Article
Chemistry, Multidisciplinary
Sung Soo Kwak, Seonggwang Yoo, Raudel Avila, Ha Uk Chung, Hyoyoung Jeong, Claire Liu, Jamie L. Vogl, Joohee Kim, Hong-Joon Yoon, Yoonseok Park, Hanjun Ryu, Geumbee Lee, Jihye Kim, Jahyun Koo, Yong Suk Oh, Sungbong Kim, Shuai Xu, Zichen Zhao, Zhaoqian Xie, Yonggang Huang, John A. Rogers
Summary: Continuous monitoring of vital signs is crucial for neonatal and pediatric intensive care units, especially for extremely premature and critically ill patients. Optimized materials, open layouts, and precurved designs significantly improve the current sensor platforms, reducing skin injuries, promoting moisture release, and enabling triggered reduction of adhesion to minimize potential harm from device removal. Systematic benchtop testing and computational modeling identify key mechanisms and considerations for continuous, clinical-grade monitoring of conventional vital signs and unconventional health indicators.
ADVANCED MATERIALS
(2021)
Article
Pediatrics
Naren Siva, Philip Knight, Akash Deep
Summary: During the COVID-19 global pandemic, there was a need to develop surge capacity in healthcare institutions, expanding roles and responsibilities within paediatric intensive care units to care for both critically ill adults and children. A UK tertiary hospital in a hard-hit area shared their experience managing this surge, providing reproducible approaches for trainees and global pediatricians assisting in critical care strategies and future pandemic planning.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Dongmei Chen, Lu Cao, Wenjing Li
Summary: The etiological distribution characteristics of pediatric patients with severe pneumonia in the Pediatric Intensive Care Unit (PICU) were analyzed in this study. The results showed that bacteria and viruses were common pathogens causing severe pneumonia in children. As age increased, the detection rate of bacteria decreased, and the pathogenic spectrum gradually shifted from bacteria to mycoplasma and viruses, with an increase in mixed infections. In clinical practice, the rational selection of antimicrobial drugs should take into account the pathogenic characteristics of different age, gender, and onset season.
Review
Medicine, General & Internal
Rebecca Bockholt, Shaleen Paschke, Lars Heubner, Bergoi Ibarlucea, Alexander Laupp, Zeljko Janicijevic, Stephanie Klinghammer, Sascha Balakin, Manfred F. Maitz, Carsten Werner, Gianaurelio Cuniberti, Larysa Baraban, Peter Markus Spieth
Summary: This narrative review summarizes the current literature on real-time monitoring of blood parameters in intensive care units. Both invasive and non-invasive methods are discussed in terms of their advantages and disadvantages. The review aims to introduce well-known and lesser-known devices, as well as discuss potential future directions in research and development of realtime sensor systems.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Maria Concetta Pastore, Federica Ilardi, Andrea Stefanini, Giulia Elena Mandoli, Stefano Palermi, Francesco Bandera, Giovanni Benfari, Roberta Esposito, Matteo Lisi, Annalisa Pasquini, Ciro Santoro, Serafina Valente, Antonello D'Andrea, Matteo Cameli
Summary: Due to advances in medical therapy and assist devices, managing patients in the cardiac intensive care unit (CICU) is becoming more challenging. Noninvasive tools, such as echocardiography, can provide personalized approaches to patients based on their clinical phenotypes, helping to optimize therapeutic strategies and guide interventions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Zongliang Zheng, Jiabin Xu, Zhipeng Li, Xu Wu, Chengliang Wang, Ping Yin, Yuanhong Zou, Yuhang Zhang, Zhenkai Zhou, Gongwen Gan, Shuyue Jia, Jingkai Zhang, Cheng-Wei Qiu, Qing Zhang
Summary: Wireless respiration monitoring of multiple human subjects is achieved using facemask-integrated flexible meta-antennas, allowing for long-term, robust, and low-cost monitoring.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Pharmacology & Pharmacy
Nicholas A. Ettinger, Amy Kiskaddon, Lindsay McNeely, Justin Craycraft, Amber Rogers, Barbara-Jo Achuff, Danielle Guffey, Matthew Musick
Summary: This study investigated the use of chloral hydrate (CH) in mechanically-ventilated, critically ill children in a pediatric intensive care unit (PICU). The findings showed that CH-exposed children were younger and had longer duration of mechanical ventilation and hospital admission compared to those who did not receive CH.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Joni Minor, Ali Smith, Frederic Deutsch, John A. Kellum
Summary: The study found that electronic urine output monitoring is more accurate than nurse-performed manual measurements, as nurses tend to overestimate hourly urine output, leading to delays in detecting oliguria and potentially missing cases of acute kidney injury (AKI).
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Marina Caballero-Bellon, Anna Alonso-Saladrigues, Sara Bobillo-Perez, Anna Faura, Laura Arques, Cristina Rivera, Albert Catala, Jose Luis Dapena, Susana Rives, Iolanda Jordan
Summary: CAR-T-cell CD19 therapy is an effective treatment for relapsed/refractory B-cell acute lymphoblastic leukemia. However, it can lead to life-threatening toxicities that often require admission to the PICU. This study aims to describe the clinical characteristics, treatment, and outcome of these patients. The results showed that the main reason for PICU admission after CAR-T therapy was cytokine release syndrome, and supportive treatment was effective in managing and improving survival. Some patients may experience a fulminant course with CAR-T-associated hemophagocytic lymphohistiocytosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Joao Jorge, Mauricio Villarroel, Hamish Tomlinson, Oliver Gibson, Julie L. Darbyshire, Jody Ede, Mirae Harford, John Duncan Young, Lionel Tarassenko, Peter Watkinson
Summary: This study aimed to evaluate the feasibility of introducing a non-contact video camera monitoring system into an acute clinical setting. The results showed that non-contact monitoring accurately assessed heart rate and respiratory rate, detected changes in vital signs, and helped track early signs of physiological deterioration during post-operative care.
NPJ DIGITAL MEDICINE
(2022)
Article
Engineering, Biomedical
Ian Costanzo, Devdip Sen, Joseph Adegite, Pratap M. Rao, Ulkuhan Guler
Summary: Transcutaneous monitoring is a noninvasive method that continuously measures oxygen and carbon dioxide diffusion through the skin, with this study demonstrating a prototype monitor using luminescence technology to accurately measure transcutaneous oxygen levels. The sensor showed a stable performance under fixed conditions, accurately measuring oxygen partial pressure changes in a relevant medical range in lab testing.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2021)
Article
Endocrinology & Metabolism
Shivani Agarwal, Justin Mathew, Georgia M. Davis, Alethea Shephardson, Ann Levine, Rita Louard, Agustina Urrutia, Citlalli Perez-Guzman, Guillermo E. Umpierrez, Limin Peng, Francisco J. Pasquel
Summary: This study conducted real-time continuous glucose monitoring in a group of COVID-19 patients, finding high accuracy and significant reduction in the frequency of point-of-care glucose testing during critical illness.
Article
Medicine, General & Internal
Gurkan Bozan, Vicente Perez-Brocal, Kaan Aslan, Eylem Kiral, Esra Sevketoglu, Mutlu Uysal Yazici, Ebru Azapagasi, Tanil Kendirli, Serhat Emeksiz, Oguz Dursun, Dincer Yildizdas, Ayse Berna Anil, Nihal Akcay, Hasan Serdar Kihtir, Merve Havan, Nazan Ulgen Tekerek, Faruk Ekinci, Omer Kilic, Andres Moya, Ener Cagri Dinleyici
Summary: The composition of microbiota in the intestines and nasopharynx of children with invasive meningococcal disease (IMD) was found to be different from that of healthy children. The infection itself or other care interventions led to changes in the microbiota composition. Understanding the interaction of microbiota with pathogens, such as N. meningitidis, could help us understand the dynamics of the disease.
Article
Biochemistry & Molecular Biology
Lucia W. J. M. Streng, Calvin J. de Wijs, Nicolaas J. H. Raat, Patricia A. C. Specht, Dimitri Sneiders, Marielle van der Kaaij, Henrik Endeman, Egbert G. Mik, Floor A. Harms
Summary: This study assessed mitochondrial function in COVID-19 patients and found that mitochondrial oxygenation and consumption may be impaired in these patients, suggesting increased metabolism and mitochondrial damage.
Article
Immunology
Tazio Maleitzke, Sijia Zhou, Dario Zocholl, Florian Nima Fleckenstein, David Alexander Back, Julius Maximilian Plewe, Jerome Weber, Tobias Winkler, Ulrich Stoeckle, Serafeim Tsitsilonis, Sven Maerdian
Summary: Knife crime has increased in Northern Europe, leading to an increase in stab injury cases. This study aims to analyze routine laboratory parameters and their association with ICU admission, hospitalization, and surgeries in stab injury patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Ulkuhan Guler, Yaoyao Jia, Maysam Ghovanloo
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2020)
Article
Engineering, Biomedical
Yaoyao Jia, Ulkuhan Guler, Yen-Pang Lai, Yan Gong, Arthur Weber, Wen Li, Maysam Ghovanloo
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2020)
Article
Engineering, Biomedical
Ian Costanzo, Devdip Sen, Joseph Adegite, Pratap M. Rao, Ulkuhan Guler
Summary: Transcutaneous monitoring is a noninvasive method that continuously measures oxygen and carbon dioxide diffusion through the skin, with this study demonstrating a prototype monitor using luminescence technology to accurately measure transcutaneous oxygen levels. The sensor showed a stable performance under fixed conditions, accurately measuring oxygen partial pressure changes in a relevant medical range in lab testing.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2021)
Article
Computer Science, Information Systems
Vladimir Vakhter, Betul Soysal, Patrick Schaumont, Ulkuhan Guler
Summary: With the proliferation of proactive mobile healthcare, the landscape of miniaturized wireless biomedical devices (MWBDs) is rapidly expanding. However, the adoption of these technologies poses privacy and security risks to their users. Therefore, ensuring the security of MWBDs is crucial, and threat modeling is the first step in this process.
IEEE INTERNET OF THINGS JOURNAL
(2022)
Article
Chemistry, Analytical
Aatreya Chakravarti, Amin Hazrati Marangalou, Ian Matthew Costanzo, Devdip Sen, Mirco Sciulli, Yusuke Tsuno, Ulkuhan Guler
Summary: This paper presents a prototype of a fully wireless photometry system with multi-color and multi-region functions, utilizing an integrated circuit and multiple functional modules to address limitations of traditional systems. The new system demonstrates excellent performance in laboratory testing, offering possibilities for future in vivo experiments.
Article
Engineering, Electrical & Electronic
Guido Di Patrizio Stanchieri, Andrea De Marcellis, Marco Faccio, Elia Palange, Ulkuhan Guler
Summary: This paper presents a novel analog front-end circuit for measuring light intensity variations in various fields. The circuit converts light intensity variations into frequency output signals, eliminating the need for amplifiers and analog-to-digital converters. Experimental results validate the performance of the proposed solution in terms of sensitivity, resolution, and time response.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Biomedical
Vladimir Vakhter, Burak Kahraman, Guixue Bu, Foroohar Foroozan, Ulkuhan Guler
Summary: Transcutaneous oxygen monitoring is a noninvasive method that measures the partial pressure of oxygen diffusing through the skin. Luminescent oxygen sensing, particularly the lifetime-based method, is effective in assessing transcutaneous oxygen. A compact prototype with custom firmware was developed for accurate transcutaneous oxygen measurements, and experiments on human volunteers demonstrated its success in detecting changes in oxygen pressure. The prototype is believed to be the first to use the lifetime-based technique in measuring transcutaneous oxygen in human subjects.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2023)
Article
Engineering, Biomedical
Tuna B. Tufan, Ulkuhan Guler
Summary: The measurement of arterial carbon dioxide plays a critical role in assessing the acid-base and respiratory status of the human body. Transcutaneous monitoring is a noninvasive method that provides continuous measurement of arterial carbon dioxide. We developed a miniaturized transcutaneous carbon dioxide monitor that accurately identifies changes in arterial carbon dioxide using a luminescence sensing film and a time-domain dual lifetime referencing method. The monitor is more reliable than current technology and has been demonstrated to effectively detect slight changes in transcutaneous carbon dioxide.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Ian Costanzo, Devdip Sen, Ulkuhan Guler
2020 IEEE CUSTOM INTEGRATED CIRCUITS CONFERENCE (CICC)
(2020)