Article
Biochemistry & Molecular Biology
Shabnam Kazemi, Mehrab Pourmadadi, Fatemeh Yazdian, Azam Ghadami
Summary: This study demonstrated the effective targeted delivery of curcumin anticancer drugs to MCF-7 breast cancer cells using CS-Fe3O4-RGO nanocomposites, showing superior performance of the nanocomposite material. The results suggest potential for the development of targeted drug delivery systems against various cancer cells in future research.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Zherui Zhao, Jun Gao, Wenrong Cai, Junyao Li, Yong Kong, Min Zhou
Summary: In this study, hydrogels based on oxCMC/CS were successfully synthesized, and the responsive drug delivery of 5-FU was achieved by doping GO and 5-FU. The acylhydrazone bonds between oxCMC and CS can be hydrolyzed in acidic solutions, and the doped GO can facilitate the release of 5-FU through hyperthermia generated by near infrared (NIR) irradiation. The developed drug delivery system exhibited high cytotoxicity against liver cancer cells.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Biomedical
Anandhavelu Sanmugam, S. Abbishek, S. Logesh Kumar, Ananda Babu Sairam, Vishnu Vardhan Palem, Raju Suresh Kumar, Abdulrahman I. Almansour, Natarajan Arumugam, Dhanasekaran Vikraman
Summary: The unique characteristics of chitosan, reduced graphene oxide (rGO), and cerium oxide (CeO2) based hybrid bionano-composites make them potential biomaterials for drug delivery and antimicrobial applications. The addition of biopolymers to rGO and CeO2 based nanocomposites has shown excellent performance in various applications such as biosensors, wound dressings, electrodes, microfluidic chips, drug delivery systems, and energy storage. The physiochemical characterization of the hybrid bionano-composites revealed their crystalline structure, interaction between chitosan and rGO-CeO2, and better thermal stability up to 550 degrees C. Additionally, the nanocomposites exhibited antibacterial properties and superior cell adhesion.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Eunkyung Ko, Onur Aydin, Zhengwei Li, Lauren Gapinske, Kai-Yu Huang, Taher Saif, Rashid Bashir, Hyunjoon Kong
Summary: This study demonstrates that tethering myoblasts with reduced graphene oxide (rGO) can slow down the regression of connexin 43 during early differentiation, increase myogenic mRNA synthesis, and improve muscle contraction. The resulting myotubes generated a three-fold larger contraction force than the rGO-free myotubes. A valveless biohybrid pump assembled with the rGO-tethered muscle also significantly increased fluid velocity and flow rate.
Article
Biochemistry & Molecular Biology
Congnan Cen, Feifei Wang, Yifan Wang, Huan Li, Linglin Fu, Yan Li, Jian Chen, Yanbo Wang
Summary: A novel composite film for food packaging was prepared using hydroxyethyl cellulose (HEC), carboxymethyl chitosan (CMCS), and zinc oxide nanoparticles by solution casting method. Spectroscopy, crystallography, and morphology observation confirmed the successful incorporation of nanoparticles. The addition of CMCS and ZnO improved the solvent resistance (reduced water solubility by 94.3%) and UV shielding ability (increased UV shielding capacity by 45.73%) of the film, enhancing its potential applications in water-rich foods. The composite film demonstrated efficient inhibition (>99.99% inhibition rate) of pathogenic bacteria Listeria monocytogenes and Pseudomonas aeruginosa, with the synergistic effect of CMCS and ZnO. Furthermore, CMCS and ZnO significantly enhanced the elasticity (494.34% improvement) and maximum load capacity (142.24% improvement) of the composite film.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Mazdak Hashempour, Mariangela Longhi, Luigi Brambilla, Antonello Vicenzo
Summary: This study reports on the formation of reduced graphene oxide/chitosan hybrids via L -ascorbic acid reduction and provides a detailed characterization of the hybrids. The study shows that the hybrids exhibit improved electrochemical performance and packing behavior compared to pure reduced graphene oxide.
APPLIED SURFACE SCIENCE
(2023)
Review
Polymer Science
Mohammad Iman Tayouri, Sara Estaji, Seyed Rasoul Mousavi, Samaneh Salkhi Khasraghi, Reza Jahanmardi, Sasan Nouranian, Mohammad Arjmand, Hossein Ali Khonakdar
Summary: This review paper provides an overview of the current research on the stabilization and degradation of GO and rGO-filled polymer nanocomposites. The structure, synthesis, properties, and applications of GO and rGO nanoparticles are discussed. The surface modification of graphene-based nanomaterials to improve their dispersion in polymers is also reviewed. The mechanisms associated with the thermal, photolytic, hydrolytic, and enzymatic degradation of the nanocomposites are summarized.
POLYMER DEGRADATION AND STABILITY
(2022)
Article
Environmental Sciences
Zhuang Wang, Fan Zhang, Martina G. Vijver, Willie J. G. M. Peijnenburg
Summary: The study revealed enhanced cytotoxicity of a mixture of graphene-based carbon nanomaterials and nano-zirconium oxide to freshwater algae, attributed to intracellular oxidative stress and cellular membrane changes. Mitochondria-generated ROS played a significant role in the cellular response, indicating oxidative damage to algal cells. Additionally, reduced graphene oxide showed higher cytotoxicity and oxidative stress compared to graphene nanoplatelets.
Article
Biochemistry & Molecular Biology
Umit Haydar Erol, Enes Guncum, Nuran Isiklan
Summary: In this study, flurbiprofen (FB) loaded chitosan-graphene oxide (CS-GO) blend nanoparticles (Nps) were synthesized as a controlled release system. The CS-GO Nps exhibited small average particle size and negative zeta potential, and enhanced thermal stability. The release of FB showed a two-stage behavior, and the incorporation of GO into CS Nps improved the sustained and controlled release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Sahand Parvaneh, Mehrab Pourmadadi, Majid Abdouss, Seied Ali Pourmousavi, Fatemeh Yazdian, Abbas Rahdar, Ana M. Diez-Pascual
Summary: Nanocomposite hydrogels composed of CMC/starch/RGO were synthesized and encapsulated in double nanoemulsions for pH-responsive delivery of curcumin. The nanocarriers exhibited improved drug loading and entrapment efficiencies compared to previous systems. The release experiments showed pH-responsiveness and faster release at lower pH. The developed nanocarriers were stable, uniform, and effective for sustained curcumin release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Xiangdong Wang, Jiaxing He, Lanhua Ma, Bin Yan, Lingying Shi, Rong Ran
Summary: A hybrid material of amphipathic hydroxyethyl cellulose modified with bromoacetic acid and graphene oxide was successfully prepared and utilized as Pickering emulsifiers to synthesize a functional porous hydrogel for pH-sensitive release. The stable, low cost, and biocompatible Pickering emulsion facilitated the polymerization of polyacrylamide organo-hydrogel with a stable template, demonstrating its potential for smart material preparation.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Polymer Science
Erhan Demirel, Yasemin Yuksel Durmaz
Summary: Combination therapy involving anticancer drugs and gene therapy agents has been proven effective in treating different types of cancer. In this study, a modified strategy was developed to enhance the use of reduced graphene oxide (rGO) as a carrier for delivering drugs and nucleotides. The newly designed copolymer allowed for the conjugation of a targeting peptide and the loading of hydrophobic drugs, resulting in a multifunctional nanoplatform with controlled drug release and high transfection efficiency. The experiments demonstrated the potential of this nanoplatform in selectively delivering different cargoes to tumor sites.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Physical
A. S. R. A. Subki, M. H. Mamat, M. Z. Musa, M. H. Abdullah, I. B. Shameem Banu, N. Vasimalai, M. K. Ahmad, N. Nafarizal, A. B. Suriani, A. Mohamad, M. D. Birowosuto, M. Rusop
Summary: This work presents a nanocomposite-based humidity sensor that achieves enhanced sensing performance at room temperature by incorporating reduced graphene oxide (rGO) into zinc oxide nanostructured powder (ZNP) nanoparticles. The nanocomposite-based humidity sensor was fabricated using cellulose filter paper and clear paper glue through a brush printing method. Various characterization techniques were employed to investigate the properties of the nanocomposites. The sensor showed the highest sensitivity and sensing response when loaded with 1.0 wt% of rGO.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Nidhi Pal, Somesh Banerjee, Partha Roy, Kaushik Pal
Summary: A hybrid biodegradable nanocomposite was fabricated by reinforcing CNC, rGO and Ag nanoparticles into a PVA polymer matrix, resulting in improved mechanical properties, sustained antibacterial release, and non-toxicity towards cells. The combination of CNC, rGO, and Ag showed potential for applications in tissue engineering and packaging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Abneris Morales, Sneha Seelam, Stacy A. Love, Sean M. O'Malley, Xiao Hu, David de la Cruz
Summary: In recent years, the research on biomaterials such as silk and cellulose has rapidly expanded due to their abundance, low cost, and tunable properties. This study investigated how the addition of reduced graphene oxide (rGO) affects the properties of cellulose-silk composites, such as carbohydrate crystallinity, protein secondary structure formation, and ionic conductivity. The results showed that the addition of rGO influenced the morphological and thermal properties of the composites and impacted the ionic conductivity by modifying the cellulose crystallinity and silk beta-sheet content.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Vahid Heydari, Zaker Bahreini, Majid Abdouss
Summary: Thermal control coatings (TCCs) are used to maintain the thermal condition of spacecraft by reflecting and emitting radiation, and porous ZnO particles as pigments prevent UV absorption.
PIGMENT & RESIN TECHNOLOGY
(2023)
Review
Polymer Science
Mehrnoosh Hasan Shahriari, Afra Hadjizadeh, Majid Abdouss
Summary: This review study presents the development of self-healing hydrogels, which have the property of self-healing and can be used for repairing biological defects in the whole body. It discusses the synthesis methods, types of polymers, and clinical applications of self-healing hydrogels, focusing on their recent ability to repair tissue defects.
Article
Materials Science, Composites
Mehdi Moghri, Mohammad Reza Kalaee, Majid Abdouss, Mojtaba Koosha
Summary: In this study, nanocomposites of polyvinyl chloride poly(epichlorohydrin-co-ethylene oxide)(ECO)/organoclay were prepared via melt processing and various parameters were adjusted to achieve the highest thermal stability. The results showed that the rotor speed and rubber content greatly influenced the intercalation and thermal stability of the nanocomposites. The hydrogen bonding between ECO and organoclay was found to be crucial for the miscibility of the components.
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
(2023)
Article
Polymer Science
Tajuddin Hafizi, Mehrnoosh Hasan Shahriari, Majid Abdouss, Shafiq Ahmad Kahdestani
Summary: Chitosan, a linear polysaccharide with excellent properties, has been used to prepare drug nanocarriers. In this study, chitosan nanoparticles were successfully prepared and loaded with vancomycin, demonstrating a sustained drug release.
Article
Biotechnology & Applied Microbiology
Maral Nouri Hajbaba, Mehrab Pourmadadi, Fatemeh Yazdian, Hamid Rashedi, Majid Abdouss, Dina Sadat Zhohrabi
Summary: This research evaluated the effects of chitosan/agarose-functionalized Fe2O3 nanoparticles on MCF-7 breast cancer cells and the expression of BCL2 and BAX genes. The results showed that the formulated nanoparticles induced apoptosis and inhibited cell migration in the cancer cells through modulating gene expression.
BIOTECHNOLOGY PROGRESS
(2023)
Article
Pharmacology & Pharmacy
Narges Ajalli, Mehrab Pourmadadi, Fatemeh Yazdian, Majid Abdouss, Hamid Rashedi, Abbas Rahdar
Summary: For the first time, a nano-wound dressing was designed to optimize wound healing. The synthesized nanocomposite showed excellent mechanical properties, biodegradability, antimicrobial activity, and non-toxicity. The scratch test and animal model results demonstrated that this nanocomposite accelerated wound healing, achieving a 92.25% wound healing rate after 14 days. Therefore, it has the potential to replace traditional methods for wound healing.
CURRENT DRUG DELIVERY
(2023)
Article
Materials Science, Paper & Wood
Mohammad Shadabfar, Morteza Ehsani, Hossein Ali Khonakdar, Majid Abdouss, Tayebeh Ameri
Summary: This study demonstrates a novel and environmentally-friendly method for synthesizing a conductive carbon paste by using carboxymethyl cellulose (CMC) as an eco-friendly binder combined with Graphene Nanoplatelets (GNPs) and Carbon Nanotubes (CNTs). The double-coated GNP/CNT/CMC paste films exhibit high electrical conductivity (80.4 S/m) and great flexibility. The results suggest that the developed conductive carbon paste has the potential to be used in various electronic devices.
Article
Chemistry, Physical
Mohammad Mohammadizadeh Boghrabad, Elaheh Kowsari, Seeram Ramakrishna, Saeedeh Sarabadani Tafreshi, Mahsa Gholambargani, Mahboobeh Rafieepoor Chirani, Shiva Orangi, Mohammad Gheibi, Majid Abdouss, Amutha Chinnappan, Nora H. de Leeuw
Summary: Covalently multifunctional graphene oxide (GO) with vinyl imidazole/4-tert-butylpyridine cobalt complex (GO-VI/TBP cobalt complex) was synthesized. This synthesized compound was used as an effective additive in sustainable nanocomposite electrolytes in dye-sensitized solar cells (DSSCs), increasing the conversion efficiency significantly. The addition of the compound enhanced the ion conductivity and electron transfer in the electrolyte, resulting in increased short circuit current density and open-circuit voltage.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Pharmacology & Pharmacy
Sepehr Darvishan, Mehrab Pourmadadi, Majid Abdouss, Saeedeh Mazinani, Fatemeh Yazdian, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A novel PAA-based hydrogel coated with ?-alumina modified with PVP was synthesized for the delivery of quercetin to cancer cells. The addition of Al2O3 increased pH-sensitivity, and the use of Span 80 surfactant led to a nano niosomal emulsion that improved stability and retention of quercetin. The microemulsion's physical interactions, crystalline structure, and morphology were analyzed, and drug loading efficiency was significantly improved with the double emulsion method. The developed ?-alumina-PAA/PVP nanoemulsion shows promise as a pH-sensitive drug delivery system.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Zahra Norouzi, Majid Abdouss
Summary: Considering the depletion of water resources, wastewater treatment is important for protecting the ecosystem and efficient use of water resources. In this study, beta-cyclodextrin was grafted onto chitosan to form beta-cyclodextrin grafted chitosan, which was further improved by developing nanofibers. The blend nanofibers were fabricated by electrospinning and their performance as molecular filters for removing hazardous materials from wastewater was investigated.
Article
Engineering, Chemical
Mehrnoosh Hasan Shahriari, Majid Abdouss, Afra Hadjizadeh
Summary: In this study, a new type of starch/chitosan/PVA/borax hydrogel was synthesized by adopting the one-pot method. The effect of concentration and ratio of raw materials on the final properties of hydrogels was investigated. The properties of the hydrogels were examined using various techniques, and it was found that the composite hydrogel had excellent mechanical properties and showed slow drug release.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Amin Foroozandeh, Majid Abdouss, Hossein SalarAmoli, Mehrab Pourmadadi, Fatemeh Yazdian
Summary: Early detection is crucial in controlling and treating deadly ovarian cancer among women. Nanobiosensors are being used as a time-saving tool with high selectivity and sensitivity for biomarker detection. This study developed an electrochemical aptasensor using graphitic carbon nitrides, magnetic nanoparticles, and polyaniline to detect ovarian cancer antigen 125 (CA125) biomarkers. The aptasensor showed excellent selectivity, stability, and a broad dynamic linear range for evaluating patients' and healthy individuals' serum.
PROCESS BIOCHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Neda Rostami, Mohammad Mahmoudi Gomari, Majid Abdouss, Alaa Moeinzadeh, Edris Choupani, Reza Davarnejad, Reza Heidari, Sidi A. Bencherif
Summary: In this study, biodegradable LTZ-loaded nanocarriers were synthesized, and folic acid was conjugated to enhance targeted delivery and improve efficacy and safety. The nanocarriers exhibited excellent cell compatibility and high drug loading capacity, allowing sustained release of LTZ and enhanced cytotoxicity against hormone-dependent breast cancer cells.
ACS APPLIED BIO MATERIALS
(2023)
Article
Agricultural Engineering
Mehrab Pourmadadi, Sepehr Darvishan, Majid Abdouss, Fatemeh Yazdian, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A pH-sensitive nanocomposite was synthesized by coating halloysite nanotubes (HNT) with polyacrylic acid (PAA)/carboxymethyl cellulose (CMC) hydrogel for controlled delivery of curcumin (CUR) to MCF-7 cancer cells. Hazelnut oil and Span 80 surfactant were added to minimize the nanocomposite size and increase its uniformity, and to enhance the stability and retention of CUR as an anticancer drug, respectively. The resulting drug delivery system exhibited high drug loading and encapsulation efficiency, pH-sensitivity, and sustained drug release. It also demonstrated strong toxicity against MCF-7 cancer cells and induced apoptosis. These results highlight the potential of PAA/CMC/HNT/CUR hydrogel nanocomposites as smart drug delivery vehicles for breast cancer treatment.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Physical
Soroush Nardini, Mohammad Sharifi, Jalal Fahimpour, Majid Abdouss
Summary: The effective factors of surfactant adsorption in an electrolyte-mineral solid system were investigated in this study. Results showed that increasing salinity reduced the adsorption of the surfactant on calcite, while the presence of magnesium and sulfate ions led to a decrease in adsorption. The findings can be used in controlling surfactant adsorption and designing wettability alteration processes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
