Review
Immunology
Li Li, Yuan-Qiang Lu
Summary: HMGB1 is a crucial player in the inflammatory response and immunosuppression of sepsis, mediating the release of inflammatory factors and potentially contributing to the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhuo Zeng, Yingying Lan, Yu Chen, Fangqing Zuo, Yali Gong, Gaoxing Luo, Yizhi Peng, Zhiqiang Yuan
Summary: This study demonstrates that GAS5 plays a crucial role in the regulation of inflammation induced by lipopolysaccharide (LPS). By modulating the miR-155-5p/SIRT1/HMGB1 axis, GAS5 suppresses inflammatory responses, offering a potential therapeutic target for sepsis inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuanyuan Wang, Zongmin Yu, Hu Yuan, Hao Chen, Ning Xie, Zhibin Wang, Qingyan Sun, Weidong Zhang
Summary: Novel Glycyrrhetinic Acid (GA) derivatives with fused heterocycles were designed and synthesized, showing potent anti-inflammatory effects. GA-60 exhibited stronger efficacy and higher affinity for HMGB1, as well as inhibiting various inflammatory mediators. These findings suggest that inhibiting HMGB1 release with fused heterocyclic GA derivatives is a promising strategy for sepsis treatment.
BIOORGANIC CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Jian Liu, Yadong Yang, Rong Lu, Qin Liu, Shukun Hong, Zhaolong Zhang, Guoxin Hu
Summary: The study confirmed that low expression of miR-381-3p in sepsis patients can be used as a marker for discrimination. MiR-381-3p restores the inflammatory response and myocardial dysfunction caused by sepsis via regulating HMGB1.
Article
Biochemistry & Molecular Biology
Nayeon Kim, Chaeyeong Kim, Soo Ho Ryu, Wonhwa Lee, Jong-Sup Bae
Summary: CN can suppress excessive permeability induced by HMGB1 and improve vascular instability by inhibiting the release of HMGB1, leading to an increased survival rate in a mouse model of sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yi-En Liao, Yongmei Xu, Katelyn Arnold, Fuming Zhang, Jine Li, Rani Sellers, Chaoyin Yin, Vijayakanth Pagadala, Anna Marie Inman, Robert J. Linhardt, Ding Xu, Rafal Pawlinski, Jian Liu
Summary: This study discovered that a synthetic heparan sulfate octadecasaccharide (18-mer) can effectively prevent sepsis and reduce related injuries and inflammation. The 18-mer inhibits the pro-inflammatory activity of histone H3 and HMGB1, while eliciting the anti-inflammatory effect of ApoA-I. By directly interacting with proteins, the 18-mer neutralizes cytotoxic histone H3 and separates HMGB1 and lipopolysaccharide complex, thereby reducing cell death and tissue damage in sepsis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Wonhwa Lee, Hui-Ji Choi, Hyunchae Sim, Samyeol Choo, Gyu Yong Song, Jong-Sup Bae
Summary: This study investigated the potential therapeutic effect of HCE on sepsis, finding that HCE can inhibit the release of HMGB1, reduce vascular hyperpermeability, alleviate HMGB1-mediated vascular disruptions, and decrease sepsis-related mortality and tissue injury in mice.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Chaisith Sivakorn, Jutamas Dechsanga, Lawan Jamjumrus, Kobporn Boonnak, Marcus J. Schultz, Arjen M. Dorndorp, Weerapong Phumratanaprapin, Ranistha Ratanarat, Thummaporn Naorungroj, Patchrapa Wattanawinitchai, Tanaya Siripoon, Chatnapa Duangdee, Tachpon Techarang
Summary: The study investigated prognostic biomarkers, HMGB1 and IL-6, at the time of admission in ICU for severe COVID-19 patients. Elevated levels of HMGB1 and IL-6 were associated with severity of illness and poor prognosis in these patients. Plasma HMGB1 and IL-6 levels at ICU admission may serve as prognostic biomarkers for critically ill COVID-19 patients.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biochemistry & Molecular Biology
Roberta Vitali, Anna Barbara Mancuso, Francesca Palone, Claudio Pioli, Vincenzo Cesi, Anna Negroni, Salvatore Cucchiara, Salvatore Oliva, Claudia Carissimi, Ilaria Laudadio, Laura Stronati
Summary: It has been found that extracellular HMGB1 has a role in inflammatory disorders, including IBD. This study explored the relationship between HMGB1 and PARP1 in controlling intestinal inflammation. The results show that PARP1 promotes HMGB1 secretion in intestinal inflammation, and inhibiting PARP1 may be a new approach to manage IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Alex R. Schuurman, Tom D. Y. Reijnders, Anno Saris, Ivan Ramirez Moral, Michiel Schinkel, Justin de Brabander, Christine van Linge, Louis Vermeulen, Brendon P. Scicluna, W. Joost Wiersinga, Felipe A. Vieira Braga, Tom van der Poll
Summary: This study integrated single-cell data from patients with COVID-19, influenza, and non-infectious controls, revealing unique immune features in CAP patients caused by different pathogens, such as varied levels of NK cells and CD8 T EMRA cells.
Article
Biotechnology & Applied Microbiology
Quan Wen, Ngaikeung Lau, Huandi Weng, Peng Ye, Shaohui Du, Chun Li, Jianping Lv, Hui Li
Summary: This study demonstrated that chrysophanol has protective effects against lipopolysaccharide-induced acute lung injury (ALI) by regulating the HMGB1/NF-κB signaling pathway through HDAC3.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Hong-Hua Song, Tian-Cheng Song, Ting Yang, Chun-Shuai Sun, Bing-Qiang He, Hui Li, Ying-Jie Wang, Yu Li, Hao Wu, Yu-Ming Hu, Yong-Jun Wang
Summary: The study demonstrates that HMGB1 mediates the astrocyte inflammatory response through regulating the COX2/PGE2 signaling pathway.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yifeng Zhang, Jing Sun, Yu Dong, Xiaoran Shen, Zhenyu Zhang
Summary: vicenin-2 shows inhibitory effects on the gastric carcinogen signaling induced by H. pylori, protecting gastric cells and enhancing antioxidant expression to prevent gastric cancer development.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jaehong Kim, Samyeol Choo, Hyunchae Sim, Moon-Chang Baek, Jong-Sup Bae
Summary: The study demonstrated that Biapenem (BIPM) reduces vascular permeability and increases survival in a septic mouse model through inhibition of HMGB1 release. BIPM significantly suppresses HMGB1 release, inhibits vascular permeability, reduces inflammatory proteins, and decreases tissue injury markers.
PHARMACOLOGICAL REPORTS
(2021)
Article
Hematology
Brian M. Dulmovits, Yuefeng Tang, Julien Papoin, Mingzhu He, Jianhua Li, Huan Yang, Meghan E. Addorisio, Lauren Kennedy, Mushran Khan, Elena Brindley, Ryan J. Ashley, Cheryl Ackert-Bicknell, John Hale, Ryo Kurita, Yukio Nakamura, Betty Diamond, Betsy J. Barnes, Olivier Hermine, Patrick G. Gallagher, Laurie A. Steiner, Jeffrey M. Lipton, Naomi Taylor, Narla Mohandas, Ulf Andersson, Yousef Al-Abed, Kevin J. Tracey, Lionel Blanc
Summary: High mobility group box-1 protein (HMGB1) interferes with EPO signaling pathways, leading to reduced expansion and increased death of EPO-sensitive erythroid precursors in patients with anemia of inflammation. This study provides important insights into the chronic phase of anemia of inflammation.
Editorial Material
Plant Sciences
Oliul Hassan, Kyung-Min Kim, Taehyun Chang
Article
Plant Sciences
Eun Chan Kang, Oliul Hassan, Kyung-Min Kim, Taehyun Chang
Summary: Jujube is a valuable crop in South Korea, used for its medicinal and economic benefits. However, anthracnose caused by Colletotrichum spp. is a significant problem for jujube growers, leading to economic losses. In this study, two species of Colletotrichum, C. gloeosporioides sensu stricto and C. nymphaeae, were identified as the causal agents of anthracnose in jujube orchards. The isolates showed high sensitivity to azoxystrobin, highlighting its potential as a control measure. This study is also the first report of jujube anthracnose caused by C. nymphaeae in South Korea.
Article
Chemistry, Physical
Dineshkumar Mani, Minh Canh Vu, Choong-Sun Lim, Jun-Beom Kim, Tae-Hyeong Jeong, Hye Jin Kim, Md Akhtarul Islam, Jung-Hyurk Lim, Kyung-Min Kim, Sung-Ryong Kim
Summary: This study fabricates stretched GnP/PU films using the stretching-induced alignment method and finds that these films exhibit excellent thermal conductivity and EMI shielding performance, with improvements of 679% and 60% compared to unstretched samples. The outstanding performance can be attributed to the horizontal alignment of GnP sheets in the PU matrix, reducing interfacial thermal resistance and facilitating effective phonon and electron transfer.
Review
Rehabilitation
Kyung-Min Kim, Alan R. Needle, Joo-Sung Kim, Yong Woo An, David Cruz-Diaz, Wolfgang Taube
Summary: The purpose of this study was to identify, critically appraise, and synthesize the existing evidence on the effects of therapeutic interventions on arthrogenic muscle inhibition (AMI) in patients with chronic ankle instability (CAI). Nine studies were included, and the findings suggest that focal ankle joint cooling and transcranial direct current stimulation may be effective in counteracting AMI. However, the current evidence is limited to primarily short-term studies to draw definitive conclusions.
DISABILITY AND REHABILITATION
(2023)
Article
Environmental Sciences
Rahmatullah Jan, Saleem Asif, Sajjad Asaf, Lubna, Xiao-Xuan Du, Jae-Ryoung Park, Kim Nari, Dibya Bhatta, In-jung Lee, Kyung-Min Kim
Summary: The increased use of arsenic in synthetic products has led to a significant increase in arsenic pollution in the environment. This study found that melatonin can reduce arsenic stress by inducing anthocyanin biosynthesis in rice plants. Melatonin also reduces arsenic uptake and translocation in rice plants.
ENVIRONMENTAL POLLUTION
(2023)
Article
Plant Sciences
Ibrahim Khan, Sajjad Asaf, Rahmatullah Jan, Saqib Bilal, Abdul Latif Lubna, Abdul Latif Khan, Kyung-Min Kim, Ahmed Al-Harrasi
Summary: This study investigated the role of WRKY and bHLH transcription factors in cadmium stress tolerance in tomato. Genomic analysis revealed duplication events and gene loss in Arabidopsis and tomato during evolution. Transcriptomics analysis showed differential expression of WRKY and bHLH genes in response to cadmium stress and their involvement in stress-signaling pathways. These findings provide insights into the transcriptional control of WRKY and bHLH genes and have implications for improving stress-tolerant tomato varieties.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Hye-In Yeom, Jingyu Kim, Guk-Jin Jeon, Jeongwoo Park, Dong Uk Han, Joohyeong Kim, Kyung Min Kim, Bonggeun Shong, Sang-Hee Ko Park
Summary: In this study, a metal-oxide semiconductor-insulator-metal (MSIM) diode was developed using atomic layer deposition-assisted interface engineering. The diode exhibited a high on-off ratio, low off-current density, and good reliability. The operation mechanism of the diode was analyzed and its conduction mechanism and energy band diagram were proposed.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Geunyoung Kim, Seoil Son, Hanchan Song, Jae Bum Jeon, Jiyun Lee, Woon Hyung Cheong, Shinhyun Choi, Kyung Min Kim
Summary: A Pt/Ta2O5/Nb2O5-x/Al2O3-y/Ti CTM stack with high retention and array-level uniformity is proposed as a reliable selector-less MCA. It exhibits self-rectifying and nonlinear current-voltage characteristics, making it suitable for non-volatile analog applications.
Article
Plant Sciences
Dan-Dan Zhao, Yoon-Hee Jang, Eun-Gyeong Kim, Jae-Ryoung Park, Rahmatullah Jan, Lubna, Sajjad Asaf, Saleem Asif, Muhammad Farooq, Hyunjung Chung, Dong-Jin Kang, Kyung-Min Kim
Summary: We identified a new quantitative trait locus (QTL) for lodging resistance in rice, specifically related to typhoon resistance. Through observation and analysis of a rice population's resistance to typhoons, we detected five QTLs for lodging resistance. The locus RM3343-RM20318 on chromosome 6, particularly the loci qTyM6 and qTyH6, exhibited significant effects on lodging resistance. Further analysis of the genes within this locus revealed potential candidates for improving lodging resistance. This study provides valuable insights into rice breeding and improving resilience to typhoons.
Article
Biochemistry & Molecular Biology
Muhammad Aizaz, Waqar Ahmad, Sajjad Asaf, Ibrahim Khan, Syed Saad Jan, Safiya Salim Alamri, Saqib Bilal, Rahmatullah Jan, Kyung-Min Kim, Ahmed Al-Harrasi
Summary: In this study, 26 halophilic fungi were isolated from the coastal region of Muscat, Oman and evaluated for their plant growth-promoting activities. Among them, 16 strains produced IAA and 11 strains significantly improved seed germination and seedling growth of wheat. Four strains (MGRF1, MGRF2, GREF2, and TQRF9) were found to alleviate 150 mM salt stress and enhance shoot length in wheat.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Yoon-Hee Jang, Jae-Ryoung Park, Eun-Gyeong Kim, Rahmatullah Jan, Saleem Asif, Muhammad Farooq, Dan-Dan Zhao, Kyung-Min Kim
Summary: The gelatinization temperature of rice plays a crucial role in its eating and cooking quality, as well as consumer preference. Alkali digestion value (ADV) is a commonly used method to assess rice quality and is highly correlated with gelatinization temperature. This study utilized QTL analysis to identify genetic factors related to ADV in brown and milled rice. Through this analysis, 12 QTLs related to ADV were identified, and a screening of candidate genes in the chromosome 6 region resulted in the selection of 20 genes. Among these, OsSS1q6 showed a high expression level and has been found to interact with starch biosynthesis-related proteins. Therefore, OsSS1q6 may play a role in regulating the gelatinization temperature of rice through the control of starch biosynthesis. This study provides valuable insights for breeding high-quality rice and offers a new genetic resource for improving rice palatability.
MOLECULAR BREEDING
(2023)
Article
Chemistry, Multidisciplinary
Ji-Young Noh, Yun-Su Kuk, Tae-Eun Kim, Ho-Jin Yoo, Sung-Ryong Kim, Ki-Young Kim, Jung-Hyurk Lim, Kyung-Min Kim
Summary: A series of PAN co- or terpolymers were synthesized as carbon fiber precursors using MA as a neutral comonomer and fa or ma as acidic comonomer. The cyclization reaction efficiency of PAN polymers containing fa or ma was significantly improved compared to PAN homopolymer. Furthermore, the char yield of PAN co- or terpolymers was similar to PAN homopolymer.
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
(2023)
Article
Chemistry, Multidisciplinary
Woojoon Park, Gwangmin Kim, Jae Hyun In, Hakseung Rhee, Hanchan Song, Juseong Park, Alba Martinez, Kyung Min Kim
Summary: By inserting Au nanodots into NbOx devices, fast threshold switching behaviors can be achieved for spike generators in neuromorphic computing and stochastic clock generators in security devices. The Au nanodots increase the threshold voltage and provide a higher ON current by modulating the oxygen contents at the electrode-oxide interface compared to nanodot-free NbOx devices. Furthermore, reducing the volume of the local switching region decreases the thermal capacitance of the system, allowing for maximum spike amplitude generation. Therefore, the incorporation of Au nanodots increases the spike amplitude of NbOx devices by 6 times, without the need for any additional external circuit elements.
Article
Environmental Sciences
Dibya Bhatta, Arjun Adhikari, Sang-Mo Kang, Eun-Hae Kwon, Rahmatullah Jan, Kyung-Min Kim, In-Jung Lee
Summary: Microorganisms, specifically the Serratia marcescens DB1, have been identified as effective in reducing heavy metal toxicity in rice crops. The DB1 inoculation resulted in decreased metal accumulation in rice shoots, enhanced morphological growth, and regulation of endogenous phytohormones and uptake of essential elements.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Jae-Ryoung Park, Eun-Gyeong Kim, Yoon-Hee Jang, Sang Yong Nam, Kyung-Min Kim
Summary: Rice is the main source of calories for the world's population, but the whitebacked planthopper (WBPH) is an insect that causes losses in rice yield. In this study, the possibility of using rice extracts (C7 and cq-9) as insect repellents was investigated. The results showed that C7 and cq-9 had low attraction for WBPH, and spraying them did not negatively affect plant height. This research is valuable for managing WBPH resistance and avoiding environmental pollution during rice cultivation.