Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Endocrinology & Metabolism
Leena Mamilly, Lucy D. Mastrandrea, Claudia Mosquera Vasquez, Brett Klamer, Mahmoud Kallash, Ahmad Aldughiem
Summary: Diabetic nephropathy is a common microvascular complication in type 1 diabetes mellitus. Urinary markers of renal damage or oxidative stress may signal early stages of DN, but their association with blood pressure patterns and glycemic variability in children is not yet well understood. This study found that while microalbuminuria was negative, urinary NGAL/Cr and pentosidine/Cr ratios were significantly elevated in diabetic patients. Additionally, poor nocturnal systolic blood pressure dipping was found in nearly half of the cases, and urinary NGAL/Cr negatively correlated with this dipping pattern. Both NGAL/Cr and pentosidine/Cr ratios were also higher in the high glycemic variability group. Overall, this pilot study highlights the potential role of ABPM and urinary markers in the early detection of diabetic nephropathy, with glycemic variability possibly playing a role in the disease process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Kurianowicz, Maria Klatka, Agnieszka Polak, Anna Hymos, Dominika Bebnowska, Martyna Podgajna, Rafal Hrynkiewicz, Olga Sierawska, Paulina Niedzwiedzka-Rystwej
Summary: This study found significant differences in the expression levels of TLR2, TLR4, and TLR9 in early stage and chronically treated DM1 patients compared to healthy controls. Additionally, differences were observed in the numbers of CD19+ B cells, CD3+ CD4+, CD3+ CD8+ T cells and NK cells among newly diagnosed DM1 individuals, chronic patients, and healthy controls. Higher levels of IL-10 were also found in newly diagnosed DM1 patients, consistent with existing literature reports.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Review
Biochemistry & Molecular Biology
Flavia Urbano, Ilaria Farella, Giacomina Brunetti, Maria Felicia Faienza
Summary: Type 1 diabetes is a common chronic disease in childhood with increasing incidence. The management of T1D requires lifelong insulin treatment and continuous healthcare support. Automated insulin delivery systems, such as continuous subcutaneous insulin infusion combined with continuous glucose monitoring, have improved metabolic control and quality of life for T1D patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Noah Gruber, Moran Shemesh-Iron, Ethel Kraft, Karen Mitelberg, Elinor Mauda, Michal Ben-Ami, Kineret Mazor-Aronovitch, Yael Levy-Shraga, Neriya Levran, Noah Levek, Eyal Zimlichman, Orit Pinhas-Hamiel
Summary: This study aimed to assess the effectiveness of virtual reality (VR) technology in reducing pain and anxiety, improving adherence and glycemic control among children with type 1 diabetes (T1D). The results showed that VR significantly improved pain and anxiety, adherence, patient-reported outcome measures (PROMs), and glycemic control in children with T1D.
ACTA DIABETOLOGICA
(2023)
Article
Medicine, General & Internal
Jing Luo, Robert Feldman, Katherine Callaway Kim, Scott Rothenberger, Mary Korytkowski, Inmaculada Hernandez, Walid F. Gellad
Summary: This retrospective cohort study aimed to assess the association between high out-of-pocket costs and the initiation of SGLT2 inhibitors or GLP-1 receptor agonists in adults with type 2 diabetes and established cardiovascular disease. The study found that patients with the highest out-of-pocket costs were 13% less likely to initiate a GLP-1 RA and 20% less likely to initiate an SGLT2 inhibitor compared to those with the lowest out-of-pocket costs.
Article
Endocrinology & Metabolism
Fiona L. Mahler, Daniel Konrad, Markus A. Landolt
Summary: This study examined the relationship between perceived stress and treatment adherence as well as metabolic control in pediatric patients with type 1 diabetes and their families. The results showed that perceived stress was associated with treatment adherence and metabolic control.
JOURNAL OF DIABETES RESEARCH
(2022)
Review
Endocrinology & Metabolism
Gianluca Piccolo, Elena Lucia De Rose, Marta Bassi, Flavia Napoli, Nicola Minuto, Mohamad Maghnie, Giuseppa Patti, Giuseppe d'Annunzio
Summary: Diabetes mellitus is associated with impaired immune response and increases the risk of severe infectious diseases. The COVID-19 pandemic has greatly affected diabetes patients, especially those with comorbidities or poor glycemic control. Advanced tools for glycemic management and improved metabolic control can mitigate the negative impact of infections in pediatric diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Otorhinolaryngology
Irfan Kara, Fatih Temiz, Adem Doganer, Saime Sagiroglu, Muhammed Gazi Yildiz, Nagihan Bilal, Israfil Orhan
Summary: This study aimed to investigate the effects of type 1 diabetes on the voice in pediatric patients. The results showed that there was a certain impact on voice quality, but the difference was not statistically significant. Further studies with larger samples are needed to confirm this effect.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Psychology, Clinical
Andreas Schmitt, Dominic Ehrmann, Nadine Kuniss, Nicolle Mueller, Bernhard Kulzer, Norbert Hermanns
Summary: The study evaluates the German version of the Fear of Diabetes Complications Questionnaire (FDCQ) in people with type 1 diabetes (T1D) and type 2 diabetes (T2D). Results show that the FDCQ is a reliable and valid tool for assessing fear of diabetes complications and is associated with diabetes distress and depressive symptoms. It may help identify individuals in need of tailored education and care and monitor treatment effects.
Review
Multidisciplinary Sciences
Colin M. Dayan, Rachel E. J. Besser, Richard A. Oram, William Hagopian, Manu Vatish, Owen Bendor-Samuel, Matthew D. Snape, John A. Todd
Summary: Recent studies have shown that monitoring pancreatic islet autoantibodies and genetic risk assessment can identify most children who will develop T1D, with immunotherapy and primary prevention methods showing success in delaying disease progression. By shifting focus towards early diagnosis and b cell preservation, a future without daily insulin injections for children with T1D is anticipated.
Article
Pediatrics
Kristen Favel, Cherry Mammen, Constadina Panagiotopoulos
Summary: This study investigates the adherence to albuminuria screening and the occurrence of abnormal urine albumin-creatinine ratio (ACR) tests in children with type 1 diabetes. The results show suboptimal adherence to albuminuria screening in the pediatric diabetes clinic, with further deterioration during the COVID-19 pandemic.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Monika Grabia, Katarzyna Socha, Jolanta Soroczynska, Artur Bossowski, Renata Markiewicz-Zukowska
Summary: The aim of this study was to evaluate the body's ability to defend against oxidative stress (OS) in individuals with type 1 diabetes mellitus (T1DM) and the impact of metabolic management, antioxidant intake, and glycemic monitoring systems (GMS). The results showed that T1DM patients were more susceptible to OS compared to healthy individuals, and flash and continuous systems were beneficial in improving OS parameters. Additionally, dietary intake of vitamin A and C had an effect on serum total antioxidant status.
Article
Endocrinology & Metabolism
Ananta Addala, Marie Auzanneau, Kellee Miller, Werner Maier, Nicole Foster, Thomas Kapellen, Ashby Walker, Joachim Rosenbauer, David M. Maahs, Reinhard W. Holl
Summary: This study examined the impact of socioeconomic status on diabetes technology use and glycemic control in youth. The results showed that in the T1DX registry in the United States, participants with lower socioeconomic status had higher levels of glycated hemoglobin, and the gap in HbA(1c) by SES widened over the past decade; whereas in the DPV registry in Germany, the influence of SES on technology use and glycemic control was weaker.