Review
Chemistry, Analytical
Gabrielle Kosoy, Benjamin L. Miller
Summary: Arrayed imaging reflectometry (AIR) is a thin-film interference sensor technique that can be used for detecting various biomolecules and pathogens, and it has high sensitivity and multiplex capability.
Article
Biochemistry & Molecular Biology
Shang-Jun Yin, Min-Woo Park, Bit-Na Lee, Jun-Mo Yang, Yong-Doo Park, Guo-Ying Qian
Summary: The study used HTS approaches to identify critical factors associated with ALDH1 in human keratinocytes, revealing novel genes related to AD and hub proteins in the PPI maps.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Oncology
Lin Lin, Nathanael Kane, Naoko Kobayashi, Evelyn A. Kono, Joyce M. Yamashiro, Nicholas G. Nickols, Robert E. Reiter
Summary: In prostate cancer models, high-dose radiotherapy induced an early increase of MDSCs, followed by a transient rise of functionally active CD8 TILs. However, systemic depletion of MDSCs did not enhance the antitumor efficacy of high-dose radiotherapy due to compensatory Treg-mediated immune suppression, suggesting that targeting both MDSCs and Tregs may be necessary to enhance radiotherapy-induced antitumor immunity.
CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
G. M. Aparna, Kishore K. R. Tetala
Summary: Microarrays have become a pioneering technology in the last two decades and have proven their significance in various fields of biology. They are extensively used to screen, identify, and gain insights into the characteristics of biomolecules individually or in complex solutions. This review explores the development of biomolecule-based microarray applications since 2018, covering different printing strategies, substrate surface modification, biomolecule immobilization techniques, detection methods, and applications. The focus from 2018 to 2022 has been on using biomolecule-based microarrays for biomarker identification, virus detection, differentiation of pathogens, etc. Potential future applications include personalized medicine, vaccine candidate screening, toxin screening, pathogen identification, and posttranslational modifications.
Article
Immunology
Basudev Paudyal, Adam McNee, Pramila Rijal, B. Veronica Carr, Alejandro Nunez, John McCauley, Rodney S. Daniels, Alain R. Townsend, John A. Hammond, Elma Tchilian
Summary: Prophylactic intravenous administration of specific monoclonal antibodies in pigs showed significant reduction in lung pathology and virus loads, but not consistent reduction in nasal shedding. The effect on lung pathology and virus load is consistent across different doses, suggesting that lower doses may be effective in reducing disease severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Ayse Gulbin Kavak, Murat Surucu, Kang-Hyun Ahn, Erik Pearson, Bulent Aydogan
Summary: This study evaluated the impact of respiratory motion on lung dose during linac-based intensity-modulated total marrow irradiation (IMTMI) using two different approaches. The results showed that respiratory motion has minimal impact on the mean lung dose, indicating negligible dose uncertainty for patients treated with IMTMI.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hideki Kojima, Masayori Ishikawa, Makoto Takigami
Summary: This study investigates the change of charge collection efficiency of ionization chambers in flattening filter free beams, and proposes a correction method to obtain chamber-independent percent depth dose profiles. The results show that using this method can reduce the deviation of percent depth dose profiles.
Article
Genetics & Heredity
Bhavani S. Kowtharapu, Jyoti Damaraju, Nitesh Kumar Singh, Josefin Ziebart, Rainer Bader, Dirk Koczan, Oliver Stachs
Summary: In this study, the effects of AC EFs on corneal epithelial cell gene and protein expression profiles were investigated. The results show that AC EFs have no harmful effects on epithelial cell function, and influence biological processes related to organic substances, chemicals, or external stimuli. Both gene and protein arrays activate pathways such as cytokine-cytokine receptor interaction, MAPK, and IL-17 signaling pathways. The protein array data demonstrate enrichment of various signaling pathways through interconnected networks.
Article
Immunology
Richard T. Kangethe, Eva M. Winger, Tirumala Bharani K. Settypalli, Sneha Datta, Viskam Wijewardana, Charles E. Lamien, Hermann Unger, Theresa H. T. Coetzer, Giovanni Cattoli, Adama Diallo
Summary: This study investigated the effects of irradiation on the infectivity and gene expression of Trypanosoma evansi, a parasite that causes surra in mammalian hosts. Irradiation at different doses affected the parasite's ability to establish disease in mice and altered gene transcript abundance. Gene ontology analysis revealed the involvement of different cellular processes at different doses and time points post-irradiation. These findings provide important insights into the infection mechanism of the parasite and suggest a potential strategy for developing a whole parasite vaccine.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shi-quan Zhu, Bian-hua Zhou, Pan-pan Tan, Jun Chai, Ya-ming Yu, Hong-wei Wang
Summary: The results of the experiment revealed that treatment with 2.5 mmol/L fluoride caused an upregulation of certain cytokines in skeletal muscle cells, including MIP-3 alpha, IL-21, and IL-13. This could induce cytotoxicity by disrupting the expression of Th17-related cytokines.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Oncology
Yanyan Jiang, Jennifer Martin, Maryam Alkadhimi, Kay Shigemori, Paul Kinchesh, Stuart Gilchrist, Veerle Kersemans, Sean Smart, James M. Thompson, Mark A. Hill, Mark J. O'Connor, Barry R. Davies, Anderson J. Ryan
Summary: The study found that the addition of olaparib increased the therapeutic index of hemithoracic radiation in a mouse model of lung cancer, enhancing anti-tumour efficacy without increasing lung toxicity.
BRITISH JOURNAL OF CANCER
(2021)
Article
Immunology
Yulin Wang, Jiaqi Li, Xue Zhang, Man Liu, Longtao Ji, Ting Yang, Kaijuan Wang, Chunhua Song, Peng Wang, Hua Ye, Jianxiang Shi, Liping Dai
Summary: This study aims to discover new autoantibodies against tumor-associated antigens (TAAs) and establish diagnostic models for the diagnosis of lung cancer and discrimination of pulmonary nodules (PNs). Ten TAAs autoantibodies were discovered using protein microarray, and their serum level in lung cancer patients was higher than that in normal individuals. A diagnostic model consisting of 4 TAAs and CEA could effectively diagnose lung cancer. Additionally, five TAAs showed significant differences between malignant and benign pulmonary nodules, and a model was developed for distinguishing between the two.
CLINICAL IMMUNOLOGY
(2023)
Article
Materials Science, Ceramics
Xinwei Yuan, Sosuke Kondo, Kiyohiro Yabuuchi, Hao Yu, Yasuyuki Ogino, Ryuta Kasada
Summary: In this study, the effect of annealing temperature on the proportion of fiber shrinkage and swelling in SiC fiber-reinforced matrix composites (SiCf/SiC) was investigated. The results showed that the compressive displacement of the fibers increased by more than 1.5 times after annealing, and significant swelling was observed. This study provides insights into the mechanism of irradiation-induced fiber amorphization and can be useful for the development of improved SiCf/SiC materials.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Multidisciplinary Sciences
Shanaz A. Ghandhi, Igor Shuryak, Brian Ponnaiya, Xuefeng Wu, Guy Garty, Shad R. Morton, Salan P. Kaur, Sally A. Amundson
Summary: The study found that analyzing gene expression levels in mouse blood can accurately reflect radiation doses, which is more reliable than using a healthy human blood model. Using 30 radiation-responsive genes, accurate dose reconstructions can be made in mice of different sexes, which is crucial for studying the health effects of radiation exposure.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Kenta Nagahori, Ning Qu, Miyuki Kuramasu, Yuki Ogawa, Daisuke Kiyoshima, Kaori Suyama, Shogo Hayashi, Kou Sakabe, Takayuki Yoshimoto, Masahiro Itoh
Summary: Re-irradiation significantly decreases testicular weights and the expression of genes related to germ cell differentiation. There are also differences in the effects of re-irradiation and single-irradiation on Sertoli cell-specific genes.
Article
Oncology
Jae-Kyung Nam, A-Ram Kim, Seo-Hyun Choi, Ji-Hee Kim, Su Chul Han, Seungwoo Park, Yong Jin Lee, Joon Kim, Jaeho Cho, Hae-June Lee, Yoon-Jin Lee
Summary: The study found that endothelial-specific HIF-1 alpha deletion can inhibit the progression of RIPF and reduce EndMT. Post-irradiation treatment with the novel HIF-1 alpha inhibitor, 2-ME, was also effective in inhibiting RIPF and EndMT.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Medicine, General & Internal
In-Ho Kim, Sang Joon Shin, Byung Woog Kang, Jihoon Kang, Dalyong Kim, Miso Kim, Jin Young Kim, Chan Kyu Kim, Hee-Jun Kim, Chi Hoon Maeng, Kwonoh Park, Inkeun Park, Woo Kyun Bae, Byeong Seok Sohn, Min-Young Lee, Jae Lyun Lee, Junglim Lee, Seung Taek Lim, Joo Han Lim, Hyun Chang, Joo Young Jung, Yoon Ji Choi, Young Seok Kim, Jaeho Cho, Jae Young Joung, Se Hoon Park, Hyo Jin Lee
Summary: The paper presents the 2nd edition of the Korean management guideline of metastatic prostate cancer, including updated changes in management and recommendations for different stages of metastatic prostate cancer. It mentions the levels of evidence (LEs) and grades of recommendation (GR) based on the principles of evidence-based medicine.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sang Yeon Kim, Jin-Mo Kim, Son Ro Lee, Hyun-Jin Kim, Jae Hee Lee, Ho Lim Choi, Yoon-Jin Lee, Yun-Sil Lee, Jaeho Cho
Summary: Lung inflammation and fibrosis caused by radiotherapy can be attenuated by inducing efferocytosis and enhancing FPR2 expression through the injection of apoptotic cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Jung Mo Lee, Hey Soo Kim, Arum Kim, Yoon Soo Chang, Jin Gu Lee, Jaeho Cho, Eun Young Kim
Summary: The study demonstrated that irradiation induced dysfunction of the autophagic pathway by activating the JAK/STAT pathway and leading to overexpression of antiapoptotic proteins. Combination treatment with ABT-737 and radiation showed significant radiosensitizing effects in K-ras mutant non-small cell lung cancer cells.
YONSEI MEDICAL JOURNAL
(2022)
Article
Oncology
Sung Uk Lee, Jae-Sung Kim, Young Seok Kim, Jaeho Cho, Seo Hee Choi, Taek-Keun Nam, Song Mi Jeong, Youngkyong Kim, Youngmin Choi, Dong Eun Lee, Won Park, Kwan Ho Cho
Summary: This study proposed the optimal definition of biochemical recurrence after salvage radiotherapy following radical prostatectomy. Serum PSA levels and PSA doubling time were important predictive parameters for distant metastasis, and their combined application enhanced predictability.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Multidisciplinary Sciences
Jason Joon Bock Lee, Eungman Lee, Won Hoon Choi, Jihun Kim, Kyung Hwan Chang, Dong Wook Kim, Han Back Shin, Tae Hyung Kim, Hwa Kyung Byun, Jaeho Cho
Summary: This study aimed to evaluate the quality of low-dose-rate prostate brachytherapy and found that appropriate dose delivery to the prostate without excessive dose to the organs at risk could be achieved with stranded seed implantation and intraoperative optimization.
Article
Oncology
Mi Sun Kim, Woong Sub Koom, Jae Ho Cho, Se-Young Kim, Ik Jae Lee
Summary: This study evaluated the outcomes and prognostic factors of salvage and palliative radiotherapy (RT) in patients with upper tract urothelial carcinoma (UTUC). The results showed that salvage and palliative RT are feasible and effective treatments for UTUC. Patients who responded to RT using intensity-modulated RT (IMRT) may have a survival benefit. Additionally, positive PD-L1 status might be associated with radiosensitivity.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Hwa Kyung Byun, Won Ick Chang, Joo Ho Lee, Chul-Kee Park, In Ah Kim, Chae-Yong Kim, Jaeho Cho, Eui Hyun Kim, Jong Hee Chang, Seok-Gu Kang, Ju Hyung Moon, Sang Hyung Lee, Jason Joon Bock Lee, Il Han Kim, Chang-Ok Suh, Chan Woo Wee, Hong In Yoon
Summary: This study aimed to compare the outcomes of adjuvant radiotherapy (ART) and surveillance in patients with grade 2 meningiomas (MNG2). The results showed that ART significantly improved progression-free survival (PFS) and progression/recurrence (P/R) in these patients, especially after complete resection.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Joongyo Lee, Hong In Yoon, Jihun Kim, Jaeho Cho, Kyung Hwan Kim, Chang-Ok Suh
Summary: This study demonstrates the association between incidental pancreatic irradiation and the risk of diabetes mellitus (DM) in patients with gastric mucosa-associated lymphoid tissue lymphoma (GML). Obesity and sex were identified as key risk factors for DM. It is important to consider the risk of DM and pay attention to the pancreas during radiotherapy planning, especially in male patients and patients with obesity.
Article
Oncology
Tae Hyung Kim, Jason Joon Bock Lee, Jaeho Cho
Summary: Our study investigated the clinical features of PSA bounce in patients undergoing brachytherapy. PSA bounce is common and distinguishing between large bounces and biochemical failures is challenging. The results showed that age, the PSA nadir value at 2 years, and prostate volume were significant factors for PSA bounce.
Review
Medicine, Research & Experimental
Eun Choi, Gil-im Mun, Joohyun Lee, Hanhee Lee, Jaeho Cho, Yun-Sil Lee
Summary: Mutations in the BRCA1 gene increase the risk of developing breast cancer, but only a minority of patients carry these mutations. A recent study suggests that reduced BRCA1 levels, rather than mutations, are responsible for almost half of all triple-negative breast cancer (TNBC) cases. Understanding the function and regulation of BRCA1 can help improve treatment strategies for BRCA1-related breast cancer patients, especially those with TNBC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Dowook Kim, Won Ick Chang, Hwa Kyung Byun, In Ah Kim, Jaeho Cho, Joo Ho Lee, Hong In Yoon, Chan Woo Wee
Summary: In patients with newly diagnosed atypical meningioma, adjuvant radiotherapy using conventional fractionation shows a dose-response relationship, with higher doses leading to better local control and survival outcomes.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Cell Biology
Seulgi Jeon, Hee Jin, Jin-Mo Kim, Youmin Hur, Eun Joo Song, Yoon-Jin Lee, Younghwa Na, Jaeho Cho, Yun-Sil Lee
Summary: The upregulation mechanisms of HSP27 during pulmonary fibrosis (PF) have been identified, and a therapeutic strategy for HSP27 inhibition to overcome PF has been provided.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Oncology
Gowoon Yang, Hong In Yoon, Joongyo Lee, Jihun Kim, Hojin Kim, Jaeho Cho, Chang Geol Lee, Jee Suk Chang, Yeona Cho, Jin Sung Kim, Kyung Hwan Kim
Summary: The study investigates the ability of effective dose to immune cells (EDIC) and pre-radiotherapy absolute lymphocyte count (ALC) to predict lymphopenia during radiotherapy (RT), treatment outcomes, and efficacy of consolidation immunotherapy in patients with non-small cell lung cancer. The combination of EDIC and pre-RT ALC can predict severe lymphopenia, recurrence, and survival, potentially serving as a biomarker for consolidation immunotherapy.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Medicine, General & Internal
Kangpyo Kim, Jaeho Cho, Ju Hyung Moon, Eui-Hyun Kim, Hong In Yoon
Summary: The efficacy of radiation therapy (RT) for recurrent or residual pituitary macroadenoma (PMA) invading extrasellar regions was evaluated in this study. The results showed that conventional RT is safe and effective for the local control of recurrent or residual PMA. Immediate postoperative RT may be beneficial for recurrent or residual PMA.
YONSEI MEDICAL JOURNAL
(2022)