High-Resolution Demultiplexing (HRdm) Ion Mobility Spectrometry–Mass Spectrometry for Aspartic and Isoaspartic Acid Determination and Screening

Unequivocal Identification of Aspartic Acid and isoAspartic Acid by MALDI-TOF/TOF: From Peptide Standards to a Therapeutic Antibody

(2021) John O. Hui et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Chip-Based Capillary Zone Electrophoresis Mass Spectrometry for Rapid Resolution and Quantitation of Critical Quality Attributes in Protein Biotherapeutics

(2021) Andrew B. Dykstra et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A Preprocessing Tool for Enhanced Ion Mobility–Mass Spectrometry-Based Omics Workflows

(2021) Aivett Bilbao et al.   JOURNAL OF PROTEOME RESEARCH

Rapid Characterization of Per- and Polyfluoroalkyl Substances (PFAS) by Ion Mobility Spectrometry–Mass Spectrometry (IMS-MS)

(2020) James N. Dodds et al.   ANALYTICAL CHEMISTRY

Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics

(2020) Kendra J. Adams et al.   JOURNAL OF PROTEOME RESEARCH

Recent advances in differentiation of isomers by ion mobility mass spectrometry

(2020) Qian Wu et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Multispecific drugs herald a new era of biopharmaceutical innovation

(2020) Raymond J. Deshaies   NATURE

High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

(2020) William S. Sawyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving glycan isomeric separation via metal ion incorporation for drift tube ion mobility-mass spectrometry

(2020) Chengyi Xie et al.   TALANTA

Resolution of Isomeric Mixtures in Ion Mobility Using a Combined Demultiplexing and Peak Deconvolution Technique

(2020) Jody C. May et al.   ANALYTICAL CHEMISTRY

Advancing Mass Spectrometry Technology in cGMP Environments

(2020) Da Ren   TRENDS IN BIOTECHNOLOGY

Ion Mobility Spectrometry: Fundamental Concepts, Instrumentation, Applications, and the Road Ahead

(2019) James N. Dodds et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structural and biochemical basis of the formation of isoaspartate in the complementarity-determining region of antibody 64M-5 Fab

(2019) Hideshi Yokoyama et al.   Scientific Reports

Ion mobility in the pharmaceutical industry: an established biophysical technique or still niche?

(2018) Iain DG Campuzano et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Gas Phase Ion Chemistry to Determine Isoaspartate in a Peptide Backbone

(2018) S. T. Ayrton et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A High-Throughput Bioluminescent Assay to Monitor the Deamidation of Asparagine and Isomerization of Aspartate Residues in Therapeutic Proteins and Antibodies

(2017) Kevin Hsiao et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Forced degradation of recombinant monoclonal antibodies: A practical guide

(2017) Christine Nowak et al.   mAbs

A Fluorescence-Based High-Throughput Coupled Enzymatic Assay for Quantitation of Isoaspartate in Proteins and Peptides

(2016) Aastha Puri et al.   AAPS PHARMSCITECH

Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses

(2016) Xueyun Zheng et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Distinguishing Aspartic and Isoaspartic Acids in Peptides by Several Mass Spectrometric Fragmentation Methods

(2016) Nick DeGraan-Weber et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Experimental and Theoretical Investigation of Sodiated Multimers of Steroid Epimers with Ion Mobility-Mass Spectrometry

(2016) Christopher D. Chouinard et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Old Proteins in Man: A Field in its Infancy

(2016) Roger J.W. Truscott et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ion Mobility-Mass Spectrometry: Time-Dispersive Instrumentation

(2015) Jody C. May et al.   ANALYTICAL CHEMISTRY

Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics

(2015) Richard S Rogers et al.   mAbs

The Negative Mode Proteome with Activated Ion Negative Electron Transfer Dissociation (AI-NETD)

(2015) Nicholas M. Riley et al.   MOLECULAR & CELLULAR PROTEOMICS

Understanding Pharmaceutical Quality by Design

(2014) Lawrence X. Yu et al.   AAPS Journal

Identification of Amino Acid Epimerization and Isomerization in Crystallin Proteins by Tandem LC-MS

(2014) Yuanqi Tao et al.   ANALYTICAL CHEMISTRY

Conformational Ordering of Biomolecules in the Gas Phase: Nitrogen Collision Cross Sections Measured on a Prototype High Resolution Drift Tube Ion Mobility-Mass Spectrometer

(2014) Jody C. May et al.   ANALYTICAL CHEMISTRY

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

(2014) Jasmin F. Sydow et al.   PLoS One

Current and future trends in UHPLC

(2014) Szabolcs Fekete et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies

(2014) Catherine M. Eakin et al.   Frontiers in Pharmacology

Protein Isoaspartate Methyltransferase-Mediated 18O-Labeling of Isoaspartic Acid for Mass Spectrometry Analysis

(2011) Min Liu et al.   ANALYTICAL CHEMISTRY

Analysis of Isoaspartic Acid by Selective Proteolysis with Asp-N and Electron Transfer Dissociation Mass Spectrometry

(2010) Wenqin Ni et al.   ANALYTICAL CHEMISTRY

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS