Article
Biotechnology & Applied Microbiology
Xiaoming Liu, Dandan Peng, Yixin Cao, Yuanzhe Zhu, Jianjun Yin, Guangxing Zhang, Xiaodong Peng, Yanqiu Meng
Summary: Recent studies have highlighted the crucial role of aberrant regulatory interactions in driving malignant phenotypes of hepatocellular carcinoma (HCC) cells. Specifically, the long noncoding RNA DLX6-AS1 was shown to promote HCC progression by modulating the miR-513c/Cul4A/ANXA10 axis, affecting cell viability, migration, invasion, and apoptosis. Silencing DLX6-AS1 could inhibit HCC development and provide potential therapeutic targets for HCC treatment.
CANCER GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yanming Qin, Xin Tu, Meifang Huang, Caifang Ma, Qiongqing Huang, Qiqi Huang, Hong Shu, Chao Ou
Summary: In this study, we aimed to identify long noncoding RNAs (lncRNAs) as biomarkers for hepatocellular carcinoma (HCC) diagnosis and prognosis. We analyzed lncRNA expression profiles from gene expression databases and selected four lncRNAs with high sensitivity and specificity. qPCR confirmed significantly differential expression of two lncRNAs in HCC and adjacent normal tissues. Overall, we demonstrated that the novel lncRNAs LINC01093 and MYLK-AS1 could serve as potential diagnostic and prognostic biomarkers for HCC.
DNA AND CELL BIOLOGY
(2023)
Article
Oncology
Chaohua Lv, Qingsong Wan, Chengxiang Shen, Hongsheng Wu, Bin Zhou, Weiwei Wang
Summary: In this study, the role of ZSCAN16-AS1 in hepatocellular carcinoma (HCC) was investigated, revealing its pro-oncogenic function by modulating the miR-451a/ATF2 axis. Understanding the competing endogenous RNA network of ZSCAN16-AS1/miR-451a/ATF2 in HCC could potentially lead to the development of novel therapeutic targets.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Jian Pu, Ya Zhang, Anmin Wang, Zebang Qin, Chenyi Zhuo, Wenchuan Li, Zuoming Xu, Qianli Tang, Jianchu Wang, Huamei Wei
Summary: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy, with long noncoding RNA (lncRNA) ADORA2A antisense RNA 1 (ADORA2A-AS1) identified as a tumor suppressor in HCC. ADORA2A-AS1 inhibits HCC cell proliferation, induces apoptosis, and represses migration and invasion by competitively binding HuR and downregulating the FSCN1/AKT pathway. Low expression of ADORA2A-AS1 is associated with poor survival outcomes in HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yun-Zhang Dai, Yong-da Liu, Jie Li, Mei-Ting Chen, Mei Huang, Fang Wang, Qing-Song Yang, Ji-Hang Yuan, Shu-Han Sun
Summary: This study identified the METTL16/RAB11B-AS1 regulatory axis in HCC, which represented novel targets for HCC prognosis and treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Cell Biology
Cong Cao, Jun Li, Guangzhi Li, Gaoyu Hu, Zhihua Deng, Bing Huang, Jing Yang, Jiequn Li, Song Cao
Summary: The study found that TMEM220-AS1 is significantly downregulated in HCC, promoting proliferation and metastasis of HCC cells through the miR-484/MAGI1 axis, demonstrating an important biological function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Hiroshi Kitajima, Reo Maruyama, Takeshi Niinuma, Eiichiro Yamamoto, Akira Takasawa, Kumi Takasawa, Kazuya Ishiguro, Akihiro Tsuyada, Ryo Suzuki, Gota Sudo, Toshiyuki Kubo, Kei Mitsuhashi, Masashi Idogawa, Shoichiro Tange, Mutsumi Toyota, Ayano Yoshido, Kohei Kumegawa, Masahiro Kai, Kazuyoshi Yanagihara, Takashi Tokino, Makoto Osanai, Hiroshi Nakase, Hiromu Suzuki
Summary: By analyzing H3K4me3 modification in non-tumorous gastric mucosa, researchers identified TM4SF1-AS1 as a dysregulated lncRNA in gastric cancer. TM4SF1-AS1 promotes GC cell growth and activates interferon signaling through interactions with Pur-α and YB-1. Furthermore, TM4SF1-AS1 induces stress granule formation and inhibits apoptosis in GC cells by sequestering RACK1.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Juanjuan Zhong, Jinlan Chen, Bei Wang, Zixian Zhou, Yujie Shen, Yibo Gong, Fangshun Tan, Chengfu Yuan
Summary: OIP5-AS1 is overexpressed in various tumors and plays a role in regulating tumor growth and progression in breast carcinoma, ovarian carcinoma, cervical carcinoma, lung carcinoma, laryngeal squamous cell gastric carcinoma, and hepatocellular carcinoma. Research evidence shows that OIP5-AS1 is involved in carcinoma proliferation, growth, migration, invasion, and apoptosis, indicating its potential as a biomarker or therapeutic target in multiple tumors.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Mengqin Shen, Ruixue Zhang, Wenzhi Jia, Zongping Zhu, Xiaoping Zhao, Li Zhao, Gang Huang, Jianjun Liu
Summary: The multifunction scaffold protein p54(nrb)/NONO has been found to play a crucial role in regulating hypoxia transcription signals, enhancing liver cancer progression. Clinical data has shown that NONO is significantly upregulated and associated with poor prognosis in HCC patients. NONO interacts with HIF-1/2 complexes and their downstream transcripts to facilitate the expression of hypoxia-induced genes, suggesting its potential as a therapeutic target for HCC.
Article
Gastroenterology & Hepatology
Guang-Lin Lei, Yan Niu, Si-Jie Cheng, Yuan-Yuan Li, Zhi-Fang Bai, Ling-Xiang Yu, Zhi-Xian Hong, Hu Liu, Hong-Hong Liu, Jin Yan, Yuan Gao, Shao-Geng Zhang, Zhu Chen, Rui-Sheng Li, Peng-Hui Yang
Summary: This study identified a novel lncRNA (lncRNA W42) and investigated its biological functions and clinical significance in HCC. Results demonstrated that lncRNA W42 was upregulated in HCC tissues and cells, promoting proliferative and invasive abilities while inhibiting apoptosis. Additionally, HCC patients with high lncRNA W42 expression showed shorter survival times.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhong-Ling Zhuo, Hai-Peng Xian, Yu-Jing Sun, Yan Long, Chang Liu, Bin Liang, Xiao-Tao Zhao
Summary: This study investigated the potential role of lncRNA ZFAS1 in gastric cancer and its clinical significance as a biomarker. The results showed that ZFAS1 expression was significantly higher in preoperative gastric cancer patients and correlated with lymph node metastasis, advanced TNM stage, and poor prognosis. ZFAS1 was found to regulate the proliferation, migration, and invasion of gastric cancer cells by modulating the expression of LIN28 and CAPRIN1. Therefore, ZFAS1 may serve as a potential diagnostic and prognostic biomarker in gastric cancer.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Chuan Tan, Yanyan Huang, Zheng Huang, Yuanjia Ning, Lizheng Huang, Xianjian Wu, Yuan Lu, Huamei Wei, Jian Pu
Summary: This study identified that the highly expressed ATP8B1-AS1 in hepatocellular carcinoma (HCC) is modified by N6-methyladenosine (m6A), and this m6A modification increases the transcriptional stability of ATP8B1-AS1, thereby activating MYC gene expression and exerting oncogenic effects in HCC.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Review
Medicine, Research & Experimental
Enjun Lv, Jiaqi Sheng, Chengpeng Yu, Dean Rao, Wenjie Huang
Summary: Long noncoding RNAs (lncRNAs) have gained widespread attention as new and crucial molecules involved in biological function regulation, particularly in tumor metastasis such as hepatocellular carcinoma; despite the incomplete understanding of their mechanisms, lncRNAs have been shown to be closely associated with various stages of tumor growth, invasion, and metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Chunchun Ma, Hongliang Wang, Gang Zong, Jie He, Yuyang Wang, Fan Yang, Zhihao Yang, Erbao Bian, Bing Zhao
Summary: In this study, the upregulation of HNF1A-AS1 in GBM was associated with poor patient survival, revealing its precise mechanism in promoting GBM malignancy, including regulating ENO1 expression by interacting with miR-22-3p. Knockdown of HNF1A-AS1 significantly inhibited the malignant phenotypes of GBM cells, indicating its potential as a therapeutic target.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Fangfang Jian, Xiaoxia Che, Jingjing Zhang, Chang Liu, Gedan Liu, Yujing Tang, Weiwei Feng
Summary: Aberrant expression of lncRNA SOCS2-AS1 is found to be associated with endometrial cancer, where it acts as a tumor suppressor by binding to AURKA and promoting its degradation, leading to cell cycle arrest and apoptosis in EC cells. This suggests that SOCS2-AS1 may serve as a prognostic predictor and biomarker for AURKA-inhibitor treatment in EC patients.
CELL DEATH & DISEASE
(2021)