Article
Orthopedics
Teemu Paatela, Anna Vasara, Markus Sormaala, Heikki Nurmi, Hannu Kautiainen, Ilkka Kiviranta
Summary: In this study, the failure rate of first-generation ACI was higher in OCD lesions than in large full-thickness cartilage lesions, suggesting that OCD lesions may affect the durability of repair tissue. Future prospective studies are needed to determine the best way to repair OCD lesions using biological tissue engineering.
Article
Orthopedics
Nicholas Pasic, Hannah L. L. Bradsell, Andres Barandiaran, Avi A. S. Robinson, Brian J. J. Cole, Armando F. F. Vidal, Rachel M. M. Frank
Summary: This study retrospectively reviewed 46 patients who underwent a MACI (or ACI) biopsy and found that only 26.1% of the patients required cartilage transplantation surgery. Additionally, the reoperation rate after surgery was 16.7%. Therefore, arthroscopic surgery performed in conjunction with the biopsy appeared to be sufficient in improving function and reducing pain in patients with knee FCDs.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Zachary Hill, Connor Delman, Trevor Shelton, Wyatt Vander Voort, Brian Haus
Summary: A study found that there was no significant difference in clinical outcomes between autologous chondrocytes harvested from osteochondral loose bodies and those harvested from the standard intercondylar notch. This suggests that osteochondral loose bodies can be a viable harvest site, reducing donor site morbidity.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2023)
Article
Orthopedics
Yoshikazu Sumida, Kaori Nakamura, Sven Feil, Maja Siebold, Joachim Kirsch, Rainer Siebold
Summary: Arthroscopic second-look evaluation showed that all-arthroscopic ACI for patellar cartilage defects resulted in high-quality cartilage regeneration, with most lesions classified as normal or nearly normal. Overall, the majority of defects were repaired effectively, indicating the reproducibility and reliability of the procedure.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Masatoshi Takahara, Masahiro Maruyama, Tomohiro Uno, Mikio Harada, Hiroshi Satake, Daiichiro Takahara, Michiaki Takagi
Summary: The study revealed that separation of the immature epiphyseal cartilage is an early event in osteochondritis dissecans (OCD), while osteonecrosis in the articular fragment is a late event. Pathological variations correspond to the progression of OCD, with different types of OCD corresponding to different clinical presentations.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Health Care Sciences & Services
David Grevenstein, Darius Schafigh, Stavros Oikonomidis, Peer Eysel, Christoph Brochhausen, Christian Karl Spies, Johannes Oppermann
Summary: The study found that short-term radiological outcomes after spheroid-based ACI in the knee are not affected by defect localization, showing good results regardless of the area of the defect.
TECHNOLOGY AND HEALTH CARE
(2022)
Review
Orthopedics
Hayden B. Schuette, Matthew J. Kraeutler, John B. Schrock, Eric C. McCarty
Summary: A systematic review comparing primary versus secondary autologous chondrocyte implantation (ACI) in knee joints found that patients undergoing secondary ACI have a significantly higher risk of treatment failure and may experience worse subjective outcomes compared to those undergoing primary ACI.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Martin Textor, Arnd Hoburg, Rex Lehnigk, Carsten Perka, Georg N. N. Duda, Simon Reinke, Antje Blankenstein, Sarah Hochmann, Andreas Stockinger, Herbert Resch, Martin Wolf, Dirk Strunk, Sven Geissler
Summary: This study found that loose bodies (LBs) from patients with osteochondritis dissecans (OCD) contain sufficient viable and functional chondrocytes that can be used for autologous chondrocyte implantation (ACI) without affecting their phenotype during prolonged in vitro expansion. The chondrocyte populations from LBs (LB-CH) showed no significant differences in cell yield per isolation and expression of chondrocyte progenitor cell markers compared to control chondrocytes from non-weight-bearing joint regions. LB-CH exhibited comparable viability, proliferation rates, and chondrogenic differentiation potential to control chondrocytes, and had a higher ability to form a hyaline cartilage matrix compared to bone marrow mesenchymal stromal cells (BMSCs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Orthopedics
Filippo Migliorini, Joerg Eschweiler, Julia Prinz, Christian David Weber, Ulf Krister Hofmann, Frank Hildebrand, Nicola Maffulli
Summary: This systematic review evaluated the efficacy and safety of autologous chondrocyte implantation (ACI) for chondral defects of the knee in skeletally immature patients. The findings suggest that ACI is effective in improving outcome measures, but the safety profile remains controversial.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Alessandro Di Martino, Simone Silva, Luca Andriolo, Giulia Merli, Davide Reale, Stefano Zaffagnini, Giuseppe Filardo
Summary: The study compared the outcomes of patients with knee OCD treated with OAT or PG. Both treatments showed significant improvement in IKDC subjective scores, with no significant differences between the two groups. PG had a higher failure rate compared to OAT.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Orthopedics
Thomas Richard Niethammer, Daniel Altmann, Martin Holzgruber, Sophia Goller, Andreas Fischer, Peter Ernst Mueller
Summary: The study results show that third-generation autologous chondrocyte implantation is a suitable treatment option for athletic individuals with full-thickness cartilage defects, significantly improving patients' sports performance and postoperative symptoms.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Review
Orthopedics
Lauren Smith, Alexander Jakubiec, Leela Biant, Gwenllian Tawy
Summary: This systematic review evaluated the biomechanical and functional outcomes of autologous chondrocyte implantation (ACI). The study found that knee range of motion generally improved following ACI, but knee strength remained poorer compared to healthy controls, particularly after 2 years postoperatively. This suggests that longer-term strength training may benefit patients. However, further research is needed to better understand the impact of ACI on knee function.
Article
Orthopedics
Michael G. Saper, Viviana Bompadre, Gregory A. Schmale, Sarah Menashe, Monique Burton, Kyle Nagle, Mahesh Thapa
Summary: The study found that the 45 degrees flexion AP view can accurately detect capitellum OCD with high confidence and substantial interobserver agreement. When added to standard AP and lateral radiographs, the 45 degrees flexion AP view aids in the identification of capitellum OCD.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Martyn Snow, Lee Middleton, Samir Mehta, Andrew Roberts, Richard Grey, James Richardson, Jan Herman Kuiper, ACTIVE Consortium
Summary: This study compared the long-term outcomes of autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management in patients with failed previous treatment. The results showed that there was no significant difference in Lysholm scores between ACI and alternative management after 5 years, indicating that both methods were equally effective. However, ACI had more adverse events compared to the alternatives.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
John G. Lane
Summary: This retrospective analysis evaluated the return to work status of patients with workers compensation insurance after autologous chondrocyte implantation (ACI). The study found that in patients with multiple large defects, ACI treatment allowed a high percentage of patients to return to their normal vigorous work activities.