Review
Pharmacology & Pharmacy
Li Yang, Yao Yang, Hongzhong Chen, Lin Mei, Xiaowei Zeng
Summary: Parenteral sustained release drug formulations have been widely used in clinical practice as preferable platforms for long-term exposure therapy. However, the requirement for hypodermic injection hinders their further applications due to issues such as needle-phobia, needle-stick injuries, and inappropriate needle reuse. Microneedles offer an alternative system that is minimally invasive and allows for self-administration.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Baorui Wang, Suohui Zhang, Guozhong Yang, Zequan Zhou, Mengzhen Xing, Han Liu, Aguo Cheng, Yunhua Gao
Summary: To reduce gastrointestinal mucosal damage caused by aspirin, a dissolvable polymeric microneedle (MN) patch loaded with aspirin was developed. The MNs, made of biodegradable polymers, puncture the skin and dissolve in the subcutaneous tissue, delivering a stable plasma concentration of aspirin through micropores created by the punctures. The stability of aspirin during MN fabrication was analyzed, and the hydrolysis rate of aspirin in the MNs was found to be less than 2%. Compared to oral administration, MN administration provides a smoother plasma concentration curve and requires a lower effective dose of antiplatelet aggregation. Aspirin-loaded MNs cause mild skin irritation and quickly recover within 24 hours.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Chemistry, Applied
Tania Moniz, Sofia A. Costa Lima, Salette Reis
Summary: Transdermal drug delivery is considered a promising route for administration of pharmaceutical and cosmetic active ingredients, with the use of microneedles as a method to enhance drug permeation. Polymer microneedles made from sustainable marine polysaccharides like chitosan have shown great potential for transdermal drug delivery.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Zhenzhen Qi, Jiaxin Cao, Xiaosheng Tao, Xinyi Wu, Subhas C. Kundu, Shenzhou Lu
Summary: Melatonin-loaded microneedles with excellent morphological, physical, and chemical properties achieved effective drug concentration through continuous release, effectively treating insomnia.
Article
Materials Science, Multidisciplinary
Tomas Bauleth-Ramos, Nesma El-Sayed, Flavia Fontana, Maria Lobita, Mohammad-Ali Shahbazi, Helder A. Santos
Summary: Dissolving microneedles (dMNs) are water-soluble polymer drug delivery systems that have become popular for transdermal drug delivery. They offer advantages such as fast dissolution, short application time, and no biohazard risk, making them suitable for various biomedical and pharmaceutical applications. The formulation of successful dMNs requires careful consideration of patch design, needles geometry, polymer composition, method of formation, and payloads, as these factors directly affect the mechanical properties and efficacy of the microneedles. This review serves as a guide for dMN formulation, discussing the challenges at each step and strategies to optimize their administration and drug release.
Article
Chemistry, Multidisciplinary
Ahlam Zaid Alkilani, Hana Abu-Zour, Anas Alshishani, Rana Abu-Huwaij, Haneen A. Basheer, Hadeel Abo-Zour
Summary: The aim of this study was to design and evaluate a transdermal delivery system for alendronate sodium (ALS) using nanocarriers to enhance permeability and prolong release. Various non-ionic formulations were produced using the ether injection method, and their characteristics were evaluated. The study successfully prepared a transdermal delivery of ALS using niosomes combined with microneedles for sustained release.
Review
Biochemistry & Molecular Biology
Zhenzhen Qi, Zheng Yan, Guohongfang Tan, Subhas C. Kundu, Shenzhou Lu
Summary: Research on smart responsive polymer microneedles aims to achieve local accurate drug release, which have advantages such as painless administration, good biocompatibility, and ease of self-administration, and hold significant research implications in transdermal drug administration.
Article
Chemistry, Multidisciplinary
Sharvari M. Kshirsagar, Thomas Kipping, Ajay K. Banga
Summary: This study demonstrated that vacuum compression molding is a novel technique for fabricating polymeric microneedles. The fabricated microneedles were pyramid-shaped, sharp, uniform, and mechanically robust. Various imaging techniques confirmed the formation of microchannels, and the release of lidocaine from the microneedles was significantly increased.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Maria C. Lobita, Nesma El-Sayed, Joao F. Pinto, Helder A. Santos
Summary: Delivery of cancer cell membranes (CM) is a new approach for cancer immunotherapy. In this study, fast dissolving microneedles (MNs) loaded with melanoma CM were developed and evaluated using two different polymers. The results show that the HA-MN system is a promising device for melanoma immunotherapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Guangsheng Du, Penghui He, Jiaxuan Zhao, Chunting He, Min Jiang, Zhihua Zhang, Zhibing Zhang, Xun Sun
Summary: Transdermal delivery systems for rheumatoid arthritis drugs, particularly biological drugs, face challenges due to skin barrier. The use of HA microneedles loaded with melittin showed promising results in inhibiting RA progression in animal models, with high mechanical strength and sustained release properties. Furthermore, the microneedles were able to suppress pro-inflammatory cytokines and increase regulatory T cell percentage, indicating potential as a new therapy for RA and other autoimmune diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Nanoscience & Nanotechnology
Yao Li, Xiao-Jie Ju, Han Fu, Chang-Hai Zhou, Yi Gao, Jun Wang, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: A composite separable microneedles system consisting of silk fibroin needle tips and hyaluronic acid base is developed for transdermal delivery of salmon calcitonin for therapy of osteoporosis. The release of salmon calcitonin can be controlled by modulating the conformation structure of silk fibroin and the interaction between salmon calcitonin peptide and silk fibroin proteins.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Chi Huang, Kaijun Gou, Xuan Yue, Shiyi Zhao, Rui Zeng, Yan Qu, Chen Zhang
Summary: This study developed a novel liposome-in-microneedles (MNs) based transdermal drug delivery system for the treatment of psoriasis. The system provides efficient drug delivery and stable drug release, improving the clinical symptoms of psoriasis. The efficacy of the system was demonstrated through in vivo experiments in mice, showing significant reduction in inflammatory response and severity of psoriatic lesions.
MATERIALS & DESIGN
(2022)
Review
Pharmacology & Pharmacy
Ziaul Karim, Preeti Karwa, Shobha Rani R. Hiremath
Summary: Transdermal drug delivery is a highly attractive route for administering pharmaceutical active ingredients. Microneedle technology, with its advantages of efficiency, painlessness, reliability, and feasibility, has gained prominence in transdermal drug delivery. Different types of microneedles can be made using various materials based on the delivery mechanism, offering promising applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Eylul Gulsen Yilmaz, Emre Ece, Ozgecan Erdem, Ismail Es, Fatih Inci
Summary: The skin, as the largest epithelial surface of the human body, is susceptible to various skin diseases. Dermal and transdermal patches or microneedles made of biocompatible and biodegradable materials offer controlled and effective delivery of medications, but their synthetic nature may have harmful environmental effects. This review explores the use of natural materials in eco-friendly patches and discusses their implementation in wound healing, skin cancer, inflammations, and infections, highlighting the importance of these studies for future perspectives.
Article
Engineering, Biomedical
Cindy Kristina Enggi, Mega Tri Satria, Nirmayanti Nirmayanti, Jesscia Theodor Usman, Julika Fajrika Nur, Rangga Meidianto Asri, Nana Juniarti Natsir Djide, Andi Dian Permana
Summary: This study developed a new transdermal gel for the treatment of hypertension by combining it with solid microneedles, which significantly enhanced the permeation of valsartan without affecting skin integrity. This approach could have significant implications for drug delivery.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Pharmacology & Pharmacy
Camila J. Picco, Emilia Utomo, Andrea McClean, Juan Dominguez-Robles, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Peter E. McKenna, Jonathan G. Acheson, Dessislava Malinova, Ryan F. Donnelly, Eneko Larraneta
Summary: Implantable drug-eluting devices have the potential to improve treatment of chronic conditions by providing sustained therapeutic effects and reducing pill burden for patients. The use of modern technologies like 3D printing allows for the production of customizable devices. In this study, subcutaneous implants loaded with olanzapine were formulated using the robocasting technique and demonstrated sustained drug release over a period of 200 days.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Correction
Pharmacology & Pharmacy
Emilia Utomo, Juan Dominguez-Robles, Natalia Moreno-Castellanos, Sarah A. Stewart, Camila J. Picco, Qonita Kurnia Anjani, Jon Ander Simon, Ivan Penuelas, Ryan F. Donnelly, Eneko Larraneta
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Engineering, Biomedical
Achmad Himawan, Lalitkumar K. Vora, Andi Dian Permana, Sumarheni Sudir, Airin R. Nurdin, Ririn Nislawati, Rafikah Hasyim, Christopher J. Scott, Ryan F. Donnelly
Summary: Extracellular tissue fluids contain important biomarkers, but their accessibility has been a challenge in clinical diagnosis and monitoring. Microneedle technology provides a minimally invasive solution to collect tissue fluid samples and utilize them for disease diagnosis and monitoring.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Qonita Kurnia Anjani, Sara Demartis, Fabiana Volpe-Zanutto, Huanhuan Li, Akmal Hidayat Bin Sabri, Elisabetta Gavini, Ryan F. F. Donnelly
Summary: Rose Bengal (RB) is a fluorescent dye used in biomedical applications, especially in dermatology. Advanced delivery systems have been developed to enhance its permeation across the skin. However, there is currently no validated method for quantitatively analyzing RB in the skin. This study proposes fluorescence-based techniques and describes the development and validation of a fluorescence-coupled HPLC method to quantify RB in the skin matrix for the first time. Qualitative analysis using multiphoton microscopy and fluorescence emission spectra provides additional insight into RB's distribution and behavior in different environments.
Article
Pharmacology & Pharmacy
Delly Ramadon, Lissa Florencia Putri Sutrisna, Yahdiana Harahap, Kurnia Sari Setio Putri, Fathin Ulayya, Pietradewi Hartrianti, Qonita Kurnia Anjani, Ryan F. Donnelly
Summary: This study aimed to formulate and evaluate Lidocaine hydrochloride (LiH)-loaded dissolving microneedles (DMNs) with different polymer bases. Based on the in vitro permeation study, LiH-loaded DMNs with hyaluronic acid (10%) and poly(vinyl pyrrolidone) (25%) were found to deposit in the skin with safe concentrations of the drug permeating into systemic circulation.+/-
Review
Pharmacology & Pharmacy
Masoud Adhami, Niamh K. Martin, Ciara Maguire, Aaron J. Courtenay, Ryan F. Donnelly, Juan Dominguez-Robles, Eneko Larraneta
Summary: Cardiovascular diseases are the leading cause of death globally. Drug eluting implants, that provide accurate drug release and minimize adverse side effects, have the potential for significant advancements in the treatment of these diseases.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Chemistry, Multidisciplinary
Li Zhao, Lalitkumar K. Vora, Stephen A. Kelly, Linlin Li, Eneko Larraneta, Helen O. McCarthy, Ryan F. Donnelly
Summary: Antibiotic resistance is a serious health problem and is expected to worsen in the future. Researchers have developed a hydrogel-forming microarray patch system that can deliver antibiotics in a sustained manner.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Ahlam Zaid Alkilani, Hadeel Abo-Zour, Haneen A. Basheer, Hana Abu-Zour, Ryan F. Donnelly
Summary: This study aimed to design and evaluate a dermal delivery system of dual antioxidants, ascorbic acid (AA) and caffeine (CAFF), using microneedles (MNs) loaded with niosomes. The results showed that AA and CAFF exhibited excellent antioxidant properties in the niosomal formulation, protecting skin cells from UV radiation and slowing down the process of photoaging. These findings are important for the development of new skincare products.
Article
Pharmacology & Pharmacy
Jon Ander Simon, Emilia Utomo, Felix Pareja, Maria Collantes, Gemma Quincoces, Aaron Otero, Margarita Ecay, Juan Dominguez-Robles, Eneko Larraneta, Ivan Penuelas
Summary: The use of intranasal implantable drug delivery systems has great potential for sustained drug delivery. This study presents a novel approach using radiolabeled risperidone intranasal implants, which can provide valuable data for the optimization of drug delivery systems. The implants were successfully administered to rats and showed a slow and steady release of the drug over a month. This experimental approach enables high-resolution imaging of drug release, contributing to the development of improved pharmaceuticals.
Review
Infectious Diseases
Adelaide Mensah, Aoife M. Rodgers, Eneko Larraneta, Lyndsey McMullan, Murtaza Tambuwala, John F. Callan, Aaron J. Courtenay
Summary: With the advancement of biomedical research, the source and delivery of antibiotics for various diseases, like periodontal diseases (PD), have gained attention. The use of antibiotics in PD treatment is important, but the emergence of resistant strains is a concern. Hydrogels, made from natural or synthetic polymers, have been extensively used in biomedical sciences for the delivery of antibacterial agents. This article reviews PD and its antibiotic treatment options, and highlights the potential of hydrogels for antibacterial agents and antibiotic drug delivery in PD.
Article
Chemistry, Medicinal
Delly Ramadon, Fathin Ulayya, Annisa Sakinah Qur'ani, Iskandarsyah Iskandarsyah, Yahdiana Harahap, Qonita Kurnia Anjani, Vania Aileen, Pietradewi Hartrianti, Ryan F. F. Donnelly
Summary: This study aimed to develop dissolving microneedles (DMN) containing ketoprofen-loaded nanosuspension (NS) and co-grinding (CG) formulations. The most promising formulations for transdermal delivery of ketoprofen were F5-MN-NS (PVA 5%-PVP 10%) and F11-MN-CG (PVA 7.5%-PVP 15%). These findings suggest that the combination of DMN with nanosuspension or a co-grinding system can effectively enhance the transdermal delivery of ketoprofen.
Article
Chemistry, Analytical
Ana-Maria Dragan, Marc Parrilla, Sofie Cambre, Juan Dominguez-Robles, Usanee Detamornrat, Ryan F. Donnelly, Radu Oprean, Cecilia Cristea, Karolien De Wael
Summary: Illicit drug consumption is a significant global concern, with MDMA being one of the commonly abused drugs. This study presents the development of a wearable electrochemical platform using a hollow microneedle array sensor for the monitoring of MDMA in interstitial fluid. The sensor exhibited excellent analytical performance, making it a promising tool for forensic toxicology and therapeutic management of patients.
MICROCHEMICAL JOURNAL
(2023)
Article
Polymer Science
Anushree Ghosh Dastidar, Susan A. Clarke, Eneko Larraneta, Fraser Buchanan, Krishna Manda
Summary: This study aimed to create porous, biomechanically comparable scaffolds and evaluate their degradation in vivo and under elevated temperature, as well as their effects on stem cells. The results showed that the scaffolds had good biomechanical properties and did not significantly affect their performance and biocompatibility during degradation.
Article
Instruments & Instrumentation
Ryan F. Donnelly, Mark R. Prausnitz
Summary: Microneedle (MN) technologies offer the opportunity to improve drug delivery and treatment by targeting specific tissues. Hollow MNs have been FDA-approved for targeted drug delivery to skin-resident immune cells and specific parts of the eye. MN technology also has applications in cosmetic products. With further research and approved products, MN technology shows promising growth potential.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Instruments & Instrumentation
Masoud Adhami, Camila J. Picco, Usanee Detamornrat, Qonita K. Anjani, Victoria A. Cornelius, Pamela Robles-Martinez, Andriana Margariti, Ryan F. Donnelly, Juan Dominguez-Robles, Eneko Larraneta
Summary: Cardiovascular diseases are a leading cause of death worldwide and significantly impact quality of life. 3D-printed biodegradable vascular grafts loaded with a drug called clopidogrel were developed using digital light processing technology. These grafts provide sustained drug release, reduce platelet deposition, and create a supportive environment for cellular attachment, viability, and growth.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)