Article
Chemistry, Physical
Kento Koga, Tatsuaki Tagami, Tetsuya Ozeki
Summary: The study developed gold nanoparticle-coated liposome/doxorubicin for controlled drug release and photothermal effect, showing synergistic therapeutic efficacy on lung cancer cells compared to monotherapy. This approach holds promise for cancer treatment with the use of near-infrared laser irradiation.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biophysics
Yuqiong Xia, Cairu Li, Jianxia Cao, Zhaoxu Chen, Jun Wang, Yankun Wu, Xianghan Zhang
Summary: Mild temperature photothermal therapy is a promising approach for clinical tumor treatment, but the overexpression of heat shock proteins (HSPs) limits its therapeutic outcome. In this study, we investigated the correlation between HSP expression and photothermal temperature, and found that 47 degrees C was the optimal temperature for HSP management. By co-administrating an HSP70 inhibitor, we achieved enhanced tumor inhibition in temperature-controlled photothermal therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Applied
Luyu Wei, Fu Jiao, Zhilong Wang, Long Wu, Daming Dong, Yiping Chen
Summary: A highly sensitive and accurate enzyme-modulated photothermal immunosensor utilizing a self-calibrated thermal imaging system (SCTIS) was developed for the detection of chloramphenicol. The immunosensor used alkaline phosphatase as a modulator of the photothermal conversion and employed SCTIS for real-time self-calibration of temperature. It achieved a LOD of 9 pg/mL for chloramphenicol detection in 2 hours, with low relative standard deviations and good average recoveries in milk and egg samples.
Article
Nanoscience & Nanotechnology
Fangqi Chen, Leqing Xu, Yanpei Tian, Andrew Caratenuto, Xiaojie Liu, Yi Zheng
Summary: This study introduces a high-energy conversion efficiency photothermal absorber using polycaprolactone nanofiber composite with the incorporation of carbon nanotubes or carbon nanoparticles, achieving ultra-high solar absorptance. Electrospinning enables scalable fabrication of nanostructured materials, providing a new approach for low-cost and high-efficiency solar energy utilization in the future.
ACS APPLIED NANO MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Natwat Srikhao, Somnuk Theerakulpisut, Prinya Chindaprasirt, Manunya Okhawilai, Ravin Narain, Pornnapa Kasemsiri
Summary: This study investigates the properties of photothermal and pH-responsive nanocomposite hydrogels containing silver nanoparticles (AgNPs). The results show that AgNPs enhance the antibacterial activities and photothermal conversion ability of the hydrogel. The hydrogel prepared with 200 mM silver nitrate combined with near infrared radiation exhibits the highest antibacterial efficiency and also demonstrates pH-responsive release of tannic acid. The nanocomposite hydrogels show good biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biophysics
Zhichao Yu, Hexiang Gong, Meijin Li, Dianping Tang
Summary: In this study, a sensitive cascade of colorimetric-photothermal biosensors was developed for prognostic management of patients with myocardial infarction. The biosensor models utilized a cascade enzymatic reaction device and a portable smartphone-adapted signal visualization platform to achieve sensitive determination of cTnI protein.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Yuen Yung Hui, Yi-Xiu Tang, Terumitsu Azuma, Hsin-Hung Lin, Fang-Zhen Liao, Qing-Ying Chen, Jen-Hwa Kuo, Yuh-Lin Wang, Huan-Cheng Chang
Summary: In this study, a low-cost and portable lateral flow immunoassay (LFIA) reader based on photothermal detection was developed. The LFIA reader utilized a low-power green laser as the heating source and a single-element infrared sensor as the detector for accurate quantitative detection of reporters captured on LFIA strips. The results showed that photothermal detection significantly enhanced the sensitivity of LFIA and enabled quantitative analysis to support critical decision-making.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Vikas, Raj Kumar, Sanjeev Soni
Summary: This study calculated the optical characteristics of gold nanorods in different doses for various tumor types, finding that increasing nanorod dose can enhance absorption cross section and result in a red-shift in plasmonic wavelength, which is important for selecting suitable irradiation sources and parameters for plasmonic photothermal therapy.
APPLIED NANOSCIENCE
(2021)
Article
Chemistry, Analytical
Zou Hong-Yan, Guo Qing-Juan, Huang Cheng-Zhi
Summary: A multifunctional composite material consisting of folate acid and the anticancer drug bortezomib was successfully developed, allowing for synergistic treatment of tumor cells through photothermal therapy and chemotherapy.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Min Wei, Jingwen Bai, Xiao Shen, Kangliang Lou, Yiyang Gao, Ruichan Lv, Peiyuan Wang, Xiaolong Liu, Guojun Zhang
Summary: A nanoprobe is designed to address the challenges in accurate margin assessments and enhance radiotherapy in breast cancer. The nanoprobe targets tumor cells efficiently, allows for precise surgery under NIR-II fluorescence imaging, and boosts radiation sensitivity by disrupting intracellular ROS homeostasis.
Article
Chemistry, Multidisciplinary
Zhichao Yu, Juan Tang, Hexiang Gong, Yuan Gao, Yongyi Zeng, Dianping Tang, Xiaolong Liu
Summary: A paper-based naked-eye recognition assay with enzyme-encapsulated protein engineered metal-organic framework-derived biominerals is developed for direct quantification of sarcosine in urine samples for screening of prostate cancer individuals. The detection strategy involves the construction of a cascade enzymatic catalytic reaction model on Pt nanoparticles (NPs)-loaded porous CeO2, which integrates a sarcosine oxidase as a recognition unit and a chromogenic substrate as a signal molecule reporter. This method shows potential in screening for minor differences in sarcosine between cancer patients and normal individuals.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Zhichao Yu, Chicheng Qiu, Lingting Huang, Yuan Gao, Dianping Tang
Summary: A portable photothermal immunosensing platform supported by a microelectromechanical microsystem (MEMS) was developed for quick and cost-effective identification of acutely toxic and low-fatality mycotoxins, which is critical for reducing population mortality.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yuan Gao, Zhichao Yu, Lingting Huang, Yongyi Zeng, Xiaolong Liu, Dianping Tang
Summary: In this work, a photoelectrochemical (PEC) biosensor for formaldehyde (FA) detection was developed based on photoinduced electron transfer (PET)-gated electron injection. The PEC platform (NFC/TiO2) was constructed by integrating an FA-responsive probe (NA-FA-COOH) and TiO2 nanoarrays. The FA treatment on NFC/TiO2 suppressed the intramolecular PET process and established the PEC platform for FA detection.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Wenxin Li, Li Sun, Xiaofei Zheng, Fen Li, Wenyue Zhang, Tao Li, Yingshu Guo, Dianping Tang
Summary: A FRET nanoplatform was designed for the quantitative detection of Furin and drug delivery in triple-negative breast cancer. The nanoprobes released drugs and generated fluorescence signals through specific enzymatic cleavage, allowing for the monitoring of cell physiology and early diagnosis of the disease.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Qianyun Lin, Zhichao Yu, Liling Lu, Xue Huang, Qiaohua Wei, Dianping Tang
Summary: The researchers developed a portable smartphone-based PEC immunoassay platform for the detection of prostate specific antigen (PSA) using Co-doped Bi2O2S nanosheets as photoactive materials. This system exhibited fast photocurrent response under visible light and excellent electrical transport rate. By incorporating a carriable flashlight, disposable screen-printed electrodes, a microelectrochemical workstation, and a smartphone as control center, point-of-care analytical detection of low-abundance small molecule analytes was successfully achieved. The system provided an effective method for portable and miniaturized PEC sensing platform for point-of-care health monitoring.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Zhichao Yu, Qianyun Lin, Hexiang Gong, Meijin Li, Dianping Tang
Summary: Considering the increasing occurrence of acute myocardial infarction at a younger age and its impact on public health, the development of rapid screening tools is crucial. In this study, we developed an artificial neural network-assisted solar-powered photoelectrochemical sensing platform for the rapid screening of cardiac troponin I protein in patients with acute myocardial infarction. By integrating a self-powered photoelectric signal output system with low-cost screen-printed paper electrodes functionalized with ultrathin Bi2O2S nanosheets, we created a solar-powered PEC immunoassay without the need for an excitation light source.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Xinyi Lin, Feida Li, Jianhua Guan, Xiaoyan Wang, Cuiping Yao, Yongyi Zeng, Xiaolong Liu
Summary: An immunomodulator based on Janus silica nanoparticles is developed to reshape the tumor microenvironment and improve the efficacy of PD-1/PD-L1 immune checkpoint blockade therapy. This immunomodulator releases a PI3K? inhibitor to reverse immunosuppression in the tumor microenvironment. The results demonstrate that this strategy significantly improves immune suppression in the tumor microenvironment and induces robust systemic antitumor immune responses, enhancing the efficacy of PD-1/PD-L1 blockade therapy.
Article
Chemistry, Analytical
Xin Wang, Haiyang Wang, Xinyu Wan, Meijin Li, Dianping Tang
Summary: The study presents a portable photoelectrochemical (PEC) immunoassay platform for rapid and low-cost detection of carcinoembryonic antigen (CEA) using a smartphone. The system utilizes disposable screen-printed carbon electrodes and a S-scheme heterojunction BiOCl/CuBi2O4 to achieve efficient electron transfer and excellent photocurrent response. The proposed immunoassay demonstrates good linearity within the concentration range of 0.01-40 ng mL-1 and a detection limit of 3.5 pg mL-1 (S/N = 3).
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Shuyun Chen, Zhichao Yu, Yunsen Wang, Juan Tang, Yongyi Zeng, Xiaolong Liu, Dianping Tang
Summary: This study successfully constructed stable platinum nanoclusters using an organic polymer surfactant and demonstrated high peroxidase-like activity, providing an enhanced method for the immunoassay of cardiac troponin I. This research is of great significance for designing artificial enzymes with high enzyme-like activity.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Di Wu, Dianping Tang
Summary: Efficient and accurate diagnostic methods are crucial for human health monitoring and prevention of major diseases. Photoelectrochemical (PEC) biosensors have gained considerable attention due to their high sensitivity, low detection background, and the advantages of combining photoexcitation and electrochemical detection. The development of highly integrated portable micro devices with wireless transmissions has enabled convenient visualization of test results, showing great potential for application. This review provides an overview of recent advances in portable PEC biosensing, including principles, photovoltaic materials, fabrication techniques, and future prospects.
Article
Chemistry, Analytical
Jiao Qin, Jinjin Li, Haisen Zeng, Fan Du, Dianping Tang, Juan Tang
Summary: In this study, the rigidified H4TCBPE-TiO2 nanospheres were developed as an effective ECL emitter for the construction of an on-off ECL biosensor. The ECL response of H4TCBPE-TiO2 was enhanced by the Ti-O network and the presence of TiO2 as an ECL co-reaction accelerator. The ultrasensitive ECL biosensor exhibited a desirable detection range and a low detection limit for Mal.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zhichao Yu, Juan Tang, Yuan Gao, Di Wu, Shuyun Chen, Yongyi Zeng, Dianping Tang, Xiaolong Liu
Summary: By anchoring sub-nanometer Co clusters on porous nitrogen-doped carbon, a non-invasive sensor for clozapine detection is successfully prepared. The Co clusters provide enhanced electrochemical performance and better substrate adsorption potential. The developed sensing system allows for monitoring of clozapine in various body fluid environments, and the correlation between blood and saliva is investigated.