Article
Radiology, Nuclear Medicine & Medical Imaging
Hyeon Ji Jang, Sang Hyun Choi, Se Jin Choi, Won-Mook Choi, Jae Ho Byun, Hyung Jin Won, Yong Moon Shin
Summary: This study aimed to develop and evaluate a modified LI-RADS version 2018 for diagnosing hepatocellular carcinoma (HCC) < 1.0 cm. Significant ancillary features associated with HCC < 1.0 cm were determined and applied to the modified LI-RADS. The sensitivity of our modified LI-RADS using restricted diffusion was significantly higher than LI-RADS v2018, with similar specificity.
EUROPEAN RADIOLOGY
(2023)
Article
Immunology
Yidi Chen, Yun Qin, Yuanan Wu, Hong Wei, Yi Wei, Zhen Zhang, Ting Duan, Hanyu Jiang, Bin Song
Summary: An easy-to-use and noninvasive risk score combining preoperative EOB-MRI and clinical indicators has been developed to accurately predict positive GPC-3 expression in hepatocellular carcinoma (HCC).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Stocker, Stefanie Hectors, Octavia Bane, Naik Vietti-Violi, Daniela Said, Paul Kennedy, Jordan Cuevas, Guilherme M. Cunha, Claude B. Sirlin, Kathryn J. Fowler, Sara Lewis, Bachir Taouli
Summary: The study aimed to compare the AIF quality and perfusion parameters of HCC using gadoxetate disodium compared to Gd-BOPTA during the first 3 minutes post-contrast injection. Results showed that gadoxetate disodium provided comparable AIF quality and HCC perfusion parameters to Gd-BOPTA during dynamic phases, despite causing delayed and decreased liver enhancement.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ting Yang, Hong Wei, Yuanan Wu, Yun Qin, Jie Chen, Hanyu Jiang, Bin Song
Summary: This study aimed to establish a preoperative score using gadoxetate disodium-enhanced magnetic resonance imaging (EOB-MRI) and clinical indicators to predict histologic differentiation of solitary hepatocellular carcinoma (HCC) measuring up to 5 cm. The predictive score, incorporating two EOB-MRI features and serum alpha-fetoprotein (AFP) level, achieved high accuracy in predicting poorly differentiated (PD) HCC in the preoperative setting. The proposed score can be a useful tool for clinical decision-making.
INSIGHTS INTO IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huanhuan Chong, Yuda Gong, Yunfei Zhang, Yongming Dai, Ruofan Sheng, Mengsu Zeng
Summary: This study investigates the use of preoperative EOB-MRI-based radiomics to predict GPC3-positive expression and recurrence-free survival in patients with HCC < 5 cm. A comprehensive nomogram incorporating GPC3-oriented radiomics models is developed and found to outperform clinicoradiologic algorithms. The radiomics score is also found to be correlated with the histological GPC3-positive phenotype and survival outcomes.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huan-Huan Chong, Li Yang, Ruo-Fan Sheng, Yang-Li Yu, Di-Jia Wu, Sheng-Xiang Rao, Chun Yang, Meng-Su Zeng
Summary: The study successfully developed radiomics-based nomograms for predicting preoperative microvascular invasion and recurrence-free survival in patients with solitary hepatocellular carcinoma <= 5 cm. Radiomics values, peritumoral enhancement, and absent capsule enhancement were identified as independent risk factors for MVI, while age, histologic MVI, alkaline phosphatase, and alanine aminotransferase were independent predictors for recurrence. The nomograms showed high accuracy in predicting MVI and stratifying RFS.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Naik Vietti Violi, Jeffrey Gnerre, Amy Law, Stefanie Hectors, Octavia Bane, John Doucette, Ghadi Abboud, Edward Kim, Myron Schwartz, M. Isabel Fiel, Bachir Taouli
Summary: This study investigated the diagnostic performance of gadoxetate disodium MRI for predicting complete pathologic necrosis (CPN) in HCC treated with TARE. The results showed that the percentage of tumor necrosis on subtraction and EASL criteria were significant independent predictors of CPN, with image subtraction being considered for assessing HCC response to TARE.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Junhan Pan, Shengli Ye, Mengchen Song, Tian Yang, Lili Yang, Yanyan Zhu, Yanci Zhao, Feng Chen
Summary: In this study, a CART algorithm was developed and validated for the diagnosis of HCC <= 3.0 cm using Gd-EOB-MRI. The algorithm showed promise for early diagnosis of HCC in high-risk patients, with higher sensitivity and specificity compared to other criteria.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Huanhuan Chong, Yuda Gong, Xianpan Pan, Aie Liu, Lei Chen, Chun Yang, Mengsu Zeng
Summary: In this study, peritumoral dilation radiomics based on Gd-EOB-DTPA MRI was used as a potential preoperative biomarker for predicting early recurrence in HCC patients without macrovascular invasion. The radiomics model showed significant improvements in early recurrence prediction compared to clinical algorithms, demonstrating its potential clinical value for patient management.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sun Hong, Sang Hyun Choi, Seung Baek Hong, So Yeon Kim, Seung Soo Lee
Summary: Comparing the clinical usefulness of multiple arterial-phase MRI (MA-MRI) and single arterial-phase MRI (SA-MRI) enhanced with gadoxetate disodium, it was found that MA-MRI may offer better image quality and lesion detection rate. However, further studies are needed to validate this finding due to study heterogeneity and publication bias.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fang-Ming Chen, Mingzhan Du, Xiumin Qi, Linjie Bian, Danping Wu, Shuang-Lin Zhang, Jitao Wang, Yongping Zhou, Xiaoli Zhu
Summary: This study aimed to develop and validate a nomogram based on MRI features to estimate VETC in HCC, and evaluate its association with postoperative recurrence. The results showed that the nomogram based on gadoxetate disodium-enhanced MRI can predict VETC preoperatively and is associated with postoperative recurrence in patients with HCC.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Roberto Cannella, Carla Camma, Francesco Matteini, Ciro Celsa, Paolo Giuffrida, Marco Enea, Albert Comelli, Alessandro Stefano, Calogero Camma, Massimo Midiri, Roberto Lagalla, Giuseppe Brancatelli, Federica Vernuccio
Summary: This study explored the potential of radiomics on gadoxetate disodium-enhanced MRI for predicting hepatocellular carcinoma (HCC) response after transarterial embolization (TAE). The results showed that radiomics models based on gadoxetate disodium-enhanced MRI can achieve good performance in predicting the response of HCCs treated with TAE.
Article
Radiology, Nuclear Medicine & Medical Imaging
Junhan Pan, Mengchen Song, Lili Yang, Yanci Zhao, Yanyan Zhu, Meng Wang, Feng Chen
Summary: This study evaluated the value of using EC or modified capsule appearance in LI-RADS for diagnosing HCC <= 3.0 cm on Gd-EOB-MRI, and explored the relationship between imaging features and the histological fibrous capsule. The results showed that EC appearance improved the diagnostic sensitivity of LI-RADS for HCC, and considering NEC as an alternative capsule appearance allowed for better inter-reader reliability and comparable diagnostic ability.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Kartik S. Jhaveri, Ali Babaei Jandaghi, Rajesh Bhayana, Khaled Y. Elbanna, Osvaldo Espin-Garcia, Sandra E. Fischer, Anand Ghanekar, Gonzalo Sapisochin
Summary: This study aimed to compare the diagnostic performance of EOB-MRI and CECT for HCC detection and LT eligibility assessment. The results showed that EOB-MRI had higher sensitivity but lower specificity compared to CECT in LR4/5 category lesions, and was inferior to CECT in the LR5 category under 2 cm. However, the accuracy for LT eligibility assessment based on Milan criteria was comparable between EOB-MRI and CECT.
Article
Medicine, General & Internal
Jiming Wang, Xiaofei Ye, Jiangfa Li, Songqing He
Summary: The study found that MRI had superior sensitivity to CEUS in diagnosing HCC, especially for lesions with a diameter of less than 30 mm. However, there was no significant difference in diagnostic specificity between MRI and CEUS for HCC lesions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Subin Heo, Sang Hyun Choi, Sun Hong, Dong Wook Kim
Summary: This study investigates the association between the visualization score of gadoxetic acid-enhanced MRI and clinical factors, and evaluates its effect on the diagnostic accuracy for HCC <= 3.0 cm.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Gastroenterology & Hepatology
Seung Baek Hong, Sun Hong, Sang Hyun Choi, Seo Young Park, Ju Hyun Shim, So Yeon Kim, Seung Soo Lee, Suk Kim
Summary: This study found that gadoxetic acid-enhanced multiple arterial-phase magnetic resonance imaging (MA-MRI) can improve the sensitivity for diagnosing hepatocellular carcinoma (HCC) <= 3.0 cm compared to single arterial-phase MRI (SA-MRI), without a significant decrease in specificity.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Hyungjin Rhee, Hyun-Ji Lim, Kyunghwa Han, Suk-Keu Yeom, Sang Hyun Choi, Ji Hoon Park, Eun-Suk Cho, Sumi Park, Mi-Jung Lee, Gi Hong Choi, Dai Hoon Han, Seung Soo Lee, Mi-Suk Park
Summary: A simple scoring system was developed to predict lymph node metastasis in patients with intrahepatic cholangiocarcinoma. The score, based on MRI and clinical findings, was associated with lymph node metastasis and outperformed MRI-suspicious LN alone in predicting pathological LN lesions.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Se Jin Choi, Sang Hyun Choi, Dong Wook Kim, Jae Ho Byun, Hyung Jin Won, Yong Moon Shin
Summary: This study found a significant association between threshold growth and hepatocellular carcinoma (HCC). Using threshold growth as a major diagnostic feature in LI-RADS v2018 can improve sensitivity in diagnosing HCC.
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ijin Joo, Jeong Min Lee, Young Hwan Koh, Sang Hyun Choi, Sunyoung Lee, Jin Wook Chung
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Won-Mook Choi, Seo Yeon Yoo, Jong-In Chang, Seungbong Han, Young Seok Kim, Dong Hyun Sinn, Sang Hyun Choi, Dong Il Gwon, Young-Suk Lim
Summary: This study aimed to develop and validate a prognostic model for identifying patients with a risk of poor short-term survival after PSSE. Results showed that baseline levels of serum albumin, total bilirubin, and international normalized ratio were significantly associated with 1-year overall survival after PSSE. The ABI score, developed based on these factors, showed good discrimination performance in predicting 3-month and 6-month survival.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Young Choi, Kyoung Won Kim, Jong Keon Jang, Sang Hyun Choi, Heon-Ju Kwon, Young -In Yoon, Gi-Won Song, Sung-Gyu Lee
Summary: This study investigated the value of Doppler ultrasonography in predicting clinical outcomes after antirejection treatment for patients with acute cellular rejection (ACR) following liver transplantation (LT). Abnormal PBVearly post-treatment and a decrease between PBVevent and PBVearly post-treatment were significantly associated with poor treatment response in patients with ACR after LT.
Article
Radiology, Nuclear Medicine & Medical Imaging
Woo Kyoung Jeong, Hyo-Jin Kang, Sang Hyun Choi, Mi-Suk Park, Mi Hye Yu, Bohyun Kim, Myung-Won You, Sanghyeok Lim, Young Seo Cho, Min Woo Lee, Jeong Ah Hwang, Jae Young Lee, Jung Hoon Kim, Ijin Joo, Jae Seok Bae, So Yeon Kim, Yong Eun Chung, Dong Hwan Kim, Jeong Min Lee
Summary: Sonazoid, a second-generation ultrasound contrast agent, has been used for the diagnosis of hepatic nodules. To address the diagnostic issues of hepatocellular carcinoma (HCC) with Sonazoid contrast-enhanced ultrasonography, the Korean Society of Radiology and Korean Society of Abdominal Radiology collaborated on evidence-based guidelines, which were selected using an electronic voting system. These guidelines cover imaging protocols, diagnostic criteria, diagnostic value for inconclusive lesions, differentiation from non-HCC malignancies, surveillance of HCC, and treatment response after locoregional and systemic treatment.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Boryeong Jeong, Se Jin Choi, Sang Hyun Choi, Hyeon Ji Jang, Jae Ho Byun, Hyung Jin Won, Yong Moon Shin
Summary: This study compared the accuracy of LI-RADS based on original threshold growth (TG) and LI-RADS based on tumor growth rate for the diagnosis of HCC. It was found that LI-RADS based on tumor growth rate showed higher diagnostic accuracy for HCC.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Na Eun Oh, Sang Hyun Choi, Sehee Kim, Habeen Lee, Hyeon Ji Jang, Jae Ho Byun, Hyung Jin Won, Yong Moon Shin
Summary: The diagnostic performance of LI-RADS v2018 on gadoxetic acid-enhanced MRI was evaluated in this study for the detection of hepatocellular carcinoma (HCC). Liver transplant candidates (LT group) were compared with patients who underwent surgical resection (SR group). It was found that LI-RADS v2018 may be insufficient in liver transplant candidates, and other diagnostic imaging tests should be considered in patients with smaller lesion size, larger lesion number, and higher Child-Pugh score.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyeon Ji Jang, Sang Hyun Choi, Se Jin Choi, Won-Mook Choi, Jae Ho Byun, Hyung Jin Won, Yong Moon Shin
Summary: This study aimed to develop and evaluate a modified LI-RADS version 2018 for diagnosing hepatocellular carcinoma (HCC) < 1.0 cm. Significant ancillary features associated with HCC < 1.0 cm were determined and applied to the modified LI-RADS. The sensitivity of our modified LI-RADS using restricted diffusion was significantly higher than LI-RADS v2018, with similar specificity.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Young Choi, Jihye Yun, Subin Heo, Dong Wook Kim, Sang Hyun Choi, Jiyoung Yoon, Kyuwon Kim, Kee Wook Jung, Seung-Jae Myung
Summary: The quantitative motility score calculated from cine MRI enables diagnosis of an adynamic small bowel and potentially discerns various degrees of bowel motility.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Subin Heo, Hyo Jeong Kang, Sang Hyun Choi, Sehee Kim, Youngeun Yoo, Won-Mook Choi, So Yeon Kim, Seung Soo Lee
Summary: This multi-reader study demonstrated that the percentage of LR-M was significantly higher in proliferative HCCs. CT/MRI LR-M was significantly associated with poor overall survival (OS) and recurrence-free survival (RFS), regardless of the pathological classification of proliferative vs. non-proliferative HCCs.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyo Jung Park, Hyoung Jung Kim, Jung Hoon Kim, So Yeon Kim, Sang Hyun Choi, Jae Ho Byun, Song Cheol Kim, Hee Sang Hwang, Seung-Mo Hong
Summary: This study aimed to evaluate the prognostic value of tumor-to-parenchymal contrast enhancement ratio on portal venous-phase CT (CER on PVP) in pancreatic neuroendocrine neoplasms (PanNENs) and compare its predictive performance with current grading and staging systems. The results showed that CER on PVP had superior predictive performance on postoperative survival compared to the current grading and staging systems, suggesting its potential as a noninvasive preoperative prognostic tool.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Keon Jang, Sang Hyun Choi, Jae Ho Byun, Seo Young Park, So Jung Lee, So Yeon Kim, Hyung Jin Won, Yong Moon Shin, Pyo-Nyun Kim
Summary: This study aimed to improve the diagnosis of HCC <= 3.0 cm by investigating new Liver Imaging Reporting and Data System category M (LR-M) criteria. The study analyzed a total of 463 hepatic observations and identified several features significantly associated with non-HCC malignancy. The new LR-M criteria showed improved sensitivity for diagnosing HCC without compromising specificity.
ABDOMINAL RADIOLOGY
(2022)