期刊
INTERVIROLOGY
卷 59, 期 5-6, 页码 285-300出版社
KARGER
DOI: 10.1159/000477808
关键词
Viruses; Fish; Diagnostics Next-generation sequencing; Aquatic virology
类别
资金
- government of Gabon, Total-Fina-Elf Gabon
- Ministsre de la Cooperation Francaise
- ERA-NET EMIDA-funded project MOLTRAQ (molecular tracing of viral pathogens in aquaculture)
The recent technological advances in nucleic acid sequencing, called next-generation sequencing (NGS), have revolutionized the field of genomics and have also influenced viral research. Aquatic viruses, and especially those infecting fish, have also greatly benefited from NGS technologies, which provide a huge amount of molecular information at a low cost in a relatively short period of time. Here, we review the use of the current high-throughput sequencing platforms with a special focus on the associated challenges (regarding sample preparation and bioinformatics) in their applications to the field of aquatic virology, especially for: (i) discovering novel viruses that may be associated with fish mortalities, (ii) elucidating the mechanisms of pathogenesis, and finally (iii) studying the molecular epidemiology of these pathogens. (C) 2017 S. Karger AG, Basel
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