期刊
ACTA BIOMATERIALIA
卷 146, 期 -, 页码 80-93出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2022.04.037
关键词
Postoperative adhesion; Tissue adhesive; Supramolecular chemistry; Gel; Sol-gel transition
资金
- Japan Society for the Promotion of Science (JSPS) KAKENHI [20K20207, 20H02470, 22H03962]
- Project for Translational Research program
- Strategic PRomotion for practical application of INnovative medical Technology from the Japan Agency of Medical Re-search and Development (AMED) [JP20lm0203114h0001, JP20lm0203010]
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [20K20207] Funding Source: KAKEN
In this study, a single-syringe hotmelt tissue adhesive was developed by controlling the sol-gel transition behavior of gelatin through a supramolecular approach. The adhesive exhibited high biocompatibility, tissue adhesiveness, and operatability, making it suitable for preventing postoperative complications and contributing to minimally invasive surgery.
Postoperative adhesion is a serious and frequent complication, but there is currently no reliable anti adhesive barrier available due to low tissue adhesiveness, undesirable chemical reactions, and poor operability. To overcome these problems, we report a single-syringe hotmelt tissue adhesive that dissolves upon warming over 40 degrees C and coheres at 37 degrees C as a postoperative barrier. Tendon-derived gelatin was conjugated with the ureidopyrimidinone unit to supramolecularly control the sol-gel transition behavior. This functionalization improved bulk mechanical strength, tissue-adhesive properties, and stability under physiological conditions through the augmentation of intermolecular hydrogen bonding by ureidopyrimidinone unit. This biocompatible adhesive prevented postoperative adhesion between cecum and abdominal wall in adhesion models of rats. This hotmelt tissue adhesive has enormous potential to prevent postoperative complications and may contribute to minimally invasive surgery.Statement of significance There is a strong need to develop medical tissue adhesives with high biocompatibility, tissue adhesiveness, and operatability to prevent postoperative complications. In this report, single syringe, hotmelt-type tissue adhesive was developed by controlling sol-gel transition behavior of gelatin through supramolecular approach. The functionalization of gelatin with quadruple hydrogen bonding improved key features necessary for anti-adhesive barrier including bulk mechanical strength, tissue adhesive property, stability under physiological conditions, and anti-adhesive property. The hotmelt tissue adhesive can be used for a sealant, hemostatic reagent, and wound dressing to prevent postoperative complications including delayed bleeding, perforation, and inflammation and contribute to minimally invasive surgery. (c) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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