Review
Pharmacology & Pharmacy
Tingting Zhang, Xuan Luo, Keming Xu, Wenying Zhong
Summary: This article provides an overview of the current developments in peptides and nanotechnology for transdermal drug delivery, as well as innovative strategies for enhancing skin penetration. It also discusses the therapeutic potential of peptide-containing nanoformulations in addressing various diseases and the challenges hindering clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Sourbh Suren Garg, Jeena Gupta
Summary: Poorly soluble drugs often degrade in the gastrointestinal tract, limiting their effectiveness. Oral administration faces barriers like acidic pH and presence of microflora and enzymes. Choosing a polymer that can stabilize and release the drug to its target site has been a challenge. Guar gum-based nanoformulations have been extensively used to improve drug delivery and minimize degradation risk, making them highly important.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Chang Liu, Shuhan Dong, Xue Wang, Huiqing Xu, Chang Liu, Xi Yang, Shanli Wu, Xin Jiang, Mujie Kan, Caina Xu
Summary: Infectious disease is a leading cause of death worldwide, especially in low-income countries. Antibiotic resistance has become a critical threat to global human health due to the extensive use of antibiotics. Polyphenolic compounds and their derivatives have positive therapeutic effects in antibacterial therapy, but their inherent properties limit their effectiveness. The use of nanoformulations has shown promising advantages in improving the antibacterial activity of polyphenols, enhancing their bioavailability, and providing a new therapeutic perspective for the treatment of infectious diseases.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Divya Thirumal, Rakesh K. Sindhu, Shuchi Goyal, Aayush Sehgal, Ashok Kumar, Marianesan Arockia Babu, Pradeep Kumar
Summary: Psoriasis is an inflammatory skin condition that causes various diseases and significantly affects patients' quality of life. It not only impairs the skin but also affects other parts of the body. Many variables can directly or indirectly impact the etiology of psoriasis. Psoriasis affects approximately 2% of the world's population, and significant progress has been made in understanding and treating alternative forms of psoriasis.
Review
Pharmacology & Pharmacy
Ekaterina-Michaela Tomou, Paraskevi Papakyriakopoulou, Elmina-Marina Saitani, Georgia Valsami, Natassa Pippa, Helen Skaltsa
Summary: This review explores the potential of various nanoformulations in improving the bioavailability of quercetin (QUE). Lipid-based and polymer-based nanocarriers have been widely used for enhanced oral absorption and targeting of QUE. Other formulation alternatives such as cyclodextrin, niosomes, and nanoemulsions are also proposed. Overall, this comprehensive review provides valuable insights into the role of advanced drug delivery nanosystems in QUE formulation and delivery.
Article
Chemistry, Multidisciplinary
James M. Kelvin, Madison L. Chimenti, Dan Y. Zhang, Evelyn K. Williams, Samuel G. Moore, Gabrielle M. Humber, Travon A. Baxter, Lacey A. Birnbaum, Min Qui, Henry Zecca, Aashis Thapa, Juhi Jain, Nathan T. Jui, Xiaodong Wang, Haian Fu, Yuhong Du, Melissa L. Kemp, Wilbur A. Lam, Douglas K. Graham, Deborah Deryckere, Erik C. Dreaden
Summary: Advances in multiagent chemotherapy have improved survival rates for ALL patients, but there is still a subset of non-responders or relapsing patients with low long-term survival rates. By conducting high-throughput combination drug screens, we found that MRX-2843 and vincristine synergistically inhibited the growth of B-ALL and T-ALL cell lines. Nanoparticle formulations of these drugs improved their anti-leukemia activity and reduced disease burden in an animal model of T-ALL.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Lisna Meylina, Muchtaridi Muchtaridi, I. Made Joni, Ahmed Fouad Abdelwahab Mohammed, Nasrul Wathoni
Summary: Natural compounds, such as alpha-mangostin, are being explored for their potential in cancer treatment, with nanoformulations showing promise in enhancing their efficacy through improved cellular uptake and accumulation in tumors. Specifically, polymeric nanoparticles and nanomicelles have demonstrated the ability to increase the accumulation of alpha-mangostin in tumors and inhibit tumor growth in vivo.
Review
Biochemistry & Molecular Biology
Jeffersson Krishan Trigo-Gutierrez, Yuliana Vega-Chacon, Amanda Brandao Soares, Ewerton Garcia de Oliveira Mima
Summary: Curcumin (CUR) is a natural substance with antimicrobial properties extracted from turmeric. To overcome its limitations in clinical use, drug delivery systems (DDSs) have been used to carry CUR effectively against various pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Milad Ashrafizadeh, Masoud Delfi, Ali Zarrabi, Ashkan Bigham, Esmaeel Sharifi, Navid Rabiee, Ana Claudia Paiva-Santos, Alan Prem Kumar, Shing Cheng Tan, Kiavash Hushmandi, Jun Ren, Ehsan Nazarzadeh Zare, Pooyan Makvandi
Summary: This review discusses the use of stimuli-responsive liposomes for targeted drug delivery in cancer therapy. These liposomes can be triggered by various stimuli such as pH, redox, enzymes, light, heat, and magnetic field to release drugs at tumor sites. The stimuli-responsive liposomes have shown great potential in improving the efficacy of anticancer drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Huxiao Sun, Mengsi Zhan, Serge Mignani, Dzmitry Shcharbin, Jean-Pierre Majoral, Joao Rodrigues, Xiangyang Shi, Mingwu Shen
Summary: This article reviews the design and development of curcumin nanoformulations in recent years and introduces their biomedical applications in common inflammatory diseases by regulating macrophage behaviors, thus accelerating therapeutic effects.
Article
Food Science & Technology
Sajmina Khatun, Tejaswini Appidi, Aravind Kumar Rengan
Summary: This review discusses the components, properties, and functions of casein phosphoproteins and casein micelles, as well as their potential applications in targeted drug delivery, tissue engineering, and the treatment of iron deficiency anemia and neuronal cognitive disorders.
Review
Biotechnology & Applied Microbiology
Tianxu Fang, Xiaona Cao, Mysha Ibnat, Guojun Chen
Summary: The CRISPR-Cas9 technology has revolutionized genome editing, showing great potential for treating currently incurable diseases. Efficient intracellular delivery of CRISPR-Cas9 components has been a major focus for expanding the impact of this technology. Stimuli-responsive non-viral delivery systems have been explored for their safety and controllable properties in genome editing. In this review, recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery are discussed, along with their rationale and biomedical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Acoustics
Sze Shin Low, Chang Nong Lim, Maxine Yew, Wai Siong Chai, Liang Ee Low, Sivakumar Manickam, Beng Ti Tey, Pau Loke Show
Summary: Recent advances in ultrasound have shown great potential in biomedical applications for both diagnosis and treatment. Coupling ultrasound-assisted drug delivery with nanobiomaterials can overcome limitations of conventional drug delivery systems. Ultrasound-mediated drug delivery, especially in combination with nanobiomaterials, holds promise for treating various diseases.
ULTRASONICS SONOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Hilda Amekyeh, Enas Alkhader, Rayan Sabra, Nashiru Billa
Summary: This review discusses the potential use of CUR-NPs in cancer treatment. CUR incorporation into nanoparticles enhances its pharmaceutical and therapeutic significance, improving solubility, absorption, bioavailability, stability, plasma half-life, targeted delivery, and anticancer effect. Promising anticancer activity suggests the potential application of CUR-NPs, but clinical reports are limited. Further clinical trials are needed to ensure effective translation into clinical applications.
Review
Chemistry, Medicinal
T. Srinivasa Reddy, Roby Zomer, Nitin Mantri
Summary: Medical cannabis has gained significant attention for its potential benefits in managing pain, anxiety, depression, and neurological disorders. The major phytocannabinoids derived from the cannabis plant, THC and CBD, have shown pharmacological and therapeutic properties. In particular, they have been studied for their use in cancer treatment due to their palliative effects and anticancer activities. However, their poor solubility and bioavailability limit their clinical application, thus nanotechnology-based drug delivery strategies are being developed to improve their efficacy.
PHYTOTHERAPY RESEARCH
(2023)
Letter
Endocrinology & Metabolism
A. De Luca, V. A. Baudry, M. Wargny, L. Chaillous, S. Hadjadj, B. Cariou, S. Dubois, C. Briet, V. Kerlan, I. Guilhem, G. Fradet, D. Gouet, C. Perlemoine, S. Ragot, P. J. Saulnier, P. H. Ducluzeau
DIABETES & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Sarra Smati, Blandine Tramunt, Matthieu Wargny, Cyrielle Caussy, Benedicte Gaborit, Camille Vatier, Bruno Verges, Deborah Ancelle, Coralie Amadou, Leila A. Bachir, Olivier Bourron, Christine Coffin-Boutreux, Sara Barraud, Anne Dorange, Benedicte Fremy, Jean-Francois Gautier, Natacha Germain, Etienne Larger, Stephanie Laugier-Robiolle, Laurent Meyer, Arnaud Monier, Isabelle Moura, Louis Potier, Nadia Sabbah, Dominique Seret-Begue, Patrice Winiszewski, Matthieu Pichelin, Pierre-Jean Saulnier, Samy Hadjadj, Bertrand Cariou, Pierre Gourdy
Summary: The study showed that overweight and obesity are linked to poor early prognosis in T2D patients hospitalized for COVID-19, especially in those under the age of 75. The negative impact of obesity on COVID-19 prognosis was not observed in elderly patients aged over 75, indicating a need for specific management in this population.
DIABETES OBESITY & METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guillaume Herpe, Mathieu Lederlin, Mathieu Naudin, Mickael Ohana, Kathia Chaumoitre, Jules Gregory, Valerie Vilgrain, Cornelia Anna Freitag, Constance De Margerie-Mellon, Violaine Flory, Marie Ludwig, Lydiane Mondot, Isabelle Fitton, Alexis Raymond Robert Jacquier, Paul Ardilouze, Isabelle Petit, Alban Gervaise, Olivier Bayle, Arielle Crombe, Magloire Mekuko Sokeng, Clement Thomas, Geraldine Henry, Virginie Bliah, Thomas Le Tat, Marc-Samir Guillot, Paul Gendrin, Marc Garetier, Estelle Bertolle, Catherine Montagne, Benjamin Langlet, Abdulrazak Kalaaji, Hampar Kayayan, Florian Desmots, Benjamin Dhaene, Pierre-Jean Saulnier, Remy Guillevin, Jean-Michel Bartoli, Jean-Paul Beregi, Jean Pierre Tasu
Summary: The French national experience using chest CT for COVID-19 was evaluated by comparing results with RT-PCR assays and final discharge diagnosis. Chest CT showed high sensitivity, specificity, negative predictive value, and positive predictive value in diagnosing COVID-19. The use of chest CT for initial diagnosis and triage of COVID-19 patients was successful, regardless of varying disease prevalence in different geographic areas.
Article
Geriatrics & Gerontology
Evelyne Liuu, Chunyun Hu, Simon Valero, Thomas Brunet, Amelie Jamet, Marie-Laure Bureau, Alberto Pilotto, Pierre-Jean Saulnier, Marc Paccalin
Article
Endocrinology & Metabolism
Jean-Daniel Lalau, Abdallah Al-Salameh, Samy Hadjadj, Thomas Goronflot, Nicolas Wiernsperger, Matthieu Pichelin, Ingrid Allix, Coralie Amadou, Olivier Bourron, Thierry Duriez, Jean-Francois Gautier, Anne Dutour, Celine Gonfroy, Didier Gouet, Michael Joubert, Ingrid Julier, Etienne Larger, Lucien Marchand, Michel Marre, Laurent Meyer, Frederique Olivier, Gaetan Prevost, Pascale Quiniou, Christelle Raffaitin-Cardin, Ronan Roussel, Pierre-Jean Saulnier, Dominique Seret-Begue, Charles Thivolet, Camille Vatier, Rachel Desailloud, Matthieu Wargny, Pierre Gourdy, Bertrand Cariou
Summary: Prior metformin use is associated with a lower risk of death in patients with diabetes hospitalized for COVID-19, suggesting potential benefits of metformin in this population.
DIABETES & METABOLISM
(2021)
Review
Medicine, Research & Experimental
Lena Guyon, Anne-Claire Groo, Aurelie Malzert-Freon
Summary: This review summarizes the research on surface functionalization of lipid-based nanocarriers in biomedical applications, focusing on the ligands used, functionalization methods, and purification techniques after ligand corona formation. The most effective experimental techniques for characterizing LBNC surface are described, along with outlining promising methods such as nuclear magnetic resonance spectroscopy and isothermal titration calorimetry for characterizing ligand surface corona.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Florian Daressy, Florian Malard, Line Seguy, Vincent Guerineau, Cecile Apel, Vincent Dumontet, Aude Robert, Anne-Claire Groo, Marc Litaudon, Jerome Bignon, Sandy Desrat, Aurelie Malzert-Freon, Joelle Wiels, Ewen Lescop, Fanny Roussi
Summary: Drimane sesquiterpenoid dialdehydes are natural compounds that act as potent inhibitors of MCL-1 and BCL-xL, two overexpressed proteins in various cancers, by covalently inhibiting MCL-1 and inducing apoptosis, showing selectivity for MCL-1/BCL-xL-dependent cell lines.
Article
Chemistry, Multidisciplinary
Claire Gazaille, Marion Sicot, Marthe Akiki, Nolwenn Lautram, Aurelien Dupont, Patrick Saulnier, Joel Eyer, Guillaume Bastiat
Summary: Characterizing the complex nanoassemblies is crucial for the translational approaches of nanomedicines, as demonstrated in a case study of NFL peptide adsorption. Using a chromatographic apparatus for characterization improved accuracy and reproducibility, showing potential for interactions between nanosystems and biological agents.
PHARMACEUTICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jessica Ceramella, Anne -Claire Groo, Domenico Iacopetta, Line Seguy, Annaluisa Mariconda, Francesco Puoci, Carmela Saturnino, Fanny Leroy, Marc Since, Pasquale Longo, Aurelie Malzert Freon, Maria Stefania Sinicropi
Summary: This study proposed a strategy for the safe use of the antitumor agent Cisplatin by combining it with the antioxidant Quercetin in nanoemulsions, which significantly enhanced the anticancer and antioxidant properties of both molecules while reducing cytotoxic effects on human renal cells. The process used to obtain the nanoemulsions, their physico-chemical properties, stability, and improved pharmaceutical effects suggest a high potential for future in vivo studies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Line Seguy, Lena Guyon, Manon Maurel, Pascal Verdie, Audrey Davis, Sophie Corvaisier, Vincent Lisowski, Patrick Dallemagne, Anne-Claire Groo, Aurelie Malzert-Freon
Summary: The study investigated the potential therapeutic effects of repurposed tegaserod for treating Alzheimer's disease by enhancing the nonamyloidogenic pathway. By encapsulating tegaserod into 50nm nanoemulsions with neutral zeta potential and functionalizing with peptide-22, the study demonstrated the potential value of tegaserod for AD treatment. The developed functionalized nanoemulsions showed efficiency in adsorption and controlled release of tegaserod without hemolytic properties, indicating their promise for future preclinical studies.
Review
Pharmacology & Pharmacy
Line Seguy, Anne-Claire Groo, Aurelie Malzert-Freon
Summary: This review summarizes the potential and advantages of nanocarriers in drug repurposing, suggesting that they could improve therapeutic efficacy by overcoming the issues of repurposed drugs. Although clinical trials on nanocarriers in Alzheimer's disease have not been conducted yet, recent preclinical results demonstrate their potential.
DRUG DISCOVERY TODAY
(2022)
Article
Medicine, Research & Experimental
Florian Daressy, Line Seguy, Loetitia Favre, Sophie Corvaisier, Cecile Apel, Anne-Claire Groo, Marc Litaudon, Vincent Dumontet, Aurelie Malzert-Freon, Sandy Desrat, Fanny Roussi, Aude Robert, Joelle Wiels
Summary: Overexpression of antiapoptotic members of the BCL-2 family contributes to tumor development and drug resistance. Inhibitors targeting these proteins have been developed, but alternative molecules are still needed. This study identifies a plant-derived compound, NA1-115-7, as a specific inducer of tumor cell apoptosis without toxicity to normal cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Line Seguy, Florian Daressy, Sophia Lahlil, Sophie Corvaisier, Vincent Dumontet, Marc Litaudon, Cecile Apel, Fanny Roussi, Joelle Wiels, Aude Robert, Anne-Claire Groo, Aurelie Malzert-Freon
Summary: MCL-1, an overexpressed anti-apoptotic protein in cancer, can be effectively targeted by the natural compound NA1-115-7 isolated from Zygogynum pancheri. Lipid nanoemulsions (NA-NEs) were used to improve the solubility, stability, and efficacy of NA1-115-7. The encapsulated drug showed improved stability in acidic conditions and significantly restored apoptosis in cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Oncology
Nathalie Baize, Isabelle Monnet, Laurent Greillier, Margaux Geier, Herve Lena, Henri Janicot, Alain Vergnenegre, Jacky Crequit, Regine Lamy, Jean-Bernard Auliac, Jacques Letreut, Herve Le Caer, Radj Gervais, Eric Dansin, Anne Madroszyk, Patrick-Aldo Renault, Gwenaelle Le Garff, Lionel Falchero, Henri Berard, Roland Schott, Patrick Saulnier, Christos Chouaid
Article
Respiratory System
Asma Mimouni, Etienne Rouleau, Patrick Saulnier, Amina Marouani, Med Lamine Abdelali, Taha Filali, Leila Beddar, Abdelhak Lakehal, Ahmed Hireche, Asma Boudersa, Mahmoud Aissaoui, Hacene Ramtani, Khalid Bouhedjar, Djamel Abdellouche, Messaouda Oudjehih, Ibtissem Boudokhane, Noureddine Abadi, Dalila Satta
PULMONARY MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
