Review
Pharmacology & Pharmacy
Yihui Song, Xiaoke Yang, Bin Yu
Summary: Drug repurposing is an attractive strategy for finding new indications for existing drugs. Three approved antidepressants have shown potential in clinical trials for cancer treatment. By conducting further medicinal chemistry research, several TCP-based inhibitors of the histone lysine specific demethylase 1 enzyme have been discovered, showing promise for cancer treatment. Repurposing antidepressants could be a promising strategy for cancer treatment.
DRUG DISCOVERY TODAY
(2022)
Review
Oncology
Daniel M. Freed, Josh Sommer, Nindo Punturi
Summary: The development of effective and personalized treatment options for rare cancers like chordoma faces challenges due to limited genomic impact and low mutation burden. However, as our understanding of oncogenic mechanisms matures, new therapeutic opportunities arise beyond the tumor's genome. This review discusses how advanced tools and approaches are uncovering vulnerabilities in chordoma and highlights the identification and evaluation of new therapeutic hypotheses for this rare cancer through emerging observations and convergence with other cancers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemical Research Methods
Giulia Fiscon, Paola Paci
Summary: SAveRUNNER is a network-based tool for drug repurposing that predicts drug-disease associations by quantifying the interplay between drug targets and disease-associated proteins in the human interactome. The tool successfully predicted off-label drugs to be repositioned against the new human coronavirus (2019-nCoV/SARS-CoV-2) and achieved high accuracy in identifying known drug indications.
BMC BIOINFORMATICS
(2021)
Article
Pharmacology & Pharmacy
Tianduanyi Wang, Otto I. Pulkkinen, Tero Aittokallio
Summary: Most drug molecules have the ability to modulate multiple target proteins, which can lead to both therapeutic effects and unwanted side effects. Evaluating the selectivity of a compound is an important factor in drug development and repurposing efforts. Traditional methods for characterizing selectivity fall short in quantifying how selective a compound is against a particular target protein. In this study, we propose an optimization-based selectivity scoring method that allows for the identification of potent and selective compounds against given kinase targets. We demonstrate the effectiveness of this method in finding highly selective compounds in computational experiments using a large-scale kinase inhibitor dataset.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Maureen J. Donlin, Marvin J. Meyers
Summary: Fungal diseases are a major concern in public health, but the development of new antifungals is limited compared to other disease classes. Repurposing existing drugs as antifungals is an approach to quickly provide new treatment options. However, the efficacy and pharmacokinetics of these drug candidates are often suboptimal for fungal diseases. This review discusses the current antifungal drug pipeline and recent strategies to optimize existing drugs into novel molecules with unique modes of action.
DRUG DISCOVERY TODAY
(2022)
Review
Oncology
Qiaoli Shi, Fei Xia, Qixin Wang, Fulong Liao, Qiuyan Guo, Chengchao Xu, Jigang Wang
Summary: The discovery of artemisinin, inspired by traditional Chinese medicine, has revolutionized the treatment of malaria and has the potential to be used in the treatment of other diseases as well. It has provided guidance for the development of traditional Chinese medicine.
FRONTIERS OF MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Popat Kumbhar, Kapil Kole, Tejashree Yadav, Ashwini Bhavar, Pramod Waghmare, Rajdeep Bhokare, Arehalli Manjappa, Niraj Kumar Jha, Dinesh Kumar Chellappan, Sunita Shinde, Sachin Kumar Singh, Kamal Dua, Ahmad Salawi, John Disouza, Vandana Patravale
Summary: Skin cancer is a common form of cancer, and its treatment with chemotherapy has limitations. Drug repurposing, using previously approved drugs for the treatment of other diseases like cancer, offers a promising approach with advantages in time and cost.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Microbiology
Annelies Van den Bergh, Patrice Guillon, Mark von Itzstein, Benjamin Bailly, Larissa Dirr
Summary: This study developed an in vitro medium-throughput screening assay to identify novel anti-HMPV drug candidates. Out of 2,400 compounds, 11 candidates were identified with inhibitory activity against HMPV infection. The mode of action of five candidates with low cytotoxicity was further described. Among them, the mycophenolic acid series displayed the highest levels of inhibition. It has significant potential for drug repurposing.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Xinlei Li, Tao Peng
Summary: Emerging or re-emerging viruses continue to pose major threats to public health. While prophylactic vaccines are effective, antivirals offer more promise for viruses against which vaccines are not effective or currently unavailable. Drug repurposing, particularly with well-characterized therapeutics, is an attractive strategy due to slow novel antiviral discovery and high costs, in identifying new directions for treating virus infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Fisheries
Poonam Yadav, Lopmudra P. Sarode, Ravinder Reddy Gaddam, Puneet Kumar, Jasvinder Singh Bhatti, Amit Khurana, Umashanker Navik
Summary: Zebrafish is a valuable model for studying thyroid development and related diseases due to its similarity in genetic structure and its small size, low cost, and transparent embryo. It shares the same molecular mechanism of thyroid organogenesis with mammals, making it a useful tool for studying thyroid hormone signaling, embryonic development, thyroid-related disorders, and novel genes involved in early thyroid development.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Editorial Material
Engineering, Environmental
Chen-Fu Chien, Kathleen Aviso, Ming-Lang Tseng, Minoru Fujii, Ming K. Lim
Summary: The limitations of traditional waste management methods and the increasing generation of solid waste necessitate the collection of research on efficient models and better treatment technologies in a virtual special issue. Strategies focusing on reuse and recycling in solid waste management have revealed their current challenges, and the progress in addressing these limitations is of growing importance for emerging economies.
RESOURCES CONSERVATION AND RECYCLING
(2023)
Review
Biochemistry & Molecular Biology
Kawthar Mohamed, Niloufar Yazdanpanah, Amene Saghazadeh, Nima Rezaei
Summary: This systematic review provides an overview of studies using computational methods for drug repurposing in COVID-19, highlighting existing drugs with the potential to impact SARS-CoV2 through various mechanisms and the need for further clinical research to determine their efficacy in treating COVID-19.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemical Research Methods
Hilal Tayara, Ibrahim Abdelbaky, Kil To Chong
Summary: The global increase in deaths due to the COVID-19 pandemic caused by SARS-CoV-2 has prompted researchers to urgently seek potential treatments using computational methods and artificial intelligence techniques. This review discusses promising studies utilizing Omics-based data and AI algorithms as well as other computational tools to combat the pandemic.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Biochemistry & Molecular Biology
Igor Jose dos Santos Nascimento, Thiago Mendonca de Aquino, Edeildo Ferreira da Silva-Junior
Summary: Viral diseases have caused numerous deaths globally, and drug repurposing is a fast and economically viable technique for finding new treatments for emerging viral diseases.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
V. S. Kulkarni, V. Alagarsamy, V. R. Solomon, P. A. Jose, S. Murugesan
Summary: Drug repurposing, which involves using existing drugs for new treatments, has gained significant attention in the context of the COVID-19 pandemic. It is seen as a crucial approach to expedite the drug discovery process and address the urgent healthcare needs. Computational and experimental methods are utilized to identify drug candidates, and artificial intelligence algorithms and bioinformatics tools are employed to understand drug-protein interactions. This article provides an overview of the strategies involved in drug repurposing and presents a list of repurposed drugs and their indications.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2023)
