Review
Biochemistry & Molecular Biology
Mikolaj Cichon, Magdalena Trzeciak, Malgorzata Sokolowska-Wojdylo, Roman J. Nowicki
Summary: Skin adverse reactions to diabetes medical devices, particularly adhesive components, have become a frequent concern. Allergic and irritant contact dermatitis have been observed due to allergens present in adhesives or medical device parts, primarily acrylate chemicals such as isobornyl acrylate (IBOA) and epoxy resin, as well as colophonium and nickel. Additionally, repetitive occlusion and maceration of the skin contribute to the development of skin lesions. This study aims to highlight the burden of contact dermatitis caused by diabetes medical devices and explore potential mechanisms in diabetic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Sayantan Majumdar, Saurabh D. Kalamkar, Shashikant Dudhgaonkar, Kishor M. Shelgikar, Saroj Ghaskadbi, Pranay Goel
Summary: This study analyzed continuous glucose monitoring data and found that the standard model for estimating glycated hemoglobin levels was not reliable for the Indian population. Two new estimation methods were proposed and 95% confidence and prediction intervals were provided.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Davida F. Kruger, John E. Anderson
Summary: Recent studies have shown the clinical utility of CGM in T2D patients, with significant reductions in A1c levels and health resource utilization. However, current eligibility criteria are denying many individuals access to this valuable technology. Therefore, modifying these criteria is necessary for more people to benefit from CGM.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Summary: The ADA Standards of Medical Care in Diabetes provides recommendations, care components, treatment goals, and evaluation tools for diabetes management. Diabetes technology includes hardware, devices, and software to help manage the condition, but the complexity and rapid changes in technology may pose barriers to implementation for patients and providers.
Article
Endocrinology & Metabolism
Summary: The American Diabetes Association (ADA) Standards of Medical Care in Diabetes provide clinical practice recommendations, treatment goals, and evaluation tools. The standards are updated by a professional committee and include a detailed introduction and evidence grading system.
Review
Pharmacology & Pharmacy
Daniel A. Domingo-Lopez, Giulia Lattanzi, Lucien H. J. Schreiber, Eimear J. Wallace, Robert Wylie, Janice O'Sullivan, Eimear B. Dolan, Garry P. Duffy
Summary: This review discusses the recent technological advances in controlling and reversing Type 1 diabetes mellitus (T1DM), including glucose monitors, hormone delivery systems, control algorithms, and islet transplantation. These advancements aim to reduce hypo- and hyperglycaemic episodes and improve the effectiveness of treatment.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Endocrinology & Metabolism
Margaret L. Lawson, Kate C. Verbeeten, Jennilea M. Courtney, Brenda J. Bradley, Karen McAssey, Cheril Clarson, Susan Kirsch, Jacqueline R. Curtis, Farid H. Mahmud, Christine Richardson, Tammy Cooper, Jason Chan, Ken Tang
Summary: This study found that initiating CGM simultaneously with insulin pump therapy and providing LGS in children and adolescents can improve CGM adherence, leading to improved HbA1c levels. There is a significant association between CGM use time and HbA1c levels.
PEDIATRIC DIABETES
(2021)
Article
Computer Science, Information Systems
Simon Lebech Cichosz, Morten Hasselstrom Jensen, Ole Hejlesen
Summary: This study aimed to develop and validate a model for predicting future CGM measurements to overcome time-delay. Using an artificial neural network regression approach, the model yielded good results in both internal and external validation, performing better than alternative methods.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2021)
Review
Endocrinology & Metabolism
Yu Song, Xiaodan Zhai, Yu Bai, Cong Liu, Le Zhang
Summary: Gestational diabetes mellitus is a common endocrine disease during pregnancy that can lead to adverse pregnancy outcomes. Continuous glucose monitoring (CGM) can effectively monitor blood glucose changes and improve gestational outcomes by reducing fluctuations and serious hypoglycemia or hyperglycemia events. Time in range (TIR) is an important indicator of blood glucose level, and patients with higher TIR during pregnancy have better outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jacquelyn Manfredo, Tyger Lin, Radhika Gupta, Kai Abiola, Margaret West, Kelly Busin, Julia Tracey, Elizabeth A. Brown, Sheela N. Magge, Risa M. Wolf
Summary: A 10-day trial of continuous glucose monitoring (CGM) did not improve short-term or long-term glycemic control in youth with type 2 diabetes (T2D). However, most participants reported behavioral changes and expressed a desire to continue using CGM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Summary: The American Diabetes Association provides clinical practice recommendations and tools for evaluating diabetes care quality through their medical care standards. The standards are updated annually and comments are welcome on their professional website.
Article
Endocrinology & Metabolism
Summary: The ADA Standards of Medical Care in Diabetes offers recommendations and guidelines for diabetes care, with updates made by a multidisciplinary expert committee annually. Readers are invited to provide feedback on the standards through the professional website.
Article
Chemistry, Applied
Haoran Liu, Longyingzi Xie, Yiwen Wang, Yanlin Liu, Ruijie Fu, Yongliang Cui, Qiyang Zhao, Chengqiu Wang, Bining Jiao, Yue He
Summary: A portable immunosensor based on ALP-labeled and secondary antibody-modified AuNPs is proposed for sensitive detection of CBD. The enzymatic reactions and signal amplification strategy involving AuNPs enable a low detection limit of 0.37 ng/mL. Good-consistency results are obtained when using this portable method to analyze citrus fruit, canned citrus, and cabbage, demonstrating its potential for CBD monitoring in resource-poor settings.
Article
Endocrinology & Metabolism
Andrea K. Steck, Fran Dong, Cristy Geno Rasmussen, Kimberly Bautista, Flor Sepulveda, Judith Baxter, Liping Yu, Brigitte I. Frohnert, Marian J. Rewers, ASK Study Grp
Summary: Continuous glucose monitoring (CGM) metrics can be used to predict the risk of children with persistently positive islet autoantibodies progressing to clinical diabetes. Higher average sensor glucose levels and increased glycemic variability are predictive factors. Children with more than 10% of time spent with glucose levels above 140 mg/dL have a high risk of developing clinical diabetes within one year. CGM should be included in the monitoring of high-risk children and could be used as an entry criterion for prevention trials.
Article
Endocrinology & Metabolism
Andrea K. Steck, Fran Dong, Cristy Geno Rasmussen, Kimberly Bautista, Flor Sepulveda, Judith Baxter, Liping Yu, Brigitte Frohnert, Marian J. Rewers, Marian Rewers
Summary: This study indicates that continuous glucose monitoring data above specific glucose levels are closely associated with the risk of antibody-positive children progressing to clinical diabetes. CGM may be an important tool for monitoring and prevention trials for high-risk children.
Review
Endocrinology & Metabolism
Lutz Heinemann, Trung Nguyen, Timothy S. S. Bailey, Ahmed Hassoun, Bernd Kulzer, Teresa Oliveria, Yves Reznik, Harold W. W. de Valk, Julia K. K. Mader
Summary: Innovations in syringe and pen needle technology have significantly improved insulin delivery for people with diabetes. Advances in needle design, including shorter lengths and finer gauges, have led to improved injection experience. Coupled with education on proper injection technique, these advancements contribute to better clinical outcomes and patient satisfaction. Insulin syringes and pens will continue to be reliable and cost-effective means of insulin delivery, especially in developing countries.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Norbert Hermanns, Dominic Ehrmann, Lutz Heinemann, Guido Freckmann, Delia Waldenmaier, Peter Calhoun
Summary: The study combined data from two landmark trials and found that continuous glucose monitoring had good diagnostic performance in predicting future severe hypoglycemia. It was also observed that the cutoff values for indicating elevated hypoglycemia risk were lower in open CGM compared to masked CGM.
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Stefan Pleus, Guido Freckmann, Sebastian Schauer, Lutz Heinemann, Ralph Ziegler, Linong Ji, Viswanathan Mohan, Luis Eduardo Calliari, Rolf Hinzmann
Summary: Self-monitoring of blood glucose (SMBG) is considered crucial for diabetes management, improving glycemic control and quality of life. Despite advancements in technology and accuracy, some SMBG systems do not meet international standards. Reports from China, India, and Brazil suggest additional obstacles for optimized SMBG usage. Nonetheless, proper utilization of SMBG data is highly relevant for managing type 2 diabetes mellitus.
Article
Endocrinology & Metabolism
Manuel Eichenlaub, Ralph Ziegler, Lutz Heinemann, Delia Waldenmaier, Ulrike Kamecke, Cornelia Haug, Guido Freckmann
Summary: Recent in vitro experiments have observed periodic fluctuations in the delivered amount of insulin during basal rate and consecutive bolus delivery in some patch pumps, calling for a more systematic characterization of these patterns. Different devices of the same patch pump model showed variability in the periodic delivery patterns. There seems to be a connection between the insulin delivery mechanism and the observed delivery patterns of the patch pumps, but the clinical impact is still unclear.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Andreas Thomas, Lutz Heinemann
Summary: Home and work environments can affect the function and safety of diabetes medical devices. Manufacturers take precautions to minimize the impact of environmental factors on their products. They investigate how various environmental factors may affect the devices during development and provide operational documents and guarantees. They also study any adverse interactions that may occur between medical devices.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
John Walsh, Ruth Roberts, Timothy S. Bailey, Lutz Heinemann
Summary: This study proposes the establishment of an Insulin Advisory Committee to develop insulin titration guidelines 100 years after its discovery. Despite significant advances in diabetes technology, glucose control metrics remain poor. The lack of clear insulin titration guidelines has led to inefficiencies in reaching recommended glycemic goals, with healthcare providers and patients managing insulin titrations as they see fit. This review details the widespread problems in current insulin delivery devices and presents a method for optimized total daily doses of insulin to address hyperglycemia.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Jennifer L. Sherr, Lutz Heinemann, G. Alexander Fleming, Richard M. Bergenstal, Daniela Bruttomesso, Helene Hanaire, Reinhard W. Holl, John R. Petrie, Anne L. Peters, Mark Evans
Summary: A technologically advanced solution for managing diabetes in patients requiring intensive insulin therapy has been sought for many years. Recent advancements in continuous glucose monitoring have led to the development of automated insulin delivery systems, which have begun to be integrated into clinical care. This consensus report provides an overview of the current landscape of these systems, with a focus on safety, and includes recommended actions for improvement.
Editorial Material
Endocrinology & Metabolism
Andreas Thomas, Lutz Heinemann
Summary: The development of technology has been remarkable in recent decades, including in the fields of information technology, biotechnology, and genetic engineering. However, despite rapid advancements in diabetes technology, a technical cure for diabetes has not yet been achieved. There seems to be a gap between high technology and its application in medical technology, leaving patients and experts questioning why modern technologies are not more visible in treating diabetes. Understanding the various steps involved in developing and implementing a product is essential for successful development and marketing.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Lutz Heinemann, Johan Jendle
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Jingtong Huang, Andrea M. Yeung, David Kerr, Sandro Gentile, Lutz Heinemann, Mohammed E. Al-Sofiani, Jeffrey I. Joseph, Jane Jeffrie Seley, David C. Klonoff
Summary: This article reviews the current status of practical knowledge related to insulin-associated lipohypertrophy (LH), a commonly caused accumulation of fatty subcutaneous nodules resulting from repeated injections and/or infusions of insulin into the same site. Injecting insulin into areas with lipohypertrophy is associated with reduced pain but may interfere with insulin absorption and increase the risk of glucose variability, hypo- and hyperglycemia. Early diagnosis of lipohypertrophy can be achieved using modern visualization technology such as ultrasound. Education on insulin injection techniques can prevent and treat the physiological and psychological consequences of developing insulin lipohypertrophy.
ENDOCRINE PRACTICE
(2023)
Editorial Material
Endocrinology & Metabolism
Norbert Hermanns, Bernd Kulzer, David C. Klonoff, Lutz Heinemann
Summary: Diabetes technology is a rapidly evolving field, but the evaluation of new technologies often lags behind. This Catch 22 dilemma presents a challenge: either the evaluation falls behind or technologies are used without proper assessment. This paper aims to discuss ideas for timely assessment that considers the pace of technological development and the need for evidence and safety improvement.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Letter
Endocrinology & Metabolism
Nina Jendrike, Guido Freckmann, Collin Krauss, Jochen Mende, Delia Waldenmaier, Lutz Heinemann, Zahra Anita Trippe, Sabine Websky
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Lutz Heinemann
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Tiffany Tian, Rachel E. Aaron, Jingtong Huang, Andrea M. Yeung, Jannet Svensson, Sandro Gentile, Angus Forbes, Lutz Heinemann, Jane Jeffrie Seley, David Kerr, David C. Klonoff
Summary: Lipohypertrophy is a common skin complication in insulin-treated diabetes that is often underestimated as a contributing factor to suboptimal blood sugar control, glucose variability, and hypoglycemia. In a recent Webinar by the Diabetes Technology Society, international experts provided updates on the latest knowledge related to lipohypertrophy for clinicians, educators, researchers, and insulin delivery industries. The recorded session of the Webinar is freely available on the Diabetes Technology Society Web site (https://www.diabetestechnology.org/).
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
