Article
Endocrinology & Metabolism
Verena Fischer, Deniz Ragipoglu, Johanna Diedrich, Lena Steppe, Anne Dudeck, Konrad Schutze, Miriam Kalbitz, Florian Gebhard, Melanie Haffner-Luntzer, Anita Ignatius
Summary: Mast cells play a critical role in osteoporosis development, with mast cell-deficient mice being protected from ovariectomy-induced bone loss. Mast cells trigger inflammatory responses and regulate osteoblast and osteoclast activities, as well as RANKL levels in the serum, negatively affecting bone fracture healing under estrogen-deficient conditions. Targeting mast cells may offer a therapeutic strategy for improving disturbed bone repair in postmenopausal osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xing Guo, Kai Zhong, LongFei Zou, Hao Xue, ShuLing Zheng, Jiang Guo, Hui Lv, Ke Duan, DengHua Huang, MeiYun Tan
Summary: This study found that antibiotic treatment leads to dysbiosis of the gut microbiota in mice, which in turn affects bone development and bone density. On the other hand, probiotic treatment promotes fracture healing in osteoporotic mice after dysbiosis, potentially through inhibiting the RAS/RANKL/RANK pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Simon Kwoon Ho Chow, Can Cui, Keith Yu Kin Cheng, Yu Ning Chim, Jinyu Wang, Carissa Hing Wai Wong, Ka Wai Ng, Ronald Man Yeung Wong, Wing Hoi Cheung
Summary: The study found that low-magnitude high-frequency vibration can improve the inflammatory response at the fracture site by activating the p38 MAPK pathway, but does not directly affect the polarization of macrophages. This suggests that p38 MAPK regulates the enhancement effects of mechanical stimulation in vivo, while the exact mechanism may involve further investigation into different subsets of immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Zhengmeng Yang, Lu Feng, Ming Wang, Yucong Li, Shanshan Bai, Xuan Lu, Haixing Wang, Xiaoting Zhang, Yaofeng Wang, Sien Lin, Micky D. Tortorella, Gang Li
Summary: Sesamin has been found to promote osteoporotic fracture healing by activating the BMP2 signaling pathway and enhancing chondrogenesis and angiogenesis activities.
Article
Biotechnology & Applied Microbiology
Zhengqiu Dai, Guoqiang Wei
Summary: Osteoporotic patients often have slow bone repair, and this study explored the role and potential mechanism of miR-100 in the osteogenic differentiation ability of BMSCs. The results showed that miR-100 expression was significantly upregulated in bone tissues and BMSCs from osteoporotic mice. MiR-100 deficiency improved the osteogenic function of BMSCs by activating the AKT/mTOR pathway.
Article
Medicine, Research & Experimental
Changju Hou, Xuepeng Wang, Wu Jiang, Zhenyu Bian, Liulong Zhu, Maoqiang Li
Summary: The study found that 11R-VIVIT promotes bone formation, accelerates fracture healing, and enhances osteogenic differentiation of osteoporotic BMSCs into osteoblasts rather than adipocytes. Mechanistic analysis revealed that 11R-VIVIT promotes autophagy by blocking the AKT/NFATc1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
J. Li, R. M. Y. Wong, Y. L. Chung, S. S. Y. Leung, S. K-H Chow, M. Ip, W-H Cheung
Summary: With the increasing aging population, fragility fractures have become one of the most common conditions. This study investigates whether microbiological outcomes and fracture-healing are worse in osteoporotic bone compared to normal bone with fracture-related infection (FRI).
BONE & JOINT RESEARCH
(2022)
Article
Engineering, Biomedical
Lena Batoon, Susan M. Millard, Liza J. Raggatt, Cheyenne Sandrock, Edmund Pickering, Kyle Williams, Lucas W. H. Sun, Andy C. Wu, Katharine M. Irvine, Peter Pivonka, Vaida Glatt, Martin E. Wullschleger, David A. Hume, Allison R. Pettit
Summary: Research using mouse models investigated the bone regenerative potential of CSF1-Fc in healthy and osteoporotic fractures, revealing an effective treatment regimen that improves fracture union and strength.
Article
Cell Biology
Maaike Schilperoort, Jan Kroon, Sander Kooijman, Annelies E. Smit, Max Gentenaar, Kathrin Mletzko, Felix N. Schmidt, Leo van Ruijven, Bjoern Busse, Alberto M. Pereira, Natasha M. Appelman-Dijkstra, Nathalie Bravenboer, Patrick C. N. Rensen, Onno C. Meijer, Elizabeth M. Winter
Summary: The flattening of the GC rhythm disrupts the circadian clock in bone, resulting in an osteoporotic phenotype in mice with reduced bone strength and stiffness. This suggests that the fracture risk associated with GC therapy may be partly due to a disturbed GC rhythm rather than just excess GC exposure, and that a dampened GC rhythm may contribute to age-related osteoporosis risk.
Article
Orthopedics
Natalie K. Y. Wee, Sanja Novak, Debolina Ghosh, Sierra H. Root, Ian M. Dickerson, Ivo Kalajzic
Summary: The aim of this study was to determine if the inhibition of CGRP signaling negatively affected fracture healing. The results showed that inhibiting CGRP by deleting CLR or using BIBN-4096 delayed bone healing.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Ju Zhang, Shibo Liu, Ze He, Hanghang Liu, Yao Liu, Pei Hu, Zhongming Li, Jiazhuang Xu, En Luo
Summary: This study explored the role of adiponectin (APN) in promoting bone fracture healing by regulating the balance between osteogenesis and adipogenesis. The results showed that APN has pro-osteogenesis and anti-adipogenesis properties in bone marrow mesenchymal stem cells. Sirt1 and Wnt signaling were also found to be involved in the commitment of APN in promoting bone formation.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Jun Peng, Sheng Xiao, Juan Xie, Wan Fu
Summary: Appropriate fracture pain management not only improves the patient's subjective perception, but also increases compliance with rehabilitation training. Bulleyaconitine A (BLA), a non-addictive analgesic medicine, has the potential to be used as a promising treatment for fracture pain. BLA can alleviate fracture-induced mechanical and thermal hyperalgesia, promote bone mineralization, and therefore enhance fracture healing.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
R. M. Y. Wong, V. M. H. Choy, J. Li, T. K. Li, Y. N. Chim, M. C. M. Li, J. C. Y. Cheng, K-S Leung, S. K-H Chow, W. H. Cheung
Summary: The study showed that LMHFV can enhance fibrinolysis, accelerate fracture healing, and improve mechanical properties. It is a promising intervention for osteoporotic fracture healing that justifies further translation to clinical studies.
BONE & JOINT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Silvia Concetta Colucci, Cinzia Buccoliero, Lorenzo Sanesi, Mariella Errede, Graziana Colaianni, Tiziana Annese, Mohd Parvez Khan, Roberta Zerlotin, Manuela Dicarlo, Ernestina Schipani, Kenneth M. Kozloff, Maria Grano
Summary: The study found that irisin promotes bone formation and accelerates the fracture healing process, suggesting its potential use as a novel pharmacologic modulator.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
WeiHang Ding, RuiQing Ji, Sai Yao, PengFei Ruan, Fei Ye, XiuLong Lou, LiPing Ni, YuChi Ji, Jie Chen, WeiFeng Ji
Summary: Hu'po Anshen decoction (HPASD) can promote the healing of traumatic brain injury (TBI) combined with a fracture by regulating the expression of bone morphogenetic protein 2 (BMP2). Our findings demonstrate that HPASD induces COX2 transcription through the BMP2-Smad1/5/9-RUNX2 axis, and then affects fracture healing through the COX2-mediated EP4-ERK1/2-RSK2-ATF4 axis.
