui Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Harnessing the Power of the Asymmetric Grignard Synthesis of Tertiary Alcohols: Ligand Development and Improved Scope Exemplified by One-Step Gossonorol Synthesis

(2020) Saranna E. Kavanagh et al.   ORGANIC LETTERS

Fast Enantio‐ and Chemoselective Arylation of Ketones with Organoboronic Esters Enabled by Nickel/N‐Heterocyclic Carbene Catalysis

(2020) Yuan Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective CuAAC of Functional Tertiary Alcohols Featuring an Ethynyl Group and Their Kinetic Resolution

(2020) Kui Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic Resolution of Tertiary 2-Alkoxycarboxamido-allylic Alcohols by Chiral Phosphoric Acid Catalyzed Intramolecular Transesterification

(2019) Subramani Rajkumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd/PC-Phos-Catalyzed Enantioselective Intermolecular Denitrogenative Cyclization of Benzotriazoles with Allenes and N-Allenamides

(2019) Pei-Chao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Catalytic Addition of Grignard Reagents to N-Heterocyclic Acceptors

(2019) Yafei Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic enantioselective addition of organometallics to unprotected carboxylic acids

(2019) Xingchen Yan et al.   Nature Communications

Design and Synthesis of WJ-Phos, and Application in Cu-Catalyzed Enantioselective Boroacylation of 1,1-Disubstituted Allenes

(2019) Jie Han et al.   ACS Catalysis

Enantioselective Difunctionalization of Alkenes by Palladium-Catalyzed Heck/Sonogashira Sequence

(2019) Junliang Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-Catalyzed Enantioselective Heck Reaction of Aryl Triflates and Alkynes

(2019) Chenghao Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Isoxazolines Enabled by Palladium-Catalyzed Carboetherification of Alkenyl Oximes

(2019) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

P-Chiral Phosphines Enabled by Palladium/Xiao-Phos-Catalyzed Asymmetric P–C Cross-Coupling of Secondary Phosphine Oxides and Aryl Bromides

(2019) Qiang Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Enantioselective Reductive Heck Reactions: Convenient Access to 3,3-Disubstituted 2,3-Dihydrobenzofuran

(2018) Zhan-Ming Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones

(2018) Kangnan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium/PC-Phos-Catalyzed Enantioselective Arylation of General Sulfenate Anions: Scope and Synthetic Applications

(2018) Lei Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Approaching sub-ppm-level asymmetric organocatalysis of a highly challenging and scalable carbon–carbon bond forming reaction

(2018) Han Yong Bae et al.   Nature Chemistry

Transition-Metal-Free Enantioselective Reactions of Organo­magnesium Reagents Mediated by Chiral Ligands

(2018) Anne Boussonnière et al.   SYNTHESIS-STUTTGART

Recent Advances in Catalytic Asymmetric Synthesis of Tertiary Alcohols via Nucleophilic Addition to Ketones

(2018) Yun-Lin Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Kinetic Resolution of Tertiary Propargylic Alcohols by Enantioselective Cu−H-Catalyzed Si−O Coupling

(2018) Jan Seliger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lewis Acid Enabled Copper-Catalyzed Asymmetric Synthesis of Chiral β-Substituted Amides

(2017) Mamen Rodríguez-Fernández et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Construction of Tertiary C–O Bond via Allylic Substitution of Vinylethylene Carbonates with Water and Alcohols

(2017) Ajmal Khan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Camptothecin and Related Natural Products by a Flexible Strategy

(2016) Ke Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereospecific Cross Couplings To Set Benzylic, All-Carbon Quaternary Stereocenters in High Enantiopurity

(2016) Qi Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic enantioselective addition of organoboron reagents to fluoroketones controlled by electrostatic interactions

(2016) KyungA Lee et al.   Nature Chemistry

Catalytic asymmetric addition of Grignard reagents to alkenyl-substituted aromatic N-heterocycles

(2016) R. P. Jumde et al.   SCIENCE

Copper-catalyzed asymmetric addition of olefin-derived nucleophiles to ketones

(2016) Y. Yang et al.   SCIENCE

Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines

(2016) Jiawei Rong et al.   Nature Communications

Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds

(2016) Juan F. Collados et al.   ACS Catalysis

Synthesis of Chiral Tertiary Alcohols by CuI-Catalyzed Enantioselective Addition of Organomagnesium Reagents to Ketones

(2015) Jiawei Rong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Addition of Pyridyl Aluminum Reagents to Aldehydes Catalyzed by a Titanium(IV) Catalytic System of (R)-H8-BINOLate

(2015) Lijun Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Direct 1,2-Addition of Aryl Grignard Reagents to Aryl Alkyl Ketones

(2015) Kazuki Osakama et al.   ORGANIC LETTERS

Enantioselective titanium-promoted 1,2-additions of carbon nucleophiles to carbonyl compounds

(2015) Hélène Pellissier   TETRAHEDRON

Catalytic Asymmetric Alkylation of Acylsilanes

(2014) Jiawei Rong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Type of Chiral Sulfinamide Monophosphine Ligands: Stereodivergent Synthesis and Application in Enantioselective Gold(I)-Catalyzed Cycloaddition Reactions

(2014) Zhan-Ming Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Alkylation of Aryl Heteroaryl Ketones

(2014) Pablo Ortiz et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Enantioselective Addition of Aryl Grignard Reagents to Ketones

(2014) Emilio Fernández-Mateos et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Aryl Bromides as Inexpensive Starting Materials in the Catalytic Enantioselective Arylation of Aryl Aldehydes: The Additive TMEDA Enhances the Enantioselectivity

(2014) Yong-Xin Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Discussion Addendum for: Applications of (2S)-(-)-3-exo-Morpholinoisoborneol [(-)MIB] in Organic Synthesis

(2014)   ORGANIC SYNTHESES

Asymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones

(2013) Francesca Caprioli et al.   CHEMICAL COMMUNICATIONS

Catalytic Enantioselective Alkylation of Aldehydes by Using Organozinc Halide Reagents

(2013) Yuichiro Kinoshita et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral 1,1-diaryl compounds as important pharmacophores

(2013) Dana Ameen et al.   MedChemComm

Asymmetric Copper-Catalyzed Addition of Grignard Reagents to Aryl Alkyl Ketones

(2012) Ashoka V. R. Madduri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Access to chiral α-bromo and α-H-substituted tertiary allylic alcohols via copper(i) catalyzed 1,2-addition of Grignard reagents to enones

(2012) Ashoka V. R. Madduri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper(i) catalyzed asymmetric 1,2-addition of Grignard reagents to α-methyl substituted α,β-unsaturated ketones

(2011) Ashoka V. R. Madduri et al.   CHEMICAL COMMUNICATIONS

Catalytic Enantioselective Allylation of Carbonyl Compounds and Imines

(2011) Miguel Yus et al.   CHEMICAL REVIEWS

Asymmetric Addition of Diorganozinc Reagents to Aldehydes and Ketones

(2011) Caitlin M. Binder et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Commercially available neat organozincs as highly reactive reagents for catalytic enantioselective addition to ketones and aldehydes under solvent free conditions

(2011) Manabu Hatano et al.   TETRAHEDRON

Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

(2011) Manabu Hatano et al.   Catalysis Science & Technology

Catalytic enantioselective synthesis of sterically demanding alcohols using di(2°-alkyl)zinc prepared by the refined Charette's method

(2010) Manabu Hatano et al.   CHEMICAL COMMUNICATIONS

Zinc(ii)-catalyzed Grignard additions to ketones with RMgBr and RMgI

(2010) Manabu Hatano et al.   CHEMICAL COMMUNICATIONS

Zinc(II)-Catalyzed Addition of Grignard Reagents to Ketones

(2010) Manabu Hatano et al.   JOURNAL OF ORGANIC CHEMISTRY

N to C Aryl Migration in Lithiated Carbamates: α-Arylation of Benzylic Alcohols

(2009) Jonathan Clayden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Aspect of Magnesium Bromide‐Promoted Enantioselective Aryl Additions of Triaryl(tetrahydrofuran)aluminum to Ketones Catalyzed by a Titanium(IV) Catalyst oftrans‐1,2‐Bis(hydroxycamphorsulfonylamino)cyclohexane

(2008) Chien‐An Chen et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic enantioselective organozinc addition toward optically active tertiary alcohol synthesis

(2008) Manabu Hatano et al.   CHEMICAL RECORD

Catalytic Asymmetric Conjugate Addition and Allylic Alkylation with Grignard Reagents

(2008) Syuzanna R. Harutyunyan et al.   CHEMICAL REVIEWS

Enantiodivergent conversion of chiral secondary alcohols into tertiary alcohols

(2008) Jake L. Stymiest et al.   NATURE